Citations (49)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (2)
Shikha Singh, Kalpana Pandey, Yogendra S. Rathore, Amin Sagar, U. Bharat K. Pattnaik & Ashish. (2014) A communication network within the cytoplasmic domain of toll-like receptors has remained conserved during evolution. Journal of Biomolecular Structure and Dynamics 32:5, pages 694-700.
Read now
Read now
Vladimir Y Toshchakov & Stefanie N Vogel. (2007) Cell-penetrating TIR BB loop decoy peptides. Expert Opinion on Biological Therapy 7:7, pages 1035-1050.
Read now
Read now
Articles from other publishers (47)
James E.B. Curson, Liping Liu, Lin Luo, Timothy W. Muusse, Richard M. Lucas, Kimberley S. Gunther, Parimala R. Vajjhala, Rishika Abrol, Alun Jones, Ronan Kapetanovic, Katryn J. Stacey, Jennifer L. Stow & Matthew J. Sweet. (2023) TLR4 phosphorylation at tyrosine 672 activates the ERK/c‐FOS signaling module for LPS‐induced cytokine responses in macrophages. European Journal of Immunology.
Crossref
Crossref
Timothy W. Muusse, Morris Y.L. Lee, Hyoyoung Kim, Marie-Odile Parat, Jeffrey D. Nanson, Bostjan Kobe, Parimala R. Vajjhala & Katryn J. Stacey. (2022) Flow cytometric reporter assays provide robust functional analysis of signaling complexes. Journal of Biological Chemistry 298:12, pages 102666.
Crossref
Crossref
Alejandra Matamoros‐Recio, Juan Felipe Franco‐Gonzalez, Lucia Perez‐Regidor, Jean‐Marc Billod, Joan Guzman‐Caldentey & Sonsoles Martin‐Santamaria. (2021) Full‐Atom Model of the Agonist LPS‐Bound Toll‐like Receptor 4 Dimer in a Membrane Environment. Chemistry – A European Journal 27:62, pages 15406-15425.
Crossref
Crossref
Ibrahim Fouad Elesh, Mohamed Ali Marey, Mohammed Ali Zinnah, Ihshan Akthar, Tomoko Kawai, Fayrouz Naim, Wael Goda, Abdel Rahman A. Rawash, Motoki Sasaki, Masayuki Shimada & Akio Miyamoto. (2021) Peptidoglycan Switches Off the TLR2-Mediated Sperm Recognition and Triggers Sperm Localization in the Bovine Endometrium. Frontiers in Immunology 11.
Crossref
Crossref
Lee Swanson, Gajanan D. KatkarJulian TamRama F. PranadinataYogitha ChareddyJane CoatesMahitha Shree Anandachar, Vanessa Castillo, Joshua OlsonVictor Nizet, Irina Kufareva, Soumita Das & Pradipta Ghosh. (2020) TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin. Proceedings of the National Academy of Sciences 117:43, pages 26895-26906.
Crossref
Crossref
Natesh Yepuri, Ravi Dhawan, Mitchell Cooney, Napat Pruekprasert, Qinghe Meng & Robert N. Cooney. (2019) Sparstolonin B: A Unique Anti-Inflammatory Agent. Shock 52:6, pages 568-576.
Crossref
Crossref
Hana Velová, Maria W Gutowska-Ding, David W Burt & Michal Vinkler. (2018) Toll-Like Receptor Evolution in Birds: Gene Duplication, Pseudogenization, and Diversifying Selection. Molecular Biology and Evolution 35:9, pages 2170-2184.
Crossref
Crossref
Lin Luo, Nilesh J. Bokil, Adam A. Wall, Ronan Kapetanovic, Natalie M. Lansdaal, Faustine Marceline, Belinda J. Burgess, Samuel J. Tong, Zhong Guo, Kirill Alexandrov, Ian L. Ross, Margaret L. Hibbs, Jennifer L. Stow & Matthew J. Sweet. (2017) SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages. Nature Communications 8:1.
Crossref
Crossref
Yan Ding, Yuan Qiu, Linyun Zou, Zhangping Tan, Jigang Dai & Wenyue Xu. (2015) Three conserved MyD88-recruiting TLR residues exert different effects on the human TLR4 signaling pathway. Immunologic Research 62:2, pages 213-221.
Crossref
Crossref
Rajendra Karki, Yan Zhang & Orisa J. Igwe. (2014) Activation of c-Src: A hub for exogenous pro-oxidant-mediated activation of Toll-like receptor 4 signaling. Free Radical Biology and Medicine 71, pages 256-269.
Crossref
Crossref
Nicholas J. Patterson & Dirk Werling. (2013) To con protection: TIR-domain containing proteins (Tcp) and innate immune evasion. Veterinary Immunology and Immunopathology 155:3, pages 147-154.
Crossref
Crossref
Josef Wagner, Narelle A. Skinner, Anthony G. Catto-Smith, Donald J. S. Cameron, Wojtek P. Michalski, Kumar Visvanathan & Carl D. Kirkwood. (2013) TLR4, IL10RA, and NOD2 mutation in paediatric Crohn’s disease patients: an association with Mycobacterium avium subspecies paratuberculosis and TLR4 and IL10RA expression. Medical Microbiology and Immunology 202:4, pages 267-276.
Crossref
Crossref
Greg A. SnyderChristine Cirl, Jiansheng JiangKang Chen, Anna Waldhuber, Patrick SmithFranziska Römmler, Nathaniel SnyderTheresa FresquezSusanne Dürr, Nico Tjandra, Thomas Miethke & Tsan Sam Xiao. (2013)
Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic
Escherichia coli
. Proceedings of the National Academy of Sciences 110:17, pages 6985-6990.
Crossref
Crossref
Dong Hyun Song & Jie-Oh Lee. (2012) Sensing of microbial molecular patterns by Toll-like receptors. Immunological Reviews 250:1, pages 216-229.
Crossref
Crossref
Julianne Stack & Andrew G. Bowie. (2012) Poxviral Protein A46 Antagonizes Toll-like Receptor 4 Signaling by Targeting BB Loop Motifs in Toll-IL-1 Receptor Adaptor Proteins to Disrupt Receptor:Adaptor Interactions. Journal of Biological Chemistry 287:27, pages 22672-22682.
Crossref
Crossref
Celia Bovijn, Peter Ulrichts, Anne-Sophie De Smet, Dominiek Catteeuw, Rudi Beyaert, Jan Tavernier & Frank Peelman. (2012) Identification of Interaction Sites for Dimerization and Adapter Recruitment in Toll/Interleukin-1 Receptor (TIR) Domain of Toll-like Receptor 4. Journal of Biological Chemistry 287:6, pages 4088-4098.
Crossref
Crossref
Shaherin Basith, Balachandran Manavalan, Rajiv Gandhi Govindaraj & Sangdun Choi. (2011) In Silico Approach to Inhibition of Signaling Pathways of Toll-Like Receptors 2 and 4 by ST2L. PLoS ONE 6:8, pages e23989.
Crossref
Crossref
Young Il Kim, Jin-Woo Lee, Mu-Hyoung Lee, Seung-Won Park, Byung-Nam Cho & Ha Kyu Lee. (2010) Effects of 15-deoxy-∆12,14-prostaglandin J2 on the production of IL-8 and the expression of Toll-like receptor 2 in human primary keratinocytes stimulated with lipopolysaccharide. Molecular Biology Reports 38:5, pages 3207-3212.
Crossref
Crossref
Vladimir Y. Toshchakov, Henryk Szmacinski, Leah A. Couture, Joseph R. Lakowicz & Stefanie N. Vogel. (2011) Targeting TLR4 Signaling by TLR4 Toll/IL-1 Receptor Domain-Derived Decoy Peptides: Identification of the TLR4 Toll/IL-1 Receptor Domain Dimerization Interface. The Journal of Immunology 186:8, pages 4819-4827.
Crossref
Crossref
Qing Zhang, Christian M. Zmasek, Xiaohui Cai & Adam Godzik. (2011) TIR domain-containing adaptor SARM is a late addition to the ongoing microbe–host dialog. Developmental & Comparative Immunology 35:4, pages 461-468.
Crossref
Crossref
Peter Ulrichts, Celia Bovijn, Sam Lievens, Rudi Beyaert, Jan Tavernier & Frank Peelman. (2010) Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction site. Journal of Cell Science 123:2, pages 256-265.
Crossref
Crossref
Tom P. Monie, Clare E. Bryant & Nicholas J. Gay. (2009) Activating immunity: lessons from the TLRs and NLRs. Trends in Biochemical Sciences 34:11, pages 553-561.
Crossref
Crossref
Siew Leong Chan, Lieh Yoon Low, Simon Hsu, Sheng Li, Tong Liu, Eugenio Santelli, Gaelle Le Negrate, John C. Reed, Virgil L. WoodsJr.Jr. & Jaime Pascual. (2009) Molecular Mimicry in Innate Immunity. Journal of Biological Chemistry 284:32, pages 21386-21392.
Crossref
Crossref
Yong-Chen Lu, Ira Kim, Elizabeth Lye, Fang Shen, Nobutaka Suzuki, Shinobu Suzuki, Steve Gerondakis, Shizuo Akira, Sarah L. Gaffen, Wen-Chen Yeh & Pamela S. Ohashi. (2009) Differential Role for c-Rel and C/EBPβ/δ in TLR-Mediated Induction of Proinflammatory Cytokines. The Journal of Immunology 182:11, pages 7212-7221.
Crossref
Crossref
Andrei E. Medvedev & Wenji Piao. 2009. Toll-Like Receptors. Toll-Like Receptors
145
167
.
Pascal Lefevre, James Witham, Claire E. Lacroix, Peter N. Cockerill & Constanze Bonifer. (2008) The LPS-Induced Transcriptional Upregulation of the Chicken Lysozyme Locus Involves CTCF Eviction and Noncoding RNA Transcription. Molecular Cell 32:1, pages 129-139.
Crossref
Crossref
Tomas Nyman, Pål Stenmark, Susanne Flodin, Ida Johansson, Martin Hammarström & Pär Nordlund. (2008) The Crystal Structure of the Human Toll-like Receptor 10 Cytoplasmic Domain Reveals a Putative Signaling Dimer. Journal of Biological Chemistry 283:18, pages 11861-11865.
Crossref
Crossref
Andrei E. Medvedev & Stefanie N. Vogel. 2008. Innate Immunity of Plants, Animals, and Humans. Innate Immunity of Plants, Animals, and Humans
135
167
.
Nicholas J. Gay & Monique Gangloff. 2008. Toll-Like Receptors (TLRs) and Innate Immunity. Toll-Like Receptors (TLRs) and Innate Immunity
181
200
.
A. Kubarenko, M. Frank & A.N.R. Weber. (2007) Structure–function relationships of Toll-like receptor domains through homology modelling and molecular dynamics. Biochemical Society Transactions 35:6, pages 1515-1518.
Crossref
Crossref
Ricardo Núñez Miguel, Joyce Wong, Julian F. Westoll, Heather J. Brooks, Luke A. J. O'Neill, Nicholas J. Gay, Clare E. Bryant & Tom P. Monie. (2007) A Dimer of the Toll-Like Receptor 4 Cytoplasmic Domain Provides a Specific Scaffold for the Recruitment of Signalling Adaptor Proteins. PLoS ONE 2:8, pages e788.
Crossref
Crossref
Andrei E. Medvedev, Wenji Piao, Joanna Shoenfelt, Sang Hoon Rhee, Haiyan Chen, Subhendu Basu, Larry M. Wahl, Matthew J. Fenton & Stefanie N. Vogel. (2007) Role of TLR4 Tyrosine Phosphorylation in Signal Transduction and Endotoxin Tolerance. Journal of Biological Chemistry 282:22, pages 16042-16053.
Crossref
Crossref
Jitendra K. Gautam, Ashish, Laurey D. Comeau, Joanna K. Krueger & Michael F. SmithJr.Jr.. (2006) Structural and Functional Evidence for the Role of the TLR2 DD Loop in TLR1/TLR2 Heterodimerization and Signaling. Journal of Biological Chemistry 281:40, pages 30132-30142.
Crossref
Crossref
Nicholas J. Gay, Monique Gangloff & Alexander N. R. Weber. (2006) Toll-like receptors as molecular switches. Nature Reviews Immunology 6:9, pages 693-698.
Crossref
Crossref
Michael V. Lasker & Satish K. Nair. (2006) Intracellular TLR Signaling: A Structural Perspective on Human Disease. The Journal of Immunology 177:1, pages 11-16.
Crossref
Crossref
Eduardo López-Collazo, Pablo Fuentes-Prior, Francisco Arnalich & Carlos del Fresno. (2006) Pathophysiology of interleukin-1 receptor-associated kinase-M: implications in refractory state. Current Opinion in Infectious Diseases 19:3, pages 237-244.
Crossref
Crossref
Sammy S.W. Kang, Lynda S. Kauls & Anthony A. Gaspari. (2006) Toll-like receptors: Applications to dermatologic disease. Journal of the American Academy of Dermatology 54:6, pages 951-983.
Crossref
Crossref
Victoria Brown, Rachel A. Brown, Adrian Ozinsky, Jay R. Hesselberth & Stanley Fields. (2006) Binding specificity of Toll-like receptor cytoplasmic domains. European Journal of Immunology 36:3, pages 742-753.
Crossref
Crossref
Vladimir U. Toshchakov, Subhendu Basu, Matthew J. Fenton & Stefanie N. Vogel. (2005) Differential Involvement of BB Loops of Toll-IL-1 Resistance (TIR) Domain-Containing Adapter Proteins in TLR4- versus TLR2-Mediated Signal Transduction. The Journal of Immunology 175:1, pages 494-500.
Crossref
Crossref
Senad Divanovic, Aurelien Trompette, Sowsan F Atabani, Rajat Madan, Douglas T Golenbock, Alberto Visintin, Robert W Finberg, Alexander Tarakhovsky, Stefanie N Vogel, Yasmine Belkaid, Evelyn A Kurt-Jones & Christopher L Karp. (2005) Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105. Nature Immunology 6:6, pages 571-578.
Crossref
Crossref
Nicole Schuetze, Sabine Schoeneberger, Uwe Mueller, Marina A. Freudenberg, Gottfried Alber & Reinhard K. Straubinger. (2005) IL-12 family members: differential kinetics of their TLR4-mediated induction by Salmonella Enteritidis and the impact of IL-10 in bone marrow-derived macrophages. International Immunology 17:5, pages 649-659.
Crossref
Crossref
Ken-ichiro Inoue, Hirohisa Takano, Rie Yanagisawa, Takamichi Ichinose, Kaori Sadakane, Shin Yoshino, Kouya Yamaki, Kazuhiko Uchiyama & Toshikazu Yoshikawa. (2005) Effects of 15-deoxy-Delta12,14-prostaglandin J2 on the expression of Toll-like receptor 4 and 2 in the murine lung in the presence of lipopolysaccharide. Clinical and Experimental Pharmacology and Physiology 32:3, pages 230-232.
Crossref
Crossref
Sonali K. Sanghavi, Raj Shankarappa & Todd A. Reinhart. (2004) Genetic analysis of Toll/Interleukin-1 Receptor (TIR) domain sequences from rhesus macaque Toll-like receptors (TLRs) 1?10 reveals high homology to human TLR/TIR sequences. Immunogenetics 56:9, pages 667-674.
Crossref
Crossref
Eva M. Palsson-McDermott & Luke A. J. O'Neill. (2004) Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4. Immunology 113:2, pages 153-162.
Crossref
Crossref
Subhendu Basu & Matthew J. Fenton. (2004) Toll-like receptors: function and roles in lung disease. American Journal of Physiology-Lung Cellular and Molecular Physiology 286:5, pages L887-L892.
Crossref
Crossref
REGINA M. DAY & MARCELLA M. MASCARENHAS. 2004. Chemistry and Biology of Hyaluronan. Chemistry and Biology of Hyaluronan
153
188
.
Aisling Dunne, Mikael Ejdebäck, Phumzile L. Ludidi, Luke A.J. O'Neill & Nicholas J. Gay. (2003) Structural Complementarity of Toll/Interleukin-1 Receptor Domains in Toll-like Receptors and the Adaptors Mal and MyD88. Journal of Biological Chemistry 278:42, pages 41443-41451.
Crossref
Crossref