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Molecular and Cellular Biology Volume 23, 2003 - Issue 4
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Gene Expression

The KH-Domain Protein αCP Has a Direct Role in mRNA Stabilization Independent of Its Cognate Binding Site

Jian KongDepartments of Genetics and Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
,
Xinjun JiDepartments of Genetics and Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
&
Stephen A. LiebhaberDepartments of Genetics and Medicine, University of Pennsylvania, Philadelphia, PennsylvaniaCorrespondence[email protected]
Pages 1125-1134 | Received 21 Aug 2002, Accepted 13 Nov 2002, Published online: 27 Mar 2023

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Louis R. Ghanem, Andrew Kromer, Ian M. Silverman, Priya Chatterji, Elizabeth Traxler, Alfredo Penzo-Mendez, Mitchell J. Weiss, Ben Z. Stanger & Stephen A. Liebhaber. (2016) The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development. Molecular and Cellular Biology 36:2, pages 304-319.
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Hemant K. Kini, Jian Kong & Stephen A. Liebhaber. (2014) Cytoplasmic Poly(A) Binding Protein C4 Serves a Critical Role in Erythroid Differentiation. Molecular and Cellular Biology 34:7, pages 1300-1309.
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Xinjun Ji, Ji Wan, Melanie Vishnu, Yi Xing & Stephen A. Liebhaber. (2013) αCP Poly(C) Binding Proteins Act as Global Regulators of Alternative Polyadenylation. Molecular and Cellular Biology 33:13, pages 2560-2573.
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Rudolf Pullmann$suffix/text()$suffix/text(), Hyeon Ho Kim, Kotb Abdelmohsen, Ashish Lal, Jennifer L. Martindale, Xiaoling Yang & Myriam Gorospe. (2007) Analysis of Turnover and Translation Regulatory RNA-Binding Protein Expression through Binding to Cognate mRNAs. Molecular and Cellular Biology 27:18, pages 6265-6278.
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Xinjun Ji, Jian Kong, Russ P. Carstens & Stephen A. Liebhaber. (2007) The 3′ Untranslated Region Complex Involved in Stabilization of Human α-globin mRNA Assembles in the Nucleus and Serves an Independent Role as a Splice Enhancer. Molecular and Cellular Biology 27:9, pages 3290-3302.
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Jian Kong, Marina Sumaroka, Dawn L. Eastmond & Stephen A. Liebhaber. (2006) Shared Stabilization Functions of Pyrimidine-Rich Determinants in the Erythroid 15-lipoxygenase and α-globin mRNAs. Molecular and Cellular Biology 26:15, pages 5603-5614.
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Alexander N. Chkheidze & Stephen A. Liebhaber. (2003) A Novel Set of Nuclear Localization Signals Determine Distributions of the αCP RNA-Binding Proteins. Molecular and Cellular Biology 23:23, pages 8405-8415.
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Articles from other publishers (27)

Ghobad Babaei, Amir Massah & Mina Koohi Habibi. (2021) Efficient translation of Eggplant mottled dwarf nucleorhabdovirus N and X genes requires both 5′ and 3′ UTRs. Virology Journal 18:1.
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Xinjun Ji, Jesse Humenik & Stephen A. Liebhaber. (2019) A cytosine-rich splice regulatory determinant enforces functional processing of the human α-globin gene transcript. Blood 133:21, pages 2338-2347.
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Seyed Yahya Anvar, Guy Allard, Elizabeth Tseng, Gloria M. Sheynkman, Eleonora de Klerk, Martijn Vermaat, Raymund H. Yin, Hans E. Johansson, Yavuz Ariyurek, Johan T. den Dunnen, Stephen W. Turner & Peter A. C. ‘t Hoen. (2018) Full-length mRNA sequencing uncovers a widespread coupling between transcription initiation and mRNA processing. Genome Biology 19:1.
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Cheol Kyu Hwang, Yadav Wagley, Ping-Yee Law, Li-Na Wei & Horace H. Loh. (2017) Phosphorylation of poly(rC) binding protein 1 (PCBP1) contributes to stabilization of mu opioid receptor (MOR) mRNA via interaction with AU-rich element RNA-binding protein 1 (AUF1) and poly A binding protein (PABP). Gene 598, pages 113-130.
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Francisco J.C. Pereira, Alexandre Teixeira, Jian Kong, Cristina Barbosa, Ana Luísa Silva, Ana Marques-Ramos, Stephen A. Liebhaber & Luísa Romão. (2015) Resistance of mRNAs with AUG-proximal nonsense mutations to nonsense-mediated decay reflects variables of mRNA structure and translational activity. Nucleic Acids Research 43:13, pages 6528-6544.
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Aditi Singh, Igor Minia, Dorothea Droll, Abeer Fadda, Christine Clayton & Esteban Erben. (2022) Trypanosome MKT1 and the RNA-binding protein ZC3H11: interactions and potential roles in post-transcriptional regulatory networks. Nucleic Acids Research 42:7, pages 4652-4668.
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Saiprasad Palusa, Christina Ndaluka, Richard A. Bowen, Carol J. Wilusz & Jeffrey Wilusz. (2012) The 3′ Untranslated Region of the Rabies Virus Glycoprotein mRNA Specifically Interacts with Cellular PCBP2 Protein and Promotes Transcript Stability. PLoS ONE 7:3, pages e33561.
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I. Peixeiro, A. Inacio, C. Barbosa, A. L. Silva, S. A. Liebhaber & L. Romao. (2011) Interaction of PABPC1 with the translation initiation complex is critical to the NMD resistance of AUG-proximal nonsense mutations. Nucleic Acids Research 40:3, pages 1160-1173.
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Sebastiaan van Zalen, Grace R. Jeschke, Elizabeth O. Hexner & J. Eric Russell. (2012) AUF-1 and YB-1 are critical determinants of β-globin mRNA expression in erythroid cells. Blood 119:4, pages 1045-1053.
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Xinjun Ji, Jian Kong & Stephen A Liebhaber. (2011) An RNA-protein complex links enhanced nuclear 3′ processing with cytoplasmic mRNA stabilization. The EMBO Journal 30:13, pages 2622-2633.
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Melanie R. Vishnu, Marina Sumaroka, Peter S. Klein & Stephen A. Liebhaber. (2011) The poly(rC)-binding protein αCP2 is a noncanonical factor in X. laevis cytoplasmic polyadenylation . RNA 17:5, pages 944-956.
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Federico Bolognani, Tania Contente-Cuomo & Nora I. Perrone-Bizzozero. (2010) Novel recognition motifs and biological functions of the RNA-binding protein HuD revealed by genome-wide identification of its targets. Nucleic Acids Research 38:1, pages 117-130.
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Camila O. dos Santos, Louis C. Dore, Eric Valentine, Suresh G. Shelat, Ross C. Hardison, Manik Ghosh, Wei Wang, Richard S. Eisenstein, Fernando F. Costa & Mitchell J. Weiss. (2008) An Iron Responsive Element-like Stem-Loop Regulates α-Hemoglobin-stabilizing Protein mRNA. Journal of Biological Chemistry 283:40, pages 26956-26964.
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Allyn Spear, Nidhi Sharma & James Bert Flanegan. (2008) Protein–RNA tethering: The role of poly(C) binding protein 2 in poliovirus RNA replication. Virology 374:2, pages 280-291.
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Ana Luísa Silva, Patrícia Ribeiro, Ângela Inácio, Stephen A. Liebhaber & Luísa Romão. (2008) Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay. RNA 14:3, pages 563-576.
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Kathryn Woolaway, Kengo Asai, Andrew Emili & Alan Cochrane. (2007) hnRNP E1 and E2 have distinct roles in modulating HIV-1 gene expression. Retrovirology 4:1.
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J. Eric Russell. (2007) A post-transcriptional process contributes to efficient γ-globin gene silencing in definitive erythroid cells. European Journal of Haematology 79:6, pages 516-525.
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Jian Kong & Stephen A Liebhaber. (2007) A cell type–restricted mRNA surveillance pathway triggered by ribosome extension into the 3′ untranslated region. Nature Structural & Molecular Biology 14:7, pages 670-676.
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Qingchang Meng, Suresh K. Rayala, Anupama E. Gururaj, Amjad H. Talukder, Bert W. O'Malley & Rakesh Kumar. (2007) Signaling-dependent and coordinated regulation of transcription, splicing, and translation resides in a single coregulator, PCBP1. Proceedings of the National Academy of Sciences 104:14, pages 5866-5871.
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Zhenning He & J. Eric Russell. (2006) Dynamic posttranscriptional regulation of ϵ-globin gene expression in vivo. Blood 109:2, pages 795-801.
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Ana Luísa Silva, Francisco J.C. Pereira, Ana Morgado, Jian Kong, Rute Martins, Paula Faustino, Stephen A. Liebhaber & Luísa Romão. (2006) The canonical UPF1-dependent nonsense-mediated mRNA decay is inhibited in transcripts carrying a short open reading frame independent of sequence context. RNA 12:12, pages 2160-2170.
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Brian Carpenter, Catriona MacKay, Ayham Alnabulsi, Morven MacKay, Colin Telfer, William T. Melvin & Graeme I. Murray. (2006) The roles of heterogeneous nuclear ribonucleoproteins in tumour development and progression. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1765:2, pages 85-100.
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Angela Inacio, Ana LuiSilva & Luisa Romao .. (2004) Mechanisms of the Human β-globin mRNA Stability. Journal of Biological Sciences 5:1, pages 21-32.
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Michael Schnekenburger, Franck Morceau, Annelyse Duvoix, Sylvie Delhalle, Chantal Trentesaux, Mario Dicato & Marc Diederich. (2004) Increased glutathione S-transferase P1-1 expression by mRNA stabilization in hemin-induced differentiation of K562 cells. Biochemical Pharmacology 68:6, pages 1269-1277.
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Ângela Inácio, Ana Luísa Silva, Joana Pinto, Xinjun Ji, Ana Morgado, Fátima Almeida, Paula Faustino, João Lavinha, Stephen A. Liebhaber & Luísa Romão. (2004) Nonsense Mutations in Close Proximity to the Initiation Codon Fail to Trigger Full Nonsense-mediated mRNA Decay. Journal of Biological Chemistry 279:31, pages 32170-32180.
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EMMANUEL VANROBAYS, JEAN-PAUL GÉLUGNE, MICHÈLE CAIZERGUES-FERRER & DENIS L.J. LAFONTAINE. (2004) Dim2p, a KH-domain protein required for small ribosomal subunit synthesis. RNA 10:4, pages 645-656.
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Mi-Hye Lim, Joonki Kim, Youn-Sung Kim, Kyung-Sook Chung, Yeon-Hee Seo, Ilha Lee, Jungmook Kim, Choo Bong Hong, Hie-Joon Kim & Chung-Mo Park. (2004) A New Arabidopsis Gene, FLK , Encodes an RNA Binding Protein with K Homology Motifs and Regulates Flowering Time via FLOWERING LOCUS C  [W] . The Plant Cell 16:3, pages 731-740.
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