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Molecular and Cellular Biology Volume 22, 2002 - Issue 7
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DNA Dynamics and Chromosome Structure

Maintenance of Double-Stranded Telomeric Repeats as the Critical Determinant for Cell Viability in Yeast Cells Lacking Ku

Serge GravelDepartment of Microbiology, RNA Group/Groupe ARN, Faculty of Medicine, Université de Sherbrooke, Sherbrooke, QuebecJ1H 5N4, Canada
&
Raymund J. WellingerDepartment of Microbiology, RNA Group/Groupe ARN, Faculty of Medicine, Université de Sherbrooke, Sherbrooke, QuebecJ1H 5N4, CanadaCorrespondence[email protected]
Pages 2182-2193 | Received 23 Oct 2001, Accepted 07 Jan 2002, Published online: 28 Mar 2023

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Franck Gallardo, Nancy Laterreur, Raymund J. Wellinger & Pascal Chartrand. (2012) Telomerase caught in the act. RNA Biology 9:9, pages 1139-1143.
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Yves Corda, Sang Eun Lee, Sylvine Guillot, André Walther, Julie Sollier, Ayelet Arbel-Eden, James E. Haber & Vincent Géli. (2005) Inactivation of Ku-Mediated End Joining Suppresses mec1Δ Lethality by Depleting the Ribonucleotide Reductase Inhibitor Sml1 through a Pathway Controlled by Tel1 Kinase and the Mre11 Complex. Molecular and Cellular Biology 25:23, pages 10652-10664.
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Kyungjae Myung, Goutam Ghosh, Farjana J. Fattah, Gang Li, Haeyoung Kim, Amalia Dutia, Evgenia Pak, Stephanie Smith & Eric A. Hendrickson. (2004) Regulation of Telomere Length and Suppression of Genomic Instability in Human Somatic Cells by Ku86. Molecular and Cellular Biology 24:11, pages 5050-5059.
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Alison A. Bertuch & Victoria Lundblad. (2003) The Ku Heterodimer Performs Separable Activities at Double-Strand Breaks and Chromosome Termini. Molecular and Cellular Biology 23:22, pages 8202-8215.
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Nathalie Grandin & Michel Charbonneau. (2003) The Rad51 Pathway of Telomerase-Independent Maintenance of Telomeres Can Amplify TG1-3 Sequences in yku and cdc13 Mutants of Saccharomyces cerevisiae. Molecular and Cellular Biology 23:11, pages 3721-3734.
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Articles from other publishers (32)

Cory L Holland, Brian A Sanderson, James K Titus, Monica F Weis, Angelica M Riojas, Eric Malczewskyj, Brian M Wasko & L Kevin Lewis. (2021) Suppression of telomere capping defects of Saccharomyces cerevisiae yku70 and yku80 mutants by telomerase . G3 Genes|Genomes|Genetics 11:12.
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Reyes Carballar, Joan M. Martínez-Láinez, Bàrbara Samper, Samuel Bru, Elisabet Bállega, Oriol Mirallas, Natalia Ricco, Josep Clotet & Javier Jiménez. (2020) CDK-mediated Yku80 Phosphorylation Regulates the Balance Between Non-homologous End Joining (NHEJ) and Homologous Directed Recombination (HDR). Journal of Molecular Biology 432:24, pages 166715.
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Borja Barbero Barcenilla & Dorothy E. Shippen. (2019) Back to the future: The intimate and evolving connection between telomere-related factors and genotoxic stress. Journal of Biological Chemistry 294:40, pages 14803-14813.
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Jinyu Wang, Haitao Zhang, Mohammed Al Shibar, Belinda Willard, Alo Ray & Kurt W. Runge. (2018) Rif1 phosphorylation site analysis in telomere length regulation and the response to damaged telomeres. DNA Repair 65, pages 26-33.
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Iglika G. Ivanova & Laura Maringele. (2016) Polymerases ε and ∂ repair dysfunctional telomeres facilitated by salt. Nucleic Acids Research 44:8, pages 3728-3738.
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Mónica Gandía, Shaomei Xu, Cristina Font & Jose F. Marcos. (2016) Disruption of ku70 involved in non-homologous end-joining facilitates homologous recombination but increases temperature sensitivity in the phytopathogenic fungus Penicillium digitatum. Fungal Biology 120:3, pages 317-323.
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Carmen de Sena-Tomás, Eun Young Yu, Arturo Calzada, William K. Holloman, Neal F. Lue & José Pérez-Martín. (2015) Fungal Ku prevents permanent cell cycle arrest by suppressing DNA damage signaling at telomeres. Nucleic Acids Research 43:4, pages 2138-2151.
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Nancy Laterreur, Sébastien H. Eschbach, Daniel A. Lafontaine & Raymund J. Wellinger. (2013) A new telomerase RNA element that is critical for telomere elongation. Nucleic Acids Research 41:16, pages 7713-7724.
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Raymund J Wellinger & Virginia A Zakian. (2012) Everything You Ever Wanted to Know About Saccharomyces cerevisiae Telomeres: Beginning to End . Genetics 191:4, pages 1073-1105.
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Margherita Paschini, Tasha B Toro, Johnathan W Lubin, Bari Braunstein-Ballew, Danna K Morris & Victoria Lundblad. (2012) A Naturally Thermolabile Activity Compromises Genetic Analysis of Telomere Function in Saccharomyces cerevisiae . Genetics 191:1, pages 79-93.
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Lea Harrington. (2012) Haploinsufficiency and telomere length homeostasis. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 730:1-2, pages 37-42.
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Franck Gallardo, Nancy Laterreur, Emilio Cusanelli, Faissal Ouenzar, Emmanuelle Querido, Raymund J. Wellinger & Pascal Chartrand. (2011) Live Cell Imaging of Telomerase RNA Dynamics Reveals Cell Cycle-Dependent Clustering of Telomerase at Elongating Telomeres. Molecular Cell 44:5, pages 819-827.
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Lidia Chico, Toni Ciudad, Min Hsu, Neal F. Lue & Germán Larriba. (2011) The Candida albicans Ku70 Modulates Telomere Length and Structure by Regulating Both Telomerase and Recombination. PLoS ONE 6:8, pages e23732.
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Savani Anbalagan, Diego Bonetti, Giovanna Lucchini & Maria Pia Longhese. (2011) Rif1 Supports the Function of the CST Complex in Yeast Telomere Capping. PLoS Genetics 7:3, pages e1002024.
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Momchil D Vodenicharov, Nancy Laterreur & Raymund J Wellinger. (2010) Telomere capping in non-dividing yeast cells requires Yku and Rap1. The EMBO Journal 29:17, pages 3007-3019.
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Yongbao Wang, Goutam Ghosh & Eric A. Hendrickson. (2009) Ku86 represses lethal telomere deletion events in human somatic cells. Proceedings of the National Academy of Sciences 106:30, pages 12430-12435.
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Stanislava Gunisova, Elhanan Elboher, Jozef Nosek, Valentin Gorkovoy, Yogev Brown, Jean-Francois Lucier, Nancy Laterreur, Raymund J. Wellinger, Yehuda Tzfati & Lubomir Tomaska. (2009) Identification and comparative analysis of telomerase RNAs from Candida species reveal conservation of functional elements . RNA 15:4, pages 546-559.
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Karel RihaMichelle L. HeacockDorothy E. Shippen. (2006) The Role of the Nonhomologous End-Joining DNA Double-Strand Break Repair Pathway in Telomere Biology. Annual Review of Genetics 40:1, pages 237-277.
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Stefanie Pöggeler & Ulrich Kück. (2006) Highly efficient generation of signal transduction knockout mutants using a fungal strain deficient in the mammalian ku70 ortholog. Gene 378, pages 1-10.
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Errol C. Friedberg, Graham C. Walker, Wolfram Siede, Richard D. Wood, Roger A. Schultz & Tom Ellenberger. 2005. DNA Repair and Mutagenesis. DNA Repair and Mutagenesis 711 750 .
Timothy S. Fisher & Virginia A. Zakian. (2005) Ku: A multifunctional protein involved in telomere maintenance. DNA Repair 4:11, pages 1215-1226.
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Eric Hendrickson, Joy Huffman & John Tainer. 2005. DNA Damage Recognition. DNA Damage Recognition.
Ofer Rog, Sarit Smolikov, Anat Krauskopf & Martin Kupiec. (2004) The yeast VPS genes affect telomere length regulation. Current Genetics 47:1, pages 18-28.
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Penny A. Jeggo. 2005. Genome Instability in Cancer Development. Genome Instability in Cancer Development 175 197 .
Fabrizio d'Adda di Fagagna, Soo-Hwang Teo & Stephen P. Jackson. (2004) Functional links between telomeres and proteins of the DNA-damage response. Genes & Development 18:15, pages 1781-1799.
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Jessica A. Downs & Stephen P. Jackson. (2004) A means to a DNA end: the many roles of Ku. Nature Reviews Molecular Cell Biology 5:5, pages 367-378.
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Lea Harrington. (2004) Those dam-aged telomeres!. Current Opinion in Genetics & Development 14:1, pages 22-28.
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Anne E. Stellwagen, Zara W. Haimberger, Joshua R. Veatch & Daniel E. Gottschling. (2003) Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends. Genes & Development 17:19, pages 2384-2395.
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Jessica A Downs, Effie Kosmidou, Alan Morgan & Stephen P Jackson. (2003) Suppression of Homologous Recombination by the Saccharomyces cerevisiae Linker Histone. Molecular Cell 11:6, pages 1685-1692.
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Lea Harrington. (2003) Biochemical aspects of telomerase function. Cancer Letters 194:2, pages 139-154.
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Karel Riha & Dorothy E. Shippen. (2003) Ku is required for telomeric C-rich strand maintenance but not for end-to-end chromosome fusions in Arabidopsis . Proceedings of the National Academy of Sciences 100:2, pages 611-615.
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. (2002) Current Awareness. Yeast 19:10, pages 903-908.
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