Advanced search
Publication Cover
Molecular and Cellular Biology Volume 22, 2002 - Issue 2
Submit an article Journal homepage
19
Views
125
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Role of Translation Initiation Factor 2B in Control of Cell Survival by the Phosphatidylinositol 3-Kinase/Akt/Glycogen Synthase Kinase 3β Signaling Pathway

Marianna Pap1 Department of Biology, Boston University, Boston, Massachusetts02215;2 Department of Biology, University Medical School of Pécs, Pécs, Hungary
&
Geoffrey M. Cooper1 Department of Biology, Boston University, Boston, Massachusetts02215Correspondence[email protected]
Pages 578-586 | Received 04 Apr 2001, Accepted 15 Oct 2001, Published online: 28 Mar 2023

Citations (125)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (5)

Cristina E Tognon & Poul HB Sorensen. (2012) Targeting the insulin-like growth factor 1 receptor (IGF1R) signaling pathway for cancer therapy. Expert Opinion on Therapeutic Targets 16:1, pages 33-48.
Read now
John W. Tullai, Julie R. Graham & Geoffrey M. Cooper. (2011) A GSK-3-mediated transcriptional network maintains repression of immediate early genes in quiescent cells. Cell Cycle 10:18, pages 3072-3077.
Read now
Seong-Ho Koh, Seung Hyun Kim & Hee-Tae Kim. (2009) Role of glycogen synthase kinase-3 in l-DOPA-induced neurotoxicity. Expert Opinion on Drug Metabolism & Toxicology 5:11, pages 1359-1368.
Read now
Yoon Hee Chung, Kyeung Min Joo, Dae Jin Kim, Sung Su Kim, Kyung Yong Kim, Won Bok Lee & Choong IK Cha. (2008) Immunohistochemical study on the distribution of glycogen synthase kinase 3α in the central nervous system of SOD1G93A transgenic mice. Neurological Research 30:9, pages 926-931.
Read now
Joseph F. Sanchez, Lynn F. Sniderhan, Andrea L. Williamson, Shongshan Fan, Shikha Chakraborty-Sett & Sanjay B. Maggirwar. (2003) Glycogen Synthase Kinase 3β-Mediated Apoptosis of Primary Cortical Astrocytes Involves Inhibition of Nuclear Factor κB Signaling. Molecular and Cellular Biology 23:13, pages 4649-4662.
Read now

Articles from other publishers (120)

Vinesh S. Kamble, Tejaswini A. Pachpor, Sukeshini B. Khandagale, Vipul V. Wagh & Satyajeet P. Khare. (2023) Translation initiation and dysregulation of initiation factors in rare diseases. Gene Reports 30, pages 101738.
Crossref
Chia-Ling Chen, Po-Chun Tseng, Rahmat Dani Satria, Thi Thuy Nguyen, Cheng-Chieh Tsai & Chiou-Feng Lin. (2022) Role of Glycogen Synthase Kinase-3 in Interferon-γ-Mediated Immune Hepatitis. International Journal of Molecular Sciences 23:9, pages 4669.
Crossref
Hyuk Sung Kwon, Ye Eun Kim, Hyun-Hee Park, Jeong-Woo Son, Hojin Choi, Young Joo Lee, Hyun Young Kim, Kyu-Yong Lee & Seong-Ho Koh. (2021) Neuroprotective Effects of GV1001 in Animal Stroke Model and Neural Cells Subject to Oxygen-Glucose Deprivation/Reperfusion Injury. Journal of Stroke 23:3, pages 420-436.
Crossref
Melisa Herrero, Maron Daw, Andrea Atzmon & Orna Elroy-Stein. (2021) The Energy Status of Astrocytes Is the Achilles’ Heel of eIF2B-Leukodystrophy. Cells 10:8, pages 1858.
Crossref
Vishal Kumar VishwakarmaTarique Mahmood Ansari, Anup Maiti, Ritesh Kumar Srivastav, Paramdeep Bagga & Farogh Ahsan. (2020) INTRUSION OF GLYCOGEN SYNTHASE KINASE-3Β TO COPE VARIOUS CARDIAC DISORDERS AT MOLECULAR LEVEL. INDIAN DRUGS 57:09, pages 7-18.
Crossref
Boris S. Shenkman. (2020) How Postural Muscle Senses Disuse? Early Signs and Signals. International Journal of Molecular Sciences 21:14, pages 5037.
Crossref
Meixi Liu, Xia Huang, Yihong Tian, Xiao Yan, Fang Wang, Junbo Chen, Qi Zhang, Qiang Zhang & Xiao Yuan. (2020) Phosphorylated GSK‑3β protects stress‑induced apoptosis of myoblasts via the PI3K/Akt signaling pathway. Molecular Medicine Reports 22:1, pages 317-327.
Crossref
Orna Elroy-Stein & Raphael Schiffmann. 2020. Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease. Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease 301 317 .
Hyun-Hee Park, Myung-Hoon Han, Hojin Choi, Young Joo Lee, Jae Min Kim, Jin Hwan Cheong, Je Il Ryu, Kyu-Yong Lee & Seong-Ho Koh. (2019) Mitochondria damaged by Oxygen Glucose Deprivation can be Restored through Activation of the PI3K/Akt Pathway and Inhibition of Calcium Influx by Amlodipine Camsylate. Scientific Reports 9:1.
Crossref
Hojin ChoiNa-Young ChoiHyun-Hee ParkKyu-Yong LeeYoung Joo LeeSeong-Ho Koh. (2019) Sublethal Doses of Zinc Protect Rat Neural Stem Cells Against Hypoxia Through Activation of the PI3K Pathway. Stem Cells and Development 28:12, pages 769-780.
Crossref
Timur M. Mirzoev, Sergey A. Tyganov, Irina O. Petrova & Boris S. Shenkman. (2019) Acute recovery from disuse atrophy: the role of stretch-activated ion channels in the activation of anabolic signaling in skeletal muscle. American Journal of Physiology-Endocrinology and Metabolism 316:1, pages E86-E95.
Crossref
T. M. Mirzoev & B. S. Shenkman. (2018) Regulation of Protein Synthesis in Inactivated Skeletal Muscle: Signal Inputs, Protein Kinase Cascades, and Ribosome Biogenesis. Biochemistry (Moscow) 83:11, pages 1299-1317.
Crossref
Michele CurcioFrank Bradke. (2018) Axon Regeneration in the Central Nervous System: Facing the Challenges from the Inside. Annual Review of Cell and Developmental Biology 34:1, pages 495-521.
Crossref
Bharath K. Velmurugan, Chien‐Hung Lee, Shang‐Lun Chiang, Chun‐Hung Hua, Mei‐Chung Chen, Shu‐Hui Lin, Kun‐Tu Yeh & Ying‐Chin Ko. (2017) PP2A deactivation is a common event in oral cancer and reactivation by FTY720 shows promising therapeutic potential. Journal of Cellular Physiology 233:2, pages 1300-1311.
Crossref
Julia V. Cramer & Arthur Liesz. 2018. Cellular and Molecular Approaches to Regeneration and Repair. Cellular and Molecular Approaches to Regeneration and Repair 491 507 .
Yufang Guo, Yan Zhao, Ying Nan, Xiang Wang, Yulong Chen & Shuang Wang. (2017) (−)-Epigallocatechin-3-gallate ameliorates memory impairment and rescues the abnormal synaptic protein levels in the frontal cortex and hippocampus in a mouse model of Alzheimer’s disease. NeuroReport 28:10, pages 590-597.
Crossref
Yanan Liu, Yasheng Yan, Yasuyoshi Inagaki, Sarah Logan, Zeljko J. Bosnjak & Xiaowen Bai. (2017) Insufficient Astrocyte-Derived Brain-Derived Neurotrophic Factor Contributes to Propofol-Induced Neuron Death Through Akt/Glycogen Synthase Kinase 3β/Mitochondrial Fission Pathway. Anesthesia & Analgesia 125:1, pages 241-254.
Crossref
Yue Lu, Jennifer S. Bradley, Sarah R. McCoski, John M. Gonzalez, Alan D. Ealy & Sally E. Johnson. (2017) Reduced skeletal muscle fiber size following caloric restriction is associated with calpain-mediated proteolysis and attenuation of IGF-1 signaling. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 312:5, pages R806-R815.
Crossref
Jongmin LeeHyun-Hee ParkSeong-Ho KohHojin Choi. (2017) Neural Stem Cell Death Mechanisms Induced by Amyloid Beta. Dementia and Neurocognitive Disorders 16:4, pages 121.
Crossref
Hojin ChoiNa-Young ChoiKyu-Yong LeeYoung Joo LeeSeong-Ho Koh. (2017) Candesartan Restores the Amyloid Beta-Inhibited Proliferation of Neural Stem Cells by Activating the Phosphatidylinositol 3-Kinase Pathway. Dementia and Neurocognitive Disorders 16:3, pages 64.
Crossref
Seong Wan Bak, Hojin Choi, Hyun-Hee Park, Kyu-Yong Lee, Young Joo Lee, Moon-Young Yoon & Seong-Ho Koh. (2015) Neuroprotective Effects of Acetyl-L-Carnitine Against Oxygen-Glucose Deprivation-Induced Neural Stem Cell Death. Molecular Neurobiology 53:10, pages 6644-6652.
Crossref
Xinzheng Guo, William D Snider & Bo Chen. (2016) GSK3β regulates AKT-induced central nervous system axon regeneration via an eIF2Bε-dependent, mTORC1-independent pathway. eLife 5.
Crossref
Jeong-Woo Son, Hojin Choi, Arum Yoo, Hyun-Hee Park, Young-Seo Kim, Kyu-Yong Lee, Young Joo Lee & Seong-Ho Koh. (2015) Activation of the phosphatidylinositol 3-kinase pathway plays important roles in reduction of cerebral infarction by cilnidipine. Journal of Neurochemistry 135:1, pages 186-193.
Crossref
LIWEI ZHAO, PENG LIU, GUANGQIN GUO & LI WANG. (2015) Combination of cytokinin and auxin induces apoptosis, cell cycle progression arrest and blockage of the Akt pathway in HeLa cells. Molecular Medicine Reports 12:1, pages 719-727.
Crossref
Orna Elroy-Stein & Raphael Schiffmann. 2015. Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease. Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease 1015 1030 .
Demirkan B. Gürsel, Matei A. Banu, Nicholas Berry, Roberta Marongiu, Jan-Karl Burkhardt, Keith Kobylarz, Michael G. Kaplitt, Shahin Rafii & John A. Boockvar. (2014) Tight regulation between cell survival and programmed cell death in GBM stem-like cells by EGFR/GSK3b/PP2A signaling. Journal of Neuro-Oncology 121:1, pages 19-29.
Crossref
Jisun Paeng, Jae Hyun Chang, Sun Ha Lee, Bo Young Nam, Hye-Young Kang, Seonghun Kim, Hyung Jung Oh, Jung Tak Park, Seung Hyeok Han, Tae-Hyun Yoo & Shin-Wook Kang. (2014) Enhanced glycogen synthase kinase-3β activity mediates podocyte apoptosis under diabetic conditions. Apoptosis 19:12, pages 1678-1690.
Crossref
Xia Zhang, Feng Zhao, Yu Si, Yuling Huang, Cuiping Yu, Chaochao Luo, Na Zhang, Qingzhang Li & Xuejun Gao. (2014) GSK3β Regulates Milk Synthesis in and Proliferation of Dairy Cow Mammary Epithelial Cells via the mTOR/S6K1 Signaling Pathway. Molecules 19:7, pages 9435-9452.
Crossref
András Balogh, Mária Németh, Ibolya Koloszár, Lajos Markó, Lukasz Przybyl, Kazushi Jinno, Csilla Szigeti, Marija Heffer, Matthias Gebhardt, József Szeberényi, Dominik N. Müller, György SétálóJr.Jr. & Marianna Pap. (2014) Overexpression of CREB protein protects from tunicamycin-induced apoptosis in various rat cell types. Apoptosis 19:7, pages 1080-1098.
Crossref
María Llorens-Marítin, Jerónimo Jurado, Félix Hernández & Jesús Ãvila. (2014) GSK-3β, a pivotal kinase in Alzheimer disease. Frontiers in Molecular Neuroscience 7.
Crossref
Suk-Won Ahn, Gye Sun Jeon, Myung-Jin Kim, Jee-Heun Shon, Jee-Eun Kim, Je-Young Shin, Sung-Min Kim, Seung Hyun Kim, In-Hae Ye, Kwang-Woo Lee, Yoon-Ho Hong & Jung-Joon Sung. (2014) Neuroprotective effects of JGK-263 in transgenic SOD1-G93A mice of amyotrophic lateral sclerosis. Journal of the Neurological Sciences 340:1-2, pages 112-116.
Crossref
Na-Young Choi, Hojin Choi, Hyun-Hee Park, Eun-Hye Lee, Hyun-Jeung Yu, Kyu-Yong Lee, Young Joo Lee & Seong-Ho Koh. (2014) Neuroprotective effects of amlodipine besylate and benidipine hydrochloride on oxidative stress-injured neural stem cells. Brain Research 1551, pages 1-12.
Crossref
Carol Dangelmaier, Bhanu Kanth Manne, Elizabetta Liverani, Jianguo Jin, Paul Bray & Satya Kunapuli. (2017) PDK1 selectively phosphorylates Thr(308) on Akt and contributes to human platelet functional responses. Thrombosis and Haemostasis 111:03, pages 508-517.
Crossref
Tonggang Qi, Wei Zhang, Yun Luan, Feng Kong, Dawei Xu, Guanghui Cheng & Yunshan Wang. (2014) Proteomic Profiling Identified Multiple Short-lived Members of the Central Proteome as the Direct Targets of the Addicted Oncogenes in Cancer Cells. Molecular & Cellular Proteomics 13:1, pages 49-62.
Crossref
Xiaoping Li, Rong Luo, Rongjian Jiang, Xianmin Meng, Xiushan Wu, Shu Zhang & Wei Hua. (2013) The role of the Hsp90/Akt pathway in myocardial calpain-induced caspase-3 activation and apoptosis during sepsis. BMC Cardiovascular Disorders 13:1.
Crossref
Hojin ChoiHyun-Hee ParkKyu-Yong LeeNa-Young ChoiHyun-Jeung YuYoung Joo LeeJinse ParkYong-Min HuhSang-Hun LeeSeong-Ho Koh. (2013) Coenzyme Q10 Restores Amyloid Beta-Inhibited Proliferation of Neural Stem Cells by Activating the PI3K Pathway. Stem Cells and Development 22:15, pages 2112-2120.
Crossref
Johanna C. Gandy, Miguel Melendez-Ferro, Gautam N. Bijur, Fred Van Leuven, Joy K. Roche, Benoit Lechat, Herman Devijver, David Demedts, Emma Perez-Costas & Rosalinda C. Roberts. (2013) Glycogen synthase kinase-3β (GSK3β) expression in a mouse model of Alzheimer's disease: A light and electron microscopy study. Synapse 67:6, pages 313-327.
Crossref
Walter Swardfager, Daniel A. Winer, Nathan Herrmann, Shawn Winer & Krista L. Lanctôt. (2013) Interleukin-17 in post-stroke neurodegeneration. Neuroscience & Biobehavioral Reviews 37:3, pages 436-447.
Crossref
Lloyd Cantley. 2013. Seldin and Giebisch's The Kidney. Seldin and Giebisch's The Kidney 369 403 .
Sangjae Kim, Kyu-Yong Lee, Seong-Ho Koh, Hyun-Hee Park, Hyun-Jeung Yu & Young Joo Lee. (2012) Role of the phosphatidylinositol 3-kinase and extracellular signal-regulated kinase pathways in the neuroprotective effects of cilnidipine against hypoxia in a primary culture of cortical neurons. Neurochemistry International 61:7, pages 1172-1182.
Crossref
G Nayak & G M Cooper. (2012) p53 is a major component of the transcriptional and apoptotic program regulated by PI 3-kinase/Akt/GSK3 signaling. Cell Death & Disease 3:10, pages e400-e400.
Crossref
Suk-Won Ahn, Jee-Eun Kim, Kyung Seok Park, Won-Jun Choi, Yoon-Ho Hong, Sung-Min Kim, Seung Hyun Kim, Kwang-Woo Lee & Jung-Joon Sung. (2012) The neuroprotective effect of the GSK-3β inhibitor and influence on the extrinsic apoptosis in the ALS transgenic mice. Journal of the Neurological Sciences 320:1-2, pages 1-5.
Crossref
Jia Luo. (2012) The role of GSK3beta in the development of the central nervous system. Frontiers in Biology 7:3, pages 212-220.
Crossref
D K Thotala, D E Hallahan & E M Yazlovitskaya. (2011) Glycogen synthase kinase 3β inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating MDM2-p53 pathway. Cell Death & Differentiation 19:3, pages 387-396.
Crossref
Keith M. Jacobs, Sandeep R. Bhave, Daniel J. Ferraro, Jerry J. Jaboin, Dennis E. Hallahan & Dinesh Thotala. (2012) GSK-3: A Bifunctional Role in Cell Death Pathways. International Journal of Cell Biology 2012, pages 1-11.
Crossref
Hojin Choi, Hyun-Hee Park, Seong-Ho Koh, Na-Young Choi, Hyun-Jeung Yu, Jinse Park, Young Joo Lee & Kyu-Yong Lee. (2012) Coenzyme Q10 protects against amyloid beta-induced neuronal cell death by inhibiting oxidative stress and activating the P13K pathway. NeuroToxicology 33:1, pages 85-90.
Crossref
Young Joo Lee, Hyun-Hee Park, Seong-Ho Koh, Na-Young Choi & Kyu-Yong Lee. (2011) Amlodipine besylate and amlodipine camsylate prevent cortical neuronal cell death induced by oxidative stress. Journal of Neurochemistry 119:6, pages 1262-1270.
Crossref
Kee Hyung Park, Na-Young Choi, Seong-Ho Koh, Hyun-Hee Park, Young Seo Kim, Min-Jung Kim, Su-Jae Lee, Hyun-Jeung Yu, Kyu-Yong Lee, Young Joo Lee & Hee-Tae Kim. (2011) L-DOPA neurotoxicity is prevented by neuroprotective effects of erythropoietin. NeuroToxicology 32:6, pages 879-887.
Crossref
John W. Tullai, Silvia Tacheva, Laura J. Owens, Julie R. Graham & Geoffrey M. Cooper. (2011) AP-1 Is a Component of the Transcriptional Network Regulated by GSK-3 in Quiescent Cells. PLoS ONE 6:5, pages e20150.
Crossref
Lei Huang, Shengnan Wu & Da Xing. (2011) High fluence low-power laser irradiation induces apoptosis via inactivation of Akt/GSK3β signaling pathway. Journal of Cellular Physiology 226:3, pages 588-601.
Crossref
Seong-Ho Koh, Wonki Baek & Seung H. Kim. (2011) Brief Review of the Role of Glycogen Synthase Kinase-3β in Amyotrophic Lateral Sclerosis. Neurology Research International 2011, pages 1-5.
Crossref
Ke-Wu Zeng, Hyeonseok Ko, Hyun Ok Yang & Xue-Mei Wang. (2010) Icariin attenuates β-amyloid-induced neurotoxicity by inhibition of tau protein hyperphosphorylation in PC12 cells. Neuropharmacology 59:6, pages 542-550.
Crossref
Jung Ok Ban, Dong Hoon Kwak, Ju Hoon Oh, Eun-Jung Park, Min-Chul Cho, Ho Seub Song, Min Jong Song, Sang Bae Han, Dong Cheul Moon, Keon Wook Kang & Jin Tae Hong. (2010) Suppression of NF-κB and GSK-3β is involved in colon cancer cell growth inhibition by the PPAR agonist troglitazone. Chemico-Biological Interactions 188:1, pages 75-85.
Crossref
Julie R. Graham, John W. Tullai & Geoffrey M. Cooper. (2010) GSK-3 Represses Growth Factor-inducible Genes by Inhibiting NF-κB in Quiescent Cells. Journal of Biological Chemistry 285:7, pages 4472-4480.
Crossref
Hyun-Hee Park, Kyu-Yong Lee, Seung Hyun Kim, Young Joo Lee & Seong-Ho Koh. (2009) l-DOPA-induced neurotoxicity is reduced by the activation of the PI3K signaling pathway. Toxicology 265:3, pages 80-86.
Crossref
Young Joo Lee, Kee Hyung Park, Hyun-Hee Park, Yun Jin Kim, Kyu-Yong Lee, Seung Hyun Kim & Seong-Ho Koh. (2009) Cilnidipine mediates a neuroprotective effect by scavenging free radicals and activating the phosphatidylinositol 3-kinase pathway. Journal of Neurochemistry 111:1, pages 90-100.
Crossref
Jia Luo. (2009) GSK3β in Ethanol Neurotoxicity. Molecular Neurobiology 40:2, pages 108-121.
Crossref
Jolyon Terragni, Julie R Graham, Kenneth W Adams, Michael E Schaffer, John W Tullai & Geoffrey M Cooper. (2008) Phosphatidylinositol 3-kinase signaling in proliferating cells maintains an anti-apoptotic transcriptional program mediated by inhibition of FOXO and non-canonical activation of NFκB transcription factors. BMC Cell Biology 9:1.
Crossref
Warren Fiskus, Rekha Rao, Pravina Fernandez, Bryan Herger, Yonghua Yang, Jianguang Chen, Ravindra Kolhe, Aditya Mandawat, Yongchao Wang, Rajeshree Joshi, Kelly Eaton, Pearl Lee, Peter Atadja, Stephen Peiper & Kapil Bhalla. (2008) Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor–resistant acute myeloid leukemia cells. Blood 112:7, pages 2896-2905.
Crossref
Olga Sokolova, Przemyslaw M. Bozko & Michael Naumann. (2008) Helicobacter pylori Suppresses Glycogen Synthase Kinase 3β to Promote β-Catenin Activity. Journal of Biological Chemistry 283:43, pages 29367-29374.
Crossref
Seong-Ho Koh, Chiwon Song, Min Young Noh, Hyun Young Kim, Kyu-Yong Lee, Young Joo Lee, Juhan Kim, Seung Hyun Kim & Hee-Tae Kim. (2008) Inhibition of glycogen synthase kinase-3 reduces l-DOPA-induced neurotoxicity. Toxicology 247:2-3, pages 112-118.
Crossref
Marianna Pap & József Szeberényi. (2007) Involvement of Proteolytic Activation of Protein Kinase R in the Apoptosis of PC12 Pheochromocytoma Cells. Cellular and Molecular Neurobiology 28:3, pages 443-456.
Crossref
Dongjun Li, Shelley August & Donna S. Woulfe. (2008) GSK3β is a negative regulator of platelet function and thrombosis. Blood 111:7, pages 3522-3530.
Crossref
Osong Kwon, Kyung A. Kim, Long He, Sun Ok Kim, Min Soo Kim, Eun Young Cha, Byung Dae Yoon, Dai Eun Sok, Mira Jung, Jong Seog Ahn & Bo Yeon Kim. (2008) Ionizing radiation can induce GSK-3β phosphorylation and NF-κB transcriptional transactivation in ATM-deficient fibroblasts. Cellular Signalling 20:4, pages 602-612.
Crossref
Kyu-Yong Lee, Seong-Ho Koh, Min Young Noh, Seung Hyun Kim & Young Joo Lee. (2008) Phosphatidylinositol-3-kinase activation blocks amyloid beta-induced neurotoxicity. Toxicology 243:1-2, pages 43-50.
Crossref
Seong-Ho Koh, Min Young Noh & Seung Hyun Kim. (2008) Amyloid-beta-induced neurotoxicity is reduced by inhibition of glycogen synthase kinase-3. Brain Research 1188, pages 254-262.
Crossref
Lloyd Cantley. 2008. Seldin and Giebisch's The Kidney. Seldin and Giebisch's The Kidney 297 324 .
Bing HanMei J. ZhuChangwei MaMin Du. (2007) Rat hindlimb unloading down-regulates insulin like growth factor-1 signaling and AMP-activated protein kinase, and leads to severe atrophy of the soleus muscle. Applied Physiology, Nutrition, and Metabolism 32:6, pages 1115-1123.
Crossref
Lilia Espada, Basavaraj Udapudi, Petar Podlesniy, Isabel Fabregat, Carme Espinet & Albert Tauler. (2007) Apoptotic action of E2F1 requires glycogen synthase kinase 3-β activity in PC12 cells. Journal of Neurochemistry 102:6, pages 2020-2028.
Crossref
Chiou-Feng Lin, Chia-Ling Chen, Chi-Wu Chiang, Ming-Shiou Jan, Wei-Ching Huang & Yee-Shin Lin. (2007) GSK-3β acts downstream of PP2A and the PI 3-kinase-Akt pathway, and upstream of caspase-2 in ceramide-induced mitochondrial apoptosis. Journal of Cell Science 120:16, pages 2935-2943.
Crossref
Seong-Ho Koh, Youngchul Kim, Hyun Y. Kim, Sejin Hwang, Chang Ho Lee & Seung H. Kim. (2007) Inhibition of glycogen synthase kinase-3 suppresses the onset of symptoms and disease progression of G93A-SOD1 mouse model of ALS. Experimental Neurology 205:2, pages 336-346.
Crossref
Jos L. J. van der Velden, Ramon C. J. Langen, Marco C. J. M. Kelders, Jodil Willems, Emiel F. M. Wouters, Yvonne M. W. Janssen-Heininger & Annemie M. W. J. Schols. (2007) Myogenic differentiation during regrowth of atrophied skeletal muscle is associated with inactivation of GSK-3β. American Journal of Physiology-Cell Physiology 292:5, pages C1636-C1644.
Crossref
Christopher G. Proud. (2007) Signalling to translation: how signal transduction pathways control the protein synthetic machinery. Biochemical Journal 403:2, pages 217-234.
Crossref
John W. Tullai, Jie Chen, Michael E. Schaffer, Eliza Kamenetsky, Simon Kasif & Geoffrey M. Cooper. (2007) Glycogen Synthase Kinase-3 Represses Cyclic AMP Response Element-binding Protein (CREB)-targeted Immediate Early Genes in Quiescent Cells. Journal of Biological Chemistry 282:13, pages 9482-9491.
Crossref
Kenneth W. Adams & Geoffrey M. Cooper. (2007) Rapid Turnover of Mcl-1 Couples Translation to Cell Survival and Apoptosis. Journal of Biological Chemistry 282:9, pages 6192-6200.
Crossref
John Brognard, Emma Sierecki, Tianyan Gao & Alexandra C. Newton. (2007) PHLPP and a Second Isoform, PHLPP2, Differentially Attenuate the Amplitude of Akt Signaling by Regulating Distinct Akt Isoforms. Molecular Cell 25:6, pages 917-931.
Crossref
Guido Kroemer, Lorenzo Galluzzi & Catherine Brenner. (2007) Mitochondrial Membrane Permeabilization in Cell Death. Physiological Reviews 87:1, pages 99-163.
Crossref
Kyu-Yong Lee, Seong-Ho Koh, Min Young Noh, Kun-Woo Park, Young Joo Lee & Seung Hyun Kim. (2007) Glycogen synthase kinase-3β activity plays very important roles in determining the fate of oxidative stress-inflicted neuronal cells. Brain Research 1129, pages 89-99.
Crossref
Julie ChaoHang YinYu-Yu YaoBo ShenRobert S. SmithJr.Jr. & Lee Chao. (2006) Novel Role of Kallistatin in Protection Against Myocardial Ischemia–Reperfusion Injury by Preventing Apoptosis and Inflammation. Human Gene Therapy 17:12, pages 1201-1213.
Crossref
Julie Chao, Hang Yin, Yu-Yu Yao, Bo Shen, Robert S. Smith & Lee Chao. (2006) Novel Role of Kallistatin in Protection Against Myocardial Ischemia?Reperfusion Injury by Preventing Apoptosis and Inflammation. Human Gene Therapy 0:0, pages 061102145552001.
Crossref
Eric Ispanovic & Tara L. Haas. (2006) JNK and PI3K differentially regulate MMP-2 and MT1-MMP mRNA and protein in response to actin cytoskeleton reorganization in endothelial cells. American Journal of Physiology-Cell Physiology 291:4, pages C579-C588.
Crossref
Gayle M. Smythe & Thomas A. Rando. (2006) Altered caveolin-3 expression disrupts PI(3) kinase signaling leading to death of cultured muscle cells. Experimental Cell Research 312:15, pages 2816-2825.
Crossref
Meng-chang WANG, Xue-de FU & Man-xiang LI. (2006) PI-3K/Akt/GSK-3βsignaling cascades stimulated by insulin like growth factor-I contribute to multiple myeloma cells proliferation and survival. Chinese Medical Journal 119:14, pages 1226-1229.
Crossref
Eléonore Beurel & Richard S. Jope. (2006) The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways. Progress in Neurobiology 79:4, pages 173-189.
Crossref
Moisés Morales, Martha E. González-Mejía, Alfonso Bernabé, Luisa C. R. Hernández-Kelly & Arturo Ortega. (2006) Glutamate Activates Protein Kinase B (PKB/Akt) through AMPA Receptors in Cultured Bergmann Glia Cells. Neurochemical Research 31:3, pages 423-429.
Crossref
Jiahua Tan, Ling Geng, Eugenia M. Yazlovitskaya & Dennis E. Hallahan. (2006) Protein Kinase B/Akt-Dependent Phosphorylation of Glycogen Synthase Kinase-3β in Irradiated Vascular Endothelium. Cancer Research 66:4, pages 2320-2327.
Crossref
Thomas Force & Jeffery D. Molkentin. 2006. Principles of Molecular Medicine. Principles of Molecular Medicine 146 156 .
G.D. Pavitt. (2005) eIF2B, a mediator of general and gene-specific translational control. Biochemical Society Transactions 33:6, pages 1487-1492.
Crossref
Manxiang LiKuan-Rau ChiouArtem BugayenkoKaikobad IraniDavid A. Kass. (2005) Reduced Wall Compliance Suppresses Akt-Dependent Apoptosis Protection Stimulated by Pulse Perfusion. Circulation Research 97:6, pages 587-595.
Crossref
Seong-Ho Koh, Hakjae Roh, Sang Mok Lee, Hyun-Jung Kim, Manho Kim, Kwang Woo Lee, Hee-Tae Kim, Juhan Kim & Seung Hyun Kim. (2005) Phosphatidylinositol 3-kinase activator reduces motor neuronal cell death induced by G93A or A4V mutant SOD1 gene. Toxicology 213:1-2, pages 45-55.
Crossref
Seong-Ho Koh, Young-Bae Lee, Kyung S. Kim, Hyun-Jung Kim, Manho Kim, Young Joo Lee, Juhan Kim, Kwang Woo Lee & Seung Hyun Kim. (2005) Role of GSK-3β activity in motor neuronal cell death induced by G93A or A4V mutant hSOD1 gene. European Journal of Neuroscience 22:2, pages 301-309.
Crossref
R. S. Kinnard, D. B. Mylabathula, S. Uddemarri, K. M. Rice, G. L. Wright & E. R. Blough. (2005) Regulation of p70S6k, GSK-3β, and calcineurin in rat striated muscle during aging. Biogerontology 6:3, pages 173-184.
Crossref
Hang Yin, Lee Chao & Julie Chao. (2005) Kallikrein/Kinin Protects against Myocardial Apoptosis after Ischemia/Reperfusion via Akt-Glycogen Synthase Kinase-3 and Akt-Bad·14-3-3 Signaling Pathways. Journal of Biological Chemistry 280:9, pages 8022-8030.
Crossref
Vera S. Gross, Mailee Hess & Geoffrey M. Cooper. (2005) Mouse embryonic stem cells and preimplantation embryos require signaling through the phosphatidylinositol 3-kinase pathway to suppress apoptosis. Molecular Reproduction and Development 70:3, pages 324-332.
Crossref
Zhao Zhong Chong, Faqi Li & Kenneth Maiese. (2005) Oxidative stress in the brain: Novel cellular targets that govern survival during neurodegenerative disease. Progress in Neurobiology 75:3, pages 207-246.
Crossref
Seong-Ho Koh, Hyugsung Kwon, Kee Hyung Park, Jin Kyung Ko, Joo Hwan Kim, Myung Sil Hwang, Young Na Yum, Ok-Hee Kim, Juhan Kim, Hee-Tae Kim, Byung-Rok Do, Kyung Suk Kim, Haekwon Kim, Hakjae Roh, Hyun-Jeung Yu, Hai Kwan Jung & Seung Hyun Kim. (2005) Protective effect of diallyl disulfide on oxidative stress-injured neuronally differentiated PC12 cells. Molecular Brain Research 133:2, pages 176-186.
Crossref
Richard S. Jope. (2004) Inhibition of glycogen synthase kinase-3: a potential therapeutic target of lithium. Clinical Neuroscience Research 4:3-4, pages 171-179.
Crossref
Laura Colombaioni & Mercedes Garcia-Gil. (2004) Sphingolipid metabolites in neural signalling and function. Brain Research Reviews 46:3, pages 328-355.
Crossref
Clara Bouché, Shanti Serdy, C. Ronald Kahn & Allison B. Goldfine. (2004) The Cellular Fate of Glucose and Its Relevance in Type 2 Diabetes. Endocrine Reviews 25:5, pages 807-830.
Crossref
Yasunari Takada, Xianjun Fang, Md. Saha Jamaluddin, Douglas D. Boyd & Bharat B. Aggarwal. (2004) Genetic Deletion of Glycogen Synthase Kinase-3β Abrogates Activation of IκBα Kinase, JNK, Akt, and p44/p42 MAPK but Potentiates Apoptosis Induced by Tumor Necrosis Factor. Journal of Biological Chemistry 279:38, pages 39541-39554.
Crossref
Seong-Ho Koh, Seung H Kim, Hyugsung Kwon, Jun Gyou Kim, Ju Hwan Kim, Ki-Hwa Yang, Juhan Kim, Seung U Kim, Hyun-Jeung Yu, Byung Rok Do, Kyung Suk Kim & Hai Kwan Jung. (2004) Phosphatidylinositol-3 Kinase/Akt and GSK-3 Mediated Cytoprotective Effect of Epigallocatechin Gallate on Oxidative Stress-Injured Neuronal-Differentiated N18D3 Cells. NeuroToxicology 25:5, pages 793-802.
Crossref
Dorottya Kövesdi, Katalin Pászty, Ágnes Enyedi, Endre Kiss, János Matkó, Katalin Ludányi, Éva Rajnavölgyi & Gabriella Sármay. (2004) Antigen receptor-mediated signaling pathways in transitional immature B cells. Cellular Signalling 16:8, pages 881-889.
Crossref
James A. Fyfe, Lilia M. Beauchamp, Anthony O. Caggiano, Raymond D. Price, Takayuki Yamaji, Nobuya Matsuoka & Thomas A. Krenitsky. (2004) KP544 amplifies the effects of nerve growth factor on cell differentiation and is neuroprotective. Drug Development Research 62:1, pages 49-59.
Crossref
Nicolas Cougot, Sylvie Babajko & Bertrand Séraphin. (2004) Cytoplasmic foci are sites of mRNA decay in human cells. Journal of Cell Biology 165:1, pages 31-40.
Crossref
Richard S Jope & Gail V.W Johnson. (2004) The glamour and gloom of glycogen synthase kinase-3. Trends in Biochemical Sciences 29:2, pages 95-102.
Crossref
Hang YinLee ChaoJulie Chao. (2004) Adrenomedullin Protects Against Myocardial Apoptosis After Ischemia/Reperfusion Through Activation of Akt-GSK Signaling. Hypertension 43:1, pages 109-116.
Crossref
Joseph F. Gera, Ingo K. Mellinghoff, Yijiang Shi, Matthew B. Rettig, Chris Tran, Jung-hsin Hsu, Charles L. Sawyers & Alan K. Lichtenstein. (2004) AKT Activity Determines Sensitivity to Mammalian Target of Rapamycin (mTOR) Inhibitors by Regulating Cyclin D1 and c-myc Expression. Journal of Biological Chemistry 279:4, pages 2737-2746.
Crossref
Ambrus Toth, Krisztina Kovacs, Peter Deres, Robert Halmosi, Laszlo Czopf, Katalin Hanto, Tamas Kalai, Kalman Hideg, Balazs Sumegi & Kalman Toth. (2003) Impact of a novel cardioprotective agent on the ischaemia-reperfusion-induced Akt kinase activation. Biochemical Pharmacology 66:11, pages 2263-2272.
Crossref
Ambrus Toth, Robert Halmosi, Krisztina Kovacs, Peter Deres, Tamas Kalai, Kalman Hideg, Kalman Toth & Balazs Sumegi. (2003) Akt activation induced by an antioxidant compound during ischemia-reperfusion. Free Radical Biology and Medicine 35:9, pages 1051-1063.
Crossref
Seong-Ho Koh, Seung H. Kim, Hyugsung Kwon, Younjoo Park, Ki Sok Kim, Chi Won Song, Juhan Kim, Myung-Ho Kim, Hyun-Jeung Yu, Jenny S. Henkel & Hai Kwan Jung. (2003) Epigallocatechin gallate protects nerve growth factor differentiated PC12 cells from oxidative-radical-stress-induced apoptosis through its effect on phosphoinositide 3-kinase/Akt and glycogen synthase kinase-3. Molecular Brain Research 118:1-2, pages 72-81.
Crossref
Richard S Jope. (2003) Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes. Trends in Pharmacological Sciences 24:9, pages 441-443.
Crossref
Martina Vojtěchová, Eva Šloncová, Dana Kučerová, Jaroslav Jiřička, Vlasta Sovová & Zdena Tuháčková. (2003) Initiation factor eIF2B not p70 S6 kinase is involved in the activation of the PI-3K signalling pathway induced by the v- src oncogene . FEBS Letters 543:1-3, pages 81-86.
Crossref
Lawrence P. Kane & Arthur Weiss. (2003) The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP 3 . Immunological Reviews 192:1, pages 7-20.
Crossref
Bogdan A Stoica, Vilen A Movsesyan, Paul M Lea IV & Alan I Faden. (2003) Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3β, and induction of the mitochondrial-dependent intrinsic caspase pathway. Molecular and Cellular Neuroscience 22:3, pages 365-382.
Crossref
Marilyn Kozak. 2003. Gene Transfer and Expression in Mammalian Cells. Gene Transfer and Expression in Mammalian Cells 471 494 .
Robert D. Loberg, Eileen Vesely & Frank C. BrosiusIIIIII. (2002) Enhanced Glycogen Synthase Kinase-3β Activity Mediates Hypoxia-induced Apoptosis of Vascular Smooth Muscle Cells and Is Prevented by Glucose Transport and Metabolism. Journal of Biological Chemistry 277:44, pages 41667-41673.
Crossref
Ling Song, Patrizia De Sarno & Richard S. Jope. (2002) Central Role of Glycogen Synthase Kinase-3β in Endoplasmic Reticulum Stress-induced Caspase-3 Activation. Journal of Biological Chemistry 277:47, pages 44701-44708.
Crossref
Nathalie Sauvonnet, Bérengère Pradet-Balade, Jose A. Garcia-Sanz & Guy R. Cornelis. (2002) Regulation of mRNA Expression in Macrophages afterYersinia enterocolitica Infection. Journal of Biological Chemistry 277:28, pages 25133-25142.
Crossref
Stefan E. HardtJunichi Sadoshima. (2002) Glycogen Synthase Kinase-3β. Circulation Research 90:10, pages 1055-1063.
Crossref
Thomas E. Dever. (2002) Gene-Specific Regulation by General Translation Factors. Cell 108:4, pages 545-556.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.