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Molecular and Cellular Biology Volume 23, 2003 - Issue 13
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DNA Dynamics and Chromosome Structure

Selectable System for Monitoring the Instability of CTG/CAG Triplet Repeats in Mammalian Cells

Vera GorbunovaVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas
,
Andrei SeluanovVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas
,
Vincent DionVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas
,
Zoltan SandorVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas
,
James L. MeservyVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas
&
John H. WilsonVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TexasCorrespondence[email protected]
Pages 4485-4493 | Received 10 Feb 2003, Accepted 17 Apr 2003, Published online: 27 Mar 2023

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Leroy Hubert$suffix/text()$suffix/text(), Yunfu Lin, Vincent Dion & John H. Wilson. (2011) Topoisomerase 1 and Single-Strand Break Repair Modulate Transcription-Induced CAG Repeat Contraction in Human Cells . Molecular and Cellular Biology 31:15, pages 3105-3112.
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Yunfu Lin, Mei Leng, Ma Wan & John H. Wilson. (2010) Convergent Transcription through a Long CAG Tract Destabilizes Repeats and Induces Apoptosis. Molecular and Cellular Biology 30:18, pages 4435-4451.
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Articles from other publishers (29)

Bin Yang, Alicia C Borgeaud, Marcela Buřičová, Lorène Aeschbach, Oscar Rodríguez-Lima, Gustavo A Ruiz Buendía, Cinzia Cinesi, Alysha S Taylor, Tuncay Baubec & Vincent Dion. (2022) Expanded CAG/CTG repeats resist gene silencing mediated by targeted epigenome editing. Human Molecular Genetics 31:3, pages 386-398.
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I. V. Grishchenko, A. A. Tulupov, Y. M. Rymareva, E. D. Petrovskiy, A. A. Savelov, A. M. Korostyshevskaya, Y. V. Maksimova, A. R. Shorina, E. M. Shitik & D. V. Yudkin. (2021) A transgenic cell line with inducible transcription for studying (CGG)n repeat expansion mechanisms. Vavilov Journal of Genetics and Breeding 25:1, pages 117-124.
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Vanessa C. Wheeler & Vincent Dion. (2021) Modifiers of CAG/CTG Repeat Instability: Insights from Mammalian Models. Journal of Huntington's Disease 10:1, pages 123-148.
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Cinzia Cinesi, Bin Yang & Vincent Dion. 2020. Trinucleotide Repeats. Trinucleotide Repeats 255 268 .
Eleni Kourkouta, Rudie Weij, Anchel González-Barriga, Melissa Mulder, Ruurd Verheul, Sieto Bosgra, Bas Groenendaal, Jukka Puoliväli, Jussi Toivanen, Judith C.T. van Deutekom & Nicole A. Datson. (2019) Suppression of Mutant Protein Expression in SCA3 and SCA1 Mice Using a CAG Repeat-Targeting Antisense Oligonucleotide. Molecular Therapy - Nucleic Acids 17, pages 601-614.
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Madhura Deshpande & Jeannine Gerhardt. (2018) Break-induced replication sparks CGG-repeat instability. Nature Structural & Molecular Biology 25:8, pages 643-644.
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Artem V. Kononenko, Thomas Ebersole, Karen M. Vasquez & Sergei M. Mirkin. (2018) Mechanisms of genetic instability caused by (CGG)n repeats in an experimental mammalian system. Nature Structural & Molecular Biology 25:8, pages 669-676.
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Thomas Massey, Branduff McAllister & Lesley Jones. 2018. Huntington’s Disease. Huntington’s Disease 483 495 .
Carlo C. Maley. 2016. Frontiers in Cancer Research. Frontiers in Cancer Research 1 16 .
John H. Wilson, Christopher Moye & David Mittelman. 2016. Genome Editing. Genome Editing 139 159 .
Beatriz A. Santillan, Christopher Moye, David Mittelman & John H. Wilson. (2014) GFP-Based Fluorescence Assay for CAG Repeat Instability in Cultured Human Cells. PLoS ONE 9:11, pages e113952.
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Vincent Dion. (2014) Tissue specificity in DNA repair: lessons from trinucleotide repeat instability. Trends in Genetics 30:6, pages 220-229.
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Guy-Franck Richard, David Viterbo, Varun Khanna, Valentine Mosbach, Lauriane Castelain & Bernard Dujon. (2014) Highly Specific Contractions of a Single CAG/CTG Trinucleotide Repeat by TALEN in Yeast. PLoS ONE 9:4, pages e95611.
Crossref
R Matthew Ward & David Mittelman. 2001. eLS. eLS.
Jonathan J. Magaña & Bulmaro Cisneros. (2011) Perspectives on gene therapy in myotonic dystrophy type 1. Journal of Neuroscience Research 89:3, pages 275-285.
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David Mittelman, Kristen Sykoudis, Megan Hersh, Yunfu Lin & John H. Wilson. (2010) Hsp90 modulates CAG repeat instability in human cells. Cell Stress and Chaperones 15:5, pages 753-759.
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Piotr Kozlowski, Mateusz de Mezer & Wlodzimierz J. Krzyzosiak. (2010) Trinucleotide repeats in human genome and exome. Nucleic Acids Research 38:12, pages 4027-4039.
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Vincent Dion & John H. Wilson. (2009) Instability and chromatin structure of expanded trinucleotide repeats. Trends in Genetics 25:7, pages 288-297.
Crossref
David Mittelman, Christopher Moye, Jason Morton, Kristen Sykoudis, Yunfu Lin, Dana Carroll & John H. Wilson. (2009) Zinc-finger directed double-strand breaks within CAG repeat tracts promote repeat instability in human cells. Proceedings of the National Academy of Sciences 106:24, pages 9607-9612.
Crossref
Yunfu Lin, Leroy HubertJr.Jr. & John H. Wilson. (2009) Transcription destabilizes triplet repeats. Molecular Carcinogenesis 48:4, pages 350-361.
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E. Soragni, D. Herman, S. Y. R. Dent, J. M. Gottesfeld, R. D. Wells & M. Napierala. (2008) Long intronic GAA•TTC repeats induce epigenetic changes and reporter gene silencing in a molecular model of Friedreich ataxia. Nucleic Acids Research 36:19, pages 6056-6065.
Crossref
Seung-Hwan Kim, Małgorzata J. Pytlos, William A. Rosche & Richard R. Sinden. (2006) (CAG)·(CTG) Repeats Associated with Neurodegenerative Diseases Are Stable in the Escherichia coli Chromosome. Journal of Biological Chemistry 281:38, pages 27950-27955.
Crossref
Mário Gomes-Pereira & Darren G. Monckton. (2006) Chemical modifiers of unstable expanded simple sequence repeats: What goes up, could come down. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 598:1-2, pages 15-34.
Crossref
Seung-Hwan Kim, Małgorzata J. Pytlos & Richard R. Sinden. (2006) Replication restart: A pathway for (CTG)·(CAG) repeat deletion in Escherichia coli. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 595:1-2, pages 5-22.
Crossref
Yunfu Lin, Vincent Dion & John H Wilson. (2006) Transcription promotes contraction of CAG repeat tracts in human cells. Nature Structural & Molecular Biology 13:2, pages 179-180.
Crossref
YUNFU LIN, VINCENT DION & JOHN H. WILSON. 2006. Genetic Instabilities and Neurological Diseases. Genetic Instabilities and Neurological Diseases 691 704 .
Richard R. Sinden, Malgorzata J. Pytlos & Vladimir N. Potaman. 2006. Human Nucleotide Expansion Disorders. Human Nucleotide Expansion Disorders 3 53 .
Yunfu Lin, Vincent Dion & John H. Wilson. (2005) A novel selectable system for detecting expansion of CAG·CTG repeats in mammalian cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 572:1-2, pages 123-131.
Crossref
Vera Gorbunova, Andrei Seluanov, David Mittelman & John H. Wilson. (2004) Genome-wide demethylation destabilizes CTG·CAG trinucleotide repeats in mammalian cells. Human Molecular Genetics 13:23, pages 2979-2989.
Crossref

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