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Molecular and Cellular Biology Volume 23, 2003 - Issue 3
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Transcriptional Regulation

Transcriptional Activities of the Zinc Finger Protein Zac Are Differentially Controlled by DNA Binding

Anke Hoffmann1 Molecular Neuroendocrinology, Max Planck Institute of Psychiatry, D-80804Munich, Germany
,
Elisabetta Ciani1 Molecular Neuroendocrinology, Max Planck Institute of Psychiatry, D-80804Munich, Germany
,
Joel Boeckardt2 UPR 9023 Centre National de la Recherche Scientifique, F-34094Montpellier Cedex 5, France
,
Florian Holsboer1 Molecular Neuroendocrinology, Max Planck Institute of Psychiatry, D-80804Munich, Germany
,
Laurent Journot2 UPR 9023 Centre National de la Recherche Scientifique, F-34094Montpellier Cedex 5, France
&
Dietmar Spengler1 Molecular Neuroendocrinology, Max Planck Institute of Psychiatry, D-80804Munich, GermanyCorrespondence[email protected]
Pages 988-1003 | Received 06 May 2002, Accepted 30 Oct 2002, Published online: 27 Mar 2023

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Udo Schmidt-Edelkraut, Guillaume Daniel, Anke Hoffmann & Dietmar Spengler. (2014) Zac1 Regulates Cell Cycle Arrest in Neuronal Progenitors via Tcf4. Molecular and Cellular Biology 34:6, pages 1020-1030.
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Anke Hoffmann & Dietmar Spengler. (2012) Transient Neonatal Diabetes Mellitus Gene Zac1 Impairs Insulin Secretion in Mice through Rasgrf1. Molecular and Cellular Biology 32:13, pages 2549-2560.
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Anke Hoffmann & Dietmar Spengler. (2008) A New Coactivator Function for Zac1's C2H2 Zinc Finger DNA-Binding Domain in Selectively Controlling PCAF Activity. Molecular and Cellular Biology 28:19, pages 6078-6093.
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Anke Hoffmann, Thomas Barz & Dietmar Spengler. (2006) Multitasking C2H2 Zinc Fingers Link Zac DNA Binding to Coordinated Regulation of p300-Histone Acetyltransferase Activity. Molecular and Cellular Biology 26:14, pages 5544-5557.
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Articles from other publishers (51)

敏 周. (2023) Research Progress of HE4 and Vimentin in Endometrial Carcinoma. Advances in Clinical Medicine 13:04, pages 6489-6495.
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Chuyi Song & Jingqing Jiang. (2022) A Novel Prediction Method for Metal-Ion Binding Sites in Protein Sequence Based on Ensemble Learning. A Novel Prediction Method for Metal-Ion Binding Sites in Protein Sequence Based on Ensemble Learning.
Mingxiang Zhang, Jaelyn Z. Current, Heather L. Chaney & Jianbo Yao. (2022) Identification of the DNA binding element of ZNFO, an oocyte-specific zinc finger transcription factor in cattle. Gene 834, pages 146655.
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Susumu Tanaka, Yoshiko Honda, Shizuka Takaku, Taro Koike, Souichi Oe, Yukie Hirahara, Takashi Yoshida, Nae Takizawa, Yasuharu Takamori, Kiyoshi Kurokawa, Tohru Kodama & Hisao Yamada. (2019) Involvement of PLAGL1/ZAC1 in hypocretin/orexin transcription. International Journal of Molecular Medicine.
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Chun-Lin Kuo, Shu-Ting Liu, Yung-Lung Chang, Chia-Chun Wu & Shih-Ming Huang. (2018) Zac1 regulates IL-11 expression in osteoarthritis. Oncotarget 9:65, pages 32478-32495.
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Qiumei Yang, Ye Li, Xulong Zhang & Daiwen Chen. (2018) Zac1/GPR39 phosphorylating CaMK-II contributes to the distinct roles of Pax3 and Pax7 in myogenic progression. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864:2, pages 407-419.
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Lata Adnani, Rajiv Dixit, Xingyu Chen, Anjali Balakrishnan, Harshil Modi, Yacine Touahri, Cairine Logan & Carol Schuurmans. (2018) Plag1 and Plagl2 have overlapping and distinct functions in telencephalic development . Biology Open.
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Annie Varrault, Christelle Dantec, Anne Le Digarcher, Laëtitia Chotard, Benoit Bilanges, Hugues Parrinello, Emeric Dubois, Stéphanie Rialle, Dany Severac, Tristan Bouschet & Laurent Journot. (2017) Identification of Plagl1/Zac1 binding sites and target genes establishes its role in the regulation of extracellular matrix genes and the imprinted gene network. Nucleic Acids Research 45:18, pages 10466-10480.
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Ana F. Vega-Benedetti, Cinthia Saucedo, Patrizia Zavattari, Roberta Vanni, José L. Zugaza & Luis Antonio Parada. (2016) PLAGL1: an important player in diverse pathological processes. Journal of Applied Genetics 58:1, pages 71-78.
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Yu Ichida, Yuko Utsunomiya & Masafumi Onodera. (2016) The third to fifth zinc fingers play an essential role in the binding of ZFP809 to the MLV-derived PBS. Biochemical and Biophysical Research Communications 469:3, pages 490-494.
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Gernot Wolf, David Greenberg & Todd S. Macfarlan. (2015) Spotting the enemy within: Targeted silencing of foreign DNA in mammalian genomes by the Krüppel-associated box zinc finger protein family. Mobile DNA 6:1.
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Lata Adnani, Lisa Marie Langevin, Elodie Gautier, Rajiv Dixit, Kari Parsons, Saiqun Li, Gaurav Kaushik, Grey Wilkinson, Richard Wilson, Sarah Childs, Minh Dang Nguyen, Laurent Journot, Colette Dehay & Carol Schuurmans. (2015) Zac1 Regulates the Differentiation and Migration of Neocortical Neurons via Pac1 . The Journal of Neuroscience 35:39, pages 13430-13447.
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Sandra Meyer & Bruno Kieffer. 2001. eLS. eLS 1 8 .
Anke Hoffmann. (2015) Role of ZAC1 in transient neonatal diabetes mellitus and glucose metabolism. World Journal of Biological Chemistry 6:3, pages 95.
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Isabel Iglesias-Platas, Alex Martin-Trujillo, Paolo Petazzi, Amy Guillaumet-Adkins, Manel Esteller & David Monk. (2014) Altered expression of the imprinted transcription factor PLAGL1 deregulates a network of genes in the human IUGR placenta. Human Molecular Genetics 23:23, pages 6275-6285.
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Anke Hoffmann, Guillaume Daniel, Udo Schmidt-Edelkraut & Dietmar Spengler. (2014) Roles of imprinted genes in neural stem cells. Epigenomics 6:5, pages 515-532.
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Yonghe Wu, Alexandre V. Patchev, Guillaume Daniel, Osborne F.X. Almeida & Dietmar Spengler. (2014) Early-Life Stress Reduces DNA Methylation of the Pomc Gene in Male Mice. Endocrinology 155:5, pages 1751-1762.
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Yunli Zhou, Xun Zhang & Anne Klibanski. (2014) Genetic and epigenetic mutations of tumor suppressive genes in sporadic pituitary adenoma. Molecular and Cellular Endocrinology 386:1-2, pages 16-33.
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Udo Schmidt-Edelkraut, Anke Hoffmann, Guillaume Daniel & Dietmar Spengler. (2013) Zac1 Regulates Astroglial Differentiation of Neural Stem Cells Through Socs3 . Stem Cells 31:8, pages 1621-1632.
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Teodora Ribarska, Klaus-Marius Bastian, Annemarie Koch & Wolfgang A Schulz. (2012) Specific changes in the expression of imprinted genes in prostate cancer—implications for cancer progression and epigenetic regulation. Asian Journal of Andrology 14:3, pages 436-450.
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G Shu, Y Tang, Y Zhou, C Wang & J-G Song. (2011) Zac1 is a histone acetylation-regulated NF-κB suppressor that mediates histone deacetylase inhibitor-induced apoptosis. Cell Death & Differentiation 18:12, pages 1825-1835.
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Pei-Yao Liu, Tsai-Yuan Hsieh, Shu-Ting Liu, Yung-Lung Chang, Wei-Shiang Lin, Wei-Ming Wang & Shih-Ming Huang. (2011) Zac1, an Sp1-like protein, regulates human p21 gene expression in HeLa cells. Experimental Cell Research 317:20, pages 2925-2937.
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Wei-Ming Wang, Shu-Ting Liu, Shih-Ming Huang, Wei-Shiang Lin, Shyi-Gen Chen & Yung-Lung Chang. (2011) Zac1 functional interactions mediate AP-1 transcriptional activity. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1813:12, pages 2050-2060.
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Xiaoyu Du, Marylene Rousseau, Houria Ounissi-Benkalha, Luc Marchand, Arif Jetha, Steven Paraskevas, Cynthia Goodyer & Constantin Polychronakos. (2011) Differential expression pattern of ZAC in developing mouse and human pancreas. Journal of Molecular Histology 42:2, pages 129-136.
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Seung-Hyuk Chung, Hassan Marzban, Kimberly Aldinger, Rajiv Dixit, Kathleen Millen, Carol Schuurmans & Richard Hawkes. (2011) Zac1 plays a key role in the development of specific neuronal subsets in the mouse cerebellum. Neural Development 6:1, pages 25.
Crossref
Lisa Stubbs, Younguk Sun & Derek Caetano-Anolles. 2011. A Handbook of Transcription Factors. A Handbook of Transcription Factors 75 94 .
Deborah J.G. Mackay & I. Karen Temple. (2010) Transient neonatal diabetes mellitus type 1. American Journal of Medical Genetics Part C: Seminars in Medical Genetics 154C:3, pages 335-342.
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Michael P. Czubryt, Lise Lamoureux, Angela Ramjiawan, Bernard Abrenica, Jaganmohan Jangamreddy & Kristin Swan. (2010) Regulation of Cardiomyocyte Glut4 Expression by ZAC1. Journal of Biological Chemistry 285:22, pages 16942-16950.
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Chris Murgatroyd, Alexandre V Patchev, Yonghe Wu, Vincenzo Micale, Yvonne Bockmühl, Dieter Fischer, Florian Holsboer, Carsten T Wotjak, Osborne F X Almeida & Dietmar Spengler. (2009) Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nature Neuroscience 12:12, pages 1559-1566.
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Yih-Sheng Yang, Meng-Chun W. Yang, Yuhong Guo, Olatunji W. Williams & Jonathan C. Weissler. (2009) PLAGL2 expression-induced lung epithelium damages at bronchiolar alveolar duct junction in emphysema: bNip3- and SP-C-associated cell death/injury activity. American Journal of Physiology-Lung Cellular and Molecular Physiology 297:3, pages L455-L466.
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Miguel A. Lanaspa, Ana Andres-Hernando, Christopher J. Rivard, Yue Dai, Nanxing Li & Tomas Berl. (2009) ZAC1 Is Up-regulated by Hypertonicity and Decreases Sorbitol Dehydrogenase Expression, Allowing Accumulation of Sorbitol in Kidney Cells. Journal of Biological Chemistry 284:30, pages 19974-19981.
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Louisa Goumidi, Dietmar Spengler, Dominique Cottel, Aline Wagner, Pierre Ducimetière, Jean-Bernard Ruidavets, Vanessa Legry, Dominique Arveiler, Annie Bingham, Jean Ferrières, Philippe Amouyel & Aline Meirhaeghe. (2009) Study of the genetic variability of ZAC1 (PLAGL1) in French population-based samples. Journal of Hypertension 27:2, pages 314-321.
Crossref
Rocio G. Urdinguio, Lidia Lopez-Serra, Pilar Lopez-Nieva, Miguel Alaminos, Ramon Diaz-Uriarte, Agustin F. Fernandez & Manel Esteller. (2008) Mecp2-Null Mice Provide New Neuronal Targets for Rett Syndrome. PLoS ONE 3:11, pages e3669.
Crossref
Yuhong Guo, Meng-Chun W. Yang, Jonathan C. Weissler & Yih-Sheng Yang. (2008) Modulation of PLAGL2 transactivation activity by Ubc9 co-activation not SUMOylation. Biochemical and Biophysical Research Communications 374:3, pages 570-575.
Crossref
Pei-Yao Liu, James Yi-Hsin Chan, Hsiu-Chen Lin, Sung-Ling Wang, Shu-Ting Liu, Ching-Liang Ho, Li-Chien Chang & Shih-Ming Huang. (2008) Modulation of the Cyclin-Dependent Kinase Inhibitor p21WAF1/Cip1 Gene by Zac1 through the Antagonistic Regulators p53 and Histone Deacetylase 1 in HeLa Cells . Molecular Cancer Research 6:7, pages 1204-1214.
Crossref
Lydia Aguilar-Bryan & Joseph Bryan. (2008) Neonatal Diabetes Mellitus. Endocrine Reviews 29:3, pages 265-291.
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Kathryn J. Brayer & David J. Segal. (2008) Keep Your Fingers Off My DNA: Protein–Protein Interactions Mediated by C2H2 Zinc Finger Domains. Cell Biochemistry and Biophysics 50:3, pages 111-131.
Crossref
F. W. Zhang, H. C. Cheng, C. D. Jiang, C. Y. Deng, Y. Z. Xiong, F. E. Li & M. G. Lei. (2007) Imprinted status of pleomorphic adenoma gene-like I and paternal expression gene 10 genes in pigs1. Journal of Animal Science 85:4, pages 886-890.
Crossref
Shih-Ming Huang, Sheng-Ping Huang, Sung-Ling Wang & Pei-Yao Liu. (2007) Importin α1 is involved in the nuclear localization of Zac1 and the induction of p21WAF1/CIP1 by Zac1. Biochemical Journal 402:2, pages 359-366.
Crossref
Abbas Abdollahi. (2007) LOT1 (ZAC1/PLAGL1) and its family members: Mechanisms and functions. Journal of Cellular Physiology 210:1, pages 16-25.
Crossref
Lin Ma, Jennifer C. Hocking, Carrie L. Hehr, Carol Schuurmans & Sarah McFarlane. (2007) Zac1 promotes a Müller glial cell fate and interferes with retinal ganglion cell differentiation inXenopus retina. Developmental Dynamics 236:1, pages 192-202.
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Thomas Barz, Anke Hoffmann, Markus Panhuysen & Dietmar Spengler. (2006) Peroxisome Proliferator-Activated Receptor γ Is a Zac Target Gene Mediating Zac Antiproliferation. Cancer Research 66:24, pages 11975-11982.
Crossref
Annie Varrault, Charlotte Gueydan, Annie Delalbre, Anja Bellmann, Souheir Houssami, Cindy Aknin, Dany Severac, Laetitia Chotard, Malik Kahli, Anne Le Digarcher, Paul Pavlidis & Laurent Journot. (2006) Zac1 Regulates an Imprinted Gene Network Critically Involved in the Control of Embryonic Growth. Developmental Cell 11:5, pages 711-722.
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Stuart Huntley, Daniel M. Baggott, Aaron T. Hamilton, Mary Tran-Gyamfi, Shan Yang, Joomyeong Kim, Laurie Gordon, Elbert Branscomb & Lisa Stubbs. (2006) A comprehensive catalog of human KRAB-associated zinc finger genes: Insights into the evolutionary history of a large family of transcriptional repressors. Genome Research 16:5, pages 669-677.
Crossref
Eugenia Basyuk, Vincent Coulon, Anne Le Digarcher, Marjorie Coisy-Quivy, Jean-Pierre Moles, Alberto Gandarillas & Laurent Journot. (2005) The Candidate Tumor Suppressor Gene ZAC Is Involved in Keratinocyte Differentiation and Its Expression Is Lost in Basal Cell Carcinomas . Molecular Cancer Research 3:9, pages 483-492.
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Deborah J. G. Mackay, I Karen Temple, Julian P. H. Shield & David O. Robinson. (2005) Bisulphite sequencing of the transient neonatal diabetes mellitus DMR facilitates a novel diagnostic test but reveals no methylation anomalies in patients of unknown aetiology. Human Genetics 116:4, pages 255-261.
Crossref
Shiro Iuchi. 2005. Zinc Finger Proteins. Zinc Finger Proteins 7 13 .
Chris Murgatroyd, Alexandra Wigger, Elisabeth Frank, Nicolas Singewald, Mirjam Bunck, Florian Holsboer, Rainer Landgraf & Dietmar Spengler. (2004) Impaired Repression at a Vasopressin Promoter Polymorphism Underlies Overexpression of Vasopressin in a Rat Model of Trait Anxiety. The Journal of Neuroscience 24:35, pages 7762-7770.
Crossref
Dan Ma, Julian P.H. Shield, Wendy Dean, Isabelle Leclerc, Claude Knauf, Rémy Burcelin, Guy A. Rutter & Gavin Kelsey. (2004) Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM. Journal of Clinical Investigation 114:3, pages 339-348.
Crossref
Takeshi Tsuda, Dessislava Markova, Hui Wang, Lucia Evangelisti, Te-Cheng Pan & Mon-Li Chu. (2004) Zinc finger proteinZac1 is expressed in chondrogenic sites of the mouse. Developmental Dynamics 229:2, pages 340-348.
Crossref
Anna Phillips, Tabitha Bullock & Nick Plant. (2003) Sodium valproate induces apoptosis in the rat hepatoma cell line, FaO. Toxicology 192:2-3, pages 219-227.
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