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Molecular and Cellular Biology Volume 23, 2003 - Issue 8
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Cell Growth and Development

A Unique Autophosphorylation Site on Tie2/Tek Mediates Dok-R Phosphotyrosine Binding Domain Binding and Function

Nina Jones1 Division of Molecular and Cellular Biology Research, Sunnybrook and Women's College Research Institute
,
Stephen H. Chen1 Division of Molecular and Cellular Biology Research, Sunnybrook and Women's College Research Institute;2 Department of Medical Biophysics, University of Toronto, Toronto, OntarioM5G 2M9
,
Celina Sturk1 Division of Molecular and Cellular Biology Research, Sunnybrook and Women's College Research Institute;2 Department of Medical Biophysics, University of Toronto, Toronto, OntarioM5G 2M9
,
Zubin Master1 Division of Molecular and Cellular Biology Research, Sunnybrook and Women's College Research Institute;2 Department of Medical Biophysics, University of Toronto, Toronto, OntarioM5G 2M9
,
Jennifer Tran1 Division of Molecular and Cellular Biology Research, Sunnybrook and Women's College Research Institute;3 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, OntarioM5G 1L5, Canada
,
Robert S. Kerbel1 Division of Molecular and Cellular Biology Research, Sunnybrook and Women's College Research Institute;2 Department of Medical Biophysics, University of Toronto, Toronto, OntarioM5G 2M9;3 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, OntarioM5G 1L5, Canada
&
Daniel J. Dumont1 Division of Molecular and Cellular Biology Research, Sunnybrook and Women's College Research Institute;2 Department of Medical Biophysics, University of Toronto, Toronto, OntarioM5G 2M9;4 Toronto-Sunnybrook Regional Cancer Center, Toronto, OntarioM4N 3M5Correspondence[email protected]
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Pages 2658-2668 | Received 11 Sep 2002, Accepted 22 Jan 2003, Published online: 27 Mar 2023

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Jay Bilimoria & Harprit Singh. (2019) The Angiopoietin ligands and Tie receptors: potential diagnostic biomarkers of vascular disease. Journal of Receptors and Signal Transduction 39:3, pages 187-193.
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Sankar P. Chaki & Gonzalo M. Rivera. (2013) Integration of signaling and cytoskeletal remodeling by Nck in directional cell migration. BioArchitecture 3:3, pages 57-63.
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Hai Tao Yuan, Eliyahu V. Khankin, S. Ananth Karumanchi & Samir M. Parikh. (2009) Angiopoietin 2 Is a Partial Agonist/Antagonist of Tie2 Signaling in the Endothelium. Molecular and Cellular Biology 29:8, pages 2011-2022.
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Kazunobu Tachibana, Nina Jones, Daniel J. Dumont, Mira C. Puri & Alan Bernstein. (2005) Selective Role of a Distinct Tyrosine Residue on Tie2 in Heart Development and Early Hematopoiesis. Molecular and Cellular Biology 25:11, pages 4693-4702.
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Pipsa Saharinen, Michael Jeltsch, Mayte M. Santoyo, Veli-Matti Leppänen & Kari Alitalo. 2015. Receptor Tyrosine Kinases: Family and Subfamilies. Receptor Tyrosine Kinases: Family and Subfamilies 743 775 .
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Tariq A. Tahir, Harprit Singh & Nicholas P.J. Brindle. (2014) The RNA binding protein hnRNP-K mediates post-transcriptional regulation of uncoupling protein-2 by angiopoietin-1. Cellular Signalling 26:7, pages 1379-1384.
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Gabriela D’Amico, Emilia A. Korhonen, Andrey Anisimov, Georgia Zarkada, Tanja Holopainen, René Hägerling, Friedemann Kiefer, Lauri Eklund, Raija Sormunen, Harri Elamaa, Rolf A. Brekken, Ralf H. Adams, Gou Young Koh, Pipsa Saharinen & Kari Alitalo. (2014) Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy. Journal of Clinical Investigation 124:2, pages 824-834.
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Andrew Moss. (2013) The angiopoietin:Tie 2 interaction: A potential target for future therapies in human vascular disease. Cytokine & Growth Factor Reviews 24:6, pages 579-592.
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Raquel Echavarria & Sabah N. A. Hussain. (2013) Regulation of Angiopoietin‐1/Tie‐2 Receptor Signaling in Endothelial Cells by Dual‐Specificity Phosphatases 1, 4, and 5. Journal of the American Heart Association 2:6.
Crossref
HSUEH-TSEN CHENG & WEN-CHUN HUNG. (2013) Inhibition of proliferation, sprouting, tube formation and Tie2 signaling of lymphatic endothelial cells by the histone deacetylase inhibitor SAHA. Oncology Reports 30:2, pages 961-967.
Crossref
Leopoldina Scotti, Dalhia Abramovich, Natalia Pascuali, Ignacio de Zúñiga, Alejandro Oubiña, Laura Kopcow, Soledad Lange, Gareth Owen, Marta Tesone & Fernanda Parborell. (2013) Involvement of the ANGPTs/Tie-2 system in ovarian hyperstimulation syndrome (OHSS). Molecular and Cellular Endocrinology 365:2, pages 223-230.
Crossref
Ernesta Fagiani & Gerhard Christofori. (2013) Angiopoietins in angiogenesis. Cancer Letters 328:1, pages 18-26.
Crossref
Xianghu Qu & H. Scott Baldwin. 2013. The Cardiac Lymphatic System. The Cardiac Lymphatic System 107 123 .
Malika OubahaMichelle I. Lin, Yoran Margaron, Dominic FilionEmily N. Price, Leonard I. Zon, Jean-François Côté & Jean-Philippe Gratton. (2012) Formation of a PKCζ/β-catenin complex in endothelial cells promotes angiopoietin-1–induced collective directional migration and angiogenic sprouting. Blood 120:16, pages 3371-3381.
Crossref
Loraine L. Y. Chiu, Milica Radisic & Gordana Vunjak-Novakovic. (2010) Bioactive Scaffolds for Engineering Vascularized Cardiac Tissues. Macromolecular Bioscience 10:11, pages 1286-1301.
Crossref
Hanhua Huang, Abhijit Bhat, Gary Woodnutt & Rodney Lappe. (2010) Targeting the ANGPT–TIE2 pathway in malignancy. Nature Reviews Cancer 10:8, pages 575-585.
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C. Sturk, H. Kim, N. Jones & D.J. Dumont. (2010) A negative regulatory role for Y1111 on the Tie-2 RTK. Cellular Signalling 22:4, pages 676-683.
Crossref
Markus Thomas & Hellmut G. Augustin. (2009) The role of the Angiopoietins in vascular morphogenesis. Angiogenesis 12:2, pages 125-137.
Crossref
Mark Winderlich, Linda Keller, Giuseppe Cagna, Andre Broermann, Olena Kamenyeva, Friedemann Kiefer, Urban Deutsch, Astrid F. Nottebaum & Dietmar Vestweber. (2009) VE-PTP controls blood vessel development by balancing Tie-2 activity. Journal of Cell Biology 185:4, pages 657-671.
Crossref
Shigetomo FukuharaKeisuke SakoKazuomi NodaKaori NagaoKoichi MiuraNaoki Mochizuki. (2009) Tie2 is tied at the cell-cell contacts and to extracellular matrix by Angiopoietin-1. Experimental and Molecular Medicine 41:3, pages 133.
Crossref
Barden Chan, Hai-Tao Yuan, S. Ananth Karumanchi & Vikas P. Sukhatme. (2008) Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules. Biochemical and Biophysical Research Communications 371:3, pages 475-479.
Crossref
Pipsa Saharinen, Lauri Eklund, Juho Miettinen, Riikka Wirkkala, Andrey Anisimov, Mark Winderlich, Astrid Nottebaum, Dietmar Vestweber, Urban Deutsch, Gou Young Koh, Bjorn R. Olsen & Kari Alitalo. (2008) Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts. Nature Cell Biology 10:5, pages 527-537.
Crossref
Ben Margolis & Linton M. Traub. 2008. Protein Science Encyclopedia. Protein Science Encyclopedia.
Hellmut G. Augustin & Ulrike Fiedler. 2008. Tumor Angiogenesis. Tumor Angiogenesis 109 120 .
Pipsa Saharinen, Lauri Eklund & Kari Alitalo. 2008. Angiogenesis. Angiogenesis 113 120 .
Young Mee Kim, Jawon Seo, Yung Hee Kim, Jaeho Jeong, Hye Joon Joo, Dong-Hee Lee, Gou Young Koh & Kong-Joo Lee. (2007) Systemic Analysis of Tyrosine Phosphorylated Proteins in Angiopoietin-1 Induced Signaling Pathway of Endothelial Cells. Journal of Proteome Research 6:8, pages 3278-3290.
Crossref
Lei Shi, Jiping Yue, Yuangang You, Bin Yin, Yanhua Gong, Caimin Xu, Boqin Qiang, Jiangang Yuan, Yongjian Liu & Xiaozhong Peng. (2006) Dok5 is substrate of TrkB and TrkC receptors and involved in neurotrophin induced MAPK activation. Cellular Signalling 18:11, pages 1995-2003.
Crossref
Elena Bogdanovic, Vicky P. K. H. Nguyen & Daniel J. Dumont. (2006) Activation of Tie2 by angiopoietin-1 and angiopoietin-2 results in their release and receptor internalization. Journal of Cell Science 119:17, pages 3551-3560.
Crossref
Young Mee Kim, Kyung Eun Kim, Gou Young Koh, Ye-Shih Ho & Kong-Joo Lee. (2006) Hydrogen Peroxide Produced by Angiopoietin-1 Mediates Angiogenesis. Cancer Research 66:12, pages 6167-6174.
Crossref
Nicholas P.J. BrindlePipsa SaharinenKari Alitalo. (2006) Signaling and Functions of Angiopoietin-1 in Vascular Protection. Circulation Research 98:8, pages 1014-1023.
Crossref
Romi BiswasDavid SteinE. Richard Stanley. (2006) Drosophila Dok is required for embryonic dorsal closure . Development 133:2, pages 217-227.
Crossref
Iohann Boulay, Jean-Guy Némorin & Pascale Duplay. (2005) Phosphotyrosine Binding-Mediated Oligomerization of Downstream of Tyrosine Kinase (Dok)-1 and Dok-2 Is Involved in CD2-Induced Dok Phosphorylation. The Journal of Immunology 175:7, pages 4483-4489.
Crossref
Shigeru Kanda, Yasuyoshi Miyata, Yasushi Mochizuki, Toshifumi Matsuyama & Hiroshi Kanetake. (2005) Angiopoietin 1 Is Mitogenic for Cultured Endothelial Cells. Cancer Research 65:15, pages 6820-6827.
Crossref
Daniel Voskas, Nina Jones, Paul Van Slyke, Celina Sturk, Wing Chang, Alex Haninec, Yael Olya Babichev, Jennifer Tran, Zubin Master, Stephen Chen, Nicole Ward, Maribelle Cruz, Jamie Jones, Robert S. Kerbel, Serge Jothy, Lina Dagnino, Jack Arbiser, Giannoula Klement & Daniel J. Dumont. (2005) A Cyclosporine-Sensitive Psoriasis-Like Disease Produced in Tie2 Transgenic Mice. The American Journal of Pathology 166:3, pages 843-855.
Crossref
Masakuni Kido, Lingling Du, Christopher C. Sullivan, Reena Deutsch, Stuart W. Jamieson & Patricia A. Thistlethwaite. (2005) Gene transfer of a TIE2 receptor antagonist prevents pulmonary hypertension in rodents. The Journal of Thoracic and Cardiovascular Surgery 129:2, pages 268-276.
Crossref
Ian Zachary. 2005. Mechanisms of Angiogenesis. Mechanisms of Angiogenesis 267 300 .
André Veillette. (2004) Specialised adaptors in immune cells. Current Opinion in Cell Biology 16:2, pages 146-155.
Crossref
H Kim & DJ Dumont. (2003) Molecular mechanisms in lymphangiogenesis: model systems and implications in human disease. Clinical Genetics 64:4, pages 282-292.
Crossref
Zubin Master, Jennifer Tran, Aseem Bishnoi, Stephen H. Chen, John M.L. Ebos, Paul Van Slyke, Robert S. Kerbel & Daniel J. Dumont. (2003) Dok-R Binds c-Abl and Regulates Abl Kinase Activity and Mediates Cytoskeletal Reorganization. Journal of Biological Chemistry 278:32, pages 30170-30179.
Crossref

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