Advanced search
Publication Cover
Molecular and Cellular Biology Volume 22, 2002 - Issue 8
Submit an article Journal homepage
21
Views
72
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Mutant Mouse Models Reveal the Relative Roles of E2F1 and E2F3 In Vivo

Jennifer E. Cloud1 Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts02139
,
Catherine Rogers1 Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts02139
,
Tammi L. Reza1 Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts02139
,
Ulrike Ziebold1 Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts02139
,
James R. Stone2 Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts02115
,
Michael H. Picard3 Cardiology Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts02114
,
Alicia M. Caron1 Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts02139
,
Roderick T. Bronson4 Department of Pathology, Tufts University School of Veterinary Medicine, Boston, Massachusetts02111
&
Jacqueline A. Lees1 Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts02139Correspondence[email protected]
 show all
Pages 2663-2672 | Received 21 Nov 2001, Accepted 18 Jan 2002, Published online: 28 Mar 2023

Citations (72)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (9)

Paul S. Danielian, Rex A. Hess & Jacqueline A. Lees. (2016) E2f4 and E2f5 are essential for the development of the male reproductive system . Cell Cycle 15:2, pages 250-260.
Read now
Marie-Claude Perry, Catherine R. Dufour, Lillian J. Eichner, David W. K. Tsang, Geneviève Deblois, William J. Muller & Vincent Giguère. (2014) ERBB2 Deficiency Alters an E2F-1-Dependent Adaptive Stress Response and Leads to Cardiac Dysfunction. Molecular and Cellular Biology 34:23, pages 4232-4243.
Read now
Glen D. Raffel, Gerald C. Chu, Jonathan L. Jesneck, Dana E. Cullen, Roderick T. Bronson, Olivier A. Bernard & D. Gary Gilliland. (2009) Ott1 (Rbm15) Is Essential for Placental Vascular Branching Morphogenesis and Embryonic Development of the Heart and Spleen. Molecular and Cellular Biology 29:2, pages 333-341.
Read now
Mary Truscott, Ryoko Harada, Charles Vadnais, François Robert & Alain Nepveu. (2008) p110 CUX1 Cooperates with E2F Transcription Factors in the Transcriptional Activation of Cell Cycle-Regulated Genes. Molecular and Cellular Biology 28:10, pages 3127-3138.
Read now
Kelly A. McClellan, Vladimir A. Ruzhynsky, David N. Douda, Jacqueline L. Vanderluit, Kerry L. Ferguson, Danian Chen, Rod Bremner, David S. Park, Gustavo Leone & Ruth S. Slack. (2007) Unique Requirement for Rb/E2F3 in Neuronal Migration: Evidence for Cell Cycle-Independent Functions. Molecular and Cellular Biology 27:13, pages 4825-4843.
Read now
Tiziana Parisi, Tina L. Yuan, Ann Marie Faust, Alicia M. Caron, Roderick Bronson & Jacqueline A. Lees. (2007) Selective Requirements for E2f3 in the Development and Tumorigenicity of Rb-Deficient Chimeric Tissues. Molecular and Cellular Biology 27:6, pages 2283-2293.
Read now
Stefan Taubert, Chiara Gorrini, Scott R. Frank, Tiziana Parisi, Miriam Fuchs, Ho-Man Chan, David M. Livingston & Bruno Amati. (2004) E2F-Dependent Histone Acetylation and Recruitment of the Tip60 Acetyltransferase Complex to Chromatin in Late G1. Molecular and Cellular Biology 24:10, pages 4546-4556.
Read now
Ulrike Ziebold, Eunice Y. Lee, Roderick T. Bronson & Jacqueline A. Lees. (2003) E2F3 Loss Has Opposing Effects on Different pRB-Deficient Tumors, Resulting in Suppression of Pituitary Tumors but Metastasis of Medullary Thyroid Carcinomas. Molecular and Cellular Biology 23:18, pages 6542-6552.
Read now
Feng X. Li, Jing W. Zhu, Christopher J. Hogan & James DeGregori. (2003) Defective Gene Expression, S Phase Progression, and Maturation during Hematopoiesis in E2F1/E2F2 Mutant Mice. Molecular and Cellular Biology 23:10, pages 3607-3622.
Read now

Articles from other publishers (63)

Paweł Uruski, Julia Matuszewska, Aleksandra Leśniewska, Daniel Rychlewski, Arkadiusz Niklas, Justyna Mikuła-Pietrasik, Andrzej Tykarski & Krzysztof Książek. (2023) An integrative review of nonobvious puzzles of cellular and molecular cardiooncology. Cellular & Molecular Biology Letters 28:1.
Crossref
Mingxing Gao, Kaizhong Wang & Hui Zhao. (2022) GABAergic neurons maturation is regulated by a delicate network. International Journal of Developmental Neuroscience 83:1, pages 3-15.
Crossref
Chandrasekharan C. KarthaChandrasekharan C. Kartha. 2021. Cardiomyocytes in Health and Disease. Cardiomyocytes in Health and Disease 25 39 .
Nahid Punjani & Dolores J. Lamb. (2020) Male infertility and genitourinary birth defects: there is more than meets the eye. Fertility and Sterility 114:2, pages 209-218.
Crossref
Xiaolian Ding, Wei Yao, Jie Zhu, Kaida Mu, Jing Zhang & Jin-an Zhang. (2020) Resveratrol Attenuates High Glucose-Induced Vascular Endothelial Cell Injury by Activating the E2F3 Pathway. BioMed Research International 2020, pages 1-7.
Crossref
Ya-Jun Deng, En-Hui Ren, Wen-Hua Yuan, Guang-Zhi Zhang, Zuo-Long Wu & Qi-Qi Xie. (2020) GRB10 and E2F3 as Diagnostic Markers of Osteoarthritis and Their Correlation with Immune Infiltration. Diagnostics 10:3, pages 171.
Crossref
Nathan Palmer, S. Zakiah A. Talib & Philipp Kaldis. (2019) Diverse roles for CDK‐associated activity during spermatogenesis. FEBS Letters 593:20, pages 2925-2949.
Crossref
Eléonore Ostermann, Stefan Loroch, Zhikang Qian, Albert Sickmann, Lüder Wiebusch & Wolfram Brune. (2018) Activation of E2F-dependent transcription by the mouse cytomegalovirus M117 protein affects the viral host range. PLOS Pathogens 14:12, pages e1007481.
Crossref
Ivonne Gamper, Deborah L. Burkhart, Megan J. Bywater, Daniel Garcia, Catherine H. Wilson, Peter A. Kreuzaler, Mark J. Arends, Yao-Wu Zheng, Alessandra Perfetto, Trevor D. Littlewood & Gerard I. Evan. (2017) Determination of the physiological and pathological roles of E2F3 in adult tissues. Scientific Reports 7:1.
Crossref
Zhixiong Tang, Nian Liu, Lan Luo, Kang Kang, Li Li, Ruiyang Ni, Huiling Qiu & Deming Gou. (2017) MicroRNA-17-92 Regulates the Transcription Factor E2F3b during Myogenesis In Vitro and In Vivo. International Journal of Molecular Sciences 18:4, pages 727.
Crossref
N. Palmer & P. Kaldis. 2016. Mammalian Preimplantation Development. Mammalian Preimplantation Development 1 53 .
Kun Wang, Lu-Yu Zhou, Jian-Xun Wang, Yin Wang, Teng Sun, Bing Zhao, Yong-Jie Yang, Tao An, Bo Long, Na Li, Cui-Yun Liu, Ying Gong, Jin-Ning Gao, Yan-Han Dong, Jian Zhang & Pei-Feng Li. (2015) E2F1-dependent miR-421 regulates mitochondrial fragmentation and myocardial infarction by targeting Pink1. Nature Communications 6:1.
Crossref
Ricarda Flöttmann, Johannes Wagner, Karolina Kobus, Cynthia J Curry, Ravi Savarirayan, Gen Nishimura, Natsuo Yasui, Jürgen Spranger, Hilde Van Esch, Michael J Lyons, Barbara R DuPont, Alka Dwivedi, Eva Klopocki, Denise Horn, Stefan Mundlos & Malte Spielmann. (2015) Microdeletions on 6p22.3 are associated with mesomelic dysplasia Savarirayan type. Journal of Medical Genetics 52:7, pages 476-483.
Crossref
K Wang, T An, L-Y Zhou, C-Y Liu, X-J Zhang, C Feng & P-F Li. (2014) E2F1-regulated miR-30b suppresses Cyclophilin D and protects heart from ischemia/reperfusion injury and necrotic cell death. Cell Death & Differentiation 22:5, pages 743-754.
Crossref
Brad Bolon & Vinicius Carreira. 2015. Pathology of the Developing Mouse. Pathology of the Developing Mouse 293 354 .
Monte S. Willis, Kristine M. Wadosky, Jessica E. Rodríguez, Jonathan C. Schisler, Pamela Lockyer, Eleanor G. Hilliard, David J. Glass & Cam Patterson. (2014) Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1-mediated gene expression in vivo . Cell Biochemistry and Function 32:1, pages 39-50.
Crossref
Madhu M. Ouseph, Jing Li, Hui-Zi Chen, Thierry Pécot, Pamela Wenzel, John C. Thompson, Grant Comstock, Veda Chokshi, Morgan Byrne, Braxton Forde, Jean-Leon Chong, Kun Huang, Raghu Machiraju, Alain de Bruin & Gustavo Leone. (2012) Atypical E2F Repressors and Activators Coordinate Placental Development. Developmental Cell 22:4, pages 849-862.
Crossref
Hongying Gang, Rimpy Dhingra, Yan Wang, Wajihah Mughal, Joseph W. Gordon & Lorrie A. Kirshenbaum. (2011) Epigenetic Regulation of E2F-1-Dependent Bnip3 Transcription and Cell Death by Nuclear Factor-κB and Histone Deacetylase-1. Pediatric Cardiology 32:3, pages 263-266.
Crossref
Jennifer Rueger & Balwant S. Tuana. 2011. Genes and Cardiovascular Function. Genes and Cardiovascular Function 29 41 .
W. Robb MacLellan. 2010. Cell Cycle Regulation and Differentiation in Cardiovascular and Neural Systems. Cell Cycle Regulation and Differentiation in Cardiovascular and Neural Systems 179 202 .
Aanchal Mehrotra, Kusum Joshi & Deepak Kaul. (2010) E2F-1 RNomics is critical for reprogramming of cancer cells to quiescent state. International Journal of Cancer, pages NA-NA.
Crossref
Jean-Leon Chong, Pamela L. Wenzel, M. Teresa Sáenz-Robles, Vivek Nair, Antoney Ferrey, John P. Hagan, Yorman M. Gomez, Nidhi Sharma, Hui-Zi Chen, Madhu Ouseph, Shu-Huei Wang, Prashant Trikha, Brian Culp, Louise Mezache, Douglas J. Winton, Owen J. Sansom, Danian Chen, Rod Bremner, Paul G. Cantalupo, Michael L. Robinson, James M. Pipas & Gustavo Leone. (2009) E2f1–3 switch from activators in progenitor cells to repressors in differentiating cells. Nature 462:7275, pages 930-934.
Crossref
Hui-Zi Chen, Shih-Yin Tsai & Gustavo Leone. (2009) Emerging roles of E2Fs in cancer: an exit from cell cycle control. Nature Reviews Cancer 9:11, pages 785-797.
Crossref
Patrik Asp, Diego Acosta-Alvear, Mary Tsikitis, Chris van Oevelen & Brian David Dynlacht. (2009) E2f3b plays an essential role in myogenic differentiation through isoform-specific gene regulation. Genes & Development 23:1, pages 37-53.
Crossref
Victoria A. Swiss & Patrizia Casaccia. (2009) Cell-context specific role of the E2F/Rb pathway in development and disease. Glia, pages NA-NA.
Crossref
James Shaw, Natalia Yurkova, Tong Zhang, Hongying Gang, Floribeth Aguilar, Danielle Weidman, Carly Scramstad, Harvey Weisman & Lorrie A. Kirshenbaum. (2008) Antagonism of E2F-1 regulated Bnip3 transcription by NF-κB is essential for basal cell survival. Proceedings of the National Academy of Sciences 105:52, pages 20734-20739.
Crossref
Satoshi Yamanaka, Ihor Zahanich, Robert P. Wersto & Kenneth R. Boheler. (2008) Enhanced Proliferation of Monolayer Cultures of Embryonic Stem (ES) Cell-Derived Cardiomyocytes Following Acute Loss of Retinoblastoma. PLoS ONE 3:12, pages e3896.
Crossref
P S Danielian, L B Friesenhahn, A M Faust, J C West, A M Caron, R T Bronson & J A Lees. (2008) E2f3a and E2f3b make overlapping but different contributions to total E2f3 activity. Oncogene 27:51, pages 6561-6570.
Crossref
Shih-Yin Tsai, Rene Opavsky, Nidhi Sharma, Lizhao Wu, Shan Naidu, Eric Nolan, Enrique Feria-Arias, Cynthia Timmers, Jana Opavska, Alain de Bruin, Jean-Leon Chong, Prashant Trikha, Soledad A. Fernandez, Paul Stromberg, Thomas J. Rosol & Gustavo Leone. (2008) Mouse development with a single E2F activator. Nature 454:7208, pages 1137-1141.
Crossref
Natalia YurkovaJames ShawKaren BlackieDanielle WeidmanRavi JayasBryan FlynnLorrie A. Kirshenbaum. (2008) The Cell Cycle Factor E2F-1 Activates Bnip3 and the Intrinsic Death Pathway in Ventricular Myocytes. Circulation Research 102:4, pages 472-479.
Crossref
Sonia B. JakowlewLeslie I. Gold & Jon Lecanda. 2008. Transforming Growth Factor-β in Cancer Therapy, Volume I. Transforming Growth Factor-β in Cancer Therapy, Volume I 213 242 .
Preeti Ahuja, Patima Sdek & W. Robb MacLellan. (2007) Cardiac Myocyte Cell Cycle Control in Development, Disease, and Regeneration. Physiological Reviews 87:2, pages 521-544.
Crossref
Jon Lecanda, Trilok V. Parekh, Patricia Gama, Ke Lin, Vladimir Liarski, Seth Uretsky, Khush Mittal & Leslie I. Gold. (2007) Transforming Growth Factor-β, Estrogen, and Progesterone Converge on the Regulation of p27Kip1 in the Normal and Malignant Endometrium. Cancer Research 67:3, pages 1007-1018.
Crossref
Kame S El-Darwish, Martti Parvinen & Jorma Toppari. (2006) Differential expression of members of the E2F family of transcription factors in rodent testes. Reproductive Biology and Endocrinology 4:1.
Crossref
Helena E. Richardson, Leonie M. Quinn, Nancy Amin, Anabel Herr, Anthony M. Brumby, Kathryn M. Doyle, Patrick O. Humbert & Julie Secombe. 2006. Encyclopedia of Molecular Cell Biology and Molecular Medicine. Encyclopedia of Molecular Cell Biology and Molecular Medicine.
S X Skapek, Y-R Pan & E Y-H P Lee. (2006) Regulation of cell lineage specification by the retinoblastoma tumor suppressor. Oncogene 25:38, pages 5268-5276.
Crossref
W Du & J Pogoriler. (2006) Retinoblastoma family genes. Oncogene 25:38, pages 5190-5200.
Crossref
Lili Yamasaki. 2006. Cell Cycle Regulation. Cell Cycle Regulation 227 256 .
Wei Du & Jennifer Pogoriler. 2006. Gene Expression and Regulation. Gene Expression and Regulation 207 217 .
Fred Dick & Nicholas Dyson. 2006. Rb and Tumorigenesis. Rb and Tumorigenesis 59 72 .
P.K. Tsantoulis & V.G. Gorgoulis. (2005) Involvement of E2F transcription factor family in cancer. European Journal of Cancer 41:16, pages 2403-2414.
Crossref
Evangelia Papadimou, Claudine Ménard, Corinne Grey & Michel Pucéat. (2005) Interplay between the retinoblastoma protein and LEK1 specifies stem cells toward the cardiac lineage. The EMBO Journal 24:9, pages 1750-1761.
Crossref
Maria A Ciemerych & Peter Sicinski. (2005) Cell cycle in mouse development. Oncogene 24:17, pages 2877-2898.
Crossref
Wing Y. Chang, Dawn M. Bryce, Sudhir J.A. D'Souza & Lina Dagnino. (2004) The DP-1 Transcription Factor Is Required for Keratinocyte Growth and Epidermal Stratification. Journal of Biological Chemistry 279:49, pages 51343-51353.
Crossref
Myint Hlaing, Paul Spitz, Krishnan Padmanabhan, Blanca Cabezas, Christopher S. Barker & Harold S. Bernstein. (2004) E2F-1 Regulates the Expression of a Subset of Target Genes during Skeletal Myoblast Hypertrophy. Journal of Biological Chemistry 279:42, pages 43625-43633.
Crossref
Michael Korenjak, Barbie Taylor-Harding, Ulrich K. Binné, John S. Satterlee, Olivier Stevaux, Rein Aasland, Helen White-Cooper, Nick Dyson & Alexander Brehm. (2004) Native E2F/RBF Complexes Contain Myb-Interacting Proteins and Repress Transcription of Developmentally Controlled E2F Target Genes. Cell 119:2, pages 181-193.
Crossref
Adrian P. Bracken, Marco Ciro, Andrea Cocito & Kristian Helin. (2004) E2F target genes: unraveling the biology. Trends in Biochemical Sciences 29:8, pages 409-417.
Crossref
Qingyu Cao, Ying Xia, Mitra Azadniv & I. Nicholas Crispe. (2004) The E2F-1 Transcription Factor Promotes Caspase-8 and Bid Expression, and Enhances Fas Signaling in T Cells. The Journal of Immunology 173:2, pages 1111-1117.
Crossref
Masamitsu Onda, Hisaki Nagai, Akira Yoshida, Shizuyo Miyamoto, Shin-ichi Asaka, Junko Akaishi, Keisuke Takatsu, Mitsuji Nagahama, Kouichi Ito, Kazuo Shimizu & Mitsuru Emi. (2004) Up-regulation of transcriptional factor E2F1 in papillary and anaplastic thyroid cancers. Journal of Human Genetics 49:6, pages 312-318.
Crossref
Ainhoa Iglesias, Matilde Murga, Usua Laresgoiti, Anouchka Skoudy, Irantzu Bernales, Asier Fullaondo, Bernardino Moreno, José Lloreta, Seth J. Field, Francisco X. Real & Ana M. Zubiaga. (2004) Diabetes and exocrine pancreatic insufficiency in E2F1/E2F2 double-mutant mice. Journal of Clinical Investigation 113:10, pages 1398-1407.
Crossref
Ainhoa Iglesias, Matilde Murga, Usua Laresgoiti, Anouchka Skoudy, Irantzu Bernales, Asier Fullaondo, Bernardino Moreno, José Lloreta, Seth J. Field, Francisco X. Real & Ana M. Zubiaga. (2004) Diabetes and exocrine pancreatic insufficiency in E2F1/E2F2 double-mutant mice. Journal of Clinical Investigation 113:10, pages 1398-1407.
Crossref
Sandra W Leung, Elzbieta H Wloga, Alejandro F Castro, Thao Nguyen, Roderick T Bronson & Lili Yamasaki. (2004) A dynamic switch in Rb+/− mediated neuroendocrine tumorigenesis. Oncogene 23:19, pages 3296-3307.
Crossref
Blanca Scheijen, Marieke Bronk, Tiffany van der Meer, Daphne De Jong & René Bernards. (2004) High Incidence of Thymic Epithelial Tumors in E2F2 Transgenic Mice. Journal of Biological Chemistry 279:11, pages 10476-10483.
Crossref
L. Hauck & R. von Harsdorf. 2004. Transcription Factors. Transcription Factors 277 308 .
Lili Yamasaki. 2004. Signal Transduction in Cancer. Signal Transduction in Cancer 209 239 .
Frederick A Dick & Nick Dyson. (2003) pRB Contains an E2F1-Specific Binding Domain that Allows E2F1-Induced Apoptosis to Be Regulated Separately from Other E2F Activities. Molecular Cell 12:3, pages 639-649.
Crossref
G. Fingerle-RowsonO. PetrenkoC. N. MetzT. G. ForsthuberR. MitchellR. HussU. MollW. MüllerR. Bucala. (2003) The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting. Proceedings of the National Academy of Sciences 100:16, pages 9354-9359.
Crossref
Dharmesh Vara, Katrina A. Bicknell, Carmen H. Coxon & Gavin Brooks. (2003) Inhibition of E2F Abrogates the Development of Cardiac Myocyte Hypertrophy. Journal of Biological Chemistry 278:24, pages 21388-21394.
Crossref
Matthew J. Kohn, Roderick T. Bronson, Ed Harlow, Nicholas J. Dyson & Lili Yamasaki. (2003) Dp1 is required for extra-embryonic development . Development 130:7, pages 1295-1305.
Crossref
Suneel D. Mundle & Gurveen Saberwal. (2003) Evolving intricacies and implications of E2F1 regulation. The FASEB Journal 17:6, pages 569-574.
Crossref
Harold I Saavedra, Baidehi Maiti, Cynthia Timmers, Rachel Altura, Yukari Tokuyama, Kenji Fukasawa & Gustavo Leone. (2003) Inactivation of E2F3 results in centrosome amplification. Cancer Cell 3:4, pages 333-346.
Crossref
Oleksi Petrenko, Gunter Fingerle-Rowson, Tina Peng, Robert A. Mitchell & Christine N. Metz. (2003) Macrophage Migration Inhibitory Factor Deficiency Is Associated with Altered Cell Growth and Reduced Susceptibility to Ras-mediated Transformation. Journal of Biological Chemistry 278:13, pages 11078-11085.
Crossref
Yiwen He & W. Douglas Cress. (2002) E2F-3B Is a Physiological Target of Cyclin A. Journal of Biological Chemistry 277:26, pages 23493-23499.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.