17
Views
48
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Rac1 Inhibits Apoptosis in Human Lymphoma Cells by Stimulating Bad Phosphorylation on Ser-75

, &
Pages 6205-6214 | Received 26 Nov 2003, Accepted 23 Apr 2004, Published online: 27 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Hiroto Horiguchi, Haiming Xu, Beatrice Duvert, Felicia Ciuculescu, Qiuming Yao, Amit Sinha, Meaghan McGuinness, Chad Harris, Christian Brendel, Anja Troeger, Roberto Chiarle & David A. Williams. (2022) Deletion of murine Rhoh leads to de-repression of Bcl-6 via decreased KAISO levels and accelerates a malignancy phenotype in a murine model of lymphoma. Small GTPases 13:1, pages 267-281.
Read now
Fang Nie, Xiao-Feng Wang, Shi-Yi Zhao, Lan Bu & Xue-Hui Liu. (2015) Gene silencing of Rac1 with RNA interference mediated by ultrasound and microbubbles in human LoVo cells: evaluation of cell invasion inhibition and metastatic. Journal of Drug Targeting 23:4, pages 380-386.
Read now
Hellinida Thomadaki & Andreas Scorilas. (2006) BCL2 Family of Apoptosis-Related Genes: Functions and Clinical Implications in Cancer. Critical Reviews in Clinical Laboratory Sciences 43:1, pages 1-67.
Read now

Articles from other publishers (45)

Rebekka Kitzinger, Gerhard Fritz & Christian Henninger. (2022) Nuclear RAC1 is a modulator of the doxorubicin-induced DNA damage response. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1869:10, pages 119320.
Crossref
Eva Crosas-Molist, Remi Samain, Leonie Kohlhammer, Jose L. Orgaz, Samantha L. George, Oscar Maiques, Jaume Barcelo & Victoria Sanz-Moreno. (2022) Rho GTPase signaling in cancer progression and dissemination. Physiological Reviews 102:1, pages 455-510.
Crossref
Yudai Matsuoka, Hani Al-Shareef, Mikihiko Kogo & Hirokazu Nakahara. (2021) Effects of decreased Rac activity and malignant state on oral squamous cell carcinoma in vitro. PLOS ONE 16:1, pages e0212323.
Crossref
Sara Rahmati, Darren D. O’Rielly, Quan Li, Dianne Codner, Amanda Dohey, Kari Jenkins, Igor Jurisica, Dafna D. Gladman, Vinod Chandran & Proton Rahman. (2020) Rho-GTPase pathways may differentiate treatment response to TNF-alpha and IL-17A inhibitors in psoriatic arthritis. Scientific Reports 10:1.
Crossref
Irma E. Cisneros, Anuja Ghorpade & Kathleen Borgmann. (2020) Methamphetamine Activates Trace Amine Associated Receptor 1 to Regulate Astrocyte Excitatory Amino Acid Transporter-2 via Differential CREB Phosphorylation During HIV-Associated Neurocognitive Disorders. Frontiers in Neurology 11.
Crossref
Margiotta & Bucci. (2019) Coordination between Rac1 and Rab Proteins: Functional Implications in Health and Disease. Cells 8:5, pages 396.
Crossref
Valerie Durand-Onaylı, Theresa Haslauer, Andrea Härzschel & Tanja Hartmann. (2018) Rac GTPases in Hematological Malignancies. International Journal of Molecular Sciences 19:12, pages 4041.
Crossref
Stephanie Pohlmann, Stefanie Scheu, Verena Ziegler, Nicole Schupp, Christian Henninger & Gerhard Fritz. (2018) Hepatic Rac1 GTPase contributes to liver-mediated basal immune homeostasis and LPS-induced endotoxemia. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1865:9, pages 1277-1292.
Crossref
Hanna Kim, Carles Calatayud, Sanjib Guha, Irene Fernández-Carasa, Laura Berkowitz, Iria Carballo-Carbajal, Mario Ezquerra, Rubén Fernández-Santiago, Pankaj Kapahi, Ángel Raya, Antonio Miranda-Vizuete, Jose Miguel Lizcano, Miquel Vila, Kim A. Caldwell, Guy A. Caldwell, Antonella Consiglio & Esther Dalfo. (2018) The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity. Molecular Neurobiology 55:9, pages 7533-7552.
Crossref
Wei Xie, Wei Zhang, Mingwei Sun, Chunhua Lu & Yuemao Shen. (2018) Deacetylmycoepoxydiene is an agonist of Rac1, and simultaneously induces autophagy and apoptosis. Applied Microbiology and Biotechnology 102:14, pages 5965-5975.
Crossref
Lakshmi Selvan, Ravikanth Danda, Anil Madugundu, Vinuth Puttamallesh, Gajanan Sathe, Uma Krishnan, Vikas Khetan, Pukhraj Rishi, Thottethodi Prasad, Akhilesh Pandey, Subramanian Krishnakumar, Harsha Gowda & Sailaja Elchuri. (2018) Phosphoproteomics of Retinoblastoma: A Pilot Study Identifies Aberrant Kinases. Molecules 23:6, pages 1454.
Crossref
Abdelilah Bouzelfen, Marion Alcantara, Hafid Kora, Jean-Michel Picquenot, Philippe Bertrand, Marie Cornic, Sylvain Mareschal, Elodie Bohers, Catherine Maingonnat, Philippe Ruminy, Sahil Adriouch, Olivier Boyer, Sydney Dubois, Christian Bastard, Hervé Tilly, Jean-Baptiste Latouche & Fabrice Jardin. (2016) HACE1 is a putative tumor suppressor gene in B-cell lymphomagenesis and is down-regulated by both deletion and epigenetic alterations. Leukemia Research 45, pages 90-100.
Crossref
Carmen Bergom, Andrew D. Hauser, Amy Rymaszewski, Patrick Gonyo, Jeremy W. Prokop, Benjamin C. Jennings, Alexis J. Lawton, Anne Frei, Ellen L. Lorimer, Irene Aguilera-Barrantes, Alexander C. Mackinnon, Kathleen Noon, Carol A. Fierke & Carol L. Williams. (2016) The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases. Journal of Biological Chemistry 291:12, pages 6534-6545.
Crossref
Meghan M. Morrison, Christian D. Young, Shan Wang, Tammy Sobolik, Violeta M. Sanchez, Donna J. Hicks, Rebecca S. Cook & Dana M. Brantley-Sieders. (2015) mTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling Axis. PLOS Genetics 11:7, pages e1005291.
Crossref
Kathrin Schäker, Susanne Bartsch, Christian Patry, Sandra J. Stoll, Jan-Luuk Hillebrands, Thomas Wieland & Jens Kroll. (2015) The Bipartite Rac1 Guanine Nucleotide Exchange Factor Engulfment and Cell Motility 1/Dedicator of Cytokinesis 180 (Elmo1/Dock180) Protects Endothelial Cells from Apoptosis in Blood Vessel Development. Journal of Biological Chemistry 290:10, pages 6408-6418.
Crossref
Ji-Ying Wang, Pei Yu, Shuying Chen, Haiyan Xing, Yirui Chen, Min Wang, Kejing Tang, Zheng Tian, Qing Rao & Jianxiang Wang. (2013) Activation of Rac1 GTPase promotes leukemia cell chemotherapy resistance, quiescence and niche interaction. Molecular Oncology 7:5, pages 907-916.
Crossref
Vanessa Walf-Vorderwülbecke, Jasper de Boer, Sarah J. Horton, Renée van Amerongen, Natalie Proost, Anton Berns & Owen Williams. (2012) Frat2 mediates the oncogenic activation of Rac by MLL fusions. Blood 120:24, pages 4819-4828.
Crossref
Jun-Jie Chen, H.-C. Jennifer Shen, Leslie A. Rivera Rosado, Yaqin Zhang, Xu Di & Baolin Zhang. (2012) Mislocalization of death receptors correlates with cellular resistance to their cognate ligands in human breast cancer cells. Oncotarget 3:8, pages 833-842.
Crossref
Heather L. Osborn-Heaford, Alan J. Ryan, Shubha Murthy, Ana-Monica Racila, Chao He, Jessica C. Sieren, Douglas R. Spitz & A. Brent Carter. (2012) Mitochondrial Rac1 GTPase Import and Electron Transfer from Cytochrome c Are Required for Pulmonary Fibrosis. Journal of Biological Chemistry 287:5, pages 3301-3312.
Crossref
Stephanie Alexander & Peter Friedl. (2012) Cancer invasion and resistance: interconnected processes of disease progression and therapy failure. Trends in Molecular Medicine 18:1, pages 13-26.
Crossref
Fang Yu, Xiudan Zhu, Chen Feng, Tianyou Wang, Qin Hong, Zhoulu Liu & Suoqin Tang. (2011) Proteomics-based identification of spontaneous regression-associated proteins in neuroblastoma. Journal of Pediatric Surgery 46:10, pages 1948-1955.
Crossref
Sunny Yang Xiang, Davy Vanhoutte, Dominic P. Del Re, Nicole H. Purcell, Haiyun Ling, Indroneal Banerjee, Julie Bossuyt, Richard A. Lang, Yi Zheng, Scot J. Matkovich, Shigeki Miyamoto, Jeffery D. Molkentin, Gerald W. DornIIII & Joan Heller Brown. (2011) RhoA protects the mouse heart against ischemia/reperfusion injury. Journal of Clinical Investigation 121:8, pages 3269-3276.
Crossref
Johanna Gutiérrez-Vargas, John Fredy Castro-Álvarez, David Velásquez-Carvajal, Maria Natalia Montañez-Velásquez, Ángel Céspedes-Rubio & Gloria Patricia Cardona-Gómez. (2010) Rac1 activity changes are associated with neuronal pathology and spatial memory long-term recovery after global cerebral ischemia. Neurochemistry International 57:7, pages 762-773.
Crossref
Tatsushi Yoshida, Yaqin Zhang, Leslie A. Rivera Rosado, Junjie Chen, Tahira Khan, Sun Young Moon & Baolin Zhang. (2010) Blockade of Rac1 Activity Induces G1 Cell Cycle Arrest or Apoptosis in Breast Cancer Cells through Downregulation of Cyclin D1, Survivin, and X-Linked Inhibitor of Apoptosis Protein. Molecular Cancer Therapeutics 9:6, pages 1657-1668.
Crossref
Emily E. Bosco, Wenjun Ni, Lei Wang, Fukun Guo, James F. Johnson & Yi Zheng. (2010) Rac1 targeting suppresses p53 deficiency–mediated lymphomagenesis. Blood 115:16, pages 3320-3328.
Crossref
Lei Wang, Hiroshi Nishihara, Taichi Kimura, Yasutaka Kato, Mishie Tanino, Mitsufumi Nishio, Masato Obara, Tomoyuki Endo, Takao Koike & Shinya Tanaka. (2010) DOCK2 regulates cell proliferation through Rac and ERK activation in B cell lymphoma. Biochemical and Biophysical Research Communications 395:1, pages 111-115.
Crossref
Devin T. Rosenthal, John Chadwick Brenner & Sofia D. Merajver. 2010. The Rho GTPases in Cancer. The Rho GTPases in Cancer 29 42 .
N. Sharmila Bharathi & Jeffrey Field. (2009) Pak2. AfCS-Nature Molecule Pages.
Crossref
Yaqin Zhang, Leslie A.Rivera Rosado, Sun Young Moon & Baolin Zhang. (2009) Silencing of D4-GDI Inhibits Growth and Invasive Behavior in MDA-MB-231 Cells by Activation of Rac-dependent p38 and JNK Signaling. Journal of Biological Chemistry 284:19, pages 12956-12965.
Crossref
Florian Fueller & Katharina F Kubatzky. (2008) The small GTPase RhoH is an atypical regulator of haematopoietic cells. Cell Communication and Signaling 6:1.
Crossref
Yaqin Zhang & Baolin Zhang. (2008) TRAIL Resistance of Breast Cancer Cells Is Associated with Constitutive Endocytosis of Death Receptors 4 and 5. Molecular Cancer Research 6:12, pages 1861-1871.
Crossref
Toshihiro Iwasaki, Akira Katsumi, Hitoshi Kiyoi, Ryohei Tanizaki, Yuichi Ishikawa, Kazutaka Ozeki, Miki Kobayashi, Akihiro Abe, Tadashi Matsushita, Takashi Watanabe, Mutsuki Amano, Tetsuhito Kojima, Kozo Kaibuchi & Tomoki Naoe. (2008) Prognostic implication and biological roles of RhoH in acute myeloid leukaemia. European Journal of Haematology 81:6, pages 454-460.
Crossref
K. Kondoh, Y. Nakata, T. Yamaoka, M. Itakura, M. Hayashi, K. Yamada, J.-i. Hata & T. Yamada. (2008) Altered cellular immunity in transgenic mice with T cell-specific expression of human D4-guanine diphosphate-dissociation inhibitor (D4-GDI). International Immunology 20:10, pages 1299-1311.
Crossref
Shi Jin, Ramesh M. Ray & Leonard R. Johnson. (2008) TNF-α/cycloheximide-induced apoptosis in intestinal epithelial cells requires Rac1-regulated reactive oxygen species. American Journal of Physiology-Gastrointestinal and Liver Physiology 294:4, pages G928-G937.
Crossref
L Garzia, A D'Angelo, A Amoresano, S K Knauer, C Cirulli, C Campanella, R H Stauber, C Steegborn, A Iolascon & M Zollo. (2007) Phosphorylation of nm23-H1 by CKI induces its complex formation with h-prune and promotes cell motility. Oncogene 27:13, pages 1853-1864.
Crossref
Alessandro Giamboi Miraglia, Sara Travaglione, Stefania Meschini, Loredana Falzano, Paola Matarrese, Maria Giovanna Quaranta, Marina Viora, Carla Fiorentini & Alessia Fabbri. (2007) Cytotoxic Necrotizing Factor 1 Prevents Apoptosis via the Akt/IκB Kinase Pathway: Role of Nuclear Factor-κB and Bcl-2. Molecular Biology of the Cell 18:7, pages 2735-2744.
Crossref
Elaine E HammJimmy D Ballard. (2007) Elucidating the in vivo targets of bacterial toxins . Future Microbiology 2:1, pages 85-92.
Crossref
Shi Jin, Ramesh M. Ray & Leonard R. Johnson. (2006) Rac1 mediates intestinal epithelial cell apoptosis via JNK. American Journal of Physiology-Gastrointestinal and Liver Physiology 291:6, pages G1137-G1147.
Crossref
Shizhen Emily Wang, Incheol Shin, Frederick Y. Wu, David B. Friedman & Carlos L. Arteaga. (2006) HER2/Neu (ErbB2) Signaling to Rac1-Pak1 Is Temporally and Spatially Modulated by Transforming Growth Factor β. Cancer Research 66:19, pages 9591-9600.
Crossref
Yaqin Zhang & Baolin Zhang. (2006) D4-GDI, a Rho GTPase Regulator, Promotes Breast Cancer Cell Invasiveness. Cancer Research 66:11, pages 5592-5598.
Crossref
Enrico Tiacci, Arcangelo Liso, Miguel Piris & Brunangelo Falini. (2006) Evolving concepts in the pathogenesis of hairy-cell leukaemia. Nature Reviews Cancer 6:6, pages 437-448.
Crossref
Benjamin Chaigne-Delalande, Lynda Deuve, Edith Reuzeau, Caroline Basoni, David Lafarge, Christine Varon, Florence Tatin, Guerric Anies, Richard Garand, Ijsbrand Kramer & Elisabeth Génot. (2006) RhoGTPases and p53 Are Involved in the Morphological Appearance and Interferon-α Response of Hairy Cells. The American Journal of Pathology 168:2, pages 562-573.
Crossref
Kideok Jin, Seunghwan Lim, Stephen E. Mercer & Eileen Friedman. (2005) The Survival Kinase Mirk/dyrk1B Is Activated through Rac1-MKK3 Signaling. Journal of Biological Chemistry 280:51, pages 42097-42105.
Crossref
Baolin Zhang, Yaqin Zhang, Marie-Claire Dagher & Emily Shacter. (2005) Rho GDP Dissociation Inhibitor Protects Cancer Cells against Drug-Induced Apoptosis. Cancer Research 65:14, pages 6054-6062.
Crossref
Kohsuke Kanekura, Yuichi Hashimoto, Yoshiko Kita, Jumpei Sasabe, Sadakazu Aiso, Ikuo Nishimoto & Masaaki Matsuoka. (2005) A Rac1/Phosphatidylinositol 3-Kinase/Akt3 Anti-apoptotic Pathway, Triggered by AlsinLF, the Product of the ALS2 Gene, Antagonizes Cu/Zn-superoxide Dismutase (SOD1) Mutant-induced Motoneuronal Cell Death. Journal of Biological Chemistry 280:6, pages 4532-4543.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.