Advanced search
Publication Cover
Molecular and Cellular Biology Volume 23, 2003 - Issue 3
Submit an article Journal homepage
19
Views
91
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Proteasome Inhibition Results in TRAIL Sensitization of Primary Keratinocytes by Removing the Resistance-Mediating Block of Effector Caspase Maturation

Martin Leverkus1 Department of DermatologyCorrespondence[email protected]
,
Martin R. Sprick2 Division of Apoptosis Regulation, Tumor Immunology Program, German Cancer Research Center, 69120Heidelberg
,
Tina Wachter1 Department of Dermatology
,
Thilo Mengling1 Department of Dermatology
,
Bernd Baumann3 Department of Physiological Chemistry, University of Ulm, 89081Ulm, Germany
,
Edgar Serfling4 Institute of Pathology, University of Würzburg Medical School, 97080Würzburg
,
Eva-B. Brücker1 Department of Dermatology
,
Matthias Goebeler1 Department of Dermatology
,
Manfred Neumann4 Institute of Pathology, University of Würzburg Medical School, 97080Würzburg
&
Henning Walczak2 Division of Apoptosis Regulation, Tumor Immunology Program, German Cancer Research Center, 69120Heidelberg
 show all
Pages 777-790 | Received 22 May 2002, Accepted 06 Nov 2002, Published online: 27 Mar 2023

Citations (91)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Daniela Siegmund, Andreas Wicovsky, Ingo Schmitz, Klaus Schulze-Osthoff, Sebastian Kreuz, Martin Leverkus, Oliver Dittrich-Breiholz, Michael Kracht & Harald Wajant. (2005) Death Receptor-Induced Signaling Pathways Are Differentially Regulated by Gamma Interferon Upstream of Caspase 8 Processing. Molecular and Cellular Biology 25:15, pages 6363-6379.
Read now
Patricia Boya, Rosa-Ana González-Polo, Noelia Casares, Jean-Luc Perfettini, Philippe Dessen, Nathanael Larochette, Didier Métivier, Daniel Meley, Sylvie Souquere, Tamotsu Yoshimori, Gérard Pierron, Patrice Codogno & Guido Kroemer. (2005) Inhibition of Macroautophagy Triggers Apoptosis. Molecular and Cellular Biology 25:3, pages 1025-1040.
Read now
John C. Wilkinson, Enrique Cepero, Lawrence H. Boise & Colin S. Duckett. (2004) Upstream Regulatory Role for XIAP in Receptor-Mediated Apoptosis. Molecular and Cellular Biology 24:16, pages 7003-7014.
Read now

Articles from other publishers (88)

Benjamin Bonavida. (2020) Sensitizing activities of nitric oxide donors for cancer resistance to anticancer therapeutic drugs. Biochemical Pharmacology 176, pages 113913.
Crossref
Rachel NeMoyer, Arindam Mondal, Mehul Vora, Elaine Langenfeld, Danea Glover, Michael Scott, Lauren Lairson, Christopher Rongo, David J. Augeri, Youyi Peng, Salma K. Jabbour & John Langenfeld. (2019) Targeting bone morphogenetic protein receptor 2 sensitizes lung cancer cells to TRAIL by increasing cytosolic Smac/DIABLO and the downregulation of X-linked inhibitor of apoptosis protein. Cell Communication and Signaling 17:1.
Crossref
Jun-Xia Zhao, Qing-Shuang Zhang, Ying Chen, Sheng-Jie Yao, Yong-Xin Yan, Ying Wang, Jin-Xiu Zhang & Li-An Wang. (2016) Iso-suillin from Suillus flavus Induces Apoptosis in Human Small Cell Lung Cancer H446 Cell Line. Chinese Medical Journal 129:10, pages 1215-1223.
Crossref
Maria Feoktistova, Fredrik Wallberg, Tencho Tenev, Peter Geserick, Martin Leverkus & Pascal Meier. (2016) Techniques to Distinguish Apoptosis from Necroptosis. Cold Spring Harbor Protocols 2016:4, pages pdb.top070375.
Crossref
Benjamin Bonavida & Hermes Garban. (2015) Nitric oxide-mediated sensitization of resistant tumor cells to apoptosis by chemo-immunotherapeutics. Redox Biology 6, pages 486-494.
Crossref
Rachana Trivedi & Durga Prasad Mishra. (2015) Trailing TRAIL Resistance: Novel Targets for TRAIL Sensitization in Cancer Cells. Frontiers in Oncology 5.
Crossref
I Karl, M Jossberger-Werner, N Schmidt, S Horn, M Goebeler, M Leverkus, H Wajant & T Giner. (2014) TRAF2 inhibits TRAIL- and CD95L-induced apoptosis and necroptosis. Cell Death & Disease 5:10, pages e1444-e1444.
Crossref
P Geserick, J Wang, M Feoktistova & M Leverkus. (2014) The ratio of Mcl-1 and Noxa determines ABT737 resistance in squamous cell carcinoma of the skin. Cell Death & Disease 5:9, pages e1412-e1412.
Crossref
Eugene Roscioli, Rhys Hamon, Richard E. Ruffin, Susan Lester & Peter Zalewski. (2013) Cellular inhibitor of apoptosis-2 is a critical regulator of apoptosis in airway epithelial cells treated with asthma-related inflammatory cytokines. Physiological Reports 1:5.
Crossref
M van Dijk, A Halpin-McCormick, T Sessler, A Samali & E Szegezdi. (2013) Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways. Cell Death & Disease 4:7, pages e702-e702.
Crossref
Simone Fulda. 2013. Cell Death Signaling in Cancer Biology and Treatment. Cell Death Signaling in Cancer Biology and Treatment 281 301 .
Muktheshwar Gandesiri, Saritha Chakilam, Jelena Ivanovska, Natalya Benderska, Matthias Ocker, Pietro Di Fazio, Maria Feoktistova, Hala Gali-Muhtasib, Margret Rave-Fränk, Olaf Prante, Hans Christiansen, Martin Leverkus, Arndt Hartmann & Regine Schneider-Stock. (2012) DAPK plays an important role in panobinostat-induced autophagy and commits cells to apoptosis under autophagy deficient conditions. Apoptosis 17:12, pages 1300-1315.
Crossref
Jun Sun, Jinzhao Han, Yi Zhao, Quangang Zhu & Jinhong Hu. (2012) Curcumin induces apoptosis in tumor necrosis factor-alpha-treated HaCaT cells. International Immunopharmacology 13:2, pages 170-174.
Crossref
Andreas Kerstan, E.-B. Bröcker & A. Trautmann. (2011) Decisive role of tumor necrosis factor-α for spongiosis formation in acute eczematous dermatitis. Archives of Dermatological Research 303:9, pages 651-658.
Crossref
Sarit Kahana, Susan Finniss, Simona Cazacu, Cunli Xiang, Hae-Kyung Lee, Shlomit Brodie, Ronald S. Goldstein, Vered Roitman, Shimon Slavin, Tom Mikkelsen & Chaya Brodie. (2011) Proteasome inhibitors sensitize glioma cells and glioma stem cells to TRAIL-induced apoptosis by PKCε-dependent downregulation of AKT and XIAP expressions. Cellular Signalling 23:8, pages 1348-1357.
Crossref
Simone Fulda. (2011) Novel insights into the synergistic interaction of Bortezomib and TRAIL: tBid provides the link. Oncotarget 2:5, pages 418-421.
Crossref
Shyam M. Kavuri, Peter Geserick, Daniela Berg, Diana Panayotova Dimitrova, Maria Feoktistova, Daniela Siegmund, Harald Gollnick, Manfred Neumann, Harald Wajant & Martin Leverkus. (2011) Cellular FLICE-inhibitory Protein (cFLIP) Isoforms Block CD95- and TRAIL Death Receptor-induced Gene Induction Irrespective of Processing of Caspase-8 or cFLIP in the Death-inducing Signaling Complex. Journal of Biological Chemistry 286:19, pages 16631-16646.
Crossref
Chahrazade Kantari & Henning Walczak. (2011) Caspase-8 and Bid: Caught in the act between death receptors and mitochondria. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1813:4, pages 558-563.
Crossref
Christina Menke, Lianghua Bin, Jacqueline Thorburn, Kian Behbakht, Heide L. Ford & Andrew Thorburn. (2011) Distinct TRAIL Resistance Mechanisms Can Be Overcome by Proteasome Inhibition but not Generally by Synergizing Agents. Cancer Research 71:5, pages 1883-1892.
Crossref
M Hörnle, N Peters, B Thayaparasingham, H Vörsmann, H Kashkar & D Kulms. (2010) Caspase-3 cleaves XIAP in a positive feedback loop to sensitize melanoma cells to TRAIL-induced apoptosis. Oncogene 30:5, pages 575-587.
Crossref
Esther P. Jane, Daniel R. Premkumar & Ian F. Pollack. (2011) Bortezomib Sensitizes Malignant Human Glioma Cells to TRAIL, Mediated by Inhibition of the NF-κB Signaling Pathway. Molecular Cancer Therapeutics 10:1, pages 198-208.
Crossref
Naoko Seki, Uhi Toh, Thomas J. Sayers, Teruhiko Fujii, Motoshi Miyagi, Yoshito Akagi, Jingo Kusukawa, Masayoshi Kage, Kazuo Shirouzu & Hideaki Yamana. (2010) Bortezomib Sensitizes Human Esophageal Squamous Cell Carcinoma Cells to TRAIL–Mediated Apoptosis via Activation of Both Extrinsic and Intrinsic Apoptosis Pathways. Molecular Cancer Therapeutics 9:6, pages 1842-1851.
Crossref
Marc Schmidt, Mike Hupe, Nicole Endres, Badrinarayanan Raghavan, Shyam Kavuri, Peter Geserick, Matthias Goebeler & Martin Leverkus. (2009) The contact allergen nickel sensitizes primary human endothelial cells and keratinocytes to TRAIL-mediated apoptosis. Journal of Cellular and Molecular Medicine 14:6b, pages 1760-1776.
Crossref
Kerstin Papenfuss, Silvia Prieske & Henning Walczak. (2010) TRAIL-Rezeptor-Agonisten, eine neue Klasse proapoptotischer KrebstherapeutikaTRAIL Receptor Agonists, a Novel Class of Pro-Apoptotic Agents in Cancer Therapy. Onkopipeline 3:1, pages 11-23.
Crossref
Peter Geserick, Mike Hupe, Maryline Moulin, W. Wei-Lynn Wong, Maria Feoktistova, Beate Kellert, Harald Gollnick, John Silke & Martin Leverkus. (2009) Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment. Journal of Cell Biology 187:7, pages 1037-1054.
Crossref
Ashok Kumar Pandey & Ajit Sodhi. (2009) Recombinant YopJ induces apoptosis in murine peritoneal macrophages in vitro: involvement of mitochondrial death pathway. International Immunology 21:11, pages 1239-1249.
Crossref
Nicole Armbruster, Axel Trautmann, Eva-Bettina Bröcker, Martin Leverkus & Andreas Kerstan. (2009) Suprabasal Spongiosis in Acute Eczematous Dermatitis: cFLIP Maintains Resistance of Basal Keratinocytes to T-Cell-Mediated Apoptosis. Journal of Investigative Dermatology 129:7, pages 1696-1702.
Crossref
Tomasz M. Basinski, David Holzmann, Thomas Eiwegger, Maya Zimmermann, Sven Klunker, Norbert Meyer, Peter Schmid-Grendelmeier, Marek Jutel & Cezmi A. Akdis. (2009) Dual nature of T cell–epithelium interaction in chronic rhinosinusitis. Journal of Allergy and Clinical Immunology 124:1, pages 74-80.e8.
Crossref
Thomas Newsom-Davis, Silvia Prieske & Henning Walczak. (2009) Is TRAIL the holy grail of cancer therapy?. Apoptosis 14:4, pages 607-623.
Crossref
Christina Falschlehner, Tom M. Ganten, Ronald Koschny, Uta Schaefer & Henning Walczak. 2009. Therapeutic Targets of the TNF Superfamily. Therapeutic Targets of the TNF Superfamily 195 206 .
Stefanie M. Cordier, Kerstin Papenfuss & Henning Walczak. 2009. Death Receptors and Cognate Ligands in Cancer. Death Receptors and Cognate Ligands in Cancer 115 143 .
Kerstin Papenfuss, Stefanie M. Cordier & Henning Walczak. (2008) Death receptors as targets for anti-cancer therapy. Journal of Cellular and Molecular Medicine 12:6b, pages 2566-2585.
Crossref
O Ndozangue-Touriguine, M Sebbagh, D Mérino, O Micheau, J Bertoglio & J Bréard. (2008) A mitochondrial block and expression of XIAP lead to resistance to TRAIL-induced apoptosis during progression to metastasis of a colon carcinoma. Oncogene 27:46, pages 6012-6022.
Crossref
Brigitte M.T. Hougardy, Nathalie Reesink‐Peters, Fiona A.J. van den Heuvel, Klaske A. ten Hoor, Harry Hollema, Elisabeth G.E. de Vries, Steven de Jong & Ate G.J. van der Zee. (2008) A robust ex vivo model for evaluation of induction of apoptosis by rhTRAIL in combination with proteasome inhibitor MG132 in human premalignant cervical explants . International Journal of Cancer 123:6, pages 1457-1465.
Crossref
Benjamin Bonavida, Stavroula Baritaki, Sara Huerta-Yepez, Mario I. Vega, Devasis Chatterjee & Kam Yeung. (2008) Novel therapeutic applications of nitric oxide donors in cancer: Roles in chemo- and immunosensitization to apoptosis and inhibition of metastases. Nitric Oxide 19:2, pages 152-157.
Crossref
Johanna Dzieran, James F. Beck & Jürgen Sonnemann. (2008) Differential responsiveness of human hepatoma cells versus normal hepatocytes to TRAIL in combination with either histone deacetylase inhibitors or conventional cytostatics . Cancer Science 99:8, pages 1685-1692.
Crossref
Martin Leverkus, Philip Diessenbacher & Peter Geserick. (2008) FLIP ing the coin? Death receptor-mediated signals during skin tumorigenesis. Experimental Dermatology 17:7, pages 614-622.
Crossref
P Geserick, C Drewniok, M Hupe, T L Haas, P Diessenbacher, M R Sprick, M P Schön, F Henkler, H Gollnick, H Walczak & M Leverkus. (2007) Suppression of cFLIP is sufficient to sensitize human melanoma cells to TRAIL- and CD95L-mediated apoptosis. Oncogene 27:22, pages 3211-3220.
Crossref
A. Shanker, A. D. Brooks, C. A. Tristan, J. W. Wine, P. J. Elliott, H. Yagita, K. Takeda, M. J. Smyth, W. J. Murphy & T. J. Sayers. (2008) Treating Metastatic Solid Tumors With Bortezomib and a Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor Agonist Antibody. JNCI Journal of the National Cancer Institute 100:9, pages 649-662.
Crossref
Stavroula Baritaki, Eriko Suzuki, Kazuo Umezawa, Demetrios A. Spandidos, James Berenson, Tracy R. Daniels, Manuel L. Penichet, Ali R. Jazirehi, Michael Palladino & Benjamin Bonavida. (2008) Inhibition of Yin Yang 1-Dependent Repressor Activity of DR5 Transcription and Expression by the Novel Proteasome Inhibitor NPI-0052 Contributes to its TRAIL-Enhanced Apoptosis in Cancer Cells. The Journal of Immunology 180:9, pages 6199-6210.
Crossref
Philip Diessenbacher, Mike Hupe, Martin R. Sprick, Andreas Kerstan, Peter Geserick, Tobias L. Haas, Tina Wachter, Manfred Neumann, Henning Walczak, John Silke & Martin Leverkus. (2008) NF-κB Inhibition Reveals Differential Mechanisms of TNF Versus TRAIL-Induced Apoptosis Upstream or at the Level of Caspase-8 Activation Independent of cIAP2. Journal of Investigative Dermatology 128:5, pages 1134-1147.
Crossref
László Kopper & István Peták. 2008. Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response. Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response 103 113 .
Ronald Koschny, Henning Walczak & Tom M. Ganten. (2007) The promise of TRAIL—potential and risks of a novel anticancer therapy. Journal of Molecular Medicine 85:9, pages 923-935.
Crossref
Christina Falschlehner, Christoph H. Emmerich, Björn Gerlach & Henning Walczak. (2007) TRAIL signalling: Decisions between life and death. The International Journal of Biochemistry & Cell Biology 39:7-8, pages 1462-1475.
Crossref
B M Kurbanov, L F Fecker, C C Geilen, W Sterry & J Eberle. (2006) Resistance of melanoma cells to TRAIL does not result from upregulation of antiapoptotic proteins by NF-κB but is related to downregulation of initiator caspases and DR4. Oncogene 26:23, pages 3364-3377.
Crossref
C G Concannon, B F Koehler, Claus Reimertz, B M Murphy, C Bonner, N Thurow, M W Ward, A Villunger, A Strasser, D Kögel & J H M Prehn. (2006) Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway. Oncogene 26:12, pages 1681-1692.
Crossref
Wenhua Li, Xiaoping Zhang & Aria F. Olumi. (2007) MG-132 Sensitizes TRAIL-Resistant Prostate Cancer Cells by Activating c-Fos/c-Jun Heterodimers and Repressing c-FLIP(L). Cancer Research 67:5, pages 2247-2255.
Crossref
K La Ferla-Brühl, M A Westhoff, S Karl, H Kasperczyk, R M Zwacka, K M Debatin & S Fulda. (2006) NF-κB-independent sensitization of glioblastoma cells for TRAIL-induced apoptosis by proteasome inhibition. Oncogene 26:4, pages 571-582.
Crossref
A Nencioni, F Grünebach, F Patrone, A Ballestrero & P Brossart. (2006) Proteasome inhibitors: antitumor effects and beyond. Leukemia 21:1, pages 30-36.
Crossref
Andreas Kerstan, Nicole Armbruster, Martin Leverkus & Thomas Hünig. (2006) Cyclosporin A Abolishes CD28-Mediated Resistance to CD95-Induced Apoptosis via Superinduction of Caspase-3. The Journal of Immunology 177:11, pages 7689-7697.
Crossref
Stefania Ceruti, Alessia Mazzola & Maria P. Abbracchio. (2006) Proteasome Inhibitors Potentiate Etoposide-Induced Cell Death in Human Astrocytoma Cells Bearing a Mutated p53 Isoform. Journal of Pharmacology and Experimental Therapeutics 319:3, pages 1424-1434.
Crossref
Martin Leverkus & Axel Trautmann. (2006) CD95-Mediated Signals in the Skin: Going Out with an (Inflammatory) Bang?. Journal of Investigative Dermatology 126:11, pages 2364-2366.
Crossref
Sabine Gröbner, Stella E. Autenrieth, Irena Soldanova, Dani S. J. Gunst, Martin Schaller, Erwin Bohn, Steffen Müller, Martin Leverkus, Sebastian Wesselborg, Ingo B. Autenrieth & Stefan Borgmann. (2006) Yersinia YopP-induced apoptotic cell death in murine dendritic cells is partially independent from action of caspases and exhibits necrosis-like features. Apoptosis 11:11, pages 1959-1968.
Crossref
Susanne J. Braeuer, Chirlei Büneker, Andrea Mohr & Ralf Michael Zwacka. (2006) Constitutively Activated Nuclear Factor-κB, but not Induced NF-κB, Leads to TRAIL Resistance by Up-Regulation of X-Linked Inhibitor of Apoptosis Protein in Human Cancer Cells. Molecular Cancer Research 4:10, pages 715-728.
Crossref
T Wenger, J Mattern, R Penzel, N Gassler, T L Haas, M R Sprick, H Walczak, P H Krammer, K-M Debatin & I Herr. (2006) Specific resistance upon lentiviral TRAIL transfer by intracellular retention of TRAIL receptors. Cell Death & Differentiation 13:10, pages 1740-1751.
Crossref
Constance Assohou-Luty, Jeanette Gerspach, Daniela Siegmund, Nicole Müller, Bertrand Huard, Gisa Tiegs, Klaus Pfizenmaier & Harald Wajant. (2006) A CD40–CD95L fusion protein interferes with CD40L-induced prosurvival signaling and allows membrane CD40L-restricted activation of CD95. Journal of Molecular Medicine 84:9, pages 785-797.
Crossref
Katalin Nagy, Kinga Székely-Szüts, Kamel Izeradjene, Leslie Douglas, Mike Tillman, Helga Barti-Juhász, Massimo Dominici, Carlotta Spano, Gian Luca Cervo, Pierfranco Conte, Janet A Houghton, Rudolf Mihalik, László Kopper & István Peták. (2006) Proteasome inhibitors sensitize colon carcinoma cells to TRAIL-induced apoptosis via enhanced release of smac/DIABLO from the mitochondria. Pathology & Oncology Research 12:3, pages 133-142.
Crossref
Bernadette Begue, Harald Wajant, Jean–Christophe Bambou, Laurent Dubuquoy, Daniela Siegmund, Jean–François Beaulieu, Danielle Canioni, Dominique Berrebi, Nicole Brousse, Pierre Desreumaux, Jacques Schmitz, Michael J. Lentze, Oliver Goulet, Nadine Cerf–Bensussan & Frank M. Ruemmele. (2006) Implication of TNF-Related Apoptosis-Inducing Ligand in Inflammatory Intestinal Epithelial Lesions. Gastroenterology 130:7, pages 1962-1974.
Crossref
Brigitte M.T. Hougardy, John H. Maduro, Ate G.J. van der Zee, Derk Jan A. de Groot, Fiona A.J. van den Heuvel, Elisabeth G.E. de Vries & Steven de Jong. (2006) Proteasome inhibitor MG132 sensitizes HPV-positive human cervical cancer cells to rhTRAIL-induced apoptosis. International Journal of Cancer 118:8, pages 1892-1900.
Crossref
Denis Lane, Marceline Côté, Roxanne Grondin, Marie-Christine Couture & Alain Piché. (2006) Acquired resistance to TRAIL-induced apoptosis in human ovarian cancer cells is conferred by increased turnover of mature caspase-3. Molecular Cancer Therapeutics 5:3, pages 509-521.
Crossref
Erika Cretney, Anil Shanker, Hideo Yagita, Mark J Smyth & Thomas J Sayers. (2006) TNF‐related apoptosis‐inducing ligand as a therapeutic agent in autoimmunity and cancer. Immunology & Cell Biology 84:1, pages 87-98.
Crossref
Thomas J. Sayers & William J. Murphy. (2005) Combining proteasome inhibition with TNF-related apoptosis-inducing ligand (Apo2L/TRAIL) for cancer therapy. Cancer Immunology, Immunotherapy 55:1, pages 76-84.
Crossref
Harald Wajant. 2006. The Link Between Inflammation and Cancer. The Link Between Inflammation and Cancer 141 165 .
Francesca Demarchi & Claudio Brancolini. (2005) Altering protein turnover in tumor cells: New opportunities for anti-cancer therapies. Drug Resistance Updates 8:6, pages 359-368.
Crossref
Ekatherina Vassina, Martin Leverkus, Shida Yousefi, Lasse R. Braathen, Hans-Uwe Simon & Dagmar Simon. (2005) Increased Expression and a Potential Anti-Inflammatory Role of TRAIL in Atopic Dermatitis. Journal of Investigative Dermatology 125:4, pages 746-752.
Crossref
Ran-Xin Shi, Choon-Nam Ong & Han-Ming Shen. (2005) Protein Kinase C Inhibition and X-Linked Inhibitor of Apoptosis Protein Degradation Contribute to the Sensitization Effect of Luteolin on Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptosis in Cancer Cells. Cancer Research 65:17, pages 7815-7823.
Crossref
Tom M. Ganten, Ronald Koschny, Tobias L. Haas, Jaromir Sykora, Min Li-Weber, Kerstin Herzer & Henning Walczak. (2005) Proteasome inhibition sensitizes hepatocellular carcinoma cells, but not human hepatocytes, to TRAIL. Hepatology 42:3, pages 588-597.
Crossref
Kerstin Herzer, Tom M. Ganten, Henning Schulze-Bergkamen, Anne Grosse-Wilde, Ronald Koschny, Peter H. Krammer & Henning Walczak. (2005) Transforming growth factor β can mediate apoptosis via the expression of TRAIL in human hepatoma cells. Hepatology 42:1, pages 183-192.
Crossref
Alessio Nencioni, Lucia Wille, Giovanna Dal Bello, Davide Boy, Gabriella Cirmena, Sebastian Wesselborg, Claus Belka, Peter Brossart, Franco Patrone & Alberto Ballestrero. (2005) Cooperative Cytotoxicity of Proteasome Inhibitors and Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand in Chemoresistant Bcl-2-Overexpressing Cells. Clinical Cancer Research 11:11, pages 4259-4265.
Crossref
Alessio NencioniFei HuaChristopher P. DillonRayka YokooChristoph ScheiermannMike H. CardoneEleonora BarbieriIlaria RoccoAnna GarutiSebastian WesselborgClaus BelkaPeter BrossartFranco PatroneAlberto Ballestrero. (2005) Evidence for a protective role of Mcl-1 in proteasome inhibitor-induced apoptosis. Blood 105:8, pages 3255-3262.
Crossref
Ruping Shao, Dung-Fang Lee, Yong Wen, Yi Ding, Weiya Xia, Bo Ping, Hideo Yagita, Bill Spohn & Mien-Chie Hung. (2005) E1A Sensitizes Cancer Cells to TRAIL-Induced Apoptosis through Enhancement of Caspase Activation. Molecular Cancer Research 3:4, pages 219-226.
Crossref
Tina Wachter, Martin Sprick, Dominikus Hausmann, Andreas Kerstan, Kirsty McPherson, Giorgio Stassi, Eva-B. Bröcker, Henning Walczak & Martin Leverkus. (2004) cFLIPL Inhibits Tumor Necrosis Factor-related Apoptosis-inducing Ligand-mediated NF-κB Activation at the Death-inducing Signaling Complex in Human Keratinocytes. Journal of Biological Chemistry 279:51, pages 52824-52834.
Crossref
Alessandra Marconi, Paola Atzei, Cristina Panza, Chiara Fila, Rossana Tiberio, Francesca Truzzi, Tina Wachter, Martin Leverkus & Carlo Pincelli. (2004) FLICE/caspase-8 activation triggers anoikis induced by β1-integrin blockade in human keratinocytes. Journal of Cell Science 117:24, pages 5815-5823.
Crossref
Stefanie E.F. Tran, Annika Meinander & John E. Eriksson. (2004) Instant decisions: transcription-independent control of death-receptor-mediated apoptosis. Trends in Biochemical Sciences 29:11, pages 601-608.
Crossref
Hideo Yagita, Kazuyoshi Takeda, Yoshihiro Hayakawa, Mark J. Smyth & Ko Okumura. (2004) TRAIL and its receptors as targets for cancer therapy. Cancer Science 95:10, pages 777-783.
Crossref
T M Ganten, T L Haas, J Sykora, H Stahl, M R Sprick, S C Fas, A Krueger, M A Weigand, A Grosse-Wilde, W Stremmel, P H Krammer & H Walczak. (2004) Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs. Cell Death & Differentiation 11:S1, pages S86-S96.
Crossref
Martin Leverkus. (2004) Imiquimod: Unexpected Killer. Journal of Investigative Dermatology 122:5, pages xv-xvi.
Crossref
Mikhail V Blagosklonny. (2004) Prospective strategies to enforce selectively cell death in cancer cells. Oncogene 23:16, pages 2967-2975.
Crossref
Huang-Ge Zhang, Jianhua Wang, Xinwen Yang, Hui-Chen Hsu & John D Mountz. (2004) Regulation of apoptosis proteins in cancer cells by ubiquitin. Oncogene 23:11, pages 2009-2015.
Crossref
Martin R. Sprick & Henning Walczak. (2004) The interplay between the Bcl-2 family and death receptor-mediated apoptosis. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1644:2-3, pages 125-132.
Crossref
Henning Schulze-Bergkamen & Peter H Krammer. (2004) Apoptosis in cancer—implications for therapy. Seminars in Oncology 31:1, pages 90-119.
Crossref
Young-Mo Seong, Hyo-Jin Park, Geun-Hye Seong, Ju-Youn Choi, Sung-Joo Kim Yoon, Byung-Re Min, Seongman Kang & Hyangshuk Rhim. (2004) N-terminal truncation circumvents proteolytic degradation of the human HtrA2/Omi serine protease in Escherichia coli: rapid purification of a proteolytically active HtrA2/Omi. Protein Expression and Purification 33:2, pages 200-208.
Crossref
Wei-Ting Liao, Kee-Lung Chang, Chai-Li Yu, Gow-Shing Chen, Louis W. Chang & Hsin-Su Yu. (2004) Arsenic Induces Human Keratinocyte Apoptosis by the FAS/FAS Ligand Pathway, Which Correlates with Alterations in Nuclear Factor-κB and Activator Protein-1 Activity. Journal of Investigative Dermatology 122:1, pages 125-129.
Crossref
Christine J Hawkins. 2004. TRAIL (TNF-Related Apoptosis-Inducing Ligand). TRAIL (TNF-Related Apoptosis-Inducing Ligand) 427 452 .
Carmen Ruiz de Almodóvar, Abelardo López-Rivas & Carmen Ruiz-Ruiz. 2004. TRAIL (TNF-Related Apoptosis-Inducing Ligand). TRAIL (TNF-Related Apoptosis-Inducing Ligand) 291 318 .
Harald Wajant. 2004. TRAIL (TNF-Related Apoptosis-Inducing Ligand). TRAIL (TNF-Related Apoptosis-Inducing Ligand) 101 132 .
E Ucur, J Mattern, T Wenger, S Okouoyo, A Schroth, K-M Debatin & I Herr. (2003) Induction of apoptosis in experimental human B cell lymphomas by conditional TRAIL-expressing T cells. British Journal of Cancer 89:11, pages 2155-2162.
Crossref
Martin Leverkus, Martin R. Sprick, Tina Wachter, Andrea Denk, Eva-Bettina Bröcker, Henning Walczak & Manfred Neumann. (2003) TRAIL-Induced Apoptosis and Gene Induction in HaCaT Keratinocytes: Differential Contribution of TRAIL Receptors 1 and 2. Journal of Investigative Dermatology 121:1, pages 149-155.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.