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Gene Expression

In Vivo Association of the Stability Control Protein αCP with Actively Translating mRNAs

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Pages 899-907 | Received 24 Sep 2002, Accepted 01 Nov 2002, Published online: 27 Mar 2023

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Read on this site (8)

Xinjun Ji, Anupama Jha, Jesse Humenik, Louis R. Ghanem, Andrew Kromer, Christopher Duncan-Lewis, Elizabeth Traxler, Mitchell J. Weiss, Yoseph Barash & Stephen A. Liebhaber. (2021) RNA-Binding Proteins PCBP1 and PCBP2 Are Critical Determinants of Murine Erythropoiesis. Molecular and Cellular Biology 41:9.
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Louis R. Ghanem, Andrew Kromer, Ian M. Silverman, Priya Chatterji, Elizabeth Traxler, Alfredo Penzo-Mendez, Mitchell J. Weiss, Ben Z. Stanger & Stephen A. Liebhaber. (2016) The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development. Molecular and Cellular Biology 36:2, pages 304-319.
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Hemant K. Kini, Jian Kong & Stephen A. Liebhaber. (2014) Cytoplasmic Poly(A) Binding Protein C4 Serves a Critical Role in Erythroid Differentiation. Molecular and Cellular Biology 34:7, pages 1300-1309.
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Xinjun Ji, Ji Wan, Melanie Vishnu, Yi Xing & Stephen A. Liebhaber. (2013) αCP Poly(C) Binding Proteins Act as Global Regulators of Alternative Polyadenylation. Molecular and Cellular Biology 33:13, pages 2560-2573.
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J. J. David Ho, G. Brett Robb, Sharon C. Tai, Paul J. Turgeon, Imtiaz A. Mawji, H. S. Jeffrey Man & Philip A. Marsden. (2013) Active Stabilization of Human Endothelial Nitric Oxide Synthase mRNA by hnRNP E1 Protects against Antisense RNA and MicroRNAs. Molecular and Cellular Biology 33:10, pages 2029-2046.
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Xinjun Ji, Jian Kong, Russ P. Carstens & Stephen A. Liebhaber. (2007) The 3′ Untranslated Region Complex Involved in Stabilization of Human α-globin mRNA Assembles in the Nucleus and Serves an Independent Role as a Splice Enhancer. Molecular and Cellular Biology 27:9, pages 3290-3302.
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Alexander N. Chkheidze & Stephen A. Liebhaber. (2003) A Novel Set of Nuclear Localization Signals Determine Distributions of the αCP RNA-Binding Proteins. Molecular and Cellular Biology 23:23, pages 8405-8415.
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Shelly A. Waggoner & Stephen A. Liebhaber. (2003) Identification of mRNAs Associated with αCP2-Containing RNP Complexes. Molecular and Cellular Biology 23:19, pages 7055-7067.
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Articles from other publishers (28)

Michael J Mallory, Sean P McClory, Rakesh Chatrikhi, Matthew R Gazzara, Robert J Ontiveros & Kristen W Lynch. (2020) Reciprocal regulation of hnRNP C and CELF2 through translation and transcription tunes splicing activity in T cells. Nucleic Acids Research 48:10, pages 5710-5719.
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Karina B. Sabalette, María Albertina Romaniuk, Griselda Noé, Alejandro Cassola, Vanina A. Campo & Javier G. De Gaudenzi. (2019) The RNA-binding protein TcUBP1 up-regulates an RNA regulon for a cell surface–associated Trypanosoma cruzi glycoprotein and promotes parasite infectivity. Journal of Biological Chemistry 294:26, pages 10349-10364.
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Xinjun Ji, Jesse Humenik & Stephen A. Liebhaber. (2019) A cytosine-rich splice regulatory determinant enforces functional processing of the human α-globin gene transcript. Blood 133:21, pages 2338-2347.
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Xinjun Ji, Jesse Humenik, Daphne Yang & Stephen A Liebhaber. (2018) PolyC-binding proteins enhance expression of the CDK2 cell cycle regulatory protein via alternative splicing. Nucleic Acids Research 46:4, pages 2030-2044.
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Veenu Tripathi, Katherine M. Sixt, Shaojian Gao, Xuan Xu, Jing Huang, Roberto Weigert, Ming Zhou & Ying E. Zhang. (2016) Direct Regulation of Alternative Splicing by SMAD3 through PCBP1 Is Essential to the Tumor-Promoting Role of TGF-β. Molecular Cell 64:3, pages 549-564.
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Javier G. De Gaudenzi, Adriana V. Jäger, Ronan Izcovich & Vanina A. Campo. (2016) Insights into the Regulation of mRNA Processing of Polycistronic Transcripts Mediated by DRBD4/PTB2, a Trypanosome Homolog of the Polypyrimidine Tract-Binding Protein. Journal of Eukaryotic Microbiology 63:4, pages 440-452.
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Xinjun Ji, Juw Won Park, Emad Bahrami-Samani, Lan Lin, Christopher Duncan-Lewis, Gordon Pherribo, Yi Xing & Stephen A. Liebhaber. (2016) αCP binding to a cytosine-rich subset of polypyrimidine tracts drives a novel pathway of cassette exon splicing in the mammalian transcriptome. Nucleic Acids Research 44:5, pages 2283-2297.
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Aditi Singh, Igor Minia, Dorothea Droll, Abeer Fadda, Christine Clayton & Esteban Erben. (2022) Trypanosome MKT1 and the RNA-binding protein ZC3H11: interactions and potential roles in post-transcriptional regulatory networks. Nucleic Acids Research 42:7, pages 4652-4668.
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Louis R. Ghanem, Priya Chatterji & Stephen A. Liebhaber. (2014) Specific enrichment of the RNA-binding proteins PCBP1 and PCBP2 in chief cells of the murine gastric mucosa. Gene Expression Patterns 14:2, pages 78-87.
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Eung Jae Yoo, Nancy E. Cooke & Stephen A. Liebhaber. (2013) Identification of a Secondary Promoter within the Human B Cell Receptor Component Gene hCD79b. Journal of Biological Chemistry 288:25, pages 18353-18365.
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Wei Han, Zhongshuai Xin, Zhiqiang Zhao, Wen Bao, Xihua Lin, Bin Yin, Jizong Zhao, Jiangang Yuan, Boqin Qiang & Xiaozhong Peng. (2013) RNA-binding protein PCBP2 modulates glioma growth by regulating FHL3. Journal of Clinical Investigation 123:5, pages 2103-2118.
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Ravi S. Shukla, Bin Qin, Yu-Jui Yvonne Wan & Kun Cheng. (2011) PCBP2 siRNA Reverses the Alcohol-induced Pro-fibrogenic Effects in Hepatic Stellate Cells. Pharmaceutical Research 28:12, pages 3058-3068.
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Xinjun Ji, Jian Kong & Stephen A Liebhaber. (2011) An RNA-protein complex links enhanced nuclear 3′ processing with cytoplasmic mRNA stabilization. The EMBO Journal 30:13, pages 2622-2633.
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Melanie R. Vishnu, Marina Sumaroka, Peter S. Klein & Stephen A. Liebhaber. (2011) The poly(rC)-binding protein αCP2 is a noncanonical factor in X. laevis cytoplasmic polyadenylation . RNA 17:5, pages 944-956.
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Ken Fujimura, Jun Katahira, Fumi Kano, Yoshihiro Yoneda & Masayuki Murata. (2009) Selective localization of PCBP2 to cytoplasmic processing bodies. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1793:5, pages 878-887.
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R B Hamanaka, E Bobrovnikova-Marjon, X Ji, S A Liebhaber & J A Diehl. (2008) PERK-dependent regulation of IAP translation during ER stress. Oncogene 28:6, pages 910-920.
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Regina M. Young, Shang-Jui Wang, John D. Gordan, Xinjun Ji, Stephen A. Liebhaber & M. Celeste Simon. (2008) Hypoxia-mediated Selective mRNA Translation by an Internal Ribosome Entry Site-independent Mechanism. Journal of Biological Chemistry 283:24, pages 16309-16319.
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Simone K. Steiner, Rosemarie Baumann & Stefanie Dragon. (2007) Regulation and localization of TOB and IFR1 in differentiating red cells. Biochemical and Biophysical Research Communications 359:4, pages 1010-1016.
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Jian Kong & Stephen A Liebhaber. (2007) A cell type–restricted mRNA surveillance pathway triggered by ribosome extension into the 3′ untranslated region. Nature Structural & Molecular Biology 14:7, pages 670-676.
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Thimmaiah P. Chendrimada, Kenneth J. Finn, Xinjun Ji, David Baillat, Richard I. Gregory, Stephen A. Liebhaber, Amy E. Pasquinelli & Ramin Shiekhattar. (2007) MicroRNA silencing through RISC recruitment of eIF6. Nature 447:7146, pages 823-828.
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Junji Kato, Masayoshi Kobune, Shunichi Ohkubo, Koshi Fujikawa, Maki Tanaka, Rishu Takimoto, Kohichi Takada, Daisuke Takahari, Yutaka Kawano, Yutaka Kohgo & Yoshiro Niitsu. (2007) Iron/IRP-1-dependent regulation of mRNA expression for transferrin receptor, DMT1 and ferritin during human erythroid differentiation. Experimental Hematology 35:6, pages 879-887.
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Zhenning He & J. Eric Russell. (2006) Dynamic posttranscriptional regulation of ϵ-globin gene expression in vivo. Blood 109:2, pages 795-801.
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Roee Atlas, Leah Behar, Stav Sapoznik & Irith Ginzburg. (2007) Dynamic association with polysomes during P19 neuronal differentiation and an untranslated-region-dependent translation regulation of the tau mRNA by the tau mRNA-associated proteins IMP1, HuD, and G3BP1. Journal of Neuroscience Research 85:1, pages 173-183.
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Willard J. Costain, Ingrid Rasquinha, Tyson Graber, Christian Luebbert, Edward Preston, Jacqueline Slinn, Xiaoqi Xie & John P. MacManus. (2006) Cerebral ischemia induces neuronal expression of novel VL30 mouse retrotransposons bound to polyribosomes. Brain Research 1094:1, pages 24-37.
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Rona S. WeinbergXinjun JiMillicent SuttonSusan PerrineYelena GalperinQiliang LiStephen A. LiebhaberGeorge StamatoyannopoulosGeorge F. Atweh. (2005) Butyrate increases the efficiency of translation of γ-globin mRNA. Blood 105:4, pages 1807-1809.
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Christoph W. Strey, Mike S. Winters, Maciej M. Markiewski & John D. Lambris. (2005) Partial hepatectomy induced liver proteome changes in mice. PROTEOMICS 5:1, pages 318-325.
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Isabela Cajiao, Aiwen Zhang, Eung Jae Yoo, Nancy E Cooke & Stephen A Liebhaber. (2004) Bystander gene activation by a locus control region. The EMBO Journal 23:19, pages 3854-3863.
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Ângela Inácio, Ana Luísa Silva, Joana Pinto, Xinjun Ji, Ana Morgado, Fátima Almeida, Paula Faustino, João Lavinha, Stephen A. Liebhaber & Luísa Romão. (2004) Nonsense Mutations in Close Proximity to the Initiation Codon Fail to Trigger Full Nonsense-mediated mRNA Decay. Journal of Biological Chemistry 279:31, pages 32170-32180.
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