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Molecular and Cellular Biology Volume 24, 2004 - Issue 11
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Cell Growth and Development

Mutations in the SAM Domain of the ETV6-NTRK3 Chimeric Tyrosine Kinase Block Polymerization and Transformation Activity

Cristina E. Tognon1 Departments of Pathology and Pediatrics, British Columbia Research Institute for Children's and Women's Health, Vancouver, British ColumbiaV5Z 4H4
,
Cameron D. Mackereth2 Departments of Biochemistry and Molecular Biology and Chemistry and Biotechnology Laboratory, University of British Columbia, Vancouver, British ColumbiaV6T 1Z3
,
Aruna M. Somasiri3 Department of Anatomy, University of British Columbia, Vancouver, British ColumbiaV6H 3V5, Canada
,
Lawrence P. McIntosh2 Departments of Biochemistry and Molecular Biology and Chemistry and Biotechnology Laboratory, University of British Columbia, Vancouver, British ColumbiaV6T 1Z3
&
Poul H. B. Sorensen1 Departments of Pathology and Pediatrics, British Columbia Research Institute for Children's and Women's Health, Vancouver, British ColumbiaV5Z 4H4Correspondence[email protected]
Pages 4636-4650 | Received 17 Oct 2003, Accepted 02 Mar 2004, Published online: 27 Mar 2023

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Jie Zhang, Thomas G. W. Graham, Pavithra Vivekanand, Lauren Cote, Maureen Cetera & Ilaria Rebay. (2010) Sterile Alpha Motif Domain-Mediated Self-Association Plays an Essential Role in Modulating the Activity of the Drosophila ETS Family Transcriptional Repressor Yan. Molecular and Cellular Biology 30:5, pages 1158-1170.
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Matthew J. Martin, Nataliya Melnyk, Michelle Pollard, Mary Bowden, Hon Leong, Thomas J. Podor, Martin Gleave & Poul H. B. Sorensen. (2006) The Insulin-Like Growth Factor I Receptor Is Required for Akt Activation and Suppression of Anoikis in Cells Transformed by the ETV6-NTRK3 Chimeric Tyrosine Kinase. Molecular and Cellular Biology 26:5, pages 1754-1769.
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Jeong Eun Park, Alexander I. Son, Rui Hua, Lianqing Wang, Xue Zhang & Renping Zhou. (2012) Human Cataract Mutations in EPHA2 SAM Domain Alter Receptor Stability and Function. PLoS ONE 7:5, pages e36564.
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C E Tognon, M J Martin, A Moradian, G Trigo, B Rotblat, S-W G Cheng, M Pollard, E Uy, C Chow, J M Carboni, M M Gottardis, M Pollak, G B Morin & P H B Sorensen. (2011) A tripartite complex composed of ETV6-NTRK3, IRS1 and IGF1R is required for ETV6-NTRK3-mediated membrane localization and transformation. Oncogene 31:10, pages 1334-1340.
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Johanna M Kralik, Wolfgang Kranewitter, Hans Boesmueller, Renate Marschon, Gertraud Tschurtschenthaler, Holger Rumpold, Kurt Wiesinger, Martin Erdel, Andreas L Petzer & Gerald Webersinke. (2011) Characterization of a newly identified ETV6-NTRK3 fusion transcript in acute myeloid leukemia. Diagnostic Pathology 6:1.
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Brian D. Slaughter, Joseph M. Huff, Winfried Wiegraebe, Joel W. Schwartz & Rong Li. (2008) SAM Domain-Based Protein Oligomerization Observed by Live-Cell Fluorescence Fluctuation Spectroscopy. PLoS ONE 3:4, pages e1931.
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Taranjit S. Gujral, Vinay K. Singh, Zongchao Jia & Lois M. Mulligan. (2006) Molecular Mechanisms of RET Receptor–Mediated Oncogenesis in Multiple Endocrine Neoplasia 2B. Cancer Research 66:22, pages 10741-10749.
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J Anderson, S Gibson & N J Sebire. (2006) Expression of ETV6-NTRK in classical, cellular and mixed subtypes of congenital mesoblastic nephroma. Histopathology 48:6, pages 748-753.
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Abdenour Soufi, Corinne Smith, Anthony R. Clarke, Kevin Gaston & Padma-Sheela Jayaraman. (2006) Oligomerisation of the Developmental Regulator Proline Rich Homeodomain (PRH/Hex) is Mediated by a Novel Proline-rich Dimerisation Domain. Journal of Molecular Biology 358:4, pages 943-962.
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Wook JinByung-Chul KimCristina TognonHo-Jae LeeSejal PatelChris L. LannonJohn M. MarisTimothy J. TrichePoul H. B. SorensenSeong-Jin Kim. (2005) The ETV6-NTRK3 chimeric tyrosine kinase suppresses TGF-β signaling by inactivating the TGF-β type II receptor. Proceedings of the National Academy of Sciences 102:45, pages 16239-16244.
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Chris L. Lannon & Poul H.B. Sorensen. (2005) ETV6–NTRK3: a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages. Seminars in Cancer Biology 15:3, pages 215-223.
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Feng QiaoJames U. Bowie. (2005) The Many Faces of SAM. Science's STKE 2005:286.
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Aykut ??ren & Jeffrey A Toretsky. (2005) Pediatric malignancies provide unique cancer therapy targets. Current Opinion in Pediatrics 17:1, pages 14-19.
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Cameron D. Mackereth, Manuela Schärpf, Lisa N. Gentile, Scott E. MacIntosh, Carolyn M. Slupsky & Lawrence P. McIntosh. (2004) Diversity in Structure and Function of the Ets Family PNT Domains. Journal of Molecular Biology 342:4, pages 1249-1264.
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