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Cell Growth and Development

p50α/p55α Phosphoinositide 3-Kinase Knockout Mice Exhibit Enhanced Insulin Sensitivity

Dong ChenResearch Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts
,
Franck Mauvais-JarvisResearch Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts
,
Matthias BluherResearch Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts
,
Simon J. FisherResearch Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts
,
Alison JozsiResearch Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts
,
Laurie J. GoodyearResearch Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts
,
Kohjiro UekiResearch Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts
&
C. Ronald KahnResearch Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MassachusettsCorrespondence[email protected]
 show all
Pages 320-329 | Received 23 Apr 2003, Accepted 18 Sep 2003, Published online: 27 Mar 2023

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Carrie E McCurdy & Dwight J Klemm. (2013) Adipose tissue insulin sensitivity and macrophage recruitment. Adipocyte 2:3, pages 135-142.
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Laura Braccini, Elisa Ciraolo, Fulvio Morello, Xiaoyun Lu & Emilio Hirsch. (2009) PI3K signaling: a crossroads of metabolic regulation. Expert Review of Endocrinology & Metabolism 4:4, pages 349-357.
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Jean S. Oak & David A. Fruman. (2007) Role of phosphoinositide 3-kinase signaling in autoimmunity. Autoimmunity 40:6, pages 433-441.
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Saskia M. Brachmann, Kohjiro Ueki, Jeffrey A. Engelman, Ronald C. Kahn & Lewis C. Cantley. (2005) Phosphoinositide 3-Kinase Catalytic Subunit Deletion and Regulatory Subunit Deletion Have Opposite Effects on Insulin Sensitivity in Mice. Molecular and Cellular Biology 25:5, pages 1596-1607.
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S Pensa, K Neoh, H K Resemann, P A Kreuzaler, K Abell, N J Clarke, T Reinheckel, C R Kahn & C J Watson. (2014) The PI3K regulatory subunits p55α and p50α regulate cell death in vivo. Cell Death & Differentiation 21:9, pages 1442-1450.
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Weijun Pang, Yu Wang, Ning Wei, Ruxiang Xu, Yan Xiong, Ping Wang, Qingwu Shen & Gongshe Yang. (2013) Sirt1 Inhibits Akt2-Mediated Porcine Adipogenesis Potentially by Direct Protein-Protein Interaction. PLoS ONE 8:8, pages e71576.
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Tamas Balla. (2013) Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation. Physiological Reviews 93:3, pages 1019-1137.
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Shafi Kuchay, Shanshan Duan, Emily Schenkein, Angelo Peschiaroli, Anita Saraf, Laurence Florens, Michael P. Washburn & Michele Pagano. (2013) FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade. Nature Cell Biology 15:5, pages 472-480.
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Carrie E. McCurdy, Simon Schenk, Michael J. Holliday, Andrew Philp, Julie A. Houck, David Patsouris, Paul S. MacLean, Susan M. Majka, Dwight J. Klemm & Jacob E. Friedman. (2012) Attenuated Pik3r1 Expression Prevents Insulin Resistance and Adipose Tissue Macrophage Accumulation in Diet-Induced Obese Mice . Diabetes 61:10, pages 2495-2505.
Crossref
Subha Krishnan, Raghuveer Singh Mali, Baskar Ramdas, Emily Sims, Peilin Ma, Joydeep Ghosh, Veerendra Munugalavadla, Philip Hanneman, Joal D. Beane & Reuben Kapur. (2012) p85β regulatory subunit of class IA PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis. Blood 119:17, pages 3951-3961.
Crossref
Alessandra Ghigo, Fulvio Morello, Alessia Perino & Emilio Hirsch. 2012. Phosphoinositides I: Enzymes of Synthesis and Degradation. Phosphoinositides I: Enzymes of Synthesis and Degradation 183 213 .
Simon Schenk, Carrie E. McCurdy, Andrew Philp, Mark Z. Chen, Michael J. Holliday, Gautum K. Bandyopadhyay, Olivia Osborn, Keith Baar & Jerrold M. Olefsky. (2011) Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction. Journal of Clinical Investigation 121:11, pages 4281-4288.
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Ida Soto-Rodríguez, Evelyn Pulido-Camarillo, Guillermo Hernández-Diaz, Alfonso Alexander-Aguilera & Hugo S. Garcia. (2011) A CLA enriched diet improves organ damage associated with the metabolic syndrome in spontaneous hypertensive rats. Grasas y Aceites 62:1, pages 49-54.
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Sandra Pereira & Adria Giacca. 2011. Insulin Resistance and Cancer. Insulin Resistance and Cancer 1 52 .
Jose Donato Jr., Renata Frazão & Carol Fuzeti Elias. (2010) The PI3K signaling pathway mediates the biological effects of leptin. Arquivos Brasileiros de Endocrinologia & Metabologia 54:7, pages 591-602.
Crossref
Jonathon N Winnay, Jeremie Boucher, Marcelo A Mori, Kohjiro Ueki & C Ronald Kahn. (2010) A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box–binding protein-1 to modulate the unfolded protein response. Nature Medicine 16:4, pages 438-445.
Crossref
Raju V.S Rajala. (2010) Phosphoinositide 3-kinase signaling in the vertebrate retina. Journal of Lipid Research 51:1, pages 4-22.
Crossref
David A. Fruman. 2010. Handbook of Cell Signaling. Handbook of Cell Signaling 1049 1060 .
Lazaros C. Foukas & Dominic J. Withers. 2011. Phosphoinositide 3-kinase in Health and Disease. Phosphoinositide 3-kinase in Health and Disease 115 141 .
David A. Fruman. 2011. Phosphoinositide 3-kinase in Health and Disease. Phosphoinositide 3-kinase in Health and Disease 225 244 .
Jennifer W. HillYong XuFrederic PreitnerMakota Fukuda, You-Ree ChoJi LuoNina Balthasar, Roberto CoppariLewis C. CantleyBarbara B. KahnJean J. ZhaoJoel K. Elmquist. (2009) Phosphatidyl Inositol 3-Kinase Signaling in Hypothalamic Proopiomelanocortin Neurons Contributes to the Regulation of Glucose Homeostasis. Endocrinology 150:11, pages 4874-4882.
Crossref
Carla Mouta-Bellum, Aleksander Kirov, Laura Miceli-Libby, Maria L. Mancini, Tatiana V. Petrova, Lucy Liaw, Igor Prudovsky, Philip E. Thorpe, Naoyuki Miura, Lewis C. Cantley, Kari Alitalo, David A. Fruman & Calvin P.H. Vary. (2009) Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85α, p55α, and p50α. Developmental Dynamics 238:10, pages 2670-2679.
Crossref
Pixu Liu, Hailing Cheng, Thomas M. Roberts & Jean J. Zhao. (2009) Targeting the phosphoinositide 3-kinase pathway in cancer. Nature Reviews Drug Discovery 8:8, pages 627-644.
Crossref
Thais de Castro Barbosa, José Edgar Nicoletti de Carvalho, Leonice Lourenço Poyares, Silvana Bordin, Ubiratan Fabres Machado & Maria Tereza Nunes. (2009) Potential Role of Growth Hormone in Impairment of Insulin Signaling in Skeletal Muscle, Adipose Tissue, and Liver of Rats Chronically Treated with Arginine. Endocrinology 150:5, pages 2080-2086.
Crossref
Kazutaka Aoki, Junji Matsui, Naoto Kubota, Hiromu Nakajima, Keiji Iwamoto, Iseki Takamoto, Youki Tsuji, Akira Ohno, Shuuichi Mori, Kumpei Tokuyama, Koji Murakami, Tomoichiro Asano, Shinichi Aizawa, Kazuyuki Tobe, Takashi Kadowaki & Yasuo Terauchi. (2009) Role of the liver in glucose homeostasis in PI 3-kinase p85 α-deficient mice . American Journal of Physiology-Endocrinology and Metabolism 296:4, pages E842-E853.
Crossref
Klaartje Kok, Barbara Geering & Bart Vanhaesebroeck. (2009) Regulation of phosphoinositide 3-kinase expression in health and disease. Trends in Biochemical Sciences 34:3, pages 115-127.
Crossref
Oliver Renner, Carmen Blanco-Aparicio & Amancio Carnero. (2008) Genetic modelling of the PTEN/AKT pathway in cancer research. Clinical and Translational Oncology 10:10, pages 618-627.
Crossref
Simon Schenk, Maziyar Saberi & Jerrold M. Olefsky. (2008) Insulin sensitivity: modulation by nutrients and inflammation. Journal of Clinical Investigation 118:9, pages 2992-3002.
Crossref
Jürgen Klammt, Roland Pfäffle, Haim Werner & Wieland Kiess. (2008) IGF signaling defects as causes of growth failure and IUGR. Trends in Endocrinology & Metabolism 19:6, pages 197-205.
Crossref
Jacob E. Friedman, John P. Kirwan, Ming Jing, Larraine Presley & Patrick M. Catalano. (2008) Increased Skeletal Muscle Tumor Necrosis Factor-α and Impaired Insulin Signaling Persist in Obese Women With Gestational Diabetes Mellitus 1 Year Postpartum. Diabetes 57:3, pages 606-613.
Crossref
Catherine Le Stunff, Agnès Dechartres, Virginie Mariot, Chantal Lotton, Cecelia Trainor, Emanuele Miraglia Del Giudice, David Meyre, Ivan Bieche, Ingrid Laurendeau, Philippe Froguel, Diana Zelenika, Dani Fallin, Mark Lathrop, Paul-Henri Roméo & Pierre Bougnères. (2008) Association Analysis Indicates That a Variant GATA-Binding Site in the PIK3CB Promoter Is a Cis-Acting Expression Quantitative Trait Locus for This Gene and Attenuates Insulin Resistance in Obese Children . Diabetes 57:2, pages 494-502.
Crossref
Deborah J. Good. 2008. Sourcebook of Models for Biomedical Research. Sourcebook of Models for Biomedical Research 683 702 .
Ling HeJohn C. MareckiGinette Serrero, Frank A. SimmenMartin J. J. RonisThomas M. Badger. (2007) Dose-Dependent Effects of Alcohol on Insulin Signaling: Partial Explanation for Biphasic Alcohol Impact on Human Health. Molecular Endocrinology 21:10, pages 2541-2550.
Crossref
Barbara Geering, Pedro R. Cutillas, Gemma Nock, Severine I. Gharbi & Bart Vanhaesebroeck. (2007) Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers. Proceedings of the National Academy of Sciences 104:19, pages 7809-7814.
Crossref
B. GeeringP.R. CutillasB. Vanhaesebroeck. (2007) Regulation of class IA PI3Ks: is there a role for monomeric PI3K subunits?. Biochemical Society Transactions 35:2, pages 199-203.
Crossref
Domingo F. BarberMaria Alvarado-KristenssonAna González-GarcíaRafael PulidoAna C. Carrera. (2006) PTEN Regulation, a Novel Function for the p85 Subunit of Phosphoinositide 3-Kinase. Science's STKE 2006:362.
Crossref
Y. Jamshidi, H. Snieder, X. Wang, M. J. Pavitt, T. D. Spector, N. D. Carter & S. D. O’Dell. (2006) Phosphatidylinositol 3-kinase p85α regulatory subunit gene PIK3R1 haplotype is associated with body fat and serum leptin in a female twin population. Diabetologia 49:11, pages 2659-2667.
Crossref
Cullen M. TaniguchiThien T. TranTatsuya KondoJi Luo, Kohjiro Ueki, Lewis C. Cantley & C. Ronald Kahn. (2006) Phosphoinositide 3-kinase regulatory subunit p85α suppresses insulin action via positive regulation of PTEN. Proceedings of the National Academy of Sciences 103:32, pages 12093-12097.
Crossref
Joan K Riley & Kelle H Moley. (2006) Glucose utilization and the PI3-K pathway: mechanisms for cell survival in preimplantation embryos. Reproduction 131:5, pages 823-835.
Crossref
Ji Luo, Cassandra L. Sobkiw, Michael F. Hirshman, M. Nicole Logsdon, Timothy Q. Li, Laurie J. Goodyear & Lewis C. Cantley. (2006) Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia. Cell Metabolism 3:5, pages 355-366.
Crossref
Ronaldo C. Araújo, Marcelo A. Mori, Vanessa F. Merino, Jean-Loup Bascands, Joost P. Schanstra, Ricardo L. Zollner, Conceição A. Villela, Clovis R. Nakaie, Antonio C.M. Paiva, Jorge L. Pesquero, Michael Bader & João B. Pesquero. (2006) Role of the kinin B1 receptor in insulin homeostasis and pancreatic islet function. Biological Chemistry 387:4, pages 431-436.
Crossref
Tuomo Rankinen, Aamir Zuberi, Yvon C. Chagnon, S. John Weisnagel, George Argyropoulos, Brandon Walts, Louis Pérusse & Claude Bouchard. (2006) The Human Obesity Gene Map: The 2005 Update. Obesity 14:4, pages 529-644.
Crossref
Cullen M. Taniguchi, Brice Emanuelli & C. Ronald Kahn. (2006) Critical nodes in signalling pathways: insights into insulin action. Nature Reviews Molecular Cell Biology 7:2, pages 85-96.
Crossref
Sudha B. Biddinger & C. Ronald Kahn. (2006) FROM MICE TO MEN: Insights into the Insulin Resistance Syndromes. Annual Review of Physiology 68:1, pages 123-158.
Crossref
N. Neubauer & R. N. Kulkarni. (2006) Molecular Approaches to Study Control of Glucose Homeostasis. ILAR Journal 47:3, pages 199-211.
Crossref
Gautam K. Bandyopadhyay, Joseph G. Yu, Jachelle Ofrecio & Jerold M. Olefsky. (2005) Increased p85/55/50 Expression and Decreased Phosphotidylinositol 3-Kinase Activity in Insulin-Resistant Human Skeletal Muscle. Diabetes 54:8, pages 2351-2359.
Crossref
Ji Luo, Seth J. Field, Jennifer Y. Lee, Jeffrey A. Engelman & Lewis C. Cantley. (2005) The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex. Journal of Cell Biology 170:3, pages 455-464.
Crossref
Ji Luo, Cassandra L. Sobkiw, Nicole M. Logsdon, John M. Watt, Sabina Signoretti, Fionnuala O'Connell, Eyoung Shin, Youngju Shim, Lily Pao, Benjamin G. Neel, Ronald A. DePinho, Massimo Loda & Lewis C. Cantley. (2005) Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN +/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase . Proceedings of the National Academy of Sciences 102:29, pages 10238-10243.
Crossref
Carrie E. McCurdy, Robert T. Davidson & Gregory D. Cartee. (2005) Calorie restriction increases the ratio of phosphatidylinositol 3-kinase catalytic to regulatory subunits in rat skeletal muscle. American Journal of Physiology-Endocrinology and Metabolism 288:5, pages E996-E1001.
Crossref
Bart Vanhaesebroeck, Khaled Ali, Antonio Bilancio, Barbara Geering & Lazaros C. Foukas. (2005) Signalling by PI3K isoforms: insights from gene-targeted mice. Trends in Biochemical Sciences 30:4, pages 194-204.
Crossref
Louis Pérusse, Tuomo Rankinen, Aamir Zuberi, Yvon C. Chagnon, S. John Weisnagel, George Argyropoulos, Brandon Walts, Eric E. Snyder & Claude Bouchard. (2005) The Human Obesity Gene Map: The 2004 Update. Obesity Research 13:3, pages 381-490.
Crossref
Thomas F. Franke & Daniel C. Berwick. 2005. Signaling Pathways in Liver Diseases. Signaling Pathways in Liver Diseases 239 257 .
Beverley Kramer & Rochelle Buffenstein. (2004) The pancreas of the naked mole-rat (Heterocephalus glaber): an ultrastructural and immunocytochemical study of the endocrine component of thermoneutral and cold acclimated animals. General and Comparative Endocrinology 139:3, pages 206-214.
Crossref
Khaled Ali, Antonio Bilancio, Matthew Thomas, Wayne Pearce, Alasdair M. Gilfillan, Christine Tkaczyk, Nicolas Kuehn, Alexander Gray, June Giddings, Emma Peskett, Roy Fox, Ian Bruce, Christoph Walker, Carol Sawyer, Klaus Okkenhaug, Peter Finan & Bart Vanhaesebroeck. (2004) Essential role for the p110δ phosphoinositide 3-kinase in the allergic response. Nature 431:7011, pages 1007-1011.
Crossref

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