Advanced search
Publication Cover
Molecular and Cellular Biology Volume 22, 2002 - Issue 8
Submit an article Journal homepage
33
Views
55
CrossRef citations to date
0
Altmetric
Transcriptional Regulation

Analysis of Sequence Upstream of the Endogenous H19 Gene Reveals Elements Both Essential and Dispensable for Imprinting

Joanne L. ThorvaldsenHoward Hughes Medical Institute and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania19104
,
Mellissa R. W. MannHoward Hughes Medical Institute and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania19104
,
Okechukwu NwokoHoward Hughes Medical Institute and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania19104
,
Kristen L. DuranHoward Hughes Medical Institute and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania19104
&
Marisa S. BartolomeiHoward Hughes Medical Institute and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania19104Correspondence[email protected]
Pages 2450-2462 | Received 10 Oct 2001, Accepted 12 Jan 2002, Published online: 28 Mar 2023

Citations (55)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (10)

Shu Lin, Anne C. Ferguson-Smith, Richard M. Schultz & Marisa S. Bartolomei. (2011) Nonallelic Transcriptional Roles of CTCF and Cohesins at Imprinted Loci. Molecular and Cellular Biology 31:15, pages 3094-3104.
Read now
Claudia Gebert, David Kunkel, Alexander Grinberg & Karl Pfeifer. (2010) H19 Imprinting Control Region Methylation Requires an Imprinted Environment Only in the Male Germ Line. Molecular and Cellular Biology 30:5, pages 1108-1115.
Read now
Hitomi Matsuzaki, Eiichi Okamura, Motoshi Shimotsuma, Akiyoshi Fukamizu & Keiji Tanimoto. (2009) A Randomly Integrated Transgenic H19 Imprinting Control Region Acquires Methylation Imprinting Independently of Its Establishment in Germ Cells. Molecular and Cellular Biology 29:17, pages 4595-4603.
Read now
Nathalie Berteaux, Nathalie Aptel, Guy Cathala, Céline Genton, Jean Coll, Anthony Daccache, Nathalie Spruyt, Hubert Hondermarck, Thierry Dugimont, Jean-Jacques Curgy, Thierry Forné & Eric Adriaenssens. (2008) A Novel H19 Antisense RNA Overexpressed in Breast Cancer Contributes to Paternal IGF2 Expression. Molecular and Cellular Biology 28:22, pages 6731-6745.
Read now
Raluca I. Verona, Joanne L. Thorvaldsen, Kimberly J. Reese & Marisa S. Bartolomei. (2008) The Transcriptional Status but Not the Imprinting Control Region Determines Allele-Specific Histone Modifications at the Imprinted H19 Locus. Molecular and Cellular Biology 28:1, pages 71-82.
Read now
Young Soo Yoon, Sangkyun Jeong, Qi Rong, Kye-Yoon Park, Jae Hoon Chung & Karl Pfeifer. (2007) Analysis of the H19ICR Insulator. Molecular and Cellular Biology 27:9, pages 3499-3510.
Read now
Joanne L. Thorvaldsen, Andrew M. Fedoriw, Son Nguyen & Marisa S. Bartolomei. (2006) Developmental Profile of H19 Differentially Methylated Domain (DMD) Deletion Alleles Reveals Multiple Roles of the DMD in Regulating Allelic Expression and DNA Methylation at the Imprinted H19/Igf2 Locus. Molecular and Cellular Biology 26:4, pages 1245-1258.
Read now
Annabelle Lewis, Kohzoh Mitsuya, Miguel Constancia & Wolf Reik. (2004) Tandem Repeat Hypothesis in Imprinting: Deletion of a Conserved Direct Repeat Element Upstream of H19 Has No Effect on Imprinting in the Igf2-H19 Region. Molecular and Cellular Biology 24:13, pages 5650-5656.
Read now
Piroska E. Szabó, Shih-Huey E. Tang, Francisco J. Silva, Walter M. K. Tsark & Jeffrey R. Mann. (2004) Role of CTCF Binding Sites in the Igf2/H19 Imprinting Control Region. Molecular and Cellular Biology 24:11, pages 4791-4800.
Read now
Candice Coombes, Philippe Arnaud, Emma Gordon, Wendy Dean, Elizabeth A. Coar, Christine M. Williamson, Robert Feil, Jo Peters & Gavin Kelsey. (2003) Epigenetic Properties and Identification of an Imprint Mark in the Nesp-Gnasxl Domain of the Mouse Gnas Imprinted Locus. Molecular and Cellular Biology 23:16, pages 5475-5488.
Read now

Articles from other publishers (45)

Suhee Chang, Diana Fulmer, Stella K Hur, Joanne L Thorvaldsen, Li Li, Yemin Lan, Eric A Rhon-Calderon, Nicolae Adrian Leu, Xiaowen Chen, Jonathan A Epstein & Marisa S Bartolomei. (2022) Dysregulated H19/Igf2 expression disrupts cardiac-placental axis during development of Silver-Russell syndrome-like mouse models. eLife 11.
Crossref
Hitomi Matsuzaki, Yu Miyajima, Akiyoshi Fukamizu & Keiji Tanimoto. (2021) Orientation of mouse H19 ICR affects imprinted H19 gene expression through promoter methylation-dependent and -independent mechanisms. Communications Biology 4:1.
Crossref
Andrea Freschi, Rosita Del Prete, Laura Pignata, Francesco Cecere, Francesco Manfrevola, Monica Mattia, Gilda Cobellis, Angela Sparago, Marisa S Bartolomei, Andrea Riccio & Flavia Cerrato. (2021) The number of the CTCF binding sites of the H19/IGF2 :IG-DMR correlates with DNA methylation and expression imprinting in a humanized mouse model . Human Molecular Genetics 30:16, pages 1509-1520.
Crossref
Suhee Chang & Marisa S. Bartolomei. (2020) Modeling human epigenetic disorders in mice: Beckwith-Wiedemann Syndrome and Silver-Russell Syndrome. Disease Models & Mechanisms.
Crossref
Qing Li, Yuanyuan Li, Qi Yin, Shuo Huang, Kai Wang, Liangchai Zhuo, Wei Li, Boran Chang & Jinsong Li. (2019) Temporal regulation of prenatal embryonic development by paternal imprinted loci. Science China Life Sciences 63:1, pages 1-17.
Crossref
Suzanne N Martos, Teng Li, Ramon Bossardi Ramos, Dan Lou, Hongzheng Dai, Jin-Chong Xu, Ganglong Gao, Yang Gao, Qinglu Wang, Cheng An, Xueli Zhang, Yankai Jia, Valina L Dawson, Ted M Dawson, Hongkai Ji & Zhibin Wang. (2017) Two approaches reveal a new paradigm of ‘switchable or genetics-influenced allele-specific DNA methylation’ with potential in human disease. Cell Discovery 3:1.
Crossref
Walid Abi Habib, Frederic Brioude, Salah Azzi, Jennifer Salem, Cristina Das Neves, Claire Personnier, Sandra Chantot-Bastaraud, Boris Keren, Yves Le Bouc, Madeleine D. Harbison & Irene Netchine. (2017) 11p15 ICR1 Partial Deletions Associated with IGF2/H19 DMR Hypomethylation and Silver-Russell Syndrome . Human Mutation 38:1, pages 105-111.
Crossref
Komal Ramani, Nirmala Mavila, Kwang Suk Ko, José M. Mato & Shelly C. Lu. (2016) Prohibitin 1 Regulates the H19-Igf2 Axis and Proliferation in Hepatocytes. Journal of Biological Chemistry 291:46, pages 24148-24159.
Crossref
Stella K. HurAndrea FreschiFolami IderaabdullahJoanne L. ThorvaldsenLacey J. LuenseAngela H. WellerShelley L. BergerFlavia CerratoAndrea Riccio & Marisa S. Bartolomei. (2016) Humanized H19/Igf2 locus reveals diverged imprinting mechanism between mouse and human and reflects Silver–Russell syndrome phenotypes . Proceedings of the National Academy of Sciences 113:39, pages 10938-10943.
Crossref
Jing Xue & Folami Y. Ideraabdullah. (2016) An assessment of molecular pathways of obesity susceptible to nutrient, toxicant and genetically induced epigenetic perturbation. The Journal of Nutritional Biochemistry 30, pages 1-13.
Crossref
Paul Ginart, Jennifer M. Kalish, Connie L. Jiang, Alice C. Yu, Marisa S. Bartolomei & Arjun Raj. (2016) Visualizing allele-specific expression in single cells reveals epigenetic mosaicism in an H19 loss-of-imprinting mutant . Genes & Development 30:5, pages 567-578.
Crossref
Cuiqing Zhong, Qi Yin, Zhenfei Xie, Meizhu Bai, Rui Dong, Wei Tang, Yu-Hang Xing, Hongling Zhang, Suming Yang, Ling-Ling Chen, Marisa S. Bartolomei, Anne Ferguson-Smith, Dangsheng Li, Li Yang, Yuxuan Wu & Jinsong Li. (2015) CRISPR-Cas9-Mediated Genetic Screening in Mice with Haploid Embryonic Stem Cells Carrying a Guide RNA Library. Cell Stem Cell 17:2, pages 221-232.
Crossref
Martha SusiarjoFrances XinAmita BansalMartha StefaniakChanghong Li, Rebecca A. SimmonsMarisa S. Bartolomei. (2015) Bisphenol A Exposure Disrupts Metabolic Health Across Multiple Generations in the Mouse. Endocrinology 156:6, pages 2049-2058.
Crossref
F. Y. Ideraabdullah, J. L. Thorvaldsen, J. A. Myers & M. S. Bartolomei. (2014) Tissue-specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region. Human Molecular Genetics 23:23, pages 6246-6259.
Crossref
William A. MacDonald & Mellissa R.W. Mann. (2014) Epigenetic regulation of genomic imprinting from germ line to preimplantation. Molecular Reproduction and Development 81:2, pages 126-140.
Crossref
Verónica M. Negrón-Pérez, Franklin D. Echevarría, Sarah R. Huffman & Rocío Melissa Rivera. (2013) Determination of Allelic Expression of H19 in Pre- and Peri-Implantation Mouse Embryos1. Biology of Reproduction 88:4.
Crossref
Folami Y. Ideraabdullah, Lara K. Abramowitz, Joanne L. Thorvaldsen, Christopher Krapp, Sherry C. Wen, Nora Engel & Marisa S. Bartolomei. (2011) Novel cis-regulatory function in ICR-mediated imprinted repression of H19. Developmental Biology 355:2, pages 349-357.
Crossref
H. Matsuzaki, E. Okamura, A. Fukamizu & K. Tanimoto. (2010) CTCF binding is not the epigenetic mark that establishes post-fertilization methylation imprinting in the transgenic H19 ICR. Human Molecular Genetics 19:7, pages 1190-1198.
Crossref
Kristin D. Kernohan, Yan Jiang, Deanna C. Tremblay, Anne C. Bonvissuto, James H. Eubanks, Mellissa R.W. Mann & Nathalie G. Bérubé. (2010) ATRX Partners with Cohesin and MeCP2 and Contributes to Developmental Silencing of Imprinted Genes in the Brain. Developmental Cell 18:2, pages 191-202.
Crossref
Nahalie Berteaux, Nathalie Spruyt & Eric Adriaenssens. 2010. RNA Technologies and Their Applications. RNA Technologies and Their Applications 419 443 .
Louis Lefebvre, Lynn Mar, Aaron Bogutz, Rosemary Oh-McGinnis, Mohammad A. Mandegar, Jana Paderova, Marina Gertsenstein, Jeremy A. Squire & Andras Nagy. (2009) The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the murine Beckwith–Wiedemann region. Human Molecular Genetics 18:22, pages 4255-4267.
Crossref
Philip C. Haycock & Michéle Ramsay. (2009) Exposure of Mouse Embryos to Ethanol During Preimplantation Development: Effect on DNA Methylation in the H19 Imprinting Control Region1. Biology of Reproduction 81:4, pages 618-627.
Crossref
Marisa S. Bartolomei. (2009) Genomic imprinting: employing and avoiding epigenetic processes. Genes & Development 23:18, pages 2124-2133.
Crossref
N. Engel, A. K. Raval, J. L. Thorvaldsen & S. M. Bartolomei. (2008) Three-dimensional conformation at the H19/Igf2 locus supports a model of enhancer tracking. Human Molecular Genetics 17:19, pages 3021-3029.
Crossref
Amanda L. Fortier, Flavia L. Lopes, Nicole Darricarrère, Josée Martel & Jacquetta M. Trasler. (2008) Superovulation alters the expression of imprinted genes in the midgestation mouse placenta. Human Molecular Genetics 17:11, pages 1653-1665.
Crossref
C.J. Marques, P. Costa, B. Vaz, F. Carvalho, S. Fernandes, A. Barros & M. Sousa. (2008) Abnormal methylation of imprinted genes in human sperm is associated with oligozoospermia. MHR: Basic science of reproductive medicine 14:2, pages 67-74.
Crossref
Rocío M. Rivera, Paula Stein, Jamie R. Weaver, Jesse Mager, Richard M. Schultz & Marisa S. Bartolomei. (2008) Manipulations of mouse embryos prior to implantation result in aberrant expression of imprinted genes on day 9.5 of development. Human Molecular Genetics 17:1, pages 1-14.
Crossref
Le‐Ben Wan & Marisa S. Bartolomei. 2008. Long-Range Control of Gene Expression. Long-Range Control of Gene Expression 207 223 .
Patricia Fauque, Pierre Jouannet, Corinne Lesaffre, Marie-Anne Ripoche, Luisa Dandolo, Daniel Vaiman & Hélène Jammes. (2007) Assisted Reproductive Technology affects developmental kinetics, H19 Imprinting Control Region methylation and H19gene expression in individual mouse embryos. BMC Developmental Biology 7:1.
Crossref
Nora Engel, Joanne L. Thorvaldsen & Marisa S. Bartolomei. (2006) CTCF binding sites promote transcription initiation and prevent DNA methylation on the maternal allele at the imprinted H19/Igf2 locus. Human Molecular Genetics 15:19, pages 2945-2954.
Crossref
Jian Qun LingTao LiJi Fan HuThanh H. VuHui Ling ChenXin Wen QiuAthena M. CherryAndrew R. Hoffman. (2006) CTCF Mediates Interchromosomal Colocalization Between Igf2/H19 and Wsb1/Nf1 . Science 312:5771, pages 269-272.
Crossref
Tao Li, Thanh H. Vu, Gary A. Ulaner, Eva Littman, Jian-Qun Ling, Hui-Ling Chen, Ji-Fan Hu, Barry Behr, Linda Giudice & Andrew R. Hoffman. (2005) IVF results in de novo DNA methylation and histone methylation at an Igf2-H19 imprinting epigenetic switch. MHR: Basic science of reproductive medicine 11:9, pages 631-640.
Crossref
Kohji Okamura, Yoshiyuki Sakaki & Takashi Ito. (2005) Comparative genomics approach toward critical determinants for the imprinting of an evolutionarily conserved gene Impact. Biochemical and Biophysical Research Communications 329:3, pages 824-830.
Crossref
Bonnie Reinhart & J.Richard Chaillet. 2005. 173 213 .
Michaël Weber, Hélène Hagège, Nathalie Aptel, Claude Brunel, Guy Cathala & Thierry Forné. 2005. Epigenetics and Chromatin. Epigenetics and Chromatin 207 236 .
Nora Engel, Adam G West, Gary Felsenfeld & Marisa S Bartolomei. (2004) Antagonism between DNA hypermethylation and enhancer-blocking activity at the H19 DMD is uncovered by CpG mutations. Nature Genetics 36:8, pages 883-888.
Crossref
Raluca I Verona & Marisa S Bartolomei. (2004) Role of H19 3′ sequences in controlling H19 and Igf2 imprinting and expression. Genomics 84:1, pages 59-68.
Crossref
R.J. Smith, P. Arnaud & G. Kelsey. (2004) Identification and properties of imprinted genes and their control elements. Cytogenetic and Genome Research 105:2-4, pages 335-345.
Crossref
Raluca I. VeronaMellissa R.W. MannMarisa S. Bartolomei. (2003) Genomic Imprinting: Intricacies of Epigenetic Regulation in Clusters. Annual Review of Cell and Developmental Biology 19:1, pages 237-259.
Crossref
Mellissa R.W. Mann, Young Gie Chung, Leisha D. Nolen, Raluca I. Verona, Keith E. Latham & Marisa S. Bartolomei. (2003) Disruption of Imprinted Gene Methylation and Expression in Cloned Preimplantation Stage Mouse Embryos1. Biology of Reproduction 69:3, pages 902-914.
Crossref
Anton E Weisstein & Hamish G Spencer. (2003) The Evolution of Genomic Imprinting via Variance Minimization: An Evolutionary Genetic Model. Genetics 165:1, pages 205-222.
Crossref
Ivona Percec, Joanne L Thorvaldsen, Robert M Plenge, Christopher J Krapp, Joseph H Nadeau, Huntington F Willard & Marisa S Bartolomei. (2003) An N -Ethyl- N -Nitrosourea Mutagenesis Screen for Epigenetic Mutations in the Mouse . Genetics 164:4, pages 1481-1494.
Crossref
Christopher J. Schoenherr, John M. Levorse & Shirley M. Tilghman. (2002) CTCF maintains differential methylation at the Igf2/H19 locus. Nature Genetics 33:1, pages 66-69.
Crossref
Katharine L Arney. (2003) H19 and Igf2 – enhancing the confusion?. Trends in Genetics 19:1, pages 17-23.
Crossref
C. Davey, R. Fraser, M. Smolle, M.W. Simmen & J. Allan. (2003) Nucleosome Positioning Signals in the DNA Sequence of the Human and Mouse H19 Imprinting Control Regions. Journal of Molecular Biology 325:5, pages 873-887.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.