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Molecular and Cellular Biology Volume 23, 2003 - Issue 22
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DNA Dynamics and Chromosome Structure

The Ku Heterodimer Performs Separable Activities at Double-Strand Breaks and Chromosome Termini

Alison A. Bertuch1 Department of Pediatrics, Hematology/Oncology Section;2 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas77030Correspondence[email protected]
&
Victoria Lundblad2 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas77030
Pages 8202-8215 | Received 14 Mar 2003, Accepted 07 Aug 2003, Published online: 27 Mar 2023

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Brian L. Ruis, Kazi R. Fattah & Eric A. Hendrickson. (2008) The Catalytic Subunit of DNA-Dependent Protein Kinase Regulates Proliferation, Telomere Length, and Genomic Stability in Human Somatic Cells . Molecular and Cellular Biology 28:20, pages 6182-6195.
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Phillip L. Palmbos, James M. Daley & Thomas E. Wilson. (2005) Mutations of the Yku80 C Terminus and Xrs2 FHA Domain Specifically Block Yeast Nonhomologous End Joining. Molecular and Cellular Biology 25:24, pages 10782-10790.
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Kyungjae Myung, Goutam Ghosh, Farjana J. Fattah, Gang Li, Haeyoung Kim, Amalia Dutia, Evgenia Pak, Stephanie Smith & Eric A. Hendrickson. (2004) Regulation of Telomere Length and Suppression of Genomic Instability in Human Somatic Cells by Ku86. Molecular and Cellular Biology 24:11, pages 5050-5059.
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Articles from other publishers (73)

Hongyan Sui, Ming Hao, Weizhong Chang & Tomozumi Imamichi. (2021) The Role of Ku70 as a Cytosolic DNA Sensor in Innate Immunity and Beyond. Frontiers in Cellular and Infection Microbiology 11.
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Ekaterina Spivakovsky-Gonzalez, Erica J Polleys, Chiara Masnovo, Jorge Cebrian, Adrian M Molina-Vargas, Catherine H Freudenreich & Sergei M Mirkin. (2021) Rad9-mediated checkpoint activation is responsible for elevated expansions of GAA repeats in CST-deficient yeast. Genetics 219:2.
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Sanna Abbasi, Gursimran Parmar, Rachel D. Kelly, Nileeka Balasuriya & Caroline Schild-Poulter. (2021) The Ku complex: recent advances and emerging roles outside of non-homologous end-joining. Cellular and Molecular Life Sciences 78:10, pages 4589-4613.
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Reyes Carballar, Joan M. Martínez-Láinez, Bàrbara Samper, Samuel Bru, Elisabet Bállega, Oriol Mirallas, Natalia Ricco, Josep Clotet & Javier Jiménez. (2020) CDK-mediated Yku80 Phosphorylation Regulates the Balance Between Non-homologous End Joining (NHEJ) and Homologous Directed Recombination (HDR). Journal of Molecular Biology 432:24, pages 166715.
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Kelly Dew-Budd, Julie Cheung, Kyle Palos, Evan S. Forsythe & Mark A. Beilstein. (2020) Evolutionary and biochemical analyses reveal conservation of the Brassicaceae telomerase ribonucleoprotein complex. PLOS ONE 15:4, pages e0222687.
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Laramie D. Lemon, Danna K. Morris & Alison A. Bertuch. (2019) Loss of Ku’s DNA end binding activity affects telomere length via destabilizing telomere-bound Est1 rather than altering TLC1 homeostasis. Scientific Reports 9:1.
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W. Stöcker. 2019. Lexikon der Medizinischen Laboratoriumsdiagnostik. Lexikon der Medizinischen Laboratoriumsdiagnostik 306 307 .
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Charlene H Emerson, Christopher R Lopez, Albert Ribes-Zamora, Erica J Polleys, Christopher L Williams, Lythou Yeo, Jacques E Zaneveld, Rui Chen & Alison A Bertuch. (2018) Ku DNA End-Binding Activity Promotes Repair Fidelity and Influences End-Processing During Nonhomologous End-Joining in Saccharomyces cerevisiae . Genetics 209:1, pages 115-128.
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Hongwen Chen, Jing Xue, Dmitri Churikov, Evan P. Hass, Shaohua Shi, Laramie D. Lemon, Pierre Luciano, Alison A. Bertuch, David C. Zappulla, Vincent Géli, Jian Wu & Ming Lei. (2018) Structural Insights into Yeast Telomerase Recruitment to Telomeres. Cell 172:1-2, pages 331-343.e13.
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W. Stöcker. 2017. Lexikon der Medizinischen Laboratoriumsdiagnostik. Lexikon der Medizinischen Laboratoriumsdiagnostik 1 2 .
Mélanie V. Larcher, Emeline Pasquier, R. Stephen MacDonald & Raymund J. Wellinger. (2016) Ku Binding on Telomeres Occurs at Sites Distal from the Physical Chromosome Ends. PLOS Genetics 12:12, pages e1006479.
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Dimitris Kyriakou, Emmanouil Stavrou, Panayiota Demosthenous, Georgia Angelidou, Bryan-Joseph San Luis, Charles Boone, Vasilis J. Promponas & Antonis Kirmizis. (2016) Functional characterisation of long intergenic non-coding RNAs through genetic interaction profiling in Saccharomyces cerevisiae. BMC Biology 14:1.
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Charlene H. EmersonAlison A. Bertuch. (2016) Consider the workhorse: Nonhomologous end-joining in budding yeast. Biochemistry and Cell Biology 94:5, pages 396-406.
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Isabella Marcomini & Susan M. Gasser. (2015) Nuclear organization in DNA end processing: Telomeres vs double-strand breaks. DNA Repair 32, pages 134-140.
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Jing Peng, Ming-Hong He, Yi-Ming Duan, Yu-Ting Liu & Jin-Qiu Zhou. (2015) Inhibition of Telomere Recombination by Inactivation of KEOPS Subunit Cgi121 Promotes Cell Longevity. PLOS Genetics 11:3, pages e1005071.
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Julien Hardy, Dmitri Churikov, Vincent Géli & Marie-Noëlle Simon. (2014) Sgs1 and Sae2 promote telomere replication by limiting accumulation of ssDNA. Nature Communications 5:1.
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Linda Rubinstein, Lior Ungar, Yaniv Harari, Vera Babin, Shay Ben-Aroya, Gabor Merenyi, Lisette Marjavaara, Andrei Chabes & Martin Kupiec. (2014) Telomere length kinetics assay (TELKA) sorts the telomere length maintenance (tlm) mutants into functional groups. Nucleic Acids Research 42:10, pages 6314-6325.
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Lisa E. Hang, Christopher R. Lopez, Xianpeng Liu, Jaime M. Williams, Inn Chung, Lei Wei, Alison A. Bertuch & Xiaolan Zhao. (2014) Regulation of Ku-DNA Association by Yku70 C-terminal Tail and SUMO Modification. Journal of Biological Chemistry 289:15, pages 10308-10317.
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Tim Snoek, Karin Voordeckers & Kevin J. Verstrepen. 2014. Subtelomeres. Subtelomeres 39 70 .
Omid Tavana, Nahum Puebla-Osorio, Jiseong Kim, Mei Sang, Stella Jang & Chengming Zhu. (2013) Ku70 Functions in Addition to Nonhomologous End Joining in Pancreatic β-Cells. Diabetes 62:7, pages 2429-2438.
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Andrew B. Dalby, Karen J. Goodrich, Jennifer S. Pfingsten & Thomas R. Cech. (2013) RNA recognition by the DNA end-binding Ku heterodimer. RNA 19:6, pages 841-851.
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Alessia Balestrini, Dejan Ristic, Isabelle Dionne, Xiao Z. Liu, Claire Wyman, Raymund J. Wellinger & John H.J. Petrini. (2013) The Ku Heterodimer and the Metabolism of Single-Ended DNA Double-Strand Breaks. Cell Reports 3:6, pages 2033-2045.
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Johnathan W Lubin, Timsi Rao, Edward K Mandell, Deborah S Wuttke & Victoria Lundblad. (2013) Dissecting Protein Function: An Efficient Protocol for Identifying Separation-of-Function Mutations That Encode Structurally Stable Proteins. Genetics 193:3, pages 715-725.
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Jayakrishnan Nandakumar & Thomas R. Cech. (2013) Finding the end: recruitment of telomerase to telomeres. Nature Reviews Molecular Cell Biology 14:2, pages 69-82.
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Kevin J. Lebo & David C. Zappulla. (2012) Stiffened yeast telomerase RNA supports RNP function in vitro and in vivo. RNA 18:9, pages 1666-1678.
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Margherita Paschini, Tasha B Toro, Johnathan W Lubin, Bari Braunstein-Ballew, Danna K Morris & Victoria Lundblad. (2012) A Naturally Thermolabile Activity Compromises Genetic Analysis of Telomere Function in Saccharomyces cerevisiae . Genetics 191:1, pages 79-93.
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Jennifer S. Pfingsten, Karen J. Goodrich, Cornelius Taabazuing, Faissal Ouenzar, Pascal Chartrand & Thomas R. Cech. (2012) Mutually Exclusive Binding of Telomerase RNA and DNA by Ku Alters Telomerase Recruitment Model. Cell 148:5, pages 922-932.
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