31
Views
62
CrossRef citations to date
0
Altmetric
Cell Growth and Development

PIM3 Proto-Oncogene Kinase Is a Common Transcriptional Target of Divergent EWS/ETS Oncoproteins

, , , , &
Pages 3897-3908 | Received 19 Nov 2002, Accepted 03 Mar 2003, Published online: 27 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Dapeng Xu, Michael G. Cobb, Lily Gavilano, Sam M. Witherspoon, Daniel Williams, Catherine D. White, Pietro Taverna, Brian K. Bednarski, Hong Jin Kim, Albert S. Baldwin & Antonio T. Baines. (2013) Inhibition of oncogenic Pim-3 kinase modulates transformed growth and chemosensitizes pancreatic cancer cells to gemcitabine. Cancer Biology & Therapy 14:6, pages 492-501.
Read now
Yesid Alvarado, Francis J Giles & Ronan T Swords. (2012) The PIM kinases in hematological cancers. Expert Review of Hematology 5:1, pages 81-96.
Read now
Yoshitaka Miyagawa, Hajime Okita, Hideki Nakaijima, Yasuomi Horiuchi, Ban Sato, Tomoko Taguchi, Masashi Toyoda, Yohko U. Katagiri, Junichiro Fujimoto, Jun-ichi Hata, Akihiro Umezawa & Nobutaka Kiyokawa. (2008) Inducible Expression of Chimeric EWS/ETS Proteins Confers Ewing's Family Tumor-Like Phenotypes to Human Mesenchymal Progenitor Cells. Molecular and Cellular Biology 28:7, pages 2125-2137.
Read now
Enrique C. Torchia, Kelli Boyd, Jerold E. Rehg, Chunxu Qu & Suzanne J. Baker. (2007) EWS/FLI-1 Induces Rapid Onset of Myeloid/Erythroid Leukemia in Mice. Molecular and Cellular Biology 27:22, pages 7918-7934.
Read now
Shingo Niimi, Mizuho Harashima, Masashi Hyuga & Teruhide Yamaguchi. (2007) Study of hepatocytes using RNA interference. Journal of Organ Dysfunction 3:3, pages 164-182.
Read now
Junhui Zou, Hitoshi Ichikawa, Michael L. Blackburn, Hsien-Ming Hu, Anna Zielinska-Kwiatkowska, Qi Mei, Gerald J. Roth, Howard A. Chansky & Liu Yang. (2005) The Oncogenic TLS-ERG Fusion Protein Exerts Different Effects in Hematopoietic Cells and Fibroblasts. Molecular and Cellular Biology 25:14, pages 6235-6246.
Read now

Articles from other publishers (56)

Le Yu, Ian J. Davis & Pengda Liu. (2023) Regulation of EWSR1-FLI1 Function by Post-Transcriptional and Post-Translational Modifications. Cancers 15:2, pages 382.
Crossref
Fumiaki Uchiumi. 2023. Bidirectional Gene Promoters. Bidirectional Gene Promoters 123 139 .
Sudhir Reddy Peddi, Ramalingam Kundenapally, Sree Kanth Sivan, Gururaj Somadi & Vijjulatha Manga. (2022) A pragmatic pharmacophore informatics strategy to discover new potent inhibitors against pim-3. Structural Chemistry 33:6, pages 2003-2021.
Crossref
Mingli Li & Chun-Wei Chen. (2022) Epigenetic and Transcriptional Signaling in Ewing Sarcoma—Disease Etiology and Therapeutic Opportunities. Biomedicines 10:6, pages 1325.
Crossref
William F Richter, Rohan N Shah & Alexander J Ruthenburg. (2021) Non-canonical H3K79me2-dependent pathways promote the survival of MLL-rearranged leukemia. eLife 10.
Crossref
Tom Malone, Lea Schäfer, Nathalie Simon, Susan Heavey, Sinead Cuffe, Stephen Finn, Gillian Moore & Kathy Gately. (2020) Current perspectives on targeting PIM kinases to overcome mechanisms of drug resistance and immune evasion in cancer. Pharmacology & Therapeutics 207, pages 107454.
Crossref
Alessia Spirli, Lydie Cheval, Anne Debonneville, David Penton, Caroline Ronzaud, Marc Maillard, Alain Doucet, Johannes Loffing & Olivier Staub. (2019) The serine‐threonine kinase PIM3 is an aldosterone‐regulated protein in the distal nephron. Physiological Reports 7:15.
Crossref
Kei Miyakawa, Satoko Matsunaga, Masaru Yokoyama, Masako Nomaguchi, Yayoi Kimura, Mayuko Nishi, Hirokazu Kimura, Hironori Sato, Hisashi Hirano, Tomohiko Tamura, Hirofumi Akari, Tomoyuki Miura, Akio Adachi, Tatsuya Sawasaki, Naoki Yamamoto & Akihide Ryo. (2019) PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation. Nature Communications 10:1.
Crossref
Goodwin G. Jinesh, Sharada Mokkapati, Keyi Zhu & Edwin E. Morales. (2016) Pim kinase isoforms: devils defending cancer cells from therapeutic and immune attacks. Apoptosis 21:11, pages 1203-1213.
Crossref
Noel A. Warfel & Andrew S. Kraft. (2015) PIM kinase (and Akt) biology and signaling in tumors. Pharmacology & Therapeutics 151, pages 41-49.
Crossref
Hao Zhuang, Man-Yin Zhao, Kai-Wen Hei, Bai-Cai Yang, Li Sun, Xue Du & Yong-Mei Li. (2015) Aberrant Expression of Pim-3 Promotes Proliferation and Migration of Ovarian Cancer Cells. Asian Pacific Journal of Cancer Prevention 16:8, pages 3325-3331.
Crossref
José L Ordóñez, Ana T Amaral & Enrique de Álava. 2001. eLS. eLS 1 11 .
BIN LIU, ZHEN WANG, HONG-YU LI, BO ZHANG, BO PING & YING-YI LI. (2014) Pim-3 promotes human pancreatic cancer growth by regulating tumor vasculogenesis. Oncology Reports 31:6, pages 2625-2634.
Crossref
Jianwei Xu, Taiping Zhang, Tianxiao Wang, Lei You & Yupei Zhao. (2014) PIM kinases: an overview in tumors and recent advances in pancreatic cancer. Future Oncology 10:5, pages 865-876.
Crossref
Maja Narlik-Grassow, Carmen Blanco-Aparicio & Amancio Carnero. (2014) The PIM Family of Serine/Threonine Kinases in Cancer. Medicinal Research Reviews 34:1, pages 136-159.
Crossref
Fei Zhang, Bin Liu, Zhen Wang, Xian-Jun Yu, Quan-Xing Ni, Wen-Tao Yang, Naofumi Mukaida & Ying-Yi Li. (2013) A Novel Regulatory Mechanism of Pim-3 Kinase Stability and Its Involvement in Pancreatic Cancer Progression. Molecular Cancer Research 11:12, pages 1508-1520.
Crossref
Stacey M. Glasgow, Dylan Laug, Vita S. Brawley, Zhiyuan Zhang, Amanda Corder, Zheng Yin, Stephen T. C. Wong, Xiao-Nan Li, Aaron E. Foster, Nabil Ahmed & Benjamin Deneen. (2013) The miR-223/Nuclear Factor I-A Axis Regulates Glial Precursor Proliferation and Tumorigenesis in the CNS. The Journal of Neuroscience 33:33, pages 13560-13568.
Crossref
Elizabeth T. Wiles, Bianca Lui-Sargent, Russell Bell & Stephen L. Lessnick. (2013) BCL11B Is Up-Regulated by EWS/FLI and Contributes to the Transformed Phenotype in Ewing Sarcoma. PLoS ONE 8:3, pages e59369.
Crossref
Carmen Blanco-Aparicio & Amancio Carnero. (2013) Pim kinases in cancer: Diagnostic, prognostic and treatment opportunities. Biochemical Pharmacology 85:5, pages 629-643.
Crossref
Stephen L. LessnickMarc Ladanyi. (2012) Molecular Pathogenesis of Ewing Sarcoma: New Therapeutic and Transcriptional Targets. Annual Review of Pathology: Mechanisms of Disease 7:1, pages 145-159.
Crossref
Xinwen Min, Jie Tang, Yinfang Wang, Minghua Yu, Libing Zhao, Handong Yang, Peng Zhang & Yexin Ma. (2012) PI3K-like kinases restrain Pim gene expression in endothelial cells. Journal of Huazhong University of Science and Technology [Medical Sciences] 32:1, pages 17-23.
Crossref
Ying-Ying Wang, Tsuyoshi Taniguchi, Tomohisa Baba, Ying-Yi Li, Hiroyuki Ishibashi & Naofumi Mukaida. (2012) Identification of a phenanthrene derivative as a potent anticancer drug with Pim kinase inhibitory activity. Cancer Science 103:1, pages 107-115.
Crossref
Naofumi Mukaida, Ying-Ying Wang & Ying-Yi Li. (2011) Roles of Pim-3, a novel survival kinase, in tumorigenesis. Cancer Science 102:8, pages 1437-1442.
Crossref
Savita Sankar & Stephen L. Lessnick. (2011) Promiscuous partnerships in Ewing's sarcoma. Cancer Genetics 204:7, pages 351-365.
Crossref
Linus Plym Forshell, Yongmei Li, Tacha Zi Plym Forshell, Martina Rudelius, Lisa Nilsson, Ulrich Keller & Jonas Nilsson. (2011) The direct Myc target Pim3 cooperates with other Pim kinases in supporting viability of Myc-induced B-cell lymphomas. Oncotarget 2:6, pages 448-460.
Crossref
Janos Sumegi, Jun Nishio, Marilu Nelson, Robert W Frayer, Deborah Perry & Julia A Bridge. (2011) A novel t(4;22)(q31;q12) produces an EWSR1–SMARCA5 fusion in extraskeletal Ewing sarcoma/primitive neuroectodermal tumor. Modern Pathology 24:3, pages 333-342.
Crossref
Kabsun Kim, Jung Ha Kim, Bang Ung Youn, Hye Mi Jin & Nacksung Kim. (2010) Pim-1 Regulates RANKL-Induced Osteoclastogenesis via NF-κB Activation and NFATc1 Induction. The Journal of Immunology 185:12, pages 7460-7466.
Crossref
Y Wu, Y Y Wang, Y Nakamoto, Y-Y Li, T Baba, S Kaneko, C Fujii & N Mukaida. (2010) Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver. Oncogene 29:15, pages 2228-2237.
Crossref
Ying-Yi Li, Ying-Ying Wang, Tsuyoshi Taniguchi, Takahiro Kawakami, Tomohisa Baba, Hiroyuki Ishibashi & Naofumi Mukaida. (2010) Identification of stemonamide synthetic intermediates as a novel potent anticancer drug with an apoptosis-inducing ability. International Journal of Cancer, pages NA-NA.
Crossref
Zhi-Fu Tao, Lisa A. Hasvold, Joel D. Leverson, Edward K. Han, Ran Guan, Eric F. Johnson, Vincent S. Stoll, Kent D. Stewart, Geoff Stamper, Nirupama Soni, Jennifer J. Bouska, Yan Luo, Thomas J. Sowin, Nan-Horng Lin, Vincent S. Giranda, Saul H. Rosenberg & Thomas D. Penning. (2009) Discovery of 3 H -Benzo[4,5]thieno[3,2- d ]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM) Kinases . Journal of Medicinal Chemistry 52:21, pages 6621-6636.
Crossref
Dan Liu, Ming He, Bo Yi, Wu-hua Guo, Ai-ling Que & Ji-xiang Zhang. (2009) Pim-3 protects against cardiomyocyte apoptosis in anoxia/reoxygenation injury via p38-mediated signal pathway. The International Journal of Biochemistry & Cell Biology 41:11, pages 2315-2322.
Crossref
José Luis Ordóñez, Daniel Osuna, David Herrero, Enrique de Álava & Juan Madoz-Gúrpide. (2009) Advances in Ewing's Sarcoma Research: Where Are We Now and What Lies Ahead?. Cancer Research 69:18, pages 7140-7150.
Crossref
Uros Midic, Christopher J Oldfield, A Keith Dunker, Zoran Obradovic & Vladimir N Uversky. (2009) Protein disorder in the human diseasome: unfoldomics of human genetic diseases. BMC Genomics 10:S1.
Crossref
Ying-Yi Li, Yu Wu, Koichi Tsuneyama, Tomohisa Baba & Naofumi Mukaida. (2009) Essential contribution of Ets-1 to constitutive Pim-3 expression in human pancreatic cancer cells. Cancer Science 100:3, pages 396-404.
Crossref
Martin S. StaegeDaniela Max. (2009) Genetics and Epigenetics of the TET-ETS Translocation Network. Genetics & Epigenetics 2, pages GEG.S2815.
Crossref
Steven G. DuBois, Holcombe E. Grier & Stephen L. Lessnick. 2009. Oncology of Infancy and Childhood. Oncology of Infancy and Childhood 829 869 .
Dolores López-Terrada & John M. Hicks. 2009. Bone Pathology. Bone Pathology 91 124 .
Changming Lu, Steven Pelech, Hong Zhang, Jeffrey Bond, Karen Spach, Rajkumar Noubade, Elizabeth P. Blankenhorn & Cory Teuscher. (2008) Pertussis toxin induces angiogenesis in brain microvascular endothelial cells. Journal of Neuroscience Research 86:12, pages 2624-2640.
Crossref
Hua-Chuan Zheng, Koichi Tsuneyama, Hiroyuki Takahashi, Shigeharu Miwa, Toshiro Sugiyama, Boryana Konstantinova Popivanova, Chifumi Fujii, Kazuhiro Nomoto, Naofumi Mukaida & Yasuo Takano. (2007) Aberrant Pim-3 expression is involved in gastric adenoma–adenocarcinoma sequence and cancer progression. Journal of Cancer Research and Clinical Oncology 134:4, pages 481-488.
Crossref
Olga Klezovitch, Michael RiskIlsa Coleman, Jared M. Lucas, Manda Null, Lawrence D. True, Peter S. Nelson & Valeri Vasioukhin. (2008) A causal role for ERG in neoplastic transformation of prostate epithelium. Proceedings of the National Academy of Sciences 105:6, pages 2105-2110.
Crossref
Gary Potikyan, Rupert O.V. Savene, Julie M. Gaulden, Kelly A. France, Zhichao Zhou, Eugenie S. Kleinerman, Stephen L. Lessnick & Christopher T. Denny. (2007) EWS/FLI1 Regulates Tumor Angiogenesis in Ewing's Sarcoma via Suppression of Thrombospondins. Cancer Research 67:14, pages 6675-6684.
Crossref
Boryana Konstantinova Popivanova, Ying-Yi Li, Huachuan Zheng, Kenji Omura, Chifumi Fujii, Koichi Tsuneyama & Naofumi Mukaida. (2007) Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis. Cancer Science 98:3, pages 321-328.
Crossref
Andrew Macdonald, David G Campbell, Rachel Toth, Hilary McLauchlan, C James Hastie & J Simon C Arthur. (2006) Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL. BMC Cell Biology 7:1.
Crossref
Ying-Yi Li, Boryana K. Popivanova, Yuichiro Nagai, Hiroshi Ishikura, Chifumi Fujii & Naofumi Mukaida. (2006) Pim-3, a Proto-Oncogene with Serine/Threonine Kinase Activity, Is Aberrantly Expressed in Human Pancreatic Cancer and Phosphorylates Bad to Block Bad-Mediated Apoptosis in Human Pancreatic Cancer Cell Lines. Cancer Research 66:13, pages 6741-6747.
Crossref
Sean Davis & Paul S. Meltzer. (2006) Ewing's sarcoma: General insights from a rare model. Cancer Cell 9:5, pages 331-332.
Crossref
Marta Mendiola, Jaime Carrillo, Eva García, Enzo Lalli, Teresa Hernández, Enrique de Alava, Franck Tirode, Olivier Delattre, Purificación García-Miguel, Fernando López-Barea, Ángel Pestaña & Javier Alonso. (2006) The orphan nuclear receptor DAX1 is up-regulated by the EWS/FLI1 oncoprotein and is highly expressed in Ewing tumors. International Journal of Cancer 118:6, pages 1381-1389.
Crossref
Ralf Janknecht. (2005) EWS–ETS oncoproteins: The linchpins of Ewing tumors. Gene 363, pages 1-14.
Crossref
Aykut ÜrenJeffrey A Toretsky. (2005) Ewing's sarcoma oncoprotein EWS–FLI1: the perfect target without a therapeutic agent. Future Oncology 1:4, pages 521-528.
Crossref
Ogan D Abaan, Amy Levenson, Osman Khan, Priscilla A Furth, Aykut Üren & Jeffrey A Toretsky. (2005) PTPL1 is a direct transcriptional target of EWS-FLI1 and modulates Ewing's Sarcoma tumorigenesis. Oncogene 24:16, pages 2715-2722.
Crossref
Christine Siligan, Jozef Ban, Radostina Bachmaier, Laura Spahn, Michael Kreppel, Karl-Ludwig Schaefer, Christopher Poremba, Dave N T Aryee & Heinrich Kovar. (2005) EWS-FLI1 target genes recovered from Ewing's sarcoma chromatin. Oncogene 24:15, pages 2512-2524.
Crossref
Chifumi Fujii, Yasunari Nakamoto, Peirong Lu, Koichi Tsuneyama, Boryana K. Popivanova, Shuichi Kaneko & Naofumi Mukaida. (2004) Aberrant expression of serine/threonine kinase Pim‐3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines. International Journal of Cancer 114:2, pages 209-218.
Crossref
Aykut ??ren & Jeffrey A Toretsky. (2005) Pediatric malignancies provide unique cancer therapy targets. Current Opinion in Pediatrics 17:1, pages 14-19.
Crossref
Lydie Cheval, Jean Paul Duong Van Huyen, Patrick Bruneval, Jean-Marc Verbavatz, Jean-Marc Elalouf & Alain Doucet. (2004) Plasticity of mouse renal collecting duct in response to potassium depletion. Physiological Genomics 19:1, pages 61-73.
Crossref
Ramugounder Ramakrishnan, Yasuo Fujimura, Jian Ping Zou, Fang Liu, Leo Lee, Veena N Rao & E Shyam P Reddy. (2004) Role of protein–protein interactions in the antiapoptotic function of EWS-Fli-1. Oncogene 23:42, pages 7087-7094.
Crossref
Banalata Sen, Douglas C Wolf & Susan D Hester. (2004) The transcriptional profile of the kidney in Tsc2 heterozygous mutant Long Evans (Eker) rats compared to wild-type. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 549:1-2, pages 213-224.
Crossref
Lee J. Helman & Paul Meltzer. (2003) Mechanisms of sarcoma development. Nature Reviews Cancer 3:9, pages 685-694.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.