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Cell Growth and Development

Both Binding and Activation of p38 Mitogen-Activated Protein Kinase (MAPK) Play Essential Roles in Regulation of the Nucleocytoplasmic Distribution of MAPK-Activated Protein Kinase 5 by Cellular Stress

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Pages 6931-6945 | Received 18 Apr 2002, Accepted 08 Jul 2002, Published online: 28 Mar 2023

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Sergiy Kostenko, Alexey Shiryaev, Gianina Dumitriu, Nancy Gerits & Ugo Moens. (2011) Cross-talk between protein kinase A and the MAPK-activated protein kinases RSK1 and MK5. Journal of Receptors and Signal Transduction 31:1, pages 1-9.
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Yu Shi, Alexey Kotlyarov, Kathrin Laaß, Achim D. Gruber, Elke Butt, Katrin Marcus, Helmut E. Meyer, Anke Friedrich, Hans-Dieter Volk & Matthias Gaestel. (2003) Elimination of Protein Kinase MK5/PRAK Activity by Targeted Homologous Recombination. Molecular and Cellular Biology 23:21, pages 7732-7741.
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Gert C. Scheper, Josep L. Parra, Mary Wilson, Barbara van Kollenburg, Alfred C. O. Vertegaal, Ze-Guang Han & Christopher G. Proud. (2003) The N and C Termini of the Splice Variants of the Human Mitogen-Activated Protein Kinase-Interacting Kinase Mnk2 Determine Activity and Localization. Molecular and Cellular Biology 23:16, pages 5692-5705.
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Yu Tina Zhao, Jianfeng Du, Naohiro Yano, Hao Wang, Jianguo Wang, Patrycja M. Dubielecka, Ling X. Zhang, Gangjian Qin, Shougang Zhuang, Paul Y. Liu, Y. Eugene Chin & Ting C. Zhao. (2019) p38-Regulated/activated protein kinase plays a pivotal role in protecting heart against ischemia-reperfusion injury and preserving cardiac performance. American Journal of Physiology-Cell Physiology 317:3, pages C525-C533.
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Manoj B. Menon & Alexey Kotlyarov. 2018. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 2934 2939 .
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Feng-Ting Huang, Juan-Fei Peng, Wen-Jie Cheng, Yan-Yan Zhuang, Ling-Yun Wang, Chu-Qiang Li, Jian Tang, Wen-Ying Chen, Yuan-Hua Li & Shi-Neng Zhang. (2017) MiR-143 Targeting TAK1 Attenuates Pancreatic Ductal Adenocarcinoma Progression via MAPK and NF-κB Pathway In Vitro. Digestive Diseases and Sciences 62:4, pages 944-957.
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Duk-Soo Kim, Su-Ji Min, Min-Ju Kim, Ji-Eun Kim & Tae-Cheon Kang. (2016) Leptomycin B ameliorates vasogenic edema formation induced by status epilepticus via inhibiting p38 MAPK/VEGF pathway. Brain Research 1651, pages 27-35.
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Alexey Shiryaev, Gianina Dumitriu & Ugo Moens. (2011) Distinct roles of MK2 and MK5 in cAMP/PKA- and stress/p38<sup>MAPK</sup>-induced heat shock protein 27 phosphorylation. Journal of Molecular Signaling 6, pages 4.
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Sergiy Kostenko. (2011) Physiological roles of mitogen-activated-protein-kinase-activated p38-regulated/activated protein kinase. World Journal of Biological Chemistry 2:5, pages 73.
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M Raman, W Chen & M H Cobb. (2007) Differential regulation and properties of MAPKs. Oncogene 26:22, pages 3100-3112.
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Joy Lengyel, Anna K. Strain, Keith D. Perkins & Stephen A. Rice. (2006) ICP27-dependent resistance of herpes simplex virus type 1 to leptomycin B is associated with enhanced nuclear localization of ICP4 and ICP0. Virology 352:2, pages 368-379.
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Matthias Gaestel. (2006) MAPKAP kinases — MKs — two's company, three's a crowd. Nature Reviews Molecular Cell Biology 7:2, pages 120-130.
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Jing Fu, Ziqiang Yang, Jinxue Wei, Jiahuai Han & Jun Gu. (2006) Nuclear protein NP60 regulates p38 MAPK activity. Journal of Cell Science 119:1, pages 115-123.
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Tracie DeVries-Seimon, Yankun Li, Pin Mei Yao, Elizabeth Stone, Yibin Wang, Roger J. Davis, Richard Flavell & Ira Tabas. (2005) Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor. Journal of Cell Biology 171:1, pages 61-73.
Crossref
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Crossref
Ole-Morten Seternes, Theresa Mikalsen, Bjarne Johansen, Espen Michaelsen, Chris G Armstrong, Nick A Morrice, Benjamin Turgeon, Sylvain Meloche, Ugo Moens & Stephen M Keyse. (2004) Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway. The EMBO Journal 23:24, pages 4780-4791.
Crossref
Stefanie Schumacher, Kathrin Laaß, Shashi Kant, Yu Shi, Axel Visel, Achim D Gruber, Alexey Kotlyarov & Matthias Gaestel. (2004) Scaffolding by ERK3 regulates MK5 in development. The EMBO Journal 23:24, pages 4770-4779.
Crossref
Yoshiko Katoh, Hiroshi Takemori, Li Min, Masaaki Muraoka, Junko Doi, Nanao Horike & Mitsuhiro Okamoto. (2004) Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm. European Journal of Biochemistry 271:21, pages 4307-4319.
Crossref
Philippe P. Roux & John Blenis. (2004) ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions. Microbiology and Molecular Biology Reviews 68:2, pages 320-344.
Crossref
Togo Ikuta, Yasuhito Kobayashi & Kaname Kawajiri. (2004) Cell Density Regulates Intracellular Localization of Aryl Hydrocarbon Receptor. Journal of Biological Chemistry 279:18, pages 19209-19216.
Crossref
. (2004) Norwegian Pharmacology 2004: Meeting of the Norwegian Society of Pharmacology and Toxicology January 29-February 1, 2004, Beito, Norway. Basic & Clinical Pharmacology & Toxicology 95:S1, pages 17-40.
Crossref
Paul Lui, Chenbo Zeng, Stephen Acton, Steven Cok, Alison Sexton & Aubrey R. Morrison. (2004) Effects of p38 MAPK isoforms on renal mesangial cell inducible nitric oxide synthase expression . American Journal of Physiology-Cell Physiology 286:1, pages C145-C152.
Crossref
Liguo New, Yong Jiang & Jiahuai Han. (2003) Regulation of PRAK Subcellular Location by p38 MAP Kinases. Molecular Biology of the Cell 14:6, pages 2603-2616.
Crossref
Ming Qiu, Abby Olsen, Emily Faivre, Kathryn B. Horwitz & Carol A. Lange. (2003) Mitogen-Activated Protein Kinase Regulates Nuclear Association of Human Progesterone Receptors. Molecular Endocrinology 17:4, pages 628-642.
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