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Molecular and Cellular Biology Volume 23, 2003 - Issue 22
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Cell Growth and Development

Retinoblastoma Tumor Suppressor: Analyses of Dynamic Behavior in Living Cells Reveal Multiple Modes of Regulation

Steven P. Angus1 Department of Cell Biology, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, Ohio45267-0521Correspondence[email protected]
,
David A. Solomon1 Department of Cell Biology, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, Ohio45267-0521
,
Lioba Kuschel2 Division of Training Applications, Carl Zeiss, Jena, Germany07740
,
Robert F. Hennigan1 Department of Cell Biology, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, Ohio45267-0521
&
Erik S. Knudsen1 Department of Cell Biology, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, Ohio45267-0521
Pages 8172-8188 | Received 29 May 2003, Accepted 06 Aug 2003, Published online: 27 Mar 2023

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Leixiang Yang, Tanjing Song, Lihong Chen, Hatem Soliman & Jiandong Chen. (2015) Nucleolar repression facilitates initiation and maintenance of senescence. Cell Cycle 14:22, pages 3613-3623.
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Florian Mueller, Timothy J. Stasevich, Davide Mazza & James G. McNally. (2013) Quantifying transcription factor kinetics: At work or at play?. Critical Reviews in Biochemistry and Molecular Biology 48:5, pages 492-514.
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Timmy Mani, Robert F. Hennigan, Lauren A. Foster, Deborah G. Conrady, Andrew B. Herr & Wallace Ip. (2011) FERM Domain Phosphoinositide Binding Targets Merlin to the Membrane and Is Essential for Its Growth-Suppressive Function. Molecular and Cellular Biology 31:10, pages 1983-1996.
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Steven P. Angus, Christopher N. Mayhew, David A. Solomon, Wesley A. Braden, Michael P. Markey, Yukiko Okuno, M. Cristina Cardoso, David M. Gilbert & Erik S. Knudsen. (2004) RB Reversibly Inhibits DNA Replication via Two Temporally Distinct Mechanisms. Molecular and Cellular Biology 24:12, pages 5404-5420.
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Chao Yu Zhen, Huy Nguyen Duc, Marko Kokotovic, Christopher J. Phiel & Xiaojun Ren. (2014) Cbx2 stably associates with mitotic chromosomes via a PRC2- or PRC1-independent mechanism and is needed for recruiting PRC1 complex to mitotic chromosomes. Molecular Biology of the Cell 25:23, pages 3726-3739.
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Yoshikazu Johmura, Midori Shimada, Toshinori Misaki, Aya Naiki-Ito, Hiroyuki Miyoshi, Noboru Motoyama, Naoko Ohtani, Eiji Hara, Motoki Nakamura, Akimichi Morita, Satoru Takahashi & Makoto Nakanishi. (2014) Necessary and Sufficient Role for a Mitosis Skip in Senescence Induction. Molecular Cell 55:1, pages 73-84.
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Jaclyn E. Quin, Jennifer R. Devlin, Donald Cameron, Kate M. Hannan, Richard B. Pearson & Ross D. Hannan. (2014) Targeting the nucleolus for cancer intervention. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1842:6, pages 802-816.
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Phillip M. Garfin, Dullei Min, Jerrod L. Bryson, Thomas Serwold, Badreddin Edris, Clare C. Blackburn, Ellen R. Richie, Kenneth I. Weinberg, Nancy R. Manley, Julien Sage & Patrick Viatour. (2013) Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression. Journal of Experimental Medicine 210:6, pages 1087-1097.
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Smitha Pillai, Karoly Szekeres, Nicholas J. Lawrence, Srikumar P. Chellappan & George Blanck. (2013) Regulation of interlocking gene regulatory network subcircuits by a small molecule inhibitor of retinoblastoma protein (RB) phosphorylation: Cancer cell expression of HLA-DR. Gene 512:2, pages 403-407.
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Jamie F. Conklin, Julie Baker & Julien Sage. (2012) The RB family is required for the self-renewal and survival of human embryonic stem cells. Nature Communications 3:1.
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Peter Hemmerich, Lars Schmiedeberg & Stephan Diekmann. (2010) Dynamic as well as stable protein interactions contribute to genome function and maintenance. Chromosome Research 19:1, pages 131-151.
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Guolin Zhou, Colleen L Doçi & Mark W Lingen. (2010) Identification and functional analysis of NOL7 nuclear and nucleolar localization signals. BMC Cell Biology 11:1.
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Kristy R. Stengel, Chellappagounder Thangavel, David A. Solomon, Steve P. Angus, Yi Zheng & Erik S. Knudsen. (2009) Retinoblastoma/p107/p130 Pocket Proteins. Journal of Biological Chemistry 284:29, pages 19265-19271.
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Shanaka R. Gunawardena, Brian L. Ruis, Julia A. Meyer, Meenal Kapoor & Kathleen F. Conklin. (2008) NOM1 Targets Protein Phosphatase I to the Nucleolus. Journal of Biological Chemistry 283:1, pages 398-404.
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Ranjaka W. Gunawardena, Sejal R. Fox, Hasan Siddiqui & Erik S. Knudsen. (2007) SWI/SNF Activity Is Required for the Repression of Deoxyribonucleotide Triphosphate Metabolic Enzymes via the Recruitment of mSin3B. Journal of Biological Chemistry 282:28, pages 20116-20123.
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Hasan Siddiqui, Sejal R. Fox, Ranjaka W. Gunawardena & Erik S. Knudsen. (2007) Loss of RB compromises specific heterochromatin modifications and modulates HP1α dynamics. Journal of Cellular Physiology 211:1, pages 131-137.
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Wan Jiao, Jashodeep Datta, Huei-Min Lin, Miroslav Dundr & Sushil G. Rane. (2006) Nucleocytoplasmic Shuttling of the Retinoblastoma Tumor Suppressor Protein via Cdk Phosphorylation-dependent Nuclear Export. Journal of Biological Chemistry 281:49, pages 38098-38108.
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Boris Snopok, Mariya Yurchenko, Laszlo Szekely, George Klein & Elena Kashuba. (2006) SPR-based immunocapture approach to creating an interfacial sensing architecture: mapping of the MRS18-2 binding site on retinoblastoma protein. Analytical and Bioanalytical Chemistry 386:7-8, pages 2063-2073.
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Rieko Oyama, Hideaki Takashima, Masato Yonezawa, Nobuhide Doi, Etsuko Miyamoto-Sato, Masataka Kinjo & Hiroshi Yanagawa. (2006) Protein–protein interaction analysis by C-terminally specific fluorescence labeling and fluorescence cross-correlation spectroscopy. Nucleic Acids Research 34:14, pages e102-e102.
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Edgar Grinstein, Ying Shan, Leonid Karawajew, Peter J.F. Snijders, Chris J.L.M. Meijer, Hans-Dieter Royer & Peter Wernet. (2006) Cell Cycle-controlled Interaction of Nucleolin with the Retinoblastoma Protein and Cancerous Cell Transformation. Journal of Biological Chemistry 281:31, pages 22223-22235.
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Erik S. Knudsen & Steven P. Angus. 2006. Rb and Tumorigenesis. Rb and Tumorigenesis 20 36 .
Leopoldo Laricchia-Robbio, Tomohiko Tamura, Tatiana Karpova, Brian L. Sprague, James G. McNally & Keiko Ozato. (2005) Partner-regulated interaction of IFN regulatory factor 8 with chromatin visualized in live macrophages. Proceedings of the National Academy of Sciences 102:40, pages 14368-14373.
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David A. Barbie, Lindus A. Conlan & Brian K. Kennedy. (2005) Nuclear tumor suppressors in space and time. Trends in Cell Biology 15:7, pages 378-385.
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Elizaveta V. Benevolenskaya, Heather L. Murray, Philip Branton, Richard A. Young & William G. KaelinJr.Jr.. (2005) Binding of pRB to the PHD Protein RBP2 Promotes Cellular Differentiation. Molecular Cell 18:6, pages 623-635.
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David A. Solomon, M. Cristina Cardoso & Erik S. Knudsen. (2004) Dynamic targeting of the replication machinery to sites of DNA damage. Journal of Cell Biology 166:4, pages 455-463.
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Ranjaka W. Gunawardena, Hasan Siddiqui, David A. Solomon, Christopher N. Mayhew, Justin Held, Steven P. Angus & Erik S. Knudsen. (2004) Hierarchical Requirement of SWI/SNF in Retinoblastoma Tumor Suppressor-mediated Repression of Plk1. Journal of Biological Chemistry 279:28, pages 29278-29285.
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