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Molecular and Cellular Biology Volume 23, 2003 - Issue 22
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Cell Growth and Development

Regulation of T-Cell Activation by Phosphodiesterase 4B2 Requires Its Dynamic Redistribution during Immunological Synapse Formation

Jacqueline Arp1 Robarts Research Institute;2 Department of Microbiology and Immunology and Department of Medicine
,
Mark G. Kirchhof1 Robarts Research Institute;2 Department of Microbiology and Immunology and Department of Medicine
,
Miren L. Baroja1 Robarts Research Institute;2 Department of Microbiology and Immunology and Department of Medicine
,
Steven H. Nazarian1 Robarts Research Institute;2 Department of Microbiology and Immunology and Department of Medicine
,
Thu A. Chau1 Robarts Research Institute;2 Department of Microbiology and Immunology and Department of Medicine
,
Craig A. Strathdee1 Robarts Research Institute
,
Eric H. Ball3 Department of Biochemistry, The University of Western Ontario, London, Ontario, CanadaN6A 5K8
&
Joaquín Madrenas1 Robarts Research Institute;2 Department of Microbiology and Immunology and Department of MedicineCorrespondence[email protected]
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Pages 8042-8057 | Received 31 Mar 2003, Accepted 11 Aug 2003, Published online: 27 Mar 2023

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Darah A. Christie, Caitlin D. Lemke, Isaac M. Elias, Luan A. Chau, Mark G. Kirchhof, Bo Li, Eric H. Ball, Stanley D. Dunn, Grant M. Hatch & Joaquín Madrenas. (2011) Stomatin-Like Protein 2 Binds Cardiolipin and Regulates Mitochondrial Biogenesis and Function. Molecular and Cellular Biology 31:18, pages 3845-3856.
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Articles from other publishers (44)

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Yudong D. He, Eric M. Wohlford, Florian Uhle, Ljubomir Buturovic, Oliver Liesenfeld & Timothy E. Sweeney. (2021) The Optimization and Biological Significance of a 29-Host-Immune-mRNA Panel for the Diagnosis of Acute Infections and Sepsis. Journal of Personalized Medicine 11:8, pages 735.
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Paul M. Epstein, Chaitali Basole & Stefan Brocke. (2021) The Role of PDE8 in T Cell Recruitment and Function in Inflammation. Frontiers in Cell and Developmental Biology 9.
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Marianna Szczypka. (2020) Role of Phosphodiesterase 7 (PDE7) in T Cell Activity. Effects of Selective PDE7 Inhibitors and Dual PDE4/7 Inhibitors on T Cell Functions. International Journal of Molecular Sciences 21:17, pages 6118.
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Haoxiao Zuo, Isabella Cattani-Cavalieri, Nshunge Musheshe, Viacheslav O. Nikolaev & Martina Schmidt. (2019) Phosphodiesterases as therapeutic targets for respiratory diseases. Pharmacology & Therapeutics 197, pages 225-242.
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Baskaran Purushothaman, Parthasarathy Arumugam & Joon Myong Song. (2018) A Novel Catecholopyrimidine Based Small Molecule PDE4B Inhibitor Suppresses Inflammatory Cytokines in Atopic Mice. Frontiers in Pharmacology 9.
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Baskaran Purushothaman, Parthasarathy Arumugam, Goutam Kulsi & Joon Myong Song. (2018) Design, synthesis, and biological evaluation of novel catecholopyrimidine based PDE4 inhibitor for the treatment of atopic dermatitis. European Journal of Medicinal Chemistry 145, pages 673-690.
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Vijay Bharathi Arumugham & Cosima T Baldari. (2017) cAMP: a multifaceted modulator of immune synapse assembly and T cell activation. Journal of Leukocyte Biology 101:6, pages 1301-1316.
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Cristina Sanabra, Emily M. Johansson & Guadalupe Mengod. (2013) Critical role for PDE4 subfamilies in the development of experimental autoimmune encephalomyelitis. Journal of Chemical Neuroanatomy 47, pages 96-105.
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Mousumi Ghosh, Daniela Garcia-Castillo, Vladimir Aguirre, Roozbeh Golshani, Coleen M. Atkins, Helen M. Bramlett, W. Dalton Dietrich & Damien D. Pearse. (2012) Proinflammatory cytokine regulation of cyclic AMP-phosphodiesterase 4 signaling in microglia in vitro and following CNS injury . Glia 60:12, pages 1839-1859.
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Emily M. Johansson, Cristina Sanabra & Guadalupe Mengod. (2012) Sex-related differences of cAMP-specific PDE4B3 mRNA in oligodendrocytes following systemic inflammation. Glia 60:12, pages 1815-1825.
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Darah A. Christie, Mark G. Kirchhof, Santosh Vardhana, Michael L. Dustin & Joaquín Madrenas. (2012) Mitochondrial and Plasma Membrane Pools of Stomatin-Like Protein 2 Coalesce at the Immunological Synapse during T Cell Activation. PLoS ONE 7:5, pages e37144.
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Emily M. Johansson, Cristina Sanabra, Roser Cortés, M. Teresa Vilaró & Guadalupe Mengod. (2011) Lipopolysaccharide administration in vivo induces differential expression of cAMP-specific phosphodiesterase 4B mRNA splice variants in the mouse brain. Journal of Neuroscience Research 89:11, pages 1761-1772.
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Sharron H. Francis, Mitsi A. Blount & Jackie D. Corbin. (2011) Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions. Physiological Reviews 91:2, pages 651-690.
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Brigitte E. Blackman, Kathleen Horner, Julia Heidmann, Dan Wang, Wito Richter, Thomas C. Rich & Marco Conti. (2011) PDE4D and PDE4B Function in Distinct Subcellular Compartments in Mouse Embryonic Fibroblasts. Journal of Biological Chemistry 286:14, pages 12590-12601.
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Elisa Bjørgo, Kristine Moltu & Kjetil Taskén. 2011. Phosphodiesterases as Drug Targets. Phosphodiesterases as Drug Targets 345 363 .
S.-L. Catherine Jin, Sho Goya, Susumu Nakae, Dan Wang, Matthew Bruss, Chiaoyin Hou, Dale Umetsu & Marco Conti. (2010) Phosphodiesterase 4B is essential for TH2-cell function and development of airway hyperresponsiveness in allergic asthma. Journal of Allergy and Clinical Immunology 126:6, pages 1252-1259.e12.
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Isabelle Cornez & Kjetil Taskén. (2010) Spatiotemporal control of cyclic AMP immunomodulation through the PKA-Csk inhibitory pathway is achieved by anchoring to an Ezrin-EBP50-PAG scaffold in effector T cells. FEBS Letters 584:12, pages 2681-2688.
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Rolf König. 2010. Handbook of Cell Signaling. Handbook of Cell Signaling 2679 2688 .
Andrés Norambuena, Claudia Metz, Lucas Vicuña, Antonia Silva, Evelyn Pardo, Claudia Oyanadel, Loreto Massardo, Alfonso González & Andrea Soza. (2009) Galectin-8 Induces Apoptosis in Jurkat T Cells by Phosphatidic Acid-mediated ERK1/2 Activation Supported by Protein Kinase A Down-regulation. Journal of Biological Chemistry 284:19, pages 12670-12679.
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Mark G. Kirchhof, Luan A. Chau, Caitlin D. Lemke, Santosh Vardhana, Peter J. Darlington, Maria E. Márquez, Roy Taylor, Kamilia Rizkalla, Isaac Blanca, Michael L. Dustin & Joaquín Madrenas. (2008) Modulation of T Cell Activation by Stomatin-Like Protein 2. The Journal of Immunology 181:3, pages 1927-1936.
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Ranjana Arya, Saima Aslam, Shivani Gupta, Roop Singh Bora, Lalitha Vijayakrishnan, Pankaj Gulati, Sudha Naithani, Shohini Mukherjee, Sunanda Dastidar, Alok Bhattacharya & Kulvinder Singh Saini. (2008) Production and characterization of pharmacologically active recombinant human phosphodiesterase 4B in Dictyostelium discoideum . Biotechnology Journal 3:7, pages 938-947.
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Janis K. BurkhardtEsteban CarrizosaMeredith H. Shaffer. (2008) The Actin Cytoskeleton in T Cell Activation. Annual Review of Immunology 26:1, pages 233-259.
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Tasmina A. Goraya, Nanako Masada, Antonio Ciruela, Debbie Willoughby, Michael A. Clynes & Dermot M.F. Cooper. (2008) Kinetic properties of Ca2+/calmodulin-dependent phosphodiesterase isoforms dictate intracellular cAMP dynamics in response to elevation of cytosolic Ca2+. Cellular Signalling 20:2, pages 359-374.
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K. M. Torgersen, E. M. Aandahl & K. Taskén. 2008. Protein-Protein Interactions as New Drug Targets. Protein-Protein Interactions as New Drug Targets 327 363 .
Elisabet Reyes-Irisarri, Antonio J. Sánchez, Juan Antonio García-Merino & Guadalupe Mengod. (2007) Selective Induction of cAMP Phosphodiesterase PDE4B2 Expression in Experimental Autoimmune Encephalomyelitis. Journal of Neuropathology and Experimental Neurology 66:10, pages 923-931.
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Daniel Peter, S. L. Catherine Jin, Marco Conti, Armin Hatzelmann & Christof Zitt. (2007) Differential Expression and Function of Phosphodiesterase 4 (PDE4) Subtypes in Human Primary CD4+ T Cells: Predominant Role of PDE4D. The Journal of Immunology 178:8, pages 4820-4831.
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S.-L. Catherine Jin, Linda Lan, Maria Zoudilova & Marco Conti. (2005) Specific Role of Phosphodiesterase 4B in Lipopolysaccharide-Induced Signaling in Mouse Macrophages. The Journal of Immunology 175:3, pages 1523-1531.
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Peter J. Darlington, Mark G. Kirchhof, Gabriel Criado, Jitin Sondhi & Joaquín Madrenas. (2005) Hierarchical Regulation of CTLA-4 Dimer-Based Lattice Formation and Its Biological Relevance for T Cell Inactivation. The Journal of Immunology 175:2, pages 996-1004.
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Tasmina A. Goraya & Dermot M.F. Cooper. (2005) Ca2+-calmodulin-dependent phosphodiesterase (PDE1): Current perspectives. Cellular Signalling 17:7, pages 789-797.
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O. Trubiani, E. Salvolini, F. Santoleri, C. D’Arcangelo, G. Spoto, R. Di Primio & L. Mazzanti. (2005) Changes of Plasma Membrane Properties in a Human Pre-T Cell Line Undergoing Apoptosis. Journal of Membrane Biology 204:2, pages 77-84.
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Ana Castro, Maria Jose Jerez, Carmen Gil & Ana Martinez. (2005) Cyclic nucleotide phosphodiesterases and their role in immunomodulatory responses: Advances in the development of specific phosphodiesterase inhibitors. Medicinal Research Reviews 25:2, pages 229-244.
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Sanjay Tiwari, Hongli Dong, Eun Jung Kim, Lewis Weintraub, Paul M. Epstein & Adam Lerner. (2005) Type 4 cAMP phosphodiesterase (PDE4) inhibitors augment glucocorticoid-mediated apoptosis in B cell chronic lymphocytic leukemia (B-CLL) in the absence of exogenous adenylyl cyclase stimulation. Biochemical Pharmacology 69:3, pages 473-483.
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Peter G. SmithFengfei WangKathryn N. WilkinsonKerry J. SavageUlf KleinDonna S. NeubergGideon BollagMargaret A. ShippRicardo C. T. Aguiar. (2005) The phosphodiesterase PDE4B limits cAMP-associated PI3K/AKT–dependent apoptosis in diffuse large B-cell lymphoma. Blood 105:1, pages 308-316.
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