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Cell Growth and Development

The Response of c-Jun/AP-1 to Chronic Hypoxia Is Hypoxia-Inducible Factor 1α Dependent

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Pages 2515-2523 | Received 11 Sep 2001, Accepted 22 Jan 2002, Published online: 28 Mar 2023

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Keith R. Laderoute, Khalid Amin, Joy M. Calaoagan, Merrill Knapp, Theresamai Le, Juan Orduna, Marc Foretz & Benoit Viollet. (2006) 5′-AMP-Activated Protein Kinase (AMPK) Is Induced by Low-Oxygen and Glucose Deprivation Conditions Found in Solid-Tumor Microenvironments. Molecular and Cellular Biology 26:14, pages 5336-5347.
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Keith R. Laderoute, Joy M. Calaoagan, Merrill Knapp & Randall S. Johnson. (2004) Glucose Utilization Is Essential for Hypoxia-Inducible Factor 1α-Dependent Phosphorylation of c-Jun. Molecular and Cellular Biology 24:10, pages 4128-4137.
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Nate J. Fry, Brittany A. Law, Olga R. Ilkayeva, Christopher L. Holley & Kyle D. Mansfield. (2017) N 6 -methyladenosine is required for the hypoxic stabilization of specific mRNAs . RNA 23:9, pages 1444-1455.
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O. Brew & M.H.F. Sullivan. (2017) Oxygen and tissue culture affect placental gene expression. Placenta 55, pages 13-20.
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Yongan Zhou, Yafang Wang, Zhengwei Zhao, Yanxia Wang, Ning Zhang, Helong Zhang & Lili Liu. (2017) 37LRP induces invasion in hypoxic lung adenocarcinoma cancer cells A549 through the JNK/ERK/c-Jun signaling cascade. Tumor Biology 39:6, pages 101042831770165.
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P. Brym & S. Kamiński. (2016) Microarray analysis of differential gene expression profiles in blood cells of naturally BLV-infected and uninfected Holstein–Friesian cows. Molecular Biology Reports 44:1, pages 109-127.
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Pankaj Khurana, Divya Tiwari, R. Sugadev, Soma Sarkar & Shashi Bala Singh. (2016) A comprehensive assessment of networks and pathways of hypoxia-associated proteins and identification of responsive protein modules. Network Modeling Analysis in Health Informatics and Bioinformatics 5:1.
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Ling Wang, Sheyla González, Wei Dai, Sophie Deng & Luo Lu. (2016) Effect of Hypoxia-regulated Polo-like Kinase 3 (Plk3) on Human Limbal Stem Cell Differentiation. Journal of Biological Chemistry 291:32, pages 16519-16529.
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Peter T. White, Chitra Subramanian, Hashim F. Motiwala & Mark S. Cohen. 2016. Anti-inflammatory Nutraceuticals and Chronic Diseases. Anti-inflammatory Nutraceuticals and Chronic Diseases 329 373 .
Georgina N. Masoud & Wei Li. (2015) HIF-1α pathway: role, regulation and intervention for cancer therapy. Acta Pharmaceutica Sinica B 5:5, pages 378-389.
Crossref
Valéry L. Payen, Lucie Brisson, Mark W. Dewhirst & Pierre Sonveaux. (2015) Common Responses of Tumors and Wounds to Hypoxia. The Cancer Journal 21:2, pages 75-87.
Crossref
Richard Man Kit Yu, Gayathri Chaturvedi, Steve Kwan Hok Tong, Suraia Nusrin, John Paul Giesy, Rudolf Shiu Sun Wu & Richard Yuen Chong Kong. (2015) Evidence for MicroRNA-Mediated Regulation of Steroidogenesis by Hypoxia. Environmental Science & Technology 49:2, pages 1138-1147.
Crossref
Soroush Merchant & Mladen Korbelik. (2013) Upregulation of genes for C-reactive protein and related pentraxin/complement proteins in photodynamic therapy-treated human tumor cells: Enrolment of PI3K/Akt and AP-1. Immunobiology 218:6, pages 869-874.
Crossref
Barbara Onnis, Nicole Fer, Annamaria Rapisarda, Victor S. Perez & Giovanni Melillo. (2013) Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells. Journal of Clinical Investigation 123:4, pages 1615-1629.
Crossref
Petr Steiner, Milan Hora, Jan Stehlik, Petr Martinek, Tomas Vanecek, Fredrik Petersson, Michal Michal, Marie Korabecna, Ivan Travnicek & Ondrej Hes. (2013) Tubulocystic renal cell carcinoma: is there a rational reason for targeted therapy using angiogenic inhibition? Analysis of seven cases. Virchows Archiv 462:2, pages 183-192.
Crossref
Johannes Schödel & David R. Mole. 2013. Next Generation Sequencing in Cancer Research. Next Generation Sequencing in Cancer Research 91 117 .
Peter Vaupel. 2011. Drug Delivery in Oncology. Drug Delivery in Oncology 33 64 .
Antonio Sica, Giovanni Melillo & Luigi Varesio. (2011) Hypoxia: a double-edged sword of immunity. Journal of Molecular Medicine 89:7, pages 657-665.
Crossref
Johannes Schödel, Spyros Oikonomopoulos, Jiannis Ragoussis, Christopher W. Pugh, Peter J. Ratcliffe & David R. Mole. (2011) High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq. Blood 117:23, pages e207-e217.
Crossref
Denise A. Chan, Albert C. Koong & Amato J. Giaccia. 2010. Handbook of Cell Signaling. Handbook of Cell Signaling 2241 2245 .
Peter Angel & Jochen Hess. 2010. Handbook of Cell Signaling. Handbook of Cell Signaling 2059 2068 .
Grace Vangeison & David A. Rempe. (2009) The Janus-Faced Effects of Hypoxia on Astrocyte Function. The Neuroscientist 15:6, pages 579-588.
Crossref
Bing Yu, Ze-Hong Miao, Yi Jiang, Mei-Hong Li, Na Yang, Ting Li & Jian Ding. (2009) c-Jun Protects Hypoxia-Inducible Factor-1α from Degradation via Its Oxygen-Dependent Degradation Domain in a Nontranscriptional Manner. Cancer Research 69:19, pages 7704-7712.
Crossref
David R. Mole, Christine Blancher, Richard R. Copley, Patrick J. Pollard, Jonathan M. Gleadle, Jiannis Ragoussis & Peter J. Ratcliffe. (2009) Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts. Journal of Biological Chemistry 284:25, pages 16767-16775.
Crossref
Kwang-Yu Chang, Meng-Ru Shen, Mei-Yi Lee, Wen-Lin Wang, Wu-Chou Su, Wen-Chang Chang & Ben-Kuen Chen. (2009) Epidermal Growth Factor-activated Aryl Hydrocarbon Receptor Nuclear Translocator/HIF-1β Signal Pathway Up-regulates Cyclooxygenase-2 Gene Expression Associated with Squamous Cell Carcinoma. Journal of Biological Chemistry 284:15, pages 9908-9916.
Crossref
Peter Vaupel. 2009. The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies. The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies 273 290 .
Maria Carla Bosco, Maura Puppo, Fabiola Blengio, Tiziana Fraone, Paola Cappello, Mirella Giovarelli & Luigi Varesio. (2008) Monocytes and dendritic cells in a hypoxic environment: Spotlights on chemotaxis and migration. Immunobiology 213:9-10, pages 733-749.
Crossref
I Papandreou, A L Lim, K Laderoute & N C Denko. (2008) Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L. Cell Death & Differentiation 15:10, pages 1572-1581.
Crossref
Ling Wang, Jie Gao, Wei Dai & Luo Lu. (2008) Activation of Polo-like Kinase 3 by Hypoxic Stresses. Journal of Biological Chemistry 283:38, pages 25928-25935.
Crossref
Orli Yogev, Keren Saadon, Shira Anzi, Kazushi Inoue & Eitan Shaulian. (2008) DNA Damage–Dependent Translocation of B23 and p19ARF Is Regulated by the Jun N-Terminal Kinase Pathway. Cancer Research 68:5, pages 1398-1406.
Crossref
Maria Vinciguerra, Ilaria Esposito, Salvatore Salzano, Antonio Madeo, Georg Nagel, Marcello Maggiolini, Adriana Gallo & Anna Maria Musti. (2008) Negative charged threonine 95 of c-Jun is essential for c-Jun N-terminal kinase-dependent phosphorylation of threonine 91/93 and stress-induced c-Jun biological activity. The International Journal of Biochemistry & Cell Biology 40:2, pages 307-316.
Crossref
Peter Vaupel & Michael Höckel. 2008. Recombinant Human Erythropoietin (rhEPO) in Clinical Oncology. Recombinant Human Erythropoietin (rhEPO) in Clinical Oncology 283 305 .
J.C. Robins, A. Heizer, A. Hardiman, M. Hubert & S. Handwerger. (2007) Oxygen Tension Directs the Differentiation Pathway of Human Cytotrophoblast Cells. Placenta 28:11-12, pages 1141-1146.
Crossref
Eui Jung MoonDavid M. BrizelJen–Tsan Ashley ChiMark W. Dewhirst. (2007) The Potential Role of Intrinsic Hypoxia Markers as Prognostic Variables in Cancer. Antioxidants & Redox Signaling 9:8, pages 1237-1294.
Crossref
Dirk Schmidt, Björn Textor, Oliver T Pein, Alexander H Licht, Sven Andrecht, Melanie Sator-Schmitt, Norbert E Fusenig, Peter Angel & Marina Schorpp-Kistner. (2007) Critical role for NF-κB-induced JunB in VEGF regulation and tumor angiogenesis. The EMBO Journal 26:3, pages 710-719.
Crossref
BJÖRN TEXTOR, MELANIE SATOR-SCHMITT, KARL HARTMUT RICHTER, PETER ANGEL & MARINA SCHORPP-KISTNER. (2006) c-Jun and JunB Are Essential for Hypoglycemia-Mediated VEGF Induction . Annals of the New York Academy of Sciences 1091:1, pages 310-318.
Crossref
Jean-Pascal Piret, Jean-Philippe Cosse, Noelle Ninane, Martine Raes & Carine Michiels. (2006) Hypoxia protects HepG2 cells against etoposide-induced apoptosis VIA a HIF-1-independent pathway. Experimental Cell Research 312:15, pages 2908-2920.
Crossref
Maria Carla Bosco, Maura Puppo, Clara Santangelo, Luca Anfosso, Ulrich Pfeffer, Paolo Fardin, Florinda Battaglia & Luigi Varesio. (2006) Hypoxia Modifies the Transcriptome of Primary Human Monocytes: Modulation of Novel Immune-Related Genes and Identification Of CC-Chemokine Ligand 20 as a New Hypoxia-Inducible Gene. The Journal of Immunology 177:3, pages 1941-1955.
Crossref
S. M. Mense, A. Sengupta, M. Zhou, C. Lan, G. Bentsman, D. J. Volsky & L. Zhang. (2006) Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes. Physiological Genomics 25:3, pages 435-449.
Crossref
J.L. James, P.R. Stone & L.W. Chamley. (2006) The regulation of trophoblast differentiation by oxygen in the first trimester of pregnancy. Human Reproduction Update 12:2, pages 137-144.
Crossref
Michele M. Hickey & M. Celeste Simon. 2006. 217 257 .
Denis Mottet, Sébastien Pyr Dit Ruys, Catherine Demazy, Martine Raes & Carine Michiels. (2005) Role for casein kinase 2 in the regulation of HIF-1 activity. International Journal of Cancer 117:5, pages 764-774.
Crossref
Keith R. Laderoute. (2005) The interaction between HIF-1 and AP-1 transcription factors in response to low oxygen. Seminars in Cell & Developmental Biology 16:4-5, pages 502-513.
Crossref
Thomas Hellwig-BürgelDaniel P. StiehlAnika E. WagnerEric MetzenWolfgang Jelkmann. (2005) Review: Hypoxia-Inducible Factor-1 (HIF-1): A Novel Transcription Factor in Immune Reactions . Journal of Interferon & Cytokine Research 25:6, pages 297-310.
Crossref
Peter Vaupel & Arnulf Mayer. (2005) Hypoxia and anemia: effects on tumor biology and treatment resistance. Transfusion Clinique et Biologique 12:1, pages 5-10.
Crossref
Sébastien Paris, Hélène Denis, Edouard Delaive, Marc Dieu, Valéry Dumont, Noëlle Ninane, Martine Raes & Carine Michiels. (2005) Up-regulation of 94-kDa glucose-regulated protein by hypoxia-inducible factor-1 in human endothelial cells in response to hypoxia. FEBS Letters 579:1, pages 105-114.
Crossref
Ioanna Papandreou, Ashley Powell, Ai Lin Lim & Nicholas Denko. (2005) Cellular reaction to hypoxia: sensing and responding to an adverse environment. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 569:1-2, pages 87-100.
Crossref
Peter Vaupel. (2004) The Role of Hypoxia-Induced Factors in Tumor Progression. The Oncologist 9:S5, pages 10-17.
Crossref
Olga Aprelikova, Gadisetti V.R. Chandramouli, Matthew Wood, James R. Vasselli, Joseph Riss, Jodi K. Maranchie, W. Marston Linehan & J. Carl Barrett. (2004) Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors. Journal of Cellular Biochemistry 92:3, pages 491-501.
Crossref
Tetyana Khomenko, Xiaoming Deng, Zsuzsanna Sandor, Andrzej S Tarnawski & Sandor Szabo. (2004) Cysteamine alters redox state, HIF-1α transcriptional interactions and reduces duodenal mucosal oxygenation: novel insight into the mechanisms of duodenal ulceration. Biochemical and Biophysical Research Communications 317:1, pages 121-127.
Crossref
Ryoichi Yamaji, Kayoko Fujita, Isao Nakanishi, Kaori Nagao, Mikihiko Naito, Takashi Tsuruo, Hiroshi Inui & Yoshihisa Nakano. (2004) Hypoxic up-regulation of triosephosphate isomerase expression in mouse brain capillary endothelial cells. Archives of Biochemistry and Biophysics 423:2, pages 332-342.
Crossref
S-C Chou, Y Azuma, M A Varia & J A Raleigh. (2004) Evidence that involucrin, a marker for differentiation, is oxygen regulated in human squamous cell carcinomas. British Journal of Cancer 90:3, pages 728-735.
Crossref
Peter Vaupel, Arnulf Mayer & Michael Höckel. 2004. Oxygen Sensing. Oxygen Sensing 335 354 .
T. R. Zacharewski & J. J. La Pres. 2004. Transcription Factors. Transcription Factors 69 93 .
Manfred Kunz, Steffen Moeller, Dirk Koczan, Peter Lorenz, Roland H. Wenger, Michael O. Glocker, Hans-Juergen Thiesen, Gerd Gross & Saleh M. Ibrahim. (2003) Mechanisms of Hypoxic Gene Regulation of Angiogenesis Factor Cyr61 in Melanoma Cells. Journal of Biological Chemistry 278:46, pages 45651-45660.
Crossref
Ladislav Tomes, Ethan Emberley, Yulian Niu, Sandra Troup, Jaromir Pastorek, Karen Strange, Adrian Harris & Peter H. Watson. (2003) Necrosis and Hypoxia in Invasive Breast Carcinoma. Breast Cancer Research and Treatment 81:1, pages 61-69.
Crossref
Russell M. Crawford, Sofija Jovanović, Grant R. Budas, Anthony M. Davies, Harish Lad, Roland H. Wenger, Kevin A. Robertson, Douglas J. Roy, Harri J. Ranki & Aleksandar Jovanović. (2003) Chronic Mild Hypoxia Protects Heart-derived H9c2 Cells against Acute Hypoxia/Reoxygenation by Regulating Expression of the SUR2A Subunit of the ATP-sensitive K+ Channel. Journal of Biological Chemistry 278:33, pages 31444-31455.
Crossref
Tsunenori Kodama, Noriaki Shimizu, Noritada Yoshikawa, Yuichi Makino, Rika Ouchida, Kensaku Okamoto, Tetsuya Hisada, Hiroshi Nakamura, Chikao Morimoto & Hirotoshi Tanaka. (2003) Role of the Glucocorticoid Receptor for Regulation of Hypoxia-dependent Gene Expression. Journal of Biological Chemistry 278:35, pages 33384-33391.
Crossref
Guochun Li, Cindy Gustafson-Brown, Steven K Hanks, Katie Nason, Jeffrey M Arbeit, Kit Pogliano, Ronald M Wisdom & Randall S Johnson. (2003) c-Jun Is Essential for Organization of the Epidermal Leading Edge. Developmental Cell 4:6, pages 865-877.
Crossref
Albert C. Koong & Amato J. Giaccia. 2003. Handbook of Cell Signaling. Handbook of Cell Signaling 277 282 .
Peter Angel. 2003. Handbook of Cell Signaling. Handbook of Cell Signaling 99 105 .

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