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Molecular and Cellular Biology Volume 24, 2004 - Issue 13
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Cell Growth and Development

IκB Kinase Is an Essential Component of the Tpl2 Signaling Pathway

Michael WaterfieldDepartment of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania17033
,
Wei JinDepartment of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania17033
,
William ReileyDepartment of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania17033
,
Minying ZhangDepartment of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania17033
&
Shao-Cong SunDepartment of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania17033Correspondence[email protected]
Pages 6040-6048 | Received 21 Oct 2003, Accepted 08 Apr 2004, Published online: 27 Mar 2023

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Karine Roget, Abduelhakem Ben-Addi, Agnes Mambole-Dema, Thorsten Gantke, Huei-Ting Yang, Julia Janzen, Nick Morrice, Derek Abbott & Steven C. Ley. (2012) IκB Kinase 2 Regulates TPL-2 Activation of Extracellular Signal-Regulated Kinases 1 and 2 by Direct Phosphorylation of TPL-2 Serine 400. Molecular and Cellular Biology 32:22, pages 4684-4690.
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Huei-Ting Yang, Stamatia Papoutsopoulou, Monica Belich, Christine Brender, Julia Janzen, Thorsten Gantke, Matt Handley & Steven C. Ley. (2012) Coordinate Regulation of TPL-2 and NF-κB Signaling in Macrophages by NF-κB1 p105. Molecular and Cellular Biology 32:17, pages 3438-3451.
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Mark Windheim, Margaret Stafford, Mark Peggie & Philip Cohen. (2008) Interleukin-1 (IL-1) Induces the Lys63-Linked Polyubiquitination of IL-1 Receptor-Associated Kinase 1 To Facilitate NEMO Binding and the Activation of IκBα Kinase. Molecular and Cellular Biology 28:5, pages 1783-1791.
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M. J. Robinson, S. Beinke, A. Kouroumalis, P. N. Tsichlis & S. C. Ley. (2007) Phosphorylation of TPL-2 on Serine 400 Is Essential for Lipopolysaccharide Activation of Extracellular Signal-Regulated Kinase in Macrophages. Molecular and Cellular Biology 27:21, pages 7355-7364.
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Hosea HandoyoMargaret J. StaffordEamon McManusDionissios BaltzisMark PeggiePhilip Cohen. (2009) IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2. Biochemical Journal 424:1, pages 109-118.
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Alain Chariot. (2009) The NF-κB-independent functions of IKK subunits in immunity and cancer. Trends in Cell Biology 19:8, pages 404-413.
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Howard CH Yim, James CB Li, Jonathan SH Lau & Allan SY Lau. (2009) HIV-1 Tat dysregulation of lipopolysaccharide-induced cytokine responses: microbial interactions in HIV infection. AIDS 23:12, pages 1473-1484.
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Kristopher Clark, Lorna Plater, Mark Peggie & Philip Cohen. (2009) Use of the Pharmacological Inhibitor BX795 to Study the Regulation and Physiological Roles of TBK1 and IκB Kinase ϵ. Journal of Biological Chemistry 284:21, pages 14136-14146.
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Takaaki Haga, Jun-ichi Suzuki, Hisanori Kosuge, Masahito Ogawa, Hitoshi Saiki, Go Haraguchi, Yasuhiro Maejima, Mitsuaki Isobe & Toshimitsu Uede. (2009) Attenuation of experimental autoimmune myocarditis by blocking T cell activation through 4-1BB pathway. Journal of Molecular and Cellular Cardiology 46:5, pages 719-727.
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Minying Zhang, Wei Jin, Xiaofei Zhou, Jiayi Yu, Andrew J. Lee & Shao-Cong Sun. (2009) Deregulation of Tpl2 and NF-κB signaling and induction of macrophage apoptosis by the anti-depressant drug lithium. Cellular Signalling 21:4, pages 559-566.
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Philip Cohen. (2009) Targeting protein kinases for the development of anti-inflammatory drugs. Current Opinion in Cell Biology 21:2, pages 317-324.
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Srividya Sriskantharajah, Monica P Belich, Stamatia Papoutsopoulou, Julia Janzen, Victor Tybulewicz, Benedict Seddon & Steven C Ley. (2008) Proteolysis of NF-κB1 p105 is essential for T cell antigen receptor–induced proliferation. Nature Immunology 10:1, pages 38-47.
Crossref
Ashish Banerjee, Raelene Grumont, Raffi Gugasyan, Christine White, Andreas Strasser & Steve Gerondakis. (2008) NF-κB1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms. Blood 112:13, pages 5063-5073.
Crossref
Dung-Fang Lee & Mien-Chie Hung. (2008) Advances in Targeting IKK and IKK-Related Kinases for Cancer Therapy. Clinical Cancer Research 14:18, pages 5656-5662.
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Johannes A. Schmid & Andreas Birbach. (2008) IκB kinase β (IKKβ/IKK2/IKBKB)—A key molecule in signaling to the transcription factor NF-κB. Cytokine & Growth Factor Reviews 19:2, pages 157-165.
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Stephen J. Skinner, Kristen M. Deleault, Ryan Fecteau & Seth A. Brooks. (2008) Extracellular Signal-regulated Kinase Regulation of Tumor Necrosis Factor-α mRNA Nucleocytoplasmic Transport Requires TAP-NxT1 Binding and the AU-rich Element. Journal of Biological Chemistry 283:6, pages 3191-3199.
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Clodia Osipo, Todd E Golde, Barbara A Osborne & Lucio A Miele. (2008) Off the beaten pathway: the complex cross talk between Notch and NF-κB. Laboratory Investigation 88:1, pages 11-17.
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Ashish Banerjee & Steve Gerondakis. (2007) Coordinating TLR‐activated signaling pathways in cells of the immune system. Immunology & Cell Biology 85:6, pages 420-424.
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Katie J. Loniewski, Sonika Patial & Narayanan Parameswaran. (2007) Sensitivity of TLR4- and -7-induced NFκB1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages. Molecular Immunology 44:15, pages 3715-3723.
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Mark WindheimChristine LangMark PeggieLorna A. PlaterPhilip Cohen. (2007) Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide. Biochemical Journal 404:2, pages 179-190.
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Wei Jin, William R. Reiley, Andrew J. Lee, Ato Wright, Xuefeng Wu, Minying Zhang & Shao-Cong Sun. (2007) Deubiquitinating Enzyme CYLD Regulates the Peripheral Development and Naive Phenotype Maintenance of B Cells. Journal of Biological Chemistry 282:21, pages 15884-15893.
Crossref
Alla V. Tsytsykova, James V. Falvo, Marc Schmidt-Supprian, Gilles Courtois, Dimitris Thanos & Anne E. Goldfeld. (2007) Post-induction, Stimulus-specific Regulation of Tumor Necrosis Factor mRNA Expression. Journal of Biological Chemistry 282:16, pages 11629-11638.
Crossref
Unhwan Ha, Jae Hyang Lim, Hirofumi Jono, Tomoaki Koga, Amit Srivastava, Richard Malley, Gilles Pagès, Jacques Pouysségur & Jian-Dong Li. (2007) A Novel Role for IκB Kinase (IKK) α and IKKβ in ERK-Dependent Up-Regulation of MUC5AC Mucin Transcription by Streptococcus pneumoniae . The Journal of Immunology 178:3, pages 1736-1747.
Crossref
Mary Kaileh, Wim Vanden Berghe, Arne Heyerick, Julie Horion, Jacques Piette, Claude Libert, Denis De Keukeleire, Tamer Essawi & Guy Haegeman. (2007) Withaferin A Strongly Elicits IκB Kinase β Hyperphosphorylation Concomitant with Potent Inhibition of Its Kinase Activity. Journal of Biological Chemistry 282:7, pages 4253-4264.
Crossref
Neil D. Perkins. (2007) Integrating cell-signalling pathways with NF-κB and IKK function. Nature Reviews Molecular Cell Biology 8:1, pages 49-62.
Crossref
JERRY L ADAMS & JOHN C. LEE. 2007. Target Validation in Drug Discovery. Target Validation in Drug Discovery 179 198 .
Narayanan Parameswaran, Christina S. Pao, Kristi S. Leonhard, Dong Soo Kang, Michelle Kratz, Steven C. Ley & Jeffrey L. Benovic. (2006) Arrestin-2 and G Protein-coupled Receptor Kinase 5 Interact with NFκB1 p105 and Negatively Regulate Lipopolysaccharide-stimulated ERK1/2 Activation in Macrophages. Journal of Biological Chemistry 281:45, pages 34159-34170.
Crossref
N D Perkins. (2006) Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway. Oncogene 25:51, pages 6717-6730.
Crossref
Yinon Ben-Neriah & Steven Ley. 2006. Handbook of Transcription Factor NF-kappaB. Handbook of Transcription Factor NF-kappaB 53 85 .
Margaret J. Stafford, Nick A. Morrice, Mark W. Peggie & Philip Cohen. (2006) Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62. FEBS Letters 580:16, pages 4010-4014.
Crossref
Geetha Babu, Michael Waterfield, Mikyoung Chang, Xuefeng Wu & Shao-Cong Sun. (2006) Deregulated Activation of Oncoprotein Kinase Tpl2/Cot in HTLV-I-transformed T Cells. Journal of Biological Chemistry 281:20, pages 14041-14047.
Crossref
Geetha R. Babu, Wei Jin, Lourdes Norman, Michael Waterfield, Mikyoung Chang, Xuefeng Wu, Minying Zhang & Shao-Cong Sun. (2006) Phosphorylation of NF-κB1/p105 by oncoprotein kinase Tpl2: Implications for a novel mechanism of Tpl2 regulation. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1763:2, pages 174-181.
Crossref
Michal F. Tomczak, Mihaela Gadjeva, Yan Yan Wang, Ketorah Brown, Ioanna Maroulakou, Philip N. Tsichlis, Susan E. Erdman, James G. Fox & Bruce H. Horwitz. (2006) Defective Activation of ERK in Macrophages Lacking the p50/p105 Subunit of NF-κB Is Responsible for Elevated Expression of IL-12 p40 Observed after Challenge with Helicobacter hepaticus . The Journal of Immunology 176:2, pages 1244-1251.
Crossref
Chistos Tsatsanis. (2006) Tpl2. AfCS-Nature Molecule Pages.
Crossref
Aristides G. Eliopoulos, Santasabuj Das & Philip N. Tsichlis. (2006) The Tyrosine Kinase Syk Regulates TPL2 Activation Signals. Journal of Biological Chemistry 281:3, pages 1371-1380.
Crossref
Kanae Oda & Hiroaki Kitano. (2006) A comprehensive map of the toll‐like receptor signaling network. Molecular Systems Biology 2:1.
Crossref
Antony Symons, Soren Beinke & Steven C. Ley. (2006) MAP kinase kinase kinases and innate immunity. Trends in Immunology 27:1, pages 40-48.
Crossref
Shao-Cong Sun & Edward W. Harhaj. 2006. NF-κB/Rel Transcription Factor Family. NF-κB/Rel Transcription Factor Family 26 40 .
Oliver Herrmann, Bernd Baumann, Rossana de Lorenzi, Sajjad Muhammad, Wen Zhang, Jens Kleesiek, Max Malfertheiner, Martin Köhrmann, Ioana Potrovita, Ira Maegele, Cordian Beyer, James R Burke, Mazahir T Hasan, Hermann Bujard, Thomas Wirth, Manolis Pasparakis & Markus Schwaninger. (2005) IKK mediates ischemia-induced neuronal death. Nature Medicine 11:12, pages 1322-1329.
Crossref
Qingfeng Yang, Wei Huang, Catherine Jozwik, Yong Lin, Mirta Glasman, Hung Caohuy, Meera Srivastava, Dominic Esposito, William Gillette, James Hartley & Harvey B. Pollard. (2005) Cardiac glycosides inhibit TNF-α/NF-κB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor. Proceedings of the National Academy of Sciences 102:27, pages 9631-9636.
Crossref
David Artis, Colleen M. Kane, James Fiore, Colby Zaph, Sagi Shapira, Karen Joyce, Andrew MacDonald, Christopher Hunter, Phillip Scott & Edward J. Pearce. (2005) Dendritic Cell-Intrinsic Expression of NF-κB1 Is Required to Promote Optimal Th2 Cell Differentiation. The Journal of Immunology 174:11, pages 7154-7159.
Crossref
Santasabuj Das, Jeonghee Cho, Irina Lambertz, Michelle A. Kelliher, Aristides G. Eliopoulos, Keyong Du & Philip N. Tsichlis. (2005) Tpl2/Cot Signals Activate ERK, JNK, and NF-κB in a Cell-type and Stimulus-specific Manner. Journal of Biological Chemistry 280:25, pages 23748-23757.
Crossref
Jeonghee Cho, Michael Melnick, Georgios P. Solidakis & Philip N. Tsichlis. (2005) Tpl2 (Tumor Progression Locus 2) Phosphorylation at Thr290 Is Induced by Lipopolysaccharide via an Iκ-B Kinase-β-dependent Pathway and Is Required for Tpl2 Activation by External Signals. Journal of Biological Chemistry 280:21, pages 20442-20448.
Crossref
Jeonghee Cho & Philip N. Tsichlis. (2005) Phosphorylation at Thr-290 regulates Tpl2 binding to NF-κB1/p105 and Tpl2 activation and degradation by lipopolysaccharide. Proceedings of the National Academy of Sciences 102:7, pages 2350-2355.
Crossref
Patrick Viatour, Marie-Paule Merville, Vincent Bours & Alain Chariot. (2005) Phosphorylation of NF-κB and IκB proteins: implications in cancer and inflammation. Trends in Biochemical Sciences 30:1, pages 43-52.
Crossref

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