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Molecular and Cellular Biology Volume 23, 2003 - Issue 17
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Cell Growth and Development

Identification of Novel Roles of the Cytochrome P450 System in Early Embryogenesis: Effects on Vasculogenesis and Retinoic Acid Homeostasis

Diana M. E. Otto1 Cancer Research UK, Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital and Medical School, DundeeDD1 9SY;2 Division of Cell and Developmental Biology, Wellcome Trust Biocentre, University of Dundee, DundeeDD1 5EH
,
Colin J. Henderson1 Cancer Research UK, Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital and Medical School, DundeeDD1 9SY
,
Dianne Carrie1 Cancer Research UK, Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital and Medical School, DundeeDD1 9SY
,
Megan Davey2 Division of Cell and Developmental Biology, Wellcome Trust Biocentre, University of Dundee, DundeeDD1 5EH
,
Thomas E. Gundersen3 Institute for Nutrition Research, 0316Oslo, Norway
,
Rune Blomhoff3 Institute for Nutrition Research, 0316Oslo, Norway
,
Ralf H. Adams4 Cancer Research UK, Vascular Development Laboratory, LondonWC2A 3PX, United Kingdom
,
Cheryll Tickle2 Division of Cell and Developmental Biology, Wellcome Trust Biocentre, University of Dundee, DundeeDD1 5EH
&
C. Roland Wolf1 Cancer Research UK, Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital and Medical School, DundeeDD1 9SYCorrespondence[email protected]
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Pages 6103-6116 | Received 05 Mar 2003, Accepted 28 May 2003, Published online: 27 Mar 2023

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Simon Horvat, Jim Mcwhir & Damjana Rozman. (2011) Defects in cholesterol synthesis genes in mouse and in humans: lessons for drug development and safer treatments. Drug Metabolism Reviews 43:1, pages 69-90.
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Katy Schmidt, Catherine Hughes, J. A. Chudek, Simon R. Goodyear, Richard M. Aspden, Richard Talbot, Thomas E. Gundersen, Rune Blomhoff, Colin Henderson, C. Roland Wolf & Cheryll Tickle. (2009) Cholesterol Metabolism: the Main Pathway Acting Downstream of Cytochrome P450 Oxidoreductase in Skeletal Development of the Limb. Molecular and Cellular Biology 29:10, pages 2716-2729.
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Colin J Henderson, Nico Scheer & C Roland Wolf. (2009) Advances in the generation of mouse models to elucidate the pathways of drug metabolism in rodents and man. Expert Review of Clinical Pharmacology 2:2, pages 105-109.
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Susanna R. Bair & Synthia H. Mellon. (2004) Deletion of the Mouse P450c17 Gene Causes Early Embryonic Lethality. Molecular and Cellular Biology 24:12, pages 5383-5390.
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Amit V. Pandey, Christa E. Flück, Ningwu Huang, Toshihiro Tajima, Kenji Fujieda & Walter L. Miller. (2004) P450 Oxidoreductase Deficiency: A New Disorder of Steroidogenesis Affecting All Microsomal P450 Enzymes. Endocrine Research 30:4, pages 881-888.
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Dharamainder Choudhary, Ingela Jansson, Mansoor Sarfarazi & John B. Schenkman. (2004) Xenobiotic‐metabolizing Cytochromes P450 in Ontogeny: Evolving Perspective. Drug Metabolism Reviews 36:3-4, pages 549-568.
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Colin J. Henderson, Diana M. E. Otto, Aileen W. McLaren, Dianne Carrie & C. Roland Wolf. (2003) Knockout Mice in Xenobiotic Metabolism. Drug Metabolism Reviews 35:4, pages 385-392.
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