20
Views
52
CrossRef citations to date
0
Altmetric
Cell Growth and Development

R-Ras Promotes Focal Adhesion Formation through Focal Adhesion Kinase and p130Cas by a Novel Mechanism That Differs from Integrins

, , , &
Pages 933-949 | Received 22 Apr 2002, Accepted 30 Oct 2002, Published online: 27 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Saeideh Nakhaei-Rad, Fereshteh Haghighi, Parivash Nouri, Soheila Rezaei Adariani, Jana Lissy, Neda S. Kazemein Jasemi, Radovan Dvorsky & Mohammad Reza Ahmadian. (2018) Structural fingerprints, interactions, and signaling networks of RAS family proteins beyond RAS isoforms. Critical Reviews in Biochemistry and Molecular Biology 53:2, pages 130-156.
Read now
Jeremy G.T. Wurtzel, Puneet Kumar & Lawrence E. Goldfinger. (2012) Palmitoylation regulates vesicular trafficking of R-Ras to membrane ruffles and effects on ruffling and cell spreading. Small GTPases 3:3, pages 139-153.
Read now
Hitomi Fujisaki, Tetsuya Ebihara, Shinkichi Irie, Takashi Kobayashi, Eijiro Adachi, Katumi Mochitate & Shunji Hattori. (2007) Keratinocyte Apoptosis on Type I Collagen Fibrils is Prevented by Erk1/2 Activation under High Calcium Condition. Connective Tissue Research 48:3, pages 159-169.
Read now
Yi Yu, Yansheng Hao & Larry A. Feig. (2006) The R-Ras GTPase Mediates Cross Talk between Estrogen and Insulin Signaling in Breast Cancer Cells. Molecular and Cellular Biology 26:17, pages 6372-6380.
Read now

Articles from other publishers (48)

Sema Oncel & Marc D. Basson. (2022) ZINC40099027 promotes monolayer circular defect closure by a novel pathway involving cytosolic activation of focal adhesion kinase and downstream paxillin and ERK1/2. Cell and Tissue Research 390:2, pages 261-279.
Crossref
Judyta Gorka, Paulina Marona, Oliwia Kwapisz, Janusz Rys, Jolanta Jura & Katarzyna Miekus. (2022) MCPIP1 regulates focal adhesion kinase and Rho GTPase-dependent migration in clear cell renal cell carcinoma. European Journal of Pharmacology 922, pages 174804.
Crossref
Shaila A. Shetu & Debasish Bandyopadhyay. (2022) Small-Molecule RAS Inhibitors as Anticancer Agents: Discovery, Development, and Mechanistic Studies. International Journal of Molecular Sciences 23:7, pages 3706.
Crossref
Huayi Li, Lorenzo Prever, Myriam Y. Hsu, Wen‐Ting Lo, Jean Piero Margaria, Maria Chiara De Santis, Cristina Zanini, Marco Forni, Francesco Novelli, Salvatore Pece, Pier Paolo Di Fiore, Paolo Ettore Porporato, Miriam Martini, Hassane Belabed, Marc Nazare, Volker Haucke, Federico Gulluni & Emilio Hirsch. (2022) Phosphoinositide Conversion Inactivates R‐RAS and Drives Metastases in Breast Cancer. Advanced Science 9:9, pages 2103249.
Crossref
Rens L. J. Van Meijel, Ping Wang, Freek Bouwman, Ellen E. Blaak, Edwin C. M. Mariman & Gijs H. Goossens. (2022) The Effects of Mild Intermittent Hypoxia Exposure on the Abdominal Subcutaneous Adipose Tissue Proteome in Overweight and Obese Men: A First-in-Human Randomized, Single-Blind, and Cross-Over Study. Frontiers in Physiology 12.
Crossref
Olga Soriano, Marta Alcón-Pérez, Miguel Vicente-Manzanares & Esther Castellano. (2021) The Crossroads between RAS and RHO Signaling Pathways in Cellular Transformation, Motility and Contraction. Genes 12:6, pages 819.
Crossref
Sharvari R Sathe, Deepak Jain, Cheng-Gee Koh & Evelyn K F Yim. (2021) POPX2 phosphatase enhances topographical contact guidance for cell morphology and migration. Biomedical Materials 16:2, pages 025020.
Crossref
Kei Nakajima, Pamela D. Arora, Ajay Plaha & Christopher A. McCulloch. (2020) Role of the small GTPase activating protein IQGAP1 in collagen phagocytosis. Journal of Cellular Physiology 236:2, pages 1270-1280.
Crossref
P. D. Arora, K. Nakajima, A. Nanda, A. Plaha, A. Wilde, D. B. Sacks & C. A. McCulloch. (2020) Flightless anchors IQGAP1 and R-ras to mediate cell extension formation and matrix remodeling. Molecular Biology of the Cell 31:15, pages 1595-1610.
Crossref
Pietro Ridone, Massimo Vassalli & Boris Martinac. (2019) Piezo1 mechanosensitive channels: what are they and why are they important. Biophysical Reviews 11:5, pages 795-805.
Crossref
Chandrika Canugovi, Mark D. Stevenson, Aleksandr E. Vendrov, Takayuki Hayami, Jacques Robidoux, Han Xiao, You-Yi Zhang, Daniel T. Eitzman, Marschall S. Runge & Nageswara R. Madamanchi. (2019) Increased mitochondrial NADPH oxidase 4 (NOX4) expression in aging is a causative factor in aortic stiffening. Redox Biology 26, pages 101288.
Crossref
P. D. Arora, T. He, K. Ng & C. A. McCulloch. (2018) The leucine-rich region of Flightless I interacts with R-ras to regulate cell extension formation. Molecular Biology of the Cell 29:20, pages 2481-2493.
Crossref
Wai Nam Liu, Mingfei Yan & Andrew M. Chan. (2017) A thirty-year quest for a role of R-Ras in cancer: from an oncogene to a multitasking GTPase. Cancer Letters 403, pages 59-65.
Crossref
Zlatko Kopecki, Ralf Ludwig & Allison Cowin. (2016) Cytoskeletal Regulation of Inflammation and Its Impact on Skin Blistering Disease Epidermolysis Bullosa Acquisita. International Journal of Molecular Sciences 17:7, pages 1116.
Crossref
J V Michael, J G T Wurtzel & L E Goldfinger. (2016) Regulation of H-Ras-driven MAPK signaling, transformation and tumorigenesis, but not PI3K signaling and tumor progression, by plasma membrane microdomains. Oncogenesis 5:5, pages e228-e228.
Crossref
DEBAO QU, HUI HUANG, JIEHUI DI, KEYU GAO, ZHENG LU & JUNNIAN ZHENG. (2016) Structure, functional regulation and signaling properties of Rap2B. Oncology Letters 11:4, pages 2339-2346.
Crossref
Joseph C. Salem, Marta M. Reviriego-Mendoza & Lorraine C. Santy. (2015) ARF-GEF cytohesin-2/ARNO regulates R-Ras and α5-integrin recycling through an EHD1-positive compartment. Molecular Biology of the Cell 26:23, pages 4265-4279.
Crossref
Jeremy G.T. Wurtzel, Seunghyung Lee, Sharad S. Singhal, Sanjay Awasthi, Mark H. Ginsberg & Lawrence E. Goldfinger. (2015) RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes. Biochemical and Biophysical Research Communications 467:4, pages 785-791.
Crossref
Ulrike May, Stuart Prince, Maria Vähätupa, Anni M. Laitinen, Katriina Nieminen, Hannele Uusitalo-Järvinen & Tero A. H. Järvinen. (2015) Resistance of R-Ras knockout mice to skin tumour induction. Scientific Reports 5:1.
Crossref
Fujun Dai, Yihua Chen, Li Huang, Jinhua Wang, Tao Zhang, Jingjie Li, Weiguang Tong, Mingyao Liu & Zhengfang Yi. (2014) A novel synthetic small molecule YH ‐306 suppresses colorectal tumour growth and metastasis via FAK pathway . Journal of Cellular and Molecular Medicine 19:2, pages 383-395.
Crossref
JIE SONG, BIN ZHENG, XIAOBO BU, YAOYUAN FEI & SHULIANG SHI. (2014) Negative association of R-Ras activation and breast cancer development. Oncology Reports 31:6, pages 2776-2784.
Crossref
Jianliang Zhang & Steven N. Hochwald. (2014) The role of FAK in tumor metabolism and therapy. Pharmacology & Therapeutics 142:2, pages 154-163.
Crossref
Crystal Johnson-Holiday, Rajesh Singh, Erica L Johnson, William E Grizzle, James W LillardJrJr & Shailesh Singh. (2011) CCR9-CCL25 interactions promote cisplatin resistance in breast cancer cell through Akt activation in a PI3K-dependent and FAK-independent fashion. World Journal of Surgical Oncology 9:1.
Crossref
Qin Wang, Gregory P. Downey & Christopher A. McCulloch. (2011) Focal adhesions and Ras are functionally and spatially integrated to mediate IL‐1 activation of ERK. The FASEB Journal 25:10, pages 3448-3464.
Crossref
Matthew W Conklin, Aude Ada-Nguema, Maddy Parsons, Kristin M Riching & Patricia J Keely. (2010) R-Ras regulates β1-integrin trafficking via effects on membrane ruffling and endocytosis. BMC Cell Biology 11:1.
Crossref
Yunping Li, Maya Reznichenko, Rachel M. Tribe, Philip E. Hess, Michael Taggart, HakRim Kim, Jon P. DeGnore, Samudra Gangopadhyay & Kathleen G. Morgan. (2009) Stretch Activates Human Myometrium via ERK, Caldesmon and Focal Adhesion Signaling. PLoS ONE 4:10, pages e7489.
Crossref
M. Rosario Hernandez & Bin Liu. 2008. Mechanisms of the Glaucomas. Mechanisms of the Glaucomas 363 391 .
Randy S. Schrecengost, Rebecca B. Riggins, Keena S. Thomas, Michael S. Guerrero & Amy H. Bouton. (2007) Breast Cancer Antiestrogen Resistance-3 Expression Regulates Breast Cancer Cell Migration through Promotion of p130Cas Membrane Localization and Membrane Ruffling. Cancer Research 67:13, pages 6174-6182.
Crossref
Tanya A. Rege, Manuel Antonio Pallero, Claudio Gomez, Hernan E. Grenett, Joanne E. Murphy-Ullrich & James S. Hagood. (2006) Thy-1, via its GPI anchor, modulates Src family kinase and focal adhesion kinase phosphorylation and subcellular localization, and fibroblast migration, in response to thrombospondin-1/hep I. Experimental Cell Research 312:19, pages 3752-3767.
Crossref
Zhong-Zong Pan & Andrew K. Godwin. 2006. Encyclopedia of Molecular Cell Biology and Molecular Medicine. Encyclopedia of Molecular Cell Biology and Molecular Medicine.
Lawrence E. Goldfinger, Celeste Ptak, Erin D. Jeffery, Jeffrey Shabanowitz, Donald F. Hunt & Mark H. Ginsberg. (2006) RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration. Journal of Cell Biology 174:6, pages 877-888.
Crossref
Louise D. Plows, Richard T. Cook, Angela J. Davies & Anthony J. Walker. (2006) Integrin engagement modulates the phosphorylation of focal adhesion kinase, phagocytosis, and cell spreading in molluscan defence cells. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1763:8, pages 779-786.
Crossref
Monique Dail, Melanie Richter, Pierre Godement & Elena B. Pasquale. (2006) Eph receptors inactivate R-Ras through different mechanisms to achieve cell repulsion. Journal of Cell Science 119:7, pages 1244-1254.
Crossref
Aude S. Ada-Nguema, Harry Xenias, Michael P. Sheetz & Patricia J. Keely. (2006) The small GTPase R-Ras regulates organization of actin and drives membrane protrusions through the activity of PLCϵ. Journal of Cell Science 119:7, pages 1307-1319.
Crossref
Jean De Gunzburg. 2006. RAS Family GTPases. RAS Family GTPases 295 339 .
Mitsutoshi Nakada, Jared A. Niska, Nhan L. Tran, Wendy S. McDonough & Michael E. Berens. (2005) EphB2/R-Ras Signaling Regulates Glioma Cell Adhesion, Growth, and Invasion. The American Journal of Pathology 167:2, pages 565-576.
Crossref
Yongliang Zhu, Xian Zhong, Shu Zheng, Zhen Ge, Qin Du & Suzhang Zhang. (2005) Transformation of immortalized colorectal crypt cells by microcystin involving constitutive activation of Akt and MAPK cascade. Carcinogenesis 26:7, pages 1207-1214.
Crossref
Yongliang Zhu, Xian Zhong, Shu Zheng, Qin Du & Weizhen Xu. (2005) Transformed immortalized gastric epithelial cells by virulence factor CagA of Helicobacter pylori through Erk mitogen-activated protein kinase pathway. Oncogene 24:24, pages 3886-3895.
Crossref
Stephen P. Holly, Mark K. Larson & Leslie V. Parise. (2005) The Unique N-Terminus of R-Ras Is Required for Rac Activation and Precise Regulation of Cell Migration. Molecular Biology of the Cell 16:5, pages 2458-2469.
Crossref
Michiko Nishigaki, Kazuhiko Aoyagi, Inaho Danjoh, Masahide Fukaya, Kazuyoshi Yanagihara, Hiromi Sakamoto, Teruhiko Yoshida & Hiroki Sasaki. (2005) Discovery of Aberrant Expression of R-RAS by Cancer-Linked DNA Hypomethylation in Gastric Cancer Using Microarrays . Cancer Research 65:6, pages 2115-2124.
Crossref
Mercedes Montiel, Enrique Pérez de la Blanca & Eugenio Jiménez. (2005) Angiotensin II induces focal adhesion kinase/paxillin phosphorylation and cell migration in human umbilical vein endothelial cells. Biochemical and Biophysical Research Communications 327:4, pages 971-978.
Crossref
Michele A. Wozniak, Lina Kwong, David Chodniewicz, Richard L. Klemke & Patricia J. Keely. (2005) R-Ras Controls Membrane Protrusion and Cell Migration through the Spatial Regulation of Rac and Rho. Molecular Biology of the Cell 16:1, pages 84-96.
Crossref
John Colicelli. (2004) Human RAS Superfamily Proteins and Related GTPases. Science's STKE 2004:250.
Crossref
Michele A Wozniak, Katarzyna Modzelewska, Lina Kwong & Patricia J Keely. (2004) Focal adhesion regulation of cell behavior. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1692:2-3, pages 103-119.
Crossref
Annika Armulik, Teet Velling & Staffan Johansson. (2004) The Integrin β1 Subunit Transmembrane Domain Regulates Phosphatidylinositol 3-Kinase-dependent Tyrosine Phosphorylation of Crk-associated Substrate. Molecular Biology of the Cell 15:6, pages 2558-2567.
Crossref
Michele A. Wozniak, Radhika Desai, Patricia A. Solski, Channing J. Der & Patricia J. Keely. (2003) ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix. Journal of Cell Biology 163:3, pages 583-595.
Crossref
Malene Hansen, Ian A Prior, Paul E Hughes, Beat Oertli, Fan-Li Chou, Berthe M Willumsen, John F Hancock & Mark H Ginsberg. (2003) C-terminal sequences in R-Ras are involved in integrin regulation and in plasma membrane microdomain distribution. Biochemical and Biophysical Research Communications 311:4, pages 829-838.
Crossref
Johanna Furuhjelm & Johan Peränen. (2003) The C-terminal end of R-Ras contains a focal adhesion targeting signal. Journal of Cell Science 116:18, pages 3729-3738.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.