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Molecular and Cellular Biology Volume 23, 2003 - Issue 11
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Cell Growth and Development

Interleukin-13 Induction of 15-Lipoxygenase Gene Expression Requires p38 Mitogen-Activated Protein Kinase-Mediated Serine 727 Phosphorylation of Stat1 and Stat3

Bo Xu1 Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio44195
,
Ashish Bhattacharjee1 Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio44195
,
Biswajit Roy1 Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio44195
,
Hong-Min Xu1 Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio44195
,
David Anthony1 Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio44195
,
David A. Frank2 Department of Adult Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts02115
,
Gerald M. Feldman3 Division of Monoclonal Antibodies, Office of Therapeutics, Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland20892
&
Martha K. Cathcart1 Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio44195Correspondence[email protected]
 show all
Pages 3918-3928 | Received 02 Oct 2002, Accepted 12 Mar 2003, Published online: 27 Mar 2023

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Articles from other publishers (67)

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Valentin P. Yakubenko, Linda C. Hsi, Martha K. Cathcart & Ashish Bhattacharjee. (2013) From Macrophage Interleukin-13 Receptor to Foam Cell Formation. Journal of Biological Chemistry 288:4, pages 2778-2788.
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Yunike Akasaka, Masaki Tsunoda, Tomomi Ogata, Tomohiro Ide & Koji Murakami. (2010) Direct evidence for leptin-induced lipid oxidation independent of long-form leptin receptor. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1801:10, pages 1115-1122.
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Christian R Geest & Paul J Coffer. (2009) MAPK signaling pathways in the regulation of hematopoiesis. Journal of Leukocyte Biology 86:2, pages 237-250.
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Kelly M Kroeger, Brandon M Sullivan & Richard M Locksley. (2009) IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38α-dependent pathway. Journal of Leukocyte Biology 86:4, pages 769-778.
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Nitin T. Aggarwal, Sandra L. Pfister, Kathryn M. Gauthier, Yuttana Chawengsub, John E. Baker & William B. Campbell. (2009) Chronic hypoxia enhances 15-lipoxygenase-mediated vasorelaxation in rabbit arteries. American Journal of Physiology-Heart and Circulatory Physiology 296:3, pages H678-H688.
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Jungsook Cho & Donna L. Gruol. (2008) The chemokine CCL2 activates p38 mitogen-activated protein kinase pathway in cultured rat hippocampal cells. Journal of Neuroimmunology 199:1-2, pages 94-103.
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Hiroki Kuniyasu. (2008) The Roles of Dietary PPAR Ligands for Metastasis in Colorectal Cancer. PPAR Research 2008, pages 1-7.
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Ashish Bhattacharjee, Ravi S. Mishra, Gerald M. Feldman & Martha K. Cathcart. (2008) In vivo validation of signaling pathways regulating human monocyte chemotaxis. Journal of Immunological Methods 330:1-2, pages 86-95.
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. 2007. Contemporary Targeted Therapies in Rheumatology. Contemporary Targeted Therapies in Rheumatology 147 162 .
M Yuri, T Sasahira, K Nakai, S Ishimaru, H Ohmori & H Kuniyasu. (2007) Reversal of expression of 15-lipoxygenase-1 to cyclooxygenase-2 is associated with development of colonic cancer. Histopathology 51:4, pages 520-527.
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Christian S. Haas, M. Asif Amin, Jeffrey H. Ruth, Brittany L. Allen, Salahuddin Ahmed, Angela Pakozdi, James M. Woods, Shiva Shahrara & Alisa E. Koch. (2007) In vivo inhibition of angiogenesis by interleukin-13 gene therapy in a rat model of rheumatoid arthritis. Arthritis & Rheumatism 56:8, pages 2535-2548.
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James G. Karras, Jeffrey R. Crosby, Mausumee Guha, David Tung, Doreen A. Miller, William A. Gaarde, Richard S. Geary, Brett P. Monia & Susan A. Gregory. (2007) Anti-Inflammatory Activity of Inhaled IL-4 Receptor-α Antisense Oligonucleotide in Mice. American Journal of Respiratory Cell and Molecular Biology 36:3, pages 276-285.
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Naftali Stern & Michael L. Tuck. 2007. Hypertension and Hormone Mechanisms. Hypertension and Hormone Mechanisms 335 364 .
Ashish Bhattacharjee, Bo Xu, David A. Frank, Gerald M. Feldman & Martha K. Cathcart. (2006) Monocyte 15-Lipoxygenase Expression Is Regulated by a Novel Cytosolic Signaling Complex with Protein Kinase C δ and Tyrosine-Phosphorylated Stat3. The Journal of Immunology 177:6, pages 3771-3781.
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Beiling Chen, Shanli Tsui, William E. Boeglin, Raymond S. Douglas, Alan R. Brash & Terry J. Smith. (2006) Interleukin-4 Induces 15-Lipoxygenase-1 Expression in Human Orbital Fibroblasts from Patients with Graves Disease. Journal of Biological Chemistry 281:27, pages 18296-18306.
Crossref
Hartmut Kühn & Valerie B. O’Donnell. (2006) Inflammation and immune regulation by 12/15-lipoxygenases. Progress in Lipid Research 45:4, pages 334-356.
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Alain Tedgui & Ziad Mallat. (2006) Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways. Physiological Reviews 86:2, pages 515-581.
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M. AbedinJ. LimT.B. TangD. ParkL.L. DemerY. Tintut. (2006) N-3 Fatty Acids Inhibit Vascular Calcification Via the p38-Mitogen-Activated Protein Kinase and Peroxisome Proliferator-Activated Receptor-γ Pathways. Circulation Research 98:6, pages 727-729.
Crossref
Marina Gartsbein, Addy Alt, Koji Hashimoto, Koichi Nakajima, Toshio Kuroki & Tamar Tennenbaum. (2006) The role of protein kinase C δ activation and STAT3 Ser727 phosphorylation in insulin-induced keratinocyte proliferation. Journal of Cell Science 119:3, pages 470-481.
Crossref
Pavlos Chaitidis & Hartmut Kuhn. (2005) Induction of 15-lipoxygenase-1 impairs expression of HIV-1 receptors CD4 and CXCR4 in monocytic cells. FEBS Letters 579:17, pages 3691-3694.
Crossref
John D. Kakisis, Sanjeev Pradhan, Alfredo Cordova, Christos D. Liapis & Bauer E. Sumpio. (2005) The role of STAT-3 in the mediation of smooth muscle cell response to cyclic strain. The International Journal of Biochemistry & Cell Biology 37:7, pages 1396-1406.
Crossref
Annong HuangYing-Yi ZhangKai ChenKazuyuki HatakeyamaJohn F. KeaneyJrJr. (2005) Cytokine-Stimulated GTP Cyclohydrolase I Expression in Endothelial Cells Requires Coordinated Activation of Nuclear Factor-κB and Stat1/Stat3. Circulation Research 96:2, pages 164-171.
Crossref
Pavlos Chaitidis, Ellen E. Billett, Valerie B. O’Donnell, Alexandra Bermudez Fajardo, Julia Fitzgerald, Ralf J. Kuban, Ute Ungethuem & Hartmut Kühn. (2004) Th2 Response of Human Peripheral Monocytes Involves Isoform-Specific Induction of Monoamine Oxidase-A. The Journal of Immunology 173:8, pages 4821-4827.
Crossref
Talal A. Chatila. (2004) Interleukin-4 receptor signaling pathways in asthma pathogenesis. Trends in Molecular Medicine 10:10, pages 493-499.
Crossref
Hartmut Kuhn. (2004) Lipoxygenases in the Cardiovascular System. Circulation Research 94:12, pages 1527-1529.
Crossref
Amy K. Y. Fu, Wing-Yu Fu, Alberto K. Y. Ng, Winnie W. Y. Chien, Yu-Pong Ng, Jerry H. Wang & Nancy Y. Ip. (2004) Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity. Proceedings of the National Academy of Sciences 101:17, pages 6728-6733.
Crossref
Bo Xu, Ashish Bhattacharjee, Biswajit Roy, Gerald M. Feldman & Martha K. Cathcart. (2004) Role of Protein Kinase C Isoforms in the Regulation of Interleukin-13-induced 15-Lipoxygenase Gene Expression in Human Monocytes. Journal of Biological Chemistry 279:16, pages 15954-15960.
Crossref
Xin TangNancy SpitzbarthHartmut KuhnPavlos ChaitidisWilliam B. Campbell. (2003) Interleukin-13 Upregulates Vasodilatory 15-Lipoxygenase Eicosanoids in Rabbit Aorta. Arteriosclerosis, Thrombosis, and Vascular Biology 23:10, pages 1768-1774.
Crossref

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