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Molecular and Cellular Biology Volume 23, 2003 - Issue 9
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Cell Growth and Development

Dimerization of MLH1 and PMS2 Limits Nuclear Localization of MutLα

Xiaosheng Wu1 Transplantation Biology;2 Departments of Biochemistry and Molecular Biology;3 Surgery
,
Jeffrey L. Platt1 Transplantation Biology;3 Surgery;4 Immunology;5 Pediatrics, Mayo Clinic, Rochester, Minnesota55905
&
Marilia Cascalho1 Transplantation Biology;3 Surgery;4 Immunology;5 Pediatrics, Mayo Clinic, Rochester, Minnesota55905Correspondence[email protected]
Pages 3320-3328 | Received 04 Nov 2002, Accepted 31 Jan 2003, Published online: 27 Mar 2023

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Stephanie S. Tseng-Rogenski, Koji Munakata, Daniel Y. Choi, Paul K. Martin, Supal Mehta, Minoru Koi, Wei Zheng, Yang Zhang & John M. Carethers. (2020) The Human DNA Mismatch Repair Protein MSH3 Contains Nuclear Localization and Export Signals That Enable Nuclear-Cytosolic Shuttling in Response to Inflammation. Molecular and Cellular Biology 40:13.
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Yuhong Luo, Fang-Tsyr Lin & Weei-Chin Lin. (2004) ATM-Mediated Stabilization of hMutL DNA Mismatch Repair Proteins Augments p53 Activation during DNA Damage. Molecular and Cellular Biology 24:14, pages 6430-6444.
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Hannah G. Daniels, Breanna G. Knicely, Anna Kristin Miller, Ana Thompson, Rina Plattner & Eva M. Goellner. (2022) Inhibition of ABL1 by tyrosine kinase inhibitors leads to a downregulation of MLH1 by Hsp70-mediated lysosomal protein degradation. Frontiers in Genetics 13.
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Hamine C. de Oliveira, Tainá D. da Silva, Guilherme H. M. Salvador, Ivan R. Moraes, Cíntia A. Fukuda, Andrea C. de Barros & Marcos R. M. Fontes. (2021) Structural and calorimetric studies reveal specific determinants for the binding of a high-affinity NLS to mammalian importin-alpha. Biochemical Journal 478:13, pages 2715-2732.
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Amanda B Abildgaard, Amelie Stein, Sofie V Nielsen, Katrine Schultz-Knudsen, Elena Papaleo, Amruta Shrikhande, Eva R Hoffmann, Inge Bernstein, Anne-Marie Gerdes, Masanobu Takahashi, Chikashi Ishioka, Kresten Lindorff-Larsen & Rasmus Hartmann-Petersen. (2019) Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome. eLife 8.
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Jiaquan Liu, Jong-Bong Lee & Richard Fishel. (2018) Stochastic Processes and Component Plasticity Governing DNA Mismatch Repair. Journal of Molecular Biology 430:22, pages 4456-4468.
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J. Blount & A. Prakash. (2018) The changing landscape of Lynch syndrome due to PMS2 mutations . Clinical Genetics 94:1, pages 61-69.
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Ana Janic, Liz J. Valente, Matthew J. Wakefield, Leon Di Stefano, Liz Milla, Stephen Wilcox, Haoyu Yang, Lin Tai, Cassandra J. Vandenberg, Andrew J. Kueh, Shinsuke Mizutani, Margs S. Brennan, Robyn L. Schenk, Lisa M. Lindqvist, Anthony T. Papenfuss, Liam O’Connor, Andreas Strasser & Marco J. Herold. (2018) DNA repair processes are critical mediators of p53-dependent tumor suppression. Nature Medicine 24:7, pages 947-953.
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Thomas Gross, Suvi Broholm & Annette Becker. (2018) CRABS CLAW Acts as a Bifunctional Transcription Factor in Flower Development. Frontiers in Plant Science 9.
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Andrea C. de Barros, Agnes A.S. Takeda, Thiago R. Dreyer, Adrian Velazquez-Campoy, Boštjan Kobe & Marcos R.M. Fontes. (2018) DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway. Biochimie 146, pages 87-96.
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Catherine Zilberg, Matthew Weicai Lee, Bing Yu, Bruce Ashford, Spiridoula Kraitsek, Marie Ranson, Kerwin Shannon, Mark Cowley, N Gopalakrishna Iyer, Carsten E Palme, Sydney Ch'ng, Tsu-Hui(Hubert) Low, Sandra O'Toole, Jonathan R Clark & Ruta Gupta. (2018) Analysis of clinically relevant somatic mutations in high-risk head and neck cutaneous squamous cell carcinoma. Modern Pathology 31:2, pages 275-287.
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ArtiS Pandey & Sudip Shrestha. (2018) A novel frameshift mutation in the MLH1 gene in a patient with Lynch syndrome. Indian Journal of Cancer 55:4, pages 410.
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Jared M. Fischer, Sandra Dudley, Ashleigh J. Miller & R. Michael Liskay. (2016) An intact Pms2 ATPase domain is not essential for male fertility. DNA Repair 39, pages 46-51.
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Javier Peña-Diaz & Lene Juel Rasmussen. (2016) Approaches to diagnose DNA mismatch repair gene defects in cancer. DNA Repair 38, pages 147-154.
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Tobias T. Schmidt & Hans Hombauer. (2016) Visualization of mismatch repair complexes using fluorescence microscopy. DNA Repair 38, pages 58-67.
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Alba Guarné & Jean-Baptiste Charbonnier. (2015) Insights from a decade of biophysical studies on MutL: Roles in strand discrimination and mismatch removal. Progress in Biophysics and Molecular Biology 117:2-3, pages 149-156.
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Zuoyun Wang, Yihua Sun, Bin Gao, Yi Lu, Rong Fang, Yijun Gao, Tian Xiao, Xin-Yuan Liu, William Pao, Yun Zhao, Haiquan Chen & Hongbin Ji. (2014) Two co-existing germline mutations P53 V157D and PMS2 R20Q promote tumorigenesis in a familial cancer syndrome. Cancer Letters 342:1, pages 36-42.
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Fernando Grigera, Alfonso Bellacosa & Amy L. Kenter. (2013) Complex Relationship between Mismatch Repair Proteins and MBD4 during Immunoglobulin Class Switch Recombination. PLoS ONE 8:10, pages e78370.
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Jinghui Jia, Yuan Zhang, Jing Cai, Junjie Wang, Hui Ding, Jun Zhou, Fang Fang & Zehua Wang. (2013) A novel function of protein kinase B as an inducer of the mismatch repair gene hPMS2 degradation. Cellular Signalling 25:6, pages 1498-1504.
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Lene Juel Rasmussen, Christopher D. Heinen, Brigitte Royer-Pokora, Mark Drost, Sean Tavtigian, Robert M.W. Hofstra & Niels de Wind. (2012) Pathological assessment of mismatch repair gene variants in Lynch syndrome: Past, present, and future. Human Mutation 33:12, pages 1617-1625.
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Guogen Mao, Sanghee Lee, Janice Ortega, Liya Gu & Guo-Min Li. (2012) Modulation of microRNA processing by mismatch repair protein MutLα. Cell Research 22:6, pages 973-985.
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Angela Brieger, Guido Plotz, Inga Hinrichsen, Sandra Passmann, Ronja Adam & Stefan Zeuzem. (2012) C-Terminal Fluorescent Labeling Impairs Functionality of DNA Mismatch Repair Proteins. PLoS ONE 7:2, pages e31863.
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Mohammed Tarique, Akash Tripathi Satsangi, Moaz Ahmad, Shailja Singh & Renu Tuteja. (2012) Plasmodium falciparum MLH is schizont stage specific endonuclease. Molecular and Biochemical Parasitology 181:2, pages 153-161.
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Angela Brieger, Ronja Adam, Sandra Passmann, Guido Plotz, Stefan Zeuzem & Jörg Trojan. (2011) A CRM1-dependent nuclear export pathway is involved in the regulation of MutLα subcellular localization. Genes, Chromosomes and Cancer 50:2, pages 59-70.
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Vivian Leong, Jessica Lorenowicz, Natalie Kozij & Alba Guarné. (2009) Nuclear import of human MLH1, PMS2, and MutLα: Redundancy is the key. Molecular Carcinogenesis 48:8, pages 742-750.
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Nina Østergaard Knudsen, Sofie Dabros Andersen, Anne Lützen, Finn Cilius Nielsen & Lene Juel Rasmussen. (2009) Nuclear translocation contributes to regulation of DNA excision repair activities. DNA Repair 8:6, pages 682-689.
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Alicia P. Hayes, Leah A. Sevi, Megan C. Feldt, Mark D. Rose & Alison E. Gammie. (2009) Reciprocal regulation of nuclear import of the yeast MutSα DNA mismatch repair proteins Msh2 and Msh6. DNA Repair 8:6, pages 739-751.
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