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Transcriptional Regulation

A Human Globin Enhancer Causes both Discrete and Widespread Alterations in Chromatin Structure

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Pages 8099-8109 | Received 23 May 2003, Accepted 30 Jul 2003, Published online: 27 Mar 2023

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Kambiz Mousavi, Hossein Zare, Miroslav Koulnis & Vittorio Sartorelli. (2014) The emerging roles of eRNAs in transcriptional regulatory networks. RNA Biology 11:2, pages 106-110.
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Christian Valdes-Quezada, Cristian Arriaga-Canon, Yael Fonseca-Guzmán, Georgina Guerrero & Félix Recillas-Targa. (2013) CTCF demarcates chicken embryonic α-globin gene autonomous silencing and contributes to adult stage-specific gene expression. Epigenetics 8:8, pages 827-838.
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Motoshi Shimotsuma, Hitomi Matsuzaki, Osamu Tanabe, Andrew D. Campbell, James Douglas Engel, Akiyoshi Fukamizu & Keiji Tanimoto. (2007) Linear Distance from the Locus Control Region Determines ε-Globin Transcriptional Activity. Molecular and Cellular Biology 27:16, pages 5664-5672.
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AeRi Kim, Hui Zhao, Ina Ifrim & Ann Dean. (2007) β-Globin Intergenic Transcription and Histone Acetylation Dependent on an Enhancer. Molecular and Cellular Biology 27:8, pages 2980-2986.
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Andrew G. Bert, Brett V. Johnson, Euan W. Baxter & Peter N. Cockerill. (2007) A Modular Enhancer Is Differentially Regulated by GATA and NFAT Elements That Direct Different Tissue-Specific Patterns of Nucleosome Positioning and Inducible Chromatin Remodeling. Molecular and Cellular Biology 27:8, pages 2870-2885.
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Brett V. Johnson, Andrew G. Bert, Gregory R. Ryan, Antony Condina & Peter N. Cockerill. (2004) Granulocyte-Macrophage Colony-Stimulating Factor Enhancer Activation Requires Cooperation between NFAT and AP-1 Elements and Is Associated with Extensive Nucleosome Reorganization. Molecular and Cellular Biology 24:18, pages 7914-7930.
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Jiwook Kim, Jin Kang, Yea Woon Kim & AeRi Kim. (2021) The human β‐globin enhancer LCR HS2 plays a role in forming a TAD by activating chromatin structure at neighboring CTCF sites. The FASEB Journal 35:6.
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Sandro Baldi, Stefan Krebs, Helmut Blum & Peter B. Becker. (2018) Genome-wide measurement of local nucleosome array regularity and spacing by nanopore sequencing. Nature Structural & Molecular Biology 25:9, pages 894-901.
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Alyssa C. Lau, Kevin P. Zhu, Elizabeth A. Brouhard, Michael B. Davis & Györgyi Csankovszki. (2016) An H4K16 histone acetyltransferase mediates decondensation of the X chromosome in C. elegans males. Epigenetics & Chromatin 9:1.
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Yea Woon Kim, Won Ju Yun & AeRi Kim. (2016) Erythroid activator NF-E2, TAL1 and KLF1 play roles in forming the LCR HSs in the human adult β-globin locus. The International Journal of Biochemistry & Cell Biology 75, pages 45-52.
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Rui Yang, Jenny L. Kerschner, Nehal Gosalia, Daniel Neems, Lidija K. Gorsic, Alexias Safi, Gregory E. Crawford, Steven T. Kosak, Shih-Hsing Leir & Ann Harris. (2016) Differential contribution of cis -regulatory elements to higher order chromatin structure and expression of the CFTR locus . Nucleic Acids Research 44:7, pages 3082-3094.
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Megha Talati, Erin Seeley, Kaori Ihida‐Stansbury, Horace Delisser, Hayes McDonald, Fei Ye, Xueqiong Zhang, Yu Shyr, Richard Caprioli & Barbara Meyrick. (2012) Altered Expression of Nuclear and Cytoplasmic Histone H1 in Pulmonary Artery and Pulmonary Artery Smooth Muscle Cells in Patients with IPAH. Pulmonary Circulation 2:3, pages 340-351.
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Tamra L. Hunsaker, Holly S. Jefferson, J. Kaitlin Morrison, Andrew J. Franklin & Brian M. Shewchuk. (2012) POU1F1-Mediated Activation of hGH-N by Deoxyribonuclease I Hypersensitive Site II of the Human Growth Hormone Locus Control Region. Journal of Molecular Biology 415:1, pages 29-45.
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Yea Woon Kim, Seoyeon Kim, Chul Geun Kim & AeRi Kim. (2011) The distinctive roles of erythroid specific activator GATA-1 and NF-E2 in transcription of the human fetal γ-globin genes. Nucleic Acids Research 39:16, pages 6944-6955.
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Grégory B. Bonello, Minh-Hieu Pham, Kazi Begum, Jose Sigala, Kavithalakshmi Sataranatarajan & Srinivas Mummidi. (2011) An Evolutionarily Conserved TNF-α–Responsive Enhancer in the Far Upstream Region of Human CCL2 Locus Influences Its Gene Expression . The Journal of Immunology 186:12, pages 7025-7038.
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Yea Woon Kim & AeRi Kim. (2011) Characterization of histone H3K27 modifications in the β-globin locus. Biochemical and Biophysical Research Communications 405:2, pages 210-215.
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Matthew J. Borok, Diana A. Tran, Margaret C. W. Ho & Robert A. Drewell. (2010) Dissecting the regulatory switches of development: lessons from enhancer evolution in Drosophila . Development 137:1, pages 5-13.
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Julie Ross, Stefania Bottardi, Vincent Bourgoin, Alex Wollenschlaeger, Elliot Drobetsky, Marie Trudel & Eric Milot. (2009) Differential requirement of a distal regulatory region for pre-initiation complex formation at globin gene promoters. Nucleic Acids Research 37:16, pages 5295-5308.
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Matilda Rentoft, Kihoon Kim, Youngran Cho, Choon-Hwan Lee & AeRi Kim. (2008) Enhancer requirement for histone methylation linked with gene activation. FEBS Journal 275:23, pages 5994-6001.
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Ya-Jun Li, Yu-Sheng Wei, Xiang-Hui Fu, De-Long Hao, Zheng Xue, Huan Gong, Zhu-Qin Zhang, De-Pei Liu & Chih-Chuan Liang. (2008) The Apolipoprotein CIII Enhancer Regulates Both Extensive Histone Modification and Intergenic Transcription of Human Apolipoprotien AI/CIII/AIV Genes but Not Apolipoprotein AV. Journal of Biological Chemistry 283:42, pages 28436-28444.
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Y. Cho, S.-H. Song, J. J. Lee, N. Choi, C. G. Kim, A. Dean & A. Kim. (2008) The role of transcriptional activator GATA-1 at human  -globin HS2. Nucleic Acids Research 36:14, pages 4521-4528.
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Sang-Hyun Song, Chunhui Hou & Ann Dean. (2007) A Positive Role for NLI/Ldb1 in Long-Range β-Globin Locus Control Region Function. Molecular Cell 28:5, pages 810-822.
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AeRi Kim, Sang-hyun Song, Marjorie Brand & Ann Dean. (2007) Nucleosome and transcription activator antagonism at human β-globin locus control region DNase I hypersensitive sites. Nucleic Acids Research 35:17, pages 5831-5838.
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Sergey V. Razin, Olga V. Iarovaia, Nikolajs Sjakste, Tatiana Sjakste, Lida Bagdoniene, Alla V. Rynditch, Elvira R. Eivazova, Marc Lipinski & Yegor S. Vassetzky. (2007) Chromatin Domains and Regulation of Transcription. Journal of Molecular Biology 369:3, pages 597-607.
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Ae-Ri Kim. (2007) Histone methylation and transcription. Journal of Life Science 17:4, pages 593-598.
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Emile Zuckerkandl & Giacomo Cavalli. (2007) Combinatorial epigenetics, “junk DNA”, and the evolution of complex organisms. Gene 390:1-2, pages 232-242.
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Hui Zhao, AeRi Kim, Sang-hyun Song & Ann Dean. (2006) Enhancer Blocking by Chicken β-Globin 5′-HS4. Journal of Biological Chemistry 281:41, pages 30573-30580.
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Arthur Bank. (2006) Regulation of human fetal hemoglobin: new players, new complexities. Blood 107:2, pages 435-443.
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Ann Dean. (2006) On a chromosome far, far away: LCRs and gene expression. Trends in Genetics 22:1, pages 38-45.
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Milind C. Mahajan, Geeta J. Narlikar, Gokul Boyapaty, Robert E. Kingston & Sherman M. Weissman. (2005) Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the β-globin locus control region. Proceedings of the National Academy of Sciences 102:42, pages 15012-15017.
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Hui Zhao & Ann Dean. (2005) Organizing the genome: enhancers and insulators. Biochemistry and Cell Biology 83:4, pages 516-524.
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Sunita Gopalan, Aneta Kasza, Weili Xu, Daniel L. Kiss, Katarzyna M. Wilczynska, Russell E. Rydel & Tomasz Kordula. (2005) Astrocyte- and hepatocyte-specific expression of genes from the distal serpin subcluster at 14q32.1 associates with tissue-specific chromatin structures. Journal of Neurochemistry 94:3, pages 763-773.
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Jane Mellor. (2005) The Dynamics of Chromatin Remodeling at Promoters. Molecular Cell 19:2, pages 147-157.
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Séverine Chambeyron & Wendy A. Bickmore. (2004) Chromatin decondensation and nuclear reorganization of the HoxB locus upon induction of transcription . Genes & Development 18:10, pages 1119-1130.
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AeRi Kim & Ann Dean. (2004) Developmental stage differences in chromatin subdomains of the β-globin locus. Proceedings of the National Academy of Sciences 101:18, pages 7028-7033.
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