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Molecular and Cellular Biology Volume 23, 2003 - Issue 18
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Cell Growth and Development

E2F3 Loss Has Opposing Effects on Different pRB-Deficient Tumors, Resulting in Suppression of Pituitary Tumors but Metastasis of Medullary Thyroid Carcinomas

Ulrike Ziebold1 Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts02139
,
Eunice Y. Lee1 Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts02139
,
Roderick T. Bronson2 Department of Pathology, Tufts University School of Veterinary Medicine, Boston, Massachusetts02111
&
Jacqueline A. Lees1 Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts02139Correspondence[email protected]
Pages 6542-6552 | Received 06 Jan 2003, Accepted 23 Jun 2003, Published online: 27 Mar 2023

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Liangliang Shi, Hao Zhu, Yonghua Shen, Xiaotan Dou, Huimin Guo, Pin Wang, Shu Zhang, Lin Zhou & Xiaoping Zou. (2020) Regulation of E2F Transcription Factor 3 by microRNA-152 Modulates Gastric Cancer Invasion and Metastasis. Cancer Management and Research 12, pages 1187-1197.
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Seda Ghazaryan, Chandler Sy, Tinghui Hu, Xiuli An, Narla Mohandas, Haiqing Fu, Mirit I. Aladjem, Victor T. Chang, Rene Opavsky & Lizhao Wu. (2014) Inactivation of Rb and E2f8 Synergizes To Trigger Stressed DNA Replication during Erythroid Terminal Differentiation. Molecular and Cellular Biology 34:15, pages 2833-2847.
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Zhen Ping, Ratna Lim, Tarig Bashir, Michele Pagano & Daniele Guardavaccaro. (2012) APC/CCdh1 controls the proteasome-mediated degradation of E2F3 during cell cycle exit. Cell Cycle 11:10, pages 1999-2005.
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Jean-Leon Chong, Shih-Yin Tsai, Nidhi Sharma, Rene Opavsky, Richard Price, Lizhao Wu, Soledad A. Fernandez & Gustavo Leone. (2009) E2f3a and E2f3b Contribute to the Control of Cell Proliferation and Mouse Development. Molecular and Cellular Biology 29:2, pages 414-424.
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Tiziana Parisi, Tina L. Yuan, Ann Marie Faust, Alicia M. Caron, Roderick Bronson & Jacqueline A. Lees. (2007) Selective Requirements for E2f3 in the Development and Tumorigenicity of Rb-Deficient Chimeric Tissues. Molecular and Cellular Biology 27:6, pages 2283-2293.
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Eros Lazzerini Denchi, Claire Attwooll, Diego Pasini & Kristian Helin. (2005) Deregulated E2F Activity Induces Hyperplasia and Senescence-Like Features in the Mouse Pituitary Gland. Molecular and Cellular Biology 25:7, pages 2660-2672.
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Chiaki Takahashi, Bernardo Contreras, Roderick T. Bronson, Massimo Loda & Mark E. Ewen. (2004) Genetic Interaction between Rb and K-ras in the Control of Differentiation and Tumor Suppression. Molecular and Cellular Biology 24:23, pages 10406-10415.
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Articles from other publishers (64)

Yiran Yao, Xiang Gu, Xiaofang Xu, Shengfang Ge & Renbing Jia. (2022) Novel insights into RB1 mutation. Cancer Letters 547, pages 215870.
Crossref
Krista M. D. La Perle. 2021. Pathology of Genetically Engineered and Other Mutant Mice. Pathology of Genetically Engineered and Other Mutant Mice 355 377 .
Alex Doan, Julia Arand, Diana Gong, Alexandros P. Drainas, Yan Ting Shue, Myung Chang Lee, Shuyuan Zhang, David M. Walter, Andrea C. Chaikovsky, David M. Feldser, Hannes Vogel, Lukas E. Dow, Jan M. Skotheim & Julien Sage. (2021) RB depletion is required for the continuous growth of tumors initiated by loss of RB. PLOS Genetics 17:12, pages e1009941.
Crossref
Hongling Zhao, Niloy J. Iqbal, Vineeth Sukrithan, Cari Nicholas, Yingjiao Xue, Cindy Yu, Joseph Locker, Juntao Zou, Edward L. Schwartz & Liang Zhu. (2020) Targeted Inhibition of the E3 Ligase SCFSkp2/Cks1 Has Antitumor Activity in RB1 -Deficient Human and Mouse Small-Cell Lung Cancer . Cancer Research 80:11, pages 2355-2367.
Crossref
Shirley Jusino & Harold I Saavedra. (2019) Role of E2Fs and mitotic regulators controlled by E2Fs in the epithelial to mesenchymal transition. Experimental Biology and Medicine 244:16, pages 1419-1429.
Crossref
Emmi Rotgers, Sheyla Cisneros-Montalvo, Mirja Nurmio & Jorma Toppari. (2019) Retinoblastoma protein represses E2F3 to maintain Sertoli cell quiescence in mouse testis. Journal of Cell Science 132:14.
Crossref
Stephanie C. Wu & Claudia A. Benavente. (2018) Chromatin remodeling protein HELLS is upregulated by inactivation of the RB-E2F pathway and is nonessential for osteosarcoma tumorigenesis. Oncotarget 9:66, pages 32580-32592.
Crossref
Junhu Wan, Hongyang Liu, Quanling Feng, Jun Liu & Liang Ming. (2018) HOXB9 promotes endometrial cancer progression by targeting E2F3. Cell Death & Disease 9:5.
Crossref
Yang Liao & Wei Du. (2018) An Rb family–independent E2F3 transcription factor variant impairs STAT5 signaling and mammary gland remodeling during pregnancy in mice. Journal of Biological Chemistry 293:9, pages 3156-3167.
Crossref
Zhi-Gang Shen, Xiao-Zhou Liu, Chang-Xiu Chen & Jing-Min Lu. (2017) Knockdown of E2F3 Inhibits Proliferation, Migration, and Invasion and Increases Apoptosis in Glioma Cells. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 25:9, pages 1555-1566.
Crossref
Yang Liao & Wei Du. (2017) Rb-independent E2F3 promotes cell proliferation and alters expression of genes involved in metabolism and inflammation. FEBS Open Bio 7:10, pages 1611-1621.
Crossref
Giovanni Vitale, Germano Gaudenzi, Luisa Circelli, Marco F Manzoni, Andrea Bassi, Niccolò Fioritti, Antongiulio Faggiano, Annamaria Colao & _ _. (2017) Animal models of medullary thyroid cancer: state of the art and view to the future. Endocrine-Related Cancer 24:1, pages R1-R12.
Crossref
P Trikha, N Sharma, C Pena, A Reyes, T Pécot, S Khurshid, M Rawahneh, J Moffitt, J A Stephens, S A Fernandez, M C Ostrowski & G Leone. (2015) E2f3 in tumor macrophages promotes lung metastasis. Oncogene 35:28, pages 3636-3646.
Crossref
Nicholas J. Dyson. (2016) RB1 : a prototype tumor suppressor and an enigma . Genes & Development 30:13, pages 1492-1502.
Crossref
Hongling Zhao, Hongbo Wang, Frederick Bauzon, Zhonglei Lu, Hao Fu, Jinhua Cui & Liang Zhu. (2016) Deletions of Retinoblastoma 1 (Rb1) and Its Repressing Target S Phase Kinase-associated protein 2 (Skp2) Are Synthetic Lethal in Mouse Embryogenesis. Journal of Biological Chemistry 291:19, pages 10201-10209.
Crossref
Liping Ye, Ling Guo, Zhenyu He, Xi Wang, Chuyong Lin, Xin Zhang, Shu Wu, Yong Bao, Qi Yang, Libing Song & Huanxin Lin. (2016) Upregulation of E2F8 promotes cell proliferation and tumorigenicity in breast cancer by modulating G1/S phase transition. Oncotarget 7:17, pages 23757-23771.
Crossref
Ruth L. Vinall, Clifford G. Tepper, Alexandra A.Z. Ripoll, Regina F. Gandour-Edwards, Blythe P. Durbin-Johnson, Stanley A. Yap, Paramita M. Ghosh & Ralph W. deVere White. (2016) Decreased expression of let-7c is associated with non-response of muscle-invasive bladder cancer patients to neoadjuvant chemotherapy. Genes & Cancer 7:3-4, pages 86-97.
Crossref
L Zhu, Z Lu & H Zhao. (2014) Antitumor mechanisms when pRb and p53 are genetically inactivated. Oncogene 34:35, pages 4547-4557.
Crossref
GUODONG TANG, JUN WU, GELEI XIAO & LEI HUO. (2015) miR-203 sensitizes glioma cells to temozolomide and inhibits glioma cell invasion by targeting E2F3. Molecular Medicine Reports 11:4, pages 2838-2844.
Crossref
E R Andrechek. (2013) HER2/Neu tumorigenesis and metastasis is regulated by E2F activator transcription factors. Oncogene 34:2, pages 217-225.
Crossref
L Wu, A de Bruin, H Wang, T Simmons, W Cleghorn, L E Goldenberg, E Sites, A Sandy, A Trimboli, S A Fernandez, C Eng, C Shapiro & G Leone. (2013) Selective roles of E2Fs for ErbB2- and Myc-mediated mammary tumorigenesis. Oncogene 34:1, pages 119-128.
Crossref
Gilbert J. Cote, Elizabeth G. Grubbs & Marie-Claude Hofmann. 2015. Medullary Thyroid Carcinoma. Medullary Thyroid Carcinoma 1 39 .
Claudia A. Benavente, David Finkelstein, Dianna A. Johnson, Jean-Christophe Marine, Ruth Ashery-Padan & Michael A. Dyer. (2014) Chromatin remodelers HELLS and UHRF1 mediate the epigenetic deregulation of genes that drive retinoblastoma tumor progression. Oncotarget 5:20, pages 9594-9608.
Crossref
Hideaki Toki, Maki Inoue, Osamu Minowa, Hiromi Motegi, Yuriko Saiki, Shigeharu Wakana, Hiroshi Masuya, Yoichi Gondo, Toshihiko Shiroishi, Ryoji Yao & Tetsuo Noda. (2014) Novel retinoblastoma mutation abrogating the interaction to E 2 F 2/3, but not E 2 F 1, led to selective suppression of thyroid tumors . Cancer Science 105:10, pages 1360-1368.
Crossref
Geoffrey W. Krampitz & Jeffrey A. Norton. (2014) RET gene mutations (genotype and phenotype) of multiple endocrine neoplasia type 2 and familial medullary thyroid carcinoma. Cancer 120:13, pages 1920-1931.
Crossref
Zhonglei Lu, Frederick Bauzon, Hao Fu, Jinhua Cui, Hongling Zhao, Keiko Nakayama, Keiich I. Nakayama & Liang Zhu. (2014) Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity. Nature Communications 5:1.
Crossref
Courtney Schaal, Smitha Pillai & Srikumar P. Chellappan. 2014. 147 182 .
Karine Pozo, Emely Castro-Rivera, Chunfeng Tan, Florian Plattner, Gert Schwach, Veronika Siegl, Douglas Meyer, Ailan Guo, Justin Gundara, Gabriel Mettlach, Edmond Richer, Jonathan A. Guevara, Li Ning, Anjali Gupta, Guiyang Hao, Li-Huei Tsai, Xiankai Sun, Pietro Antich, Stanley Sidhu, Bruce G. Robinson, Herbert Chen, Fiemu E. Nwariaku, Roswitha Pfragner, James A. Richardson & James A. Bibb. (2013) The Role of Cdk5 in Neuroendocrine Thyroid Cancer. Cancer Cell 24:4, pages 499-511.
Crossref
Ruth L. Vinall, Alexandra Z. Ripoll, Sisi Wang, Chong-Xian Pan & Ralph W. deVere White. (2012) MiR-34a chemosensitizes bladder cancer cells to cisplatin treatment regardless of p53-Rb pathway status. International Journal of Cancer 130:11, pages 2526-2538.
Crossref
Tinghui HuSeda GhazaryanChandler SyCharles WiedmeyerVictor Chang & Lizhao Wu. (2012) Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia. Blood 119:19, pages 4532-4542.
Crossref
Björn von Eyss, Jonas Maaskola, Sebastian Memczak, Katharina Möllmann, Anja Schuetz, Christoph Loddenkemper, Mai-Dinh Tanh, Albrecht Otto, Kathrin Muegge, Udo Heinemann, Nikolaus Rajewsky & Ulrike Ziebold. (2012) The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation. The EMBO Journal 31:4, pages 972-985.
Crossref
Caroline Schreiber, Kirsten Vormbrock & Ulrike Ziebold. 2012. Metastasis Research Protocols. Metastasis Research Protocols 217 228 .
Ting-Chiu Hsieh, Brandon N. Nicolay, Maxim V. Frolov & Nam-Sung Moon. (2010) Tuberous Sclerosis Complex 1 Regulates dE2F1 Expression during Development and Cooperates with RBF1 to Control Proliferation and Survival. PLoS Genetics 6:8, pages e1001071.
Crossref
Hongbo Wang, Frederick Bauzon, Peng Ji, Xiaoliang Xu, Daqian Sun, Joseph Locker, Rani S Sellers, Keiko Nakayama, Keiich I Nakayama, David Cobrinik & Liang Zhu. (2009) Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/− mice. Nature Genetics 42:1, pages 83-88.
Crossref
Hui-Zi Chen, Shih-Yin Tsai & Gustavo Leone. (2009) Emerging roles of E2Fs in cancer: an exit from cell cycle control. Nature Reviews Cancer 9:11, pages 785-797.
Crossref
Eunice Y. Lee, Tina L. Yuan, Paul S. Danielian, Julie C. West & Jacqueline A. Lees. (2009) E2F4 cooperates with pRB in the development of extra-embryonic tissues. Developmental Biology 332:1, pages 104-115.
Crossref
Awad Shamma, Yujiro Takegami, Takao Miki, Shunsuke Kitajima, Makoto Noda, Takao Obara, Takahiro Okamoto & Chiaki Takahashi. (2009) Rb Regulates DNA Damage Response and Cellular Senescence through E2F-Dependent Suppression of N-Ras Isoprenylation. Cancer Cell 15:4, pages 255-269.
Crossref
T Parisi, R T Bronson & J A Lees. (2008) Inhibition of pituitary tumors in Rb mutant chimeras through E2f4 loss reveals a key suppressive role for the pRB/E2F pathway in urothelium and ganglionic carcinogenesis. Oncogene 28:4, pages 500-508.
Crossref
Hai Xiao, Xiaojing Zhang & David W. Goodrich. (2009) Construction of a dual affinity tagged allele of the Rb1 tumor suppressor gene in the mouse . genesis, pages NA-NA.
Crossref
P S Danielian, L B Friesenhahn, A M Faust, J C West, A M Caron, R T Bronson & J A Lees. (2008) E2f3a and E2f3b make overlapping but different contributions to total E2f3 activity. Oncogene 27:51, pages 6561-6570.
Crossref
Brandon N. Nicolay & Maxim V. Frolov. (2008) Context-Dependent Requirement for dE2F during Oncogenic Proliferation. PLoS Genetics 4:10, pages e1000205.
Crossref
Deborah L. Burkhart & Julien Sage. (2008) Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nature Reviews Cancer 8:9, pages 671-682.
Crossref
C D Hurst, D C Tomlinson, S V Williams, F M Platt & M A Knowles. (2007) Inactivation of the Rb pathway and overexpression of both isoforms of E2F3 are obligate events in bladder tumours with 6p22 amplification. Oncogene 27:19, pages 2716-2727.
Crossref
Alexandra Dirlam & Kay F. Macleod. 2005. The Cancer Handbook. The Cancer Handbook.
Zhong-yan FU, Jin-xiang HAN & Hai-yan HUANG. (2007) Effects of emodin on gene expression profile in small cell lung cancer NCI-H446 cells. Chinese Medical Journal 120:19, pages 1710-1715.
Crossref
Gregory M. Buchold, Patricia L. Magyar, Ramamani Arumugam, Mary M. Lee & Deborah A. O'Brien. (2007) p19Ink4d and p18Ink4c cyclin-dependent kinase inhibitors in the male reproductive axis. Molecular Reproduction and Development 74:8, pages 997-1007.
Crossref
Gregory M. Buchold, Patricia L. Magyar & Deborah A. O'Brien. (2007) Mice lacking cyclin-dependent kinase inhibitor p19Ink4d show strain-specific effects on male reproduction. Molecular Reproduction and Development 74:8, pages 1008-1020.
Crossref
K. A. B. Knostman, S. M. Jhiang & C. C. Capen. (2016) Genetic Alterations in Thyroid Cancer: The Role of Mouse Models. Veterinary Pathology 44:1, pages 1-14.
Crossref
Huan Qiao, Luisa Di Stefano, Chan Tian, Yun-Yan Li, Yan-Hui Yin, Xiao-Ping Qian, Xue-Wen Pang, Yan Li, Michael Allen McNutt, Kristian Helin, Yu Zhang & Wei-Feng Chen. (2007) Human TFDP3, a Novel DP Protein, Inhibits DNA Binding and Transactivation by E2F. Journal of Biological Chemistry 282:1, pages 454-466.
Crossref
Monica Fedele, Giovanna Maria Pierantoni, Rosa Visone & Alfredo Fusco. (2006) E2F1 activation is responsible for pituitary adenomas induced by HMGA2 gene overexpression. Cell Division 1:1.
Crossref
W Du & J Pogoriler. (2006) Retinoblastoma family genes. Oncogene 25:38, pages 5190-5200.
Crossref
Takeshi Suzuki, Ken-ichi Minehata, Keiko Akagi, Nancy A Jenkins & Neal G Copeland. (2006) Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice. The EMBO Journal 25:14, pages 3422-3431.
Crossref
Lili Yamasaki. 2006. Cell Cycle Regulation. Cell Cycle Regulation 227 256 .
Liang Zhu. (2005) Tumour suppressor retinoblastoma protein Rb: A transcriptional regulator. European Journal of Cancer 41:16, pages 2415-2427.
Crossref
P.K. Tsantoulis & V.G. Gorgoulis. (2005) Involvement of E2F transcription factor family in cancer. European Journal of Cancer 41:16, pages 2403-2414.
Crossref
Drazen B. Zimonjic, Yasuhito Kato, Hao Ying, Nicholas C. Popescu & Sheue-Yann Cheng. (2005) Chromosomal aberrations in cell lines derived from thyroid tumors spontaneously developed in TRβPV/PV mice. Cancer Genetics and Cytogenetics 161:2, pages 104-109.
Crossref
Wan Jiao, Huei-Min Lin, Jamie Timmons, Akhilesh K. Nagaich, Shu-Wing Ng, Tom Misteli & Sushil G. Rane. (2005) E2F-Dependent Repression of Topoisomerase II Regulates Heterochromatin Formation and Apoptosis in Cells with Melanoma-Prone Mutation. Cancer Research 65:10, pages 4067-4077.
Crossref
Desssislava K Dimova & Nicholas J Dyson. (2005) The E2F transcriptional network: old acquaintances with new faces. Oncogene 24:17, pages 2810-2826.
Crossref
Zongxiang Zhou, Andrea Flesken-Nikitin, Corinna G. Levine, Elena N. Shmidt, Jessica P. Eng, Ekaterina Yu. Nikitina, David M. Spencer & Alexander Yu. Nikitin. (2005) Suppression of Melanotroph Carcinogenesis Leads to Accelerated Progression of Pituitary Anterior Lobe Tumors and Medullary Thyroid Carcinomas in Rb +/− Mice . Cancer Research 65:3, pages 787-796.
Crossref
P.J. IAQUINTA, A. ASLANIAN & J.A. LEES. (2005) Regulation of the Arf/p53 Tumor Surveillance Network by E2F. Cold Spring Harbor Symposia on Quantitative Biology 70:0, pages 309-316.
Crossref
Vincent Detours, Jacques E. Dumont & Carine Maenhaut. 2005. Multidisciplinary Approaches to Theory in Medicine. Multidisciplinary Approaches to Theory in Medicine 265 279 .
Aaron Aslanian, Phillip J. Iaquinta, Raluca Verona & Jacqueline A. Lees. (2004) Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics . Genes & Development 18:12, pages 1413-1422.
Crossref
Sandra W Leung, Elzbieta H Wloga, Alejandro F Castro, Thao Nguyen, Roderick T Bronson & Lili Yamasaki. (2004) A dynamic switch in Rb+/− mediated neuroendocrine tumorigenesis. Oncogene 23:19, pages 3296-3307.
Crossref
L. Hauck & R. von Harsdorf. 2004. Transcription Factors. Transcription Factors 277 308 .

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