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Transcriptional Regulation

Antithetic Effects of MBD2a on Gene Regulation

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Pages 2645-2657 | Received 30 Aug 2002, Accepted 31 Jan 2003, Published online: 27 Mar 2023

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Moshe Szyf. (2011) The early life social environment and DNA methylation. Epigenetics 6:8, pages 971-978.
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Shelley E. Brown & Moshe Szyf. (2007) Epigenetic Programming of the rRNA Promoter by MBD3. Molecular and Cellular Biology 27:13, pages 4938-4952.
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Nancy T. Ruddock-D'Cruz, Jun Xue, Katrina J. Wilson, Corey Heffernan, Sivachelvi Prashadkumar, Melissa A. Cooney, L. Gabriel Sanchez-Partida, Andrew J. French & Michael K. Holland. (2008) Dynamic changes in the localization of five members of the methyl binding domain (MBD) gene family during murine and bovine preimplantation embryo development. Molecular Reproduction and Development 75:1, pages 48-59.
Crossref
Frank Wischnewski, Olaf Friese, Klaus Pantel & Heidi Schwarzenbach. (2007) Methyl-CpG Binding Domain Proteins and Their Involvement in the Regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 Gene Promoters. Molecular Cancer Research 5:7, pages 749-759.
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Ana C. D’AlessioMoshe Szyf. (2006) Epigenetic tête-à-tête: the bilateral relationship between chromatin modifications and DNA methylationThis paper is one of a selection of papers published in this Special Issue, entitled 27th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.. Biochemistry and Cell Biology 84:4, pages 463-466.
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Esteban Ballestar & Manel Esteller. (2005) Methyl-CpG-binding proteins in cancer: blaming the DNA methylation messenger. Biochemistry and Cell Biology 83:3, pages 374-384.
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Guoping FAN & Leah HUTNICK. (2005) Methyl-CpG binding proteins in the nervous system. Cell Research 15:4, pages 255-261.
Crossref
Takeshi Ego, Yuetsu Tanaka & Kunitada Shimotohno. (2005) Interaction of HTLV-1 Tax and methyl-CpG-binding domain 2 positively regulates the gene expression from the hypermethylated LTR. Oncogene 24:11, pages 1914-1923.
Crossref
Hannah Elisabeth Mischo, Peter Hemmerich, Frank Grosse & Suisheng Zhang. (2005) Actinomycin D Induces Histone γ-H2AX Foci and Complex Formation of γ-H2AX with Ku70 and Nuclear DNA Helicase II. Journal of Biological Chemistry 280:10, pages 9586-9594.
Crossref
Joachim Marhold, Katja Kramer, Elisabeth Kremmer & Frank Lyko. (2004) The Drosophila MBD2/3 protein mediates interactions between the MI-2 chromatin complex and CpT/A-methylated DNA . Development 131:24, pages 6033-6039.
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Joshua M. Spin, Shriram Nallamshetty, Raymond Tabibiazar, Euan A. Ashley, Jennifer Y. King, Mary Chen, Phillip S. Tsao & Thomas Quertermous. (2004) Transcriptional profiling of in vitro smooth muscle cell differentiation identifies specific patterns of gene and pathway activation. Physiological Genomics 19:3, pages 292-302.
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