Advanced search
Publication Cover
Molecular and Cellular Biology Volume 23, 2003 - Issue 8
Submit an article Journal homepage
37
Views
158
CrossRef citations to date
0
Altmetric
Transcriptional Regulation

The Tumor Suppressor p53 and Histone Deacetylase 1 Are Antagonistic Regulators of the Cyclin-Dependent Kinase Inhibitor p21/WAF1/CIP1 Gene

Gerda Lagger1 Institute of Medical Biochemistry, Division of Molecular Biology, Vienna Biocenter, University of Vienna, A-1030Vienna, Austria
,
Angelika Doetzlhofer1 Institute of Medical Biochemistry, Division of Molecular Biology, Vienna Biocenter, University of Vienna, A-1030Vienna, Austria
,
Bernd Schuettengruber1 Institute of Medical Biochemistry, Division of Molecular Biology, Vienna Biocenter, University of Vienna, A-1030Vienna, Austria
,
Eva Haidweger1 Institute of Medical Biochemistry, Division of Molecular Biology, Vienna Biocenter, University of Vienna, A-1030Vienna, Austria
,
Elisabeth Simboeck1 Institute of Medical Biochemistry, Division of Molecular Biology, Vienna Biocenter, University of Vienna, A-1030Vienna, Austria
,
Julia Tischler1 Institute of Medical Biochemistry, Division of Molecular Biology, Vienna Biocenter, University of Vienna, A-1030Vienna, Austria
,
Susanna Chiocca2 European Institute of Oncology, Department of Experimental Oncology, 20141Milan, Italy
,
Guntram Suske3 Institute of Molecular Biology and Tumor Research, Phillips University of Marburg, Marburg, Germany
,
Hans Rotheneder1 Institute of Medical Biochemistry, Division of Molecular Biology, Vienna Biocenter, University of Vienna, A-1030Vienna, Austria
,
Erhard Wintersberger1 Institute of Medical Biochemistry, Division of Molecular Biology, Vienna Biocenter, University of Vienna, A-1030Vienna, Austria
&
Christian Seiser1 Institute of Medical Biochemistry, Division of Molecular Biology, Vienna Biocenter, University of Vienna, A-1030Vienna, AustriaCorrespondence[email protected]
 show all
Pages 2669-2679 | Received 22 Aug 2002, Accepted 21 Jan 2003, Published online: 27 Mar 2023

Citations (158)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (5)

Ji-Hye Yim, Jung Mi Yun, Ji Young Kim, Seon Young Nam & Cha Soon Kim. (2017) Estimation of low-dose radiation-responsive proteins in the absence of genomic instability in normal human fibroblast cells. International Journal of Radiation Biology 93:11, pages 1197-1206.
Read now
Kyunghwan Kim, Kyu Heo, Jongkyu Choi, Sarah Jackson, Hyunjung Kim, Yue Xiong & Woojin An. (2012) Vpr-Binding Protein Antagonizes p53-Mediated Transcription via Direct Interaction with H3 Tail. Molecular and Cellular Biology 32:4, pages 783-796.
Read now
Gordin Zupkovitz, Reinhard Grausenburger, Reinhard Brunmeir, Silvia Senese, Julia Tischler, Jennifer Jurkin, Martina Rembold, Dominique Meunier, Gerda Egger, Sabine Lagger, Susanna Chiocca, Fritz Propst, Georg Weitzer & Christian Seiser. (2010) The Cyclin-Dependent Kinase Inhibitor p21 Is a Crucial Target for Histone Deacetylase 1 as a Regulator of Cellular Proliferation. Molecular and Cellular Biology 30:5, pages 1171-1181.
Read now
Silvia Senese, Katrin Zaragoza, Simone Minardi, Ivan Muradore, Simona Ronzoni, Alfonso Passafaro, Loris Bernard, Giulio F. Draetta, Myriam Alcalay, Christian Seiser & Susanna Chiocca. (2007) Role for Histone Deacetylase 1 in Human Tumor Cell Proliferation. Molecular and Cellular Biology 27:13, pages 4784-4795.
Read now
Ying Zhao, Shaoli Lu, Lipeng Wu, Guolin Chai, Haiying Wang, Yingqi Chen, Jia Sun, Yu Yu, Wen Zhou, Quanhui Zheng, Mian Wu, Gregory A. Otterson & Wei-Guo Zhu. (2006) Acetylation of p53 at Lysine 373/382 by the Histone Deacetylase Inhibitor Depsipeptide Induces Expression of p21Waf1/Cip1. Molecular and Cellular Biology 26:7, pages 2782-2790.
Read now

Articles from other publishers (153)

Duen-Yi Huang, Shang-Te Lu, Yuan-Shen Chen, Ching-Yuan Cheng & Wan-Wan Lin. (2023) Epigenetic upregulation of spleen tyrosine kinase in cancer cells through p53-dependent downregulation of DNA methyltransferase. Experimental Cell Research 425:2, pages 113540.
Crossref
Mahsa Naghashpour, Dian Dayer, Hadi Karami, Mahshid Naghashpour, Mahin Taheri Moghadam, Seyed Mohammad Jafar Haeri & Katsuhiko Suzuki. (2023) Evaluating the Magnolol Anticancer Potential in MKN-45 Gastric Cancer Cells. Medicina 59:2, pages 286.
Crossref
Christiana O. Appiah, Manjulata Singh, Lauren May, Ishita Bakshi, Ashish Vaidyanathan, Paul Dent, Gordon Ginder, Steven Grant, Harry Bear & Joseph Landry. 2023. Epigenetic Regulation of Cancer in Response to Chemotherapy. Epigenetic Regulation of Cancer in Response to Chemotherapy 337 385 .
Appu Rathinavelu & Umamaheswari Natarajan. 2023. Epigenetics in Organ Specific Disorders. Epigenetics in Organ Specific Disorders 63 97 .
Katerina Trtkova, Petra Luzna, Denisa Drozdkova, Katerina Cizkova, Lucie Janovska, Jan Gursky, Dana Prukova, Ivo Frydrych, Marian Hajduch & Jiri Minarik. (2022) The epigenetic impact of suberohydroxamic acid and 5‑Aza‑2'‑deoxycytidine on DNMT3B expression in myeloma cell lines differing in IL‑6 expression. Molecular Medicine Reports 26:4.
Crossref
Asif Sukri, Alfizah Hanafiah & Nik Ritza Kosai. (2022) The Roles of Immune Cells in Gastric Cancer: Anti-Cancer or Pro-Cancer?. Cancers 14:16, pages 3922.
Crossref
Ying Zhang, Yi Xiang See, Vinay Tergaonkar & Melissa Jane Fullwood. (2022) Long-Distance Repression by Human Silencers: Chromatin Interactions and Phase Separation in Silencers. Cells 11:9, pages 1560.
Crossref
Sara Vanessa Bernhard, Katarzyna Seget-Trzensiok, Christian Kuffer, Dragomir B. Krastev, Lisa-Marie Stautmeister, Mirko Theis, Kristina Keuper, Jan-Eric Boekenkamp, Maik Kschischo, Frank Buchholz & Zuzana Storchova. (2021) Loss of USP28 and SPINT2 expression promotes cancer cell survival after whole genome doubling. Cellular Oncology 45:1, pages 103-119.
Crossref
Harsha Ganesan, M. K. Makalakshmi, Antara Banerjee, Hong Zhang, Xiao-Feng Sun & Surajit Pathak. 2022. Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Handbook of Oxidative Stress in Cancer: Therapeutic Aspects 1681 1698 .
Harsha Ganesan, M. K. Makalakshmi, Antara Banerjee, Hong Zhang, Xiao-Feng Sun & Surajit Pathak. 2021. Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Handbook of Oxidative Stress in Cancer: Therapeutic Aspects 1 18 .
R¯uta Navakauskien˙e, Dalius Navakauskas, Veronika Borutinskait˙e & Dalius Matuzevi˘ciusRūta Navakauskienė, Dalius Navakauskas, Veronika Borutinskaitė & Dalius Matuzevičius. 2021. Epigenetics and Proteomics of Leukemia. Epigenetics and Proteomics of Leukemia 67 122 .
Se Lim Kim, Minh Thanh, Min Woo Shin, Sang‑Wook Kim & Hee‑Kwon Kim. (2020) A novel HDAC1 inhibitor, CBUD‑1001, exerts anticancer effects by modulating the apoptosis and EMT of colorectal cancer cells. International Journal of Oncology.
Crossref
Mariacristina Siotto, Massimo Santoro & Irene Aprile. (2020) Vitamin D and Rehabilitation after Stroke: Status of Art. Applied Sciences 10:6, pages 1973.
Crossref
Choong Man Lee, Il Yong Chung, Yangsoon Park, Keong Won Yun, Hwi Gyeong Jo, Hye Jin Park, Hee Jin Lee, Sae Byul Lee, Hee Jeong Kim, Beom Seok Ko, Jong Won Lee, Byung Ho Son, Sei Hyun Ahn & Jisun Kim. (2020) The Impact of Androgen Receptor and Histone Deacetylase 1 Expression on the Prognosis of Ductal Carcinoma In Situ . Journal of Breast Cancer 23:6, pages 610.
Crossref
Chia-Yang Hung, Tsung-I Hsu, Jian-Ying Chuang, Tsung-Ping Su, Wen-Chang Chang & Jan-Jong Hung. (2019) Sp1 in Astrocyte Is Important for Neurite Outgrowth and Synaptogenesis. Molecular Neurobiology 57:1, pages 261-277.
Crossref
H. Boughanem, B. Bandera-Merchan & M. Macias-Gonzalez. 2019. Nutrition and Cancer Prevention. Nutrition and Cancer Prevention 27 49 .
Huaqin Li, Lianjie Hou, Yu Zhang, Fangyi Jiang, Yifan Zhu, Qing X. Li, Ching Yuan Hu & Chong Wang. (2019) PFN2a Suppresses C2C12 Myogenic Development by Inhibiting Proliferation and Promoting Apoptosis via the p53 Pathway. Cells 8:9, pages 959.
Crossref
Kanjoormana Manu, Pham Cao, Tin Chai, Patrick Casey & Mei Wang. (2019) p21cip1/waf1 Coordinates Autophagy, Proliferation and Apoptosis in Response to Metabolic Stress. Cancers 11:8, pages 1112.
Crossref
Rebecca S. DeVaux & Jason I. Herschkowitz. (2018) Beyond DNA: the Role of Epigenetics in the Premalignant Progression of Breast Cancer. Journal of Mammary Gland Biology and Neoplasia 23:4, pages 223-235.
Crossref
Yujuan Zhang, Zhigang Wang, Yanqing Huang, Muying Ying, Yifan Wang, Juan Xiong, Qi Liu, Fan Cao, Rakesh Joshi, Yanling Liu, Derong Xu, Meng Zhang, Keng Yuan, Nanjin Zhou, James Koropatnick & Weiping Min. (2018) TdIF1: a putative oncogene in NSCLC tumor progression. Signal Transduction and Targeted Therapy 3:1.
Crossref
Gordin Zupkovitz, Sabine Lagger, David Martin, Marianne Steiner, Astrid Hagelkruys, Christian Seiser, Christian Schöfer & Oliver Pusch. (2018) Histone deacetylase 1 expression is inversely correlated with age in the short-lived fish Nothobranchius furzeri. Histochemistry and Cell Biology 150:3, pages 255-269.
Crossref
S Dewi, R Karsono, S Pramana & S I Wanandi. (2018) Expression profile of stem cell pathway genes in patients with advanced breast cancer after neoadjuvant therapy. Journal of Physics: Conference Series 1073, pages 032037.
Crossref
Kendra J. Royston, Bidisha Paul, Susan Nozell, Rajani Rajbhandari & Trygve O. Tollefsbol. (2018) Withaferin A and sulforaphane regulate breast cancer cell cycle progression through epigenetic mechanisms. Experimental Cell Research 368:1, pages 67-74.
Crossref
Bo Yoon Choi, Jong Cheon Joo, Yeon Kyu Lee, Ik-Soon Jang, Soo Jung Park & Yoon Jung Park. (2017) Anti-cancer effect of Scutellaria baicalensis in combination with cisplatin in human ovarian cancer cell. BMC Complementary and Alternative Medicine 17:1.
Crossref
Preethi G. Anantharaju, Deepa B. Reddy, Mahesh A. Padukudru, CH. M. Kumari Chitturi, Manjunath G. Vimalambike & SubbaRao V. Madhunapantula. (2017) Induction of colon and cervical cancer cell death by cinnamic acid derivatives is mediated through the inhibition of Histone Deacetylases (HDAC). PLOS ONE 12:11, pages e0186208.
Crossref
Chia-Yang Hung, Yi-Chang Wang, Jian-Ying Chuang, Ming-Jer Young, Hungjiun Liaw, Wen-Chang Chang & Jan-Jong Hung. (2017) Nm23-H1-stabilized hnRNPA2/B1 promotes internal ribosomal entry site (IRES)-mediated translation of Sp1 in the lung cancer progression. Scientific Reports 7:1.
Crossref
Sang Chul Park. (2017) Survive or thrive: tradeoff strategy for cellular senescence. Experimental & Molecular Medicine 49:6, pages e342-e342.
Crossref
Zu-Qing Su, Yu-Hong Liu, Hui-Zhen Guo, Chao-Yue Sun, Jian-Hui Xie, Yu-Cui Li, Jian-Nan Chen, Xiao-Ping Lai, Zi-Ren Su & Hai-Ming Chen. (2017) Effect-enhancing and toxicity-reducing activity of usnic acid in ascitic tumor-bearing mice treated with bleomycin. International Immunopharmacology 46, pages 146-155.
Crossref
Borja Bandera Merchan, Sonsoles Morcillo, Gracia Martin-Nuñez, Francisco José Tinahones & Manuel Macías-González. (2017) The role of vitamin D and VDR in carcinogenesis: Through epidemiology and basic sciences. The Journal of Steroid Biochemistry and Molecular Biology 167, pages 203-218.
Crossref
Jay Whelan, Yi Zhao, E-Chu Huang, Amber MacDonald & Dallas Donohoe. 2016. Complementary and Alternative Medicines in Prostate Cancer. Complementary and Alternative Medicines in Prostate Cancer 197 220 .
Igor Hrgovic, Monika Doll, Johannes Kleemann, Xiao-Fan Wang, Nadja Zoeller, Andreas Pinter, Stefan Kippenberger, Roland Kaufmann & Markus Meissner. (2016) The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways. BMC Cancer 16:1.
Crossref
Haishan Zhao, Zhaojin Yu, Lin Zhao, Miao He, Jie Ren, Huizhe Wu, Qiuchen Chen, Weifan Yao & Minjie Wei. (2016) HDAC2 overexpression is a poor prognostic factor of breast cancer patients with increased multidrug resistance-associated protein expression who received anthracyclines therapy. Japanese Journal of Clinical Oncology 46:10, pages 893-902.
Crossref
Rayna Rosati, Bailing Chen, Mugdha Patki, Thomas McFall, Siyu Ou, Elisabeth Heath, Manohar Ratnam & Zhihui Qin. (2016) Hybrid Enzalutamide Derivatives with Histone Deacetylase Inhibitor Activity Decrease Heat Shock Protein 90 and Androgen Receptor Levels and Inhibit Viability in Enzalutamide-Resistant C4-2 Prostate Cancer Cells. Molecular Pharmacology 90:3, pages 225-237.
Crossref
Guizhou Zhu, Tao Tao, Dongmei Zhang, Xiaojuan Liu, Huiyuan Qiu, LiJian Han, Zhiwei Xu, Ying Xiao, Chun Cheng & Aiguo Shen. (2016) O-GlcNAcylation of histone deacetylases 1 in hepatocellular carcinoma promotes cancer progression. Glycobiology 26:8, pages 820-833.
Crossref
Shabir Ahmad Ganai. (2016) Histone deacetylase inhibitor sulforaphane: The phytochemical with vibrant activity against prostate cancer. Biomedicine & Pharmacotherapy 81, pages 250-257.
Crossref
Ansar Karimian, Yasin Ahmadi & Bahman Yousefi. (2016) Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage. DNA Repair 42, pages 63-71.
Crossref
Samel Park, Il-woong Hwang, Jin-sheon Kim, Hyo-chul Kang, Su-Yeon Park, Hyo-wook Gil, Ho-yeon Song & Sae-yong Hong. (2015) The effects of nonyl phenoxypolyethoxyl ethanol on cell damage pathway gene expression in SK-NSH cells. The Korean Journal of Internal Medicine 30:6, pages 873-883.
Crossref
H Yang, B Yan, D Liao, S Huang & Y Qiu. (2015) Acetylation of HDAC1 and degradation of SIRT1 form a positive feedback loop to regulate p53 acetylation during heat-shock stress. Cell Death & Disease 6:5, pages e1747-e1747.
Crossref
Kate Beishline & Jane Azizkhan-Clifford. (2015) Sp1 and the ‘hallmarks of cancer’. FEBS Journal 282:2, pages 224-258.
Crossref
Ding-Guo Zhang, Jun-Nian Zheng & Dong-Sheng Pei. (2014) P53/microRNA-34-induced metabolic regulation: new opportunities in anticancer therapy. Molecular Cancer 13:1.
Crossref
E-Chu Huang, Yi Zhao, Guoxun Chen, Seung Joon Baek, Michael F McEntee, Steven Minkin, John P Biggerstaff & Jay Whelan. (2014) Zyflamend, a polyherbal mixture, down regulates class I and class II histone deacetylases and increases p21 levels in castrate-resistant prostate cancer cells. BMC Complementary and Alternative Medicine 14:1.
Crossref
Chia-Yang Hung, Wen-Bin Yang, Shao-An Wang, Tsung-I Hsu, Wen-Chang Chang & Jan-Jong Hung. (2014) Nucleolin enhances internal ribosomal entry site (IRES)-mediated translation of Sp1 in tumorigenesis. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1843:12, pages 2843-2854.
Crossref
Yingzi He, Chengfu Cai, Dongmei Tang, Shan Sun & Huawei Li. (2014) Effect of histone deacetylase inhibitors trichostatin A and valproic acid on hair cell regeneration in zebrafish lateral line neuromasts. Frontiers in Cellular Neuroscience 8.
Crossref
Irfete S. Fetahu, Julia Höbaus & Enikő Kállay. (2014) Vitamin D and the epigenome. Frontiers in Physiology 5.
Crossref
Natasha Kolesnikoff, Joanne L. Attema, Suraya Roslan, Andrew G. Bert, Quenten P. Schwarz, Philip A. Gregory & Gregory J. Goodall. (2014) Specificity Protein 1 (Sp1) Maintains Basal Epithelial Expression of the miR-200 Family. Journal of Biological Chemistry 289:16, pages 11194-11205.
Crossref
Hyun-Seok Kim, Jee-In Heo, Seong-Hoon Park, Jong-Yeon Shin, Hong-Jun Kang, Min-Ju Kim, Sung Chan Kim, Jaebong Kim, Jae-Bong Park & Jae-Yong Lee. (2014) Transcriptional activation of p21WAF1/CIP1 is mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic fibroblasts. Molecular Biology Reports 41:4, pages 2397-2408.
Crossref
Bryan C. Mounce, Wadzanai P. Mboko, Adam J. Kanack & Vera L. Tarakanova. (2014) Primary Macrophages Rely on Histone Deacetylase 1 and 2 Expression To Induce Type I Interferon in Response to Gammaherpesvirus Infection. Journal of Virology 88:4, pages 2268-2278.
Crossref
Sabnam ParbinSwayamsiddha KarArunima ShilpiDipta SenguptaMoonmoon DebSandip Kumar RathSamir Kumar Patra. (2013) Histone Deacetylases. Journal of Histochemistry & Cytochemistry 62:1, pages 11-33.
Crossref
Shuai Wu, Shui-Di Zheng, Hong-Ling Huang, Li-Chong Yan, Xiao-Fei Yin, Hai-Neng Xu, Kang-Jian Zhang, Jing-Hua Gui, Liang Chu & Xin-Yuan Liu. (2013) Lithium Down-regulates Histone Deacetylase 1 (HDAC1) and Induces Degradation of Mutant Huntingtin. Journal of Biological Chemistry 288:49, pages 35500-35510.
Crossref
Biyin Cao, Jie Li, Jingyu Zhu, Mingyun Shen, Kunkun Han, Zubin Zhang, Yang Yu, Yali Wang, Depei Wu, Suning Chen, Aining Sun, Xiaowen Tang, Yun Zhao, Chunhua Qiao, Tingjun Hou & Xinliang Mao. (2013) The Antiparasitic Clioquinol Induces Apoptosis in Leukemia and Myeloma Cells by Inhibiting Histone Deacetylase Activity. Journal of Biological Chemistry 288:47, pages 34181-34189.
Crossref
Wooyoung Jeong, Whasun Lim, Suzie E. Ahn, Chul-Hong Lim, Jin-Young Lee, Seung-Min Bae, Jinyoung Kim, Fuller W. Bazer & Gwonhwa Song. (2013) Recrudescence Mechanisms and Gene Expression Profile of the Reproductive Tracts from Chickens during the Molting Period. PLoS ONE 8:10, pages e76784.
Crossref
Jane Zhao, Paul Lammers, Chris J Torrance & Andreas G Bader. (2013) TP53-independent Function of miR-34a via HDAC1 and p21CIP1/WAF1. Molecular Therapy 21:9, pages 1678-1686.
Crossref
Ji Young Janice Yoo, Matt Larouche & Dan Goldowitz. (2013) The Expression of HDAC1 and HDAC2 During Cerebellar Cortical Development. The Cerebellum 12:4, pages 534-546.
Crossref
Jessica Heath, Joshua Weiss, Catherine Lavau & Daniel Wechsler. (2013) Iron Deprivation in Cancer––Potential Therapeutic Implications. Nutrients 5:8, pages 2836-2859.
Crossref
Xiaowen Lu, Philip R. Kensche, Martijn A. Huynen & Richard A. Notebaart. (2013) Genome evolution predicts genetic interactions in protein complexes and reveals cancer drug targets. Nature Communications 4:1.
Crossref
Jeremy Worley, Xiangxia Luo & Andrew P. Capaldi. (2013) Inositol Pyrophosphates Regulate Cell Growth and the Environmental Stress Response by Activating the HDAC Rpd3L. Cell Reports 3:5, pages 1476-1482.
Crossref
Yi Wang, Ying Tian, Michael P. Morley, Min M. Lu, Francesco J. DeMayo, Eric N. Olson & Edward E. Morrisey. (2013) Development and Regeneration of Sox2+ Endoderm Progenitors Are Regulated by a HDAC1/2-Bmp4/Rb1 Regulatory Pathway. Developmental Cell 24:4, pages 345-358.
Crossref
Brook T. Chernet & Michael Levin. (2013) Transmembrane voltage potential is an essential cellular parameter for the detection and control of tumor development in a Xenopus model . Disease Models & Mechanisms.
Crossref
Yukihiro Itoh, Takayoshi Suzuki & Naoki Miyata. (2013) Small-molecular modulators of cancer-associated epigenetic mechanisms. Molecular BioSystems 9:5, pages 873.
Crossref
Yoshiaki Mizuguchi, Susan Specht, John G LunzIIIIII, Kumiko Isse, Natasha Corbitt, Toshihiro Takizawa & Anthony J Demetris. (2012) SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity. BMC Molecular Biology 13:1.
Crossref
Hsin‐Yi Huang, Demeral D. Liu, Hui‐Fen Chang, Wu‐Fu Chen, Hui‐Ru Hsu, Jon‐Son Kuo & Mei‐Jen Wang. (2012) Histone Deacetylase Inhibition Mediates Urocortin‐Induced Antiproliferation and Neuronal Differentiation in Neural Stem Cells. STEM CELLS 30:12, pages 2760-2773.
Crossref
Tao Yang, Wei Jian, Yi Luo, Xueqi Fu, Constance Noguchi, Jörg Bungert, Suming Huang & Yi Qiu. (2012) Acetylation of Histone Deacetylase 1 Regulates NuRD Corepressor Complex Activity. Journal of Biological Chemistry 287:48, pages 40279-40291.
Crossref
Nina Reichert, Mohamed-Amin Choukrallah & Patrick Matthias. (2012) Multiple roles of class I HDACs in proliferation, differentiation, and development. Cellular and Molecular Life Sciences 69:13, pages 2173-2187.
Crossref
Nelson S. Yee, Weiqiang Zhou, Stephen G. Chun, I-Chau Liang & Rosemary K. Yee. (2012) Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer. Biology Open 1:4, pages 295-307.
Crossref
Hong Jian Xie, Ji Heon Noh, Jeong Kyu Kim, Kwang Hwa Jung, Jung Woo Eun, Hyun Jin Bae, Min Gyu Kim, Young Gyoon Chang, Jung Young Lee, Hanna Park & Suk Woo Nam. (2012) HDAC1 Inactivation Induces Mitotic Defect and Caspase-Independent Autophagic Cell Death in Liver Cancer. PLoS ONE 7:4, pages e34265.
Crossref
Bi-Qing Li, Tao Huang, Lei Liu, Yu-Dong Cai & Kuo-Chen Chou. (2012) Identification of Colorectal Cancer Related Genes with mRMR and Shortest Path in Protein-Protein Interaction Network. PLoS ONE 7:4, pages e33393.
Crossref
Inês Milagre, Maria João Nunes, Margarida Castro-Caldas, Miguel Moutinho, Maria João Gama & Elsa Rodrigues. (2012) Neuronal differentiation alters the ratio of Sp transcription factors recruited to the CYP46A1 promoter. Journal of Neurochemistry 120:2, pages 220-229.
Crossref
Raimana Ho, Andreas Nievergelt, Claudia Simoes Pires & Muriel Cuendet. 2012. Bioactive Natural Products. Bioactive Natural Products 247 267 .
Jurate Savickiene, Grazina Treigyte, Violeta Jonusiene, Renata Bruzaite, Veronika-Viktorija Borutinskaite & Ruta Navakauskiene. (2011) Epigenetic changes by zebularine leading to enhanced differentiation of human promyelocytic leukemia NB4 and KG1 cells. Molecular and Cellular Biochemistry 359:1-2, pages 245-261.
Crossref
Pei-Yao Liu, Tsai-Yuan Hsieh, Shu-Ting Liu, Yung-Lung Chang, Wei-Shiang Lin, Wei-Ming Wang & Shih-Ming Huang. (2011) Zac1, an Sp1-like protein, regulates human p21 gene expression in HeLa cells. Experimental Cell Research 317:20, pages 2925-2937.
Crossref
Lianying Xie, Yongjun Wang, Shengyu Wang, Na Wu, Yuqiang Chen & Jianghua Yan. (2011) Adiponectin induces growth inhibition and apoptosis in cervical cancer HeLa cells. Biologia 66:4, pages 712-720.
Crossref
Markus Kaller, Sven-Thorsten Liffers, Silke Oeljeklaus, Katja Kuhlmann, Simone Röh, Reinhard Hoffmann, Bettina Warscheid & Heiko Hermeking. (2011) Genome-wide Characterization of miR-34a Induced Changes in Protein and mRNA Expression by a Combined Pulsed SILAC and Microarray Analysis. Molecular & Cellular Proteomics 10:8, pages M111.010462.
Crossref
L. Wang, L. Sun, J. Huang & M. Jiang. (2011) Cyclin-dependent kinase inhibitor 3 (CDKN3) novel cell cycle computational network between human non-malignancy associated hepatitis/cirrhosis and hepatocellular carcinoma (HCC) transformation. Cell Proliferation 44:3, pages 291-299.
Crossref
P Andorfer & H Rotheneder. (2011) EAPP: Gatekeeper at the crossroad of apoptosis and p21-mediated cell-cycle arrest. Oncogene 30:23, pages 2679-2690.
Crossref
Zhixiong Dong, Ruikang Tan, Jian Cao, Yang Yang, Chenfei Kong, Juan Du, Shan Zhu, Yu Zhang, Jun Lu, Baiqu Huang & Shuxia Liu. (2011) Discovery of polyoxometalate-based HDAC inhibitors with profound anticancer activity in vitro and in vivo. European Journal of Medicinal Chemistry 46:6, pages 2477-2484.
Crossref
Zhihao Wang, Bo Yang, Lanlan Dong, Biwen Peng, Xiaohua He & Wanhong Liu. (2011) A novel oncoprotein Pirh2: rising from the shadow of MDM2. Cancer Science 102:5, pages 909-917.
Crossref
I Savelyeva & M Dobbelstein. (2010) Infection with E1B-mutant adenovirus stabilizes p53 but blocks p53 acetylation and activity through E1A. Oncogene 30:7, pages 865-875.
Crossref
Anatoly A. Philimonenko, Jiri Janacek, Luc Snyers, Marlene Almeder, Walter Berger, Wolfgang Schmidt, Christian Schöfer, Pavel Hozák & Klara Weipoltshammer. (2011) Chromosomal dynamics of cell cycle regulator gene p21 during transcriptional activation. Journal of Structural Biology 173:2, pages 382-390.
Crossref
PENG GAO, FEI ZHAI, LEI GUAN & JIE ZHENG. (2011) Nordihydroguaiaretic acid inhibits growth of cervical cancer SiHa cells by up-regulating p21. Oncology Letters 2:1, pages 123-128.
Crossref
Guoqiang Sun, Chelsea Fu, Caroline Shen & Yanhong Shi. (2011) Histone Deacetylases in Neural Stem Cells and Induced Pluripotent Stem Cells. Journal of Biomedicine and Biotechnology 2011, pages 1-6.
Crossref
Elisabeth Simboeck, Anna Sawicka, Gordin Zupkovitz, Silvia Senese, Stefan Winter, Franck Dequiedt, Egon Ogris, Luciano Di Croce, Susanna Chiocca & Christian Seiser. (2010) A Phosphorylation Switch Regulates the Transcriptional Activation of Cell Cycle Regulator p21 by Histone Deacetylase Inhibitors. Journal of Biological Chemistry 285:52, pages 41062-41073.
Crossref
Lin Li & James R. Davie. (2010) The role of Sp1 and Sp3 in normal and cancer cell biology. Annals of Anatomy - Anatomischer Anzeiger 192:5, pages 275-283.
Crossref
Santhi D. KonduriRajesh MedisettyWensheng LiuBenny Abraham KaipparettuPratima SrivastavaHiltrud BrauchPeter FritzWendy M. SwetzigAmanda E. Gardner, Sohaib A. Khan & Gokul M. Das. (2010) Mechanisms of estrogen receptor antagonism toward p53 and its implications in breast cancer therapeutic response and stem cell regulation. Proceedings of the National Academy of Sciences 107:34, pages 15081-15086.
Crossref
Ruo-Kai Lin, Chiu-Yi Wu, Jer-Wei Chang, Li-Jung Juan, Han-Shui Hsu, Chih-Yi Chen, Yun-Yueh Lu, Yen-An Tang, Yi-Chieh Yang, Pan-Chyr Yang & Yi-Ching Wang. (2010) Dysregulation of p53/Sp1 Control Leads to DNA Methyltransferase-1 Overexpression in Lung Cancer. Cancer Research 70:14, pages 5807-5817.
Crossref
Thorsten Stühmer, Janine Arts, Manik Chatterjee, Johanna Borawski, André Wolff, Peter King, Hermann Einsele, Eugen Leo & Ralf C. Bargou. (2010) Preclinical anti-myeloma activity of the novel HDAC-inhibitor JNJ-26481585. British Journal of Haematology 149:4, pages 529-536.
Crossref
Jun-ichi AbeChen Yan. (2010) CCN Notch Signaling in Vascular Smooth Muscle Cells. Arteriosclerosis, Thrombosis, and Vascular Biology 30:4, pages 667-668.
Crossref
Teppei Yamaguchi, Fabien Cubizolles, Yu Zhang, Nina Reichert, Hubertus Kohler, Christian Seiser & Patrick Matthias. (2010) Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression. Genes & Development 24:5, pages 455-469.
Crossref
Matthias Ocker. (2010) Deacetylase inhibitors - focus on non-histone targets and effects. World Journal of Biological Chemistry 1:5, pages 55.
Crossref
Zahid H. Siddik. 2009. Checkpoint Controls and Targets in Cancer Therapy. Checkpoint Controls and Targets in Cancer Therapy 199 213 .
Janine Arts, Peter King, Ann Marin, Wim Floren, Ann Belin, Lut Janssen, Isabelle Pilatte, Bruno Roux, Laurence Decrane, Ron Gilissen, Ian Hickson, Veronique Vreys, Eugene Cox, Kees Bol, Willem Talloen, Ilse Goris, Luc Andries, Marc Du Jardin, Michel Janicot, Martin Page, Kristof van Emelen & Patrick Angibaud. (2009) JNJ-26481585, a Novel Second-Generation Oral Histone Deacetylase Inhibitor, Shows Broad-Spectrum Preclinical Antitumoral Activity. Clinical Cancer Research 15:22, pages 6841-6851.
Crossref
Magdalena Banach-Orlowska, Iwona Pilecka, Anna Torun, Beata Pyrzynska & Marta Miaczynska. (2009) Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex. Biochemical Journal 423:3, pages 389-400.
Crossref
T Cherrier, S Suzanne, L Redel, M Calao, C Marban, B Samah, R Mukerjee, C Schwartz, G Gras, B E Sawaya, S L Zeichner, D Aunis, C Van Lint & O Rohr. (2009) p21WAF1 gene promoter is epigenetically silenced by CTIP2 and SUV39H1. Oncogene 28:38, pages 3380-3389.
Crossref
Fraczek Joanna, Vinken Mathieu, Snykers Sarah, Deleu Sarah, Vanderkerken Karin, Vanhaecke Tamara & Rogiers Vera. (2009) Histone deacetylase inhibition and the regulation of cell growth with particular reference to liver pathobiology. Journal of Cellular and Molecular Medicine 13:9b, pages 2990-3005.
Crossref
Jurate Savickiene, Grazina Treigyte, Karl-Eric Magnusson & Ruta Navakauskiene. (2009) Response of Retinoic Acid-Resistant KG1 Cells to Combination of Retinoic Acid with Diverse Histone Deacetylase Inhibitors. Annals of the New York Academy of Sciences 1171:1, pages 321-333.
Crossref
Takuya Kato, Yohei Shimono, Masaki Hasegawa, Mayumi Jijiwa, Atsushi Enomoto, Naoya Asai, Yoshiki Murakumo & Masahide Takahashi. (2009) Characterization of the HDAC1 Complex That Regulates the Sensitivity of Cancer Cells to Oxidative Stress. Cancer Research 69:8, pages 3597-3604.
Crossref
Runhua Liu, Lizhong Wang, Guoyun Chen, Hiroto Katoh, Chong Chen, Yang Liu & Pan Zheng. (2009) FOXP3 Up-regulates p21 Expression by Site-Specific Inhibition of Histone Deacetylase 2/Histone Deacetylase 4 Association to the Locus . Cancer Research 69:6, pages 2252-2259.
Crossref
Ascensión Cuesta, Alberto Zambrano, María Royo & Angel Pascual. (2009) The tumour suppressor p53 regulates the expression of amyloid precursor protein (APP). Biochemical Journal 418:3, pages 643-650.
Crossref
Jasper Mullenders, Armida W. M. Fabius, Mandy Madiredjo, René Bernards & Roderick L. Beijersbergen. (2009) A Large Scale shRNA Barcode Screen Identifies the Circadian Clock Component ARNTL as Putative Regulator of the p53 Tumor Suppressor Pathway. PLoS ONE 4:3, pages e4798.
Crossref
D Mottet, S Pirotte, V Lamour, M Hagedorn, S Javerzat, A Bikfalvi, A Bellahcène, E Verdin & V Castronovo. (2008) HDAC4 represses p21WAF1/Cip1 expression in human cancer cells through a Sp1-dependent, p53-independent mechanism. Oncogene 28:2, pages 243-256.
Crossref
Patrick McDonel, Ita Costello & Brian Hendrich. (2009) Keeping things quiet: Roles of NuRD and Sin3 co-repressor complexes during mammalian development. The International Journal of Biochemistry & Cell Biology 41:1, pages 108-116.
Crossref
Zahid H. Siddik. 2009. Drug Resistance in Cancer Cells. Drug Resistance in Cancer Cells 209 231 .
Lukas Vrba, Damian J Junk, Petr Novak & Bernard W Futscher. (2008) p53 induces distinct epigenetic states at its direct target promoters. BMC Genomics 9:1.
Crossref
Arabinda Samanta, Bin Li, Xiaomin Song, Kathryn Bembas, Geng Zhang, Makoto Katsumata, Sandra J. Saouaf, Qiang Wang, Wayne W. Hancock, Yuan Shen & Mark I. Greene. (2008) TGF-β and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3. Proceedings of the National Academy of Sciences 105:37, pages 14023-14027.
Crossref
Shih-Shin Chang, You-Chang Lo, Huey-Huey Chua, Hsin-Yi Chiu, Shu-Chun Tsai, Jen-Yang Chen, Kwok-Wai Lo & Ching-Hwa Tsai. (2008) Critical Role of p53 in Histone Deacetylase Inhibitor-Induced Epstein-Barr Virus Zta Expression. Journal of Virology 82:15, pages 7745-7751.
Crossref
Pei-Yao Liu, James Yi-Hsin Chan, Hsiu-Chen Lin, Sung-Ling Wang, Shu-Ting Liu, Ching-Liang Ho, Li-Chien Chang & Shih-Ming Huang. (2008) Modulation of the Cyclin-Dependent Kinase Inhibitor p21WAF1/Cip1 Gene by Zac1 through the Antagonistic Regulators p53 and Histone Deacetylase 1 in HeLa Cells . Molecular Cancer Research 6:7, pages 1204-1214.
Crossref
Inken Wierstra. (2008) Sp1: Emerging roles—Beyond constitutive activation of TATA-less housekeeping genes. Biochemical and Biophysical Research Communications 372:1, pages 1-13.
Crossref
Axel Weber, Judith Marquardt, David Elzi, Nicole Forster, Sven Starke, Andre Glaum, Daisuke Yamada, Pierre-Antoine Defossez, Jeffrey Delrow, Robert N Eisenman, Holger Christiansen & Martin Eilers. (2008) Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation. The EMBO Journal 27:11, pages 1563-1574.
Crossref
C. Habold, A. Poehlmann, K. Bajbouj, R. Hartig, K.S. Korkmaz, A. Roessner & R. Schneider-Stock. (2008) Trichostatin A causes p53 to switch oxidative-damaged colorectal cancer cells from cell cycle arrest into apoptosis. Journal of Cellular and Molecular Medicine 12:2, pages 607-621.
Crossref
Panagiotis K. Politis, Sofia Akrivou, Catherine Hurel, Olga Papadodima & Rebecca Matsas. (2008) BM88/Cend1 is involved in histone deacetylase inhibition-mediated growth arrest and differentiation of neuroblastoma cells. FEBS Letters 582:5, pages 741-748.
Crossref
Colleen C. Spurling, Cassandra A. Godman, Emily J. Noonan, Theodore P. Rasmussen, Daniel W. Rosenberg & Charles Giardina. (2008) HDAC3 overexpression and colon cancer cell proliferation and differentiation. Molecular Carcinogenesis 47:2, pages 137-147.
Crossref
Abde M. AbukhdeirMichele I. Vitolo, Pedram ArganiAngelo M. De MarzoBedri KarakasHiroyuki KonishiJohn P. GustinJosh LauringJoseph P. GarayCourtney PendletonYuko KonishiBrian G. BlairKeith BrennerElizabeth Garrett-Mayer, Hetty CarrawayKurtis E. Bachman & Ben Ho Park. (2008) Tamoxifen-stimulated growth of breast cancer due to p21 loss. Proceedings of the National Academy of Sciences 105:1, pages 288-293.
Crossref
Wei-Yuan Chou, Ching-Liang Ho, Mei-Ling Tseng, Shu-Ting Liu, Li-Chen Yen & Shih-Ming Huang. (2008) Human Spot 14 protein is a p53-dependent transcriptional coactivator via the recruitment of thyroid receptor and Zac1. The International Journal of Biochemistry & Cell Biology 40:9, pages 1826-1834.
Crossref
Elena A. Ostrakhovitch, Per-Erik Olsson, Jonas von Hofsten & M. George Cherian. (2007) P53 mediated regulation of metallothionein transcription in breast cancer cells. Journal of Cellular Biochemistry 102:6, pages 1571-1583.
Crossref
J Arts, P Angibaud, A Mariën, W Floren, B Janssens, P King, J van Dun, L Janssen, T Geerts, R W Tuman, D L Johnson, L Andries, M Jung, M Janicot & K van Emelen. (2007) R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies. British Journal of Cancer 97:10, pages 1344-1353.
Crossref
P. Papeleu, A. Wullaert, G. Elaut, T. Henkens, M. Vinken, G. Laus, D. Tourwé, R. Beyaert, V. Rogiers & T. Vanhaecke. (2007) Inhibition of NF-?B activation by the histone deacetylase inhibitor 4-Me 2 N-BAVAH induces an early G 1 cell cycle arrest in primary hepatocytes . Cell Proliferation 40:5, pages 640-655.
Crossref
Debdutta Bandyopadhyay, Jonathan L. Curry, Qiushi Lin, Hunter W. Richards, Dahu Chen, Peter J. Hornsby, Nikolai A. Timchenko & Estela E. Medrano. (2007) Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi. Aging Cell 6:4, pages 577-591.
Crossref
Matthias Ocker & Regine Schneider-Stock. (2007) Histone deacetylase inhibitors: Signalling towards p21cip1/waf1. The International Journal of Biochemistry & Cell Biology 39:7-8, pages 1367-1374.
Crossref
Stephen H. K. Wong, Yangqing Zhao, Norberta W. Schoene, Chung-Ting Han, Rita S. M. Shih & Kai Y. Lei. (2007) Zinc deficiency depresses p21 gene expression: inhibition of cell cycle progression is independent of the decrease in p21 protein level in HepG2 cells. American Journal of Physiology-Cell Physiology 292:6, pages C2175-C2184.
Crossref
Lisa Y. Zhao, Aleixo Santiago, Jilin Liu & Daiqing Liao. (2007) Repression of p53-mediated Transcription by Adenovirus E1B 55-kDa Does Not Require Corepressor mSin3A and Histone Deacetylases. Journal of Biological Chemistry 282:10, pages 7001-7010.
Crossref
Paola Gallinari, Stefania Di Marco, Phillip Jones, Michele Pallaoro & Christian Steinkühler. (2007) HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics. Cell Research 17:3, pages 195-211.
Crossref
Stuart P. Atkinson & W. Nicol Keith. (2007) Epigenetic control of cellular senescence in disease: opportunities for therapeutic intervention. Expert Reviews in Molecular Medicine 9:7, pages 1-26.
Crossref
Kiyofumi Kaneshiro, Shuichi Tsutsumi, Shingo Tsuji, Katsuhiko Shirahige & Hiroyuki Aburatani. (2007) An integrated map of p53-binding sites and histone modification in the human ENCODE regions. Genomics 89:2, pages 178-188.
Crossref
Gerda Egger, Ana M. Aparicio, Sonia G. Escobar & Peter A. Jones. (2007) Inhibition of Histone Deacetylation Does Not Block Resilencing of p16 after 5-Aza-2′-Deoxycytidine Treatment. Cancer Research 67:1, pages 346-353.
Crossref
Pierre-Olivier Estève, Hang Gyeong Chin & Sriharsa Pradhan. (2007) Molecular Mechanisms of Transactivation and Doxorubicin-mediated Repression of survivin Gene in Cancer Cells. Journal of Biological Chemistry 282:4, pages 2615-2625.
Crossref
A Rebbaa, X Zheng, F Chu & B L Mirkin. (2006) The role of histone acetylation versus DNA damage in drug-induced senescence and apoptosis. Cell Death & Differentiation 13:11, pages 1960-1967.
Crossref
Jurate Savickiene, Veronika-Viktorija Borutinskaite, Grazina Treigyte, Karl-Eric Magnusson & Ruta Navakauskiene. (2006) The novel histone deacetylase inhibitor BML-210 exerts growth inhibitory, proapoptotic and differentiation stimulating effects on the human leukemia cell lines. European Journal of Pharmacology 549:1-3, pages 9-18.
Crossref
Ann Beliën, Stefanie De Schepper, Wim Floren, Boud Janssens, Ann Mariën, Peter King, Jacky Van Dun, Luc Andries, Jan Voeten, Luc Bijnens, Michel Janicot & Janine Arts. (2006) Real-time gene expression analysis in human xenografts for evaluation of histone deacetylase inhibitors. Molecular Cancer Therapeutics 5:9, pages 2317-2323.
Crossref
James G. Jackson & Olivia M. Pereira-Smith. (2006) p53 Is Preferentially Recruited to the Promoters of Growth Arrest Genes p21 and GADD45 during Replicative Senescence of Normal Human Fibroblasts . Cancer Research 66:17, pages 8356-8360.
Crossref
Chiachen Chen, Yuan-Ching Chang, Chien-Liang Liu, King-Jen Chang & Ing-Cherng Guo. (2006) Leptin-induced growth of human ZR-75-1 breast cancer cells is associated with up-regulation of cyclin D1 and c-Myc and down-regulation of tumor suppressor p53 and p21WAF1/CIP1. Breast Cancer Research and Treatment 98:2, pages 121-132.
Crossref
Jaron Lockett, Shuping Yin, Xiaohua Li, Yonghong Meng & Shijie Sheng. (2006) Tumor suppressive maspin and epithelial homeostasis. Journal of Cellular Biochemistry 97:4, pages 651-660.
Crossref
Dominique Meunier & Christian Seiser. 2006. Histone Deacetylases. Histone Deacetylases 3 22 .
Stuart A. Scott, Wei-Feng Dong, Ryo Ichinohasama, Calley Hirsch, David Sheridan, Stephen E. Sanche, C. Ronald Geyer & John F. DeCoteau. (2006) 5-Aza-2′-deoxycytidine (decitabine) can relieve p21WAF1 repression in human acute myeloid leukemia by a mechanism involving release of histone deacetylase 1 (HDAC1) without requiring p21WAF1 promoter demethylation. Leukemia Research 30:1, pages 69-76.
Crossref
Robert F Place, Emily J Noonan & Charles Giardina. (2005) HDACs and the senescent phenotype of WI-38 cells. BMC Cell Biology 6:1.
Crossref
Xiao-Nan Li, Qin Shu, Jack Men-Feng Su, Laszlo Perlaky, Susan M. Blaney & Ching C. Lau. (2005) Valproic acid induces growth arrest, apoptosis, and senescence in medulloblastomas by increasing histone hyperacetylation and regulating expression of p21Cip1, CDK4, and CMYC. Molecular Cancer Therapeutics 4:12, pages 1912-1922.
Crossref
. (2005) Modulacon of Cell Cycle Control by Histone Deacetylase Inhibitor Trichostatin A in A549 Human Non-small Cell Lung Cancer Cells. Journal of Life Science 15:5, pages 726-733.
Crossref
Regine Schneider-Stock, Albert Roessner & Oliver Ullrich. (2005) Methyltransferases in apoptosis and cancer. Signal Transduction 5:4, pages 169-176.
Crossref
George Koutsodontis, Eleftheria Vasilaki, Wan-Chih Chou, Paraskevi Papakosta & Dimitris Kardassis. (2005) Physical and functional interactions between members of the tumour suppressor p53 and the Sp families of transcription factors: importance for the regulation of genes involved in cell-cycle arrest and apoptosis. Biochemical Journal 389:2, pages 443-455.
Crossref
Jan-Hermen Dannenberg, Gregory David, Sheng Zhong, Jaco van der Torre, Wing H. Wong & Ronald A. DePinho. (2005) mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival. Genes & Development 19:13, pages 1581-1595.
Crossref
Andrei L. Gartel & Senthil K. Radhakrishnan. (2005) Lost in Transcription: p21 Repression, Mechanisms, and Consequences. Cancer Research 65:10, pages 3980-3985.
Crossref
S Roy, K Packman, R Jeffrey & M Tenniswood. (2005) Histone deacetylase inhibitors differentially stabilize acetylated p53 and induce cell cycle arrest or apoptosis in prostate cancer cells. Cell Death & Differentiation 12:5, pages 482-491.
Crossref
Claudia A. Krusche, Pia W�lfing, Christian Kersting, Anne Vloet, Werner B�cker, Ludwig Kiesel, Henning M. Beier & Joachim Alfer. (2005) Histone deacetylase-1 and -3 protein expression in human breast cancer: a tissue microarray analysis. Breast Cancer Research and Treatment 90:1, pages 15-23.
Crossref
Steven A. Innocente & Jonathan M. Lee. (2005) p53 is a NF-Y- and p21-independent, Sp1-dependent repressor of cyclin B1 transcription. FEBS Letters 579:5, pages 1001-1007.
Crossref
Abraham NudelmanInesa LevovichSuzanne M. CuttsDon R. PhillipsAda Rephaeli. (2005) The Role of Intracellularly Released Formaldehyde and Butyric Acid in the Anticancer Activity of Acyloxyalkyl Esters. Journal of Medicinal Chemistry 48:4, pages 1042-1054.
Crossref
Hao Fan, Jessica R. Harrell, Susana Dipp, Zubaida Saifudeen & Samir S. El-Dahr. (2005) A novel pathological role of p53 in kidney development revealed by gene-environment interactions. American Journal of Physiology-Renal Physiology 288:1, pages F98-F107.
Crossref
Yoshitsugu Mitani, Naohide Oue, Yoichi Hamai, Phyu Phyu Aung, Shunji Matsumura, Hirofumi Nakayama, Nobuyuki Kamata & Wataru Yasui. (2005) Histone H3 acetylation is associated with reduced p21WAF1/CIP1 expression by gastric carcinoma. The Journal of Pathology 205:1, pages 65-73.
Crossref
Jinghai Wu & Jerry B Lingrel. (2004) KLF2 inhibits Jurkat T leukemia cell growth via upregulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1. Oncogene 23:49, pages 8088-8096.
Crossref
Hidetaka Uramoto, Anders Hackzell, Daniel Wetterskog, Andrea Ballági, Hiroto Izumi & Keiko Funa. (2004) pRb, Myc and p53 are critically involved in SV40 large T antigen repression of PDGF β-receptor transcription. Journal of Cell Science 117:17, pages 3855-3865.
Crossref
Tomoya Yokota, Youichirou Matsuzaki, Kazuhiro Miyazawa, Frederique Zindy, Martine F Roussel & Toshiyuki Sakai. (2004) Histone deacetylase inhibitors activate INK4d gene through Sp1 site in its promoter. Oncogene 23:31, pages 5340-5349.
Crossref
Hanxin Lu, Cynthia A. Pise-Masison, Rebecca Linton, Hyeon Ung Park, R. Louis Schiltz, Vittorio Sartorelli & John N. Brady. (2004) Tax Relieves Transcriptional Repression by Promoting Histone Deacetylase 1 Release from the Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat. Journal of Virology 78:13, pages 6735-6743.
Crossref
Moon-Moo Kim, Sang-Oh Yoon, Yee Sook Cho & An-Sik Chung. (2004) Histone deacetylases, HDAC1 and HSIR2, act as a negative regulator of ageing through p53 in human gingival fibroblast. Mechanisms of Ageing and Development 125:5, pages 351-357.
Crossref
Yu-Long Liang, Yi Fu, Si-Gang Chen, Xiu-Mei Cai, Jian-Min Su, Jia-Wei Jin, Dong-Zhu Ma, Zeng-Xia Li, Wen Zhang & Xiliang Zha. (2004) Integrin β1 subunit overexpressed in the SMMC-7721 cells regulates the promoter activity of p21 CIP1 and enhances its transcription . FEBS Letters 558:1-3, pages 107-113.
Crossref
Paul A. Marks, Victoria M. Richon, Thomas Miller & William Kevin Kelly. 2004. 137 168 .
Natalia N Kartasheva, Claudia Lenz-Bauer, Oliver Hartmann, Helmut Schäfer, Martin Eilers & Matthias Dobbelstein. (2003) ΔNp73 can modulate the expression of various genes in a p53-independent fashion. Oncogene 22:51, pages 8246-8254.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.