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Cell Growth and Development

Pak1 Protein Kinase Regulates Activation and Nuclear Localization of Snf1-Gal83 Protein Kinase

Kristina Hedbacker1 Departments of Genetics and Development
,
Seung-Pyo Hong1 Departments of Genetics and Development
&
Marian Carlson1 Departments of Genetics and Development;2 Microbiology, Columbia University, New York, New YorkCorrespondence[email protected]
Pages 8255-8263 | Received 23 Dec 2003, Accepted 09 Jun 2004, Published online: 27 Mar 2023

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Margaret B. Wierman, Nazif Maqani, Erika Strickler, Mingguang Li & Jeffrey S. Smith. (2017) Caloric Restriction Extends Yeast Chronological Life Span by Optimizing the Snf1 (AMPK) Signaling Pathway. Molecular and Cellular Biology 37:13.
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Atsushi Suzuki, Shiki Okamoto, Suni Lee, Kumiko Saito, Tetsuya Shiuchi & Yasuhiko Minokoshi. (2007) Leptin Stimulates Fatty Acid Oxidation and Peroxisome Proliferator-Activated Receptor α Gene Expression in Mouse C2C12 Myoblasts by Changing the Subcellular Localization of the α2 Form of AMP-Activated Protein Kinase. Molecular and Cellular Biology 27:12, pages 4317-4327.
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Xu Yang, Lu Meng, Xue Lin, Huan-Yuan Jiang, Xiao-Ping Hu & Cong-Fa Li. (2021) Role of Elm1, Tos3, and Sak1 Protein Kinases in the Maltose Metabolism of Baker’s Yeast. Frontiers in Microbiology 12.
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Xue Lin. (2021) The regulation of Saccharomyces cerevisiae Snf1 protein kinase on glucose utilization is in a glucose-dependent manner. Current Genetics 67:2, pages 245-248.
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Aishwarya Shevade, Vera Strogolova, Marianna Orlova, Chay Teng Yeo & Sergei Kuchin. (2018) Mitochondrial Voltage-Dependent Anion Channel Protein Por1 Positively Regulates the Nuclear Localization of Saccharomyces cerevisiae AMP-Activated Protein Kinase. mSphere 3:1.
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Dan Wang, Yingying Li, Haichuan Wang, Dongsheng Wei, Oren Akhberdi, Yanjie Liu, Biyun Xiang, Xiaoran Hao & Xudong Zhu. (2018) The AMP-Activated Protein Kinase Homolog Snf1 Concerts Carbon Utilization, Conidia Production and the Biosynthesis of Secondary Metabolites in the Taxol-Producer Pestalotiopsis microspora. Genes 9:2, pages 59.
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Fiorella Galello, Constanza Pautasso, Sol Reca, Luciana Cañonero, Paula Portela, Silvia Moreno & Silvia Rossi. (2017) Transcriptional regulation of the protein kinase a subunits in Saccharomyces cerevisiae during fermentative growth . Yeast 34:12, pages 495-508.
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Yuichi Kimura, Kenji Irie & Tomoaki Mizuno. (2017) Expression control of the AMPK regulatory subunit and its functional significance in yeast ER stress response. Scientific Reports 7:1.
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Tom Broeckx, Sander Hulsmans & Filip Rolland. (2016) The plant energy sensor: evolutionary conservation and divergence of SnRK1 structure, regulation, and function. Journal of Experimental Botany 67:22, pages 6215-6252.
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Dakshayini G. Chandrashekarappa, Rhonda R. McCartney, Allyson F. O'Donnell & Martin C. Schmidt. (2016) The β subunit of yeast AMP-activated protein kinase directs substrate specificity in response to alkaline stress. Cellular Signalling 28:12, pages 1881-1893.
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Rhonda R. McCartney, Leopold Garnar-Wortzel, Dakshayini G. Chandrashekarappa & Martin C. Schmidt. (2016) Activation and inhibition of Snf1 kinase activity by phosphorylation within the activation loop. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1864:11, pages 1518-1528.
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Antero Salminen, Anu Kauppinen & Kai Kaarniranta. (2016) AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions. Cellular Signalling 28:8, pages 887-895.
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Dwayne D. Hegedus, Kelsey Gerbrandt & Cathy Coutu. (2016) The eukaryotic protein kinase superfamily of the necrotrophic fungal plant pathogen, S clerotinia sclerotiorum . Molecular Plant Pathology 17:4, pages 634-647.
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Pascual Sanz, Rosa Viana & Maria Adelaida Garcia-Gimeno. 2016. AMP-activated Protein Kinase. AMP-activated Protein Kinase 353 374 .
Timo Lubitz, Niek Welkenhuysen, Sviatlana Shashkova, Loubna Bendrioua, Stefan Hohmann, Edda Klipp & Marcus Krantz. (2015) Network reconstruction and validation of the Snf1/AMPK pathway in baker’s yeast based on a comprehensive literature review. npj Systems Biology and Applications 1:1.
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Ömur Kayikci & Jens Nielsen. (2015) Glucose repression in Saccharomyces cerevisiae . FEMS Yeast Research 15:6, pages fov068.
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Kobi J. Simpson-Lavy, Alex Bronstein, Martin Kupiec & Mark Johnston. (2015) Cross-Talk between Carbon Metabolism and the DNA Damage Response in S. cerevisiae. Cell Reports 12:11, pages 1865-1875.
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Sviatlana Shashkova, Niek Welkenhuysen & Stefan Hohmann. (2015) Molecular communication: crosstalk between the Snf1 and other signaling pathways. FEMS Yeast Research 15:4.
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Jofre Ferrer-Dalmau, Francisca Randez-Gil, Maribel Marquina, José A. Prieto & Antonio Casamayor. (2015) Protein kinase Snf1 is involved in the proper regulation of the unfolded protein response in Saccharomyces cerevisiae . Biochemical Journal 468:1, pages 33-47.
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Neil Andrew Brown, Laure Nicolas Annick Ries & Gustavo Henrique Goldman. (2014) How nutritional status signalling coordinates metabolism and lignocellulolytic enzyme secretion. Fungal Genetics and Biology 72, pages 48-63.
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Pierre Crozet, Leonor Margalha, Ana Confraria, Américo Rodrigues, Cláudia Martinho, Mattia Adamo, Carlos A. Elias & Elena Baena-González. (2014) Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases. Frontiers in Plant Science 5.
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Michaela Conrad, Joep Schothorst, Harish Nag Kankipati, Griet Van Zeebroeck, Marta Rubio-Texeira & Johan M. Thevelein. (2014) Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae . FEMS Microbiology Reviews 38:2, pages 254-299.
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Jungheon Yu, Hokyoung Son, Ae Ran Park, Seung-Ho Lee, Gyung Ja Choi, Jin-Cheol Kim & Yin-Won Lee. (2013) Functional characterization of sucrose non-fermenting 1 protein kinase complex genes in the Ascomycete Fusarium graminearum. Current Genetics 60:1, pages 35-47.
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Ken Peeters & Johan M. Thevelein. 2014. Molecular Mechanisms in Yeast Carbon Metabolism. Molecular Mechanisms in Yeast Carbon Metabolism 21 56 .
John Seip, Raymond Jackson, Hongxian He, Quinn Zhu & Seung-Pyo Hong. (2013) Snf1 Is a Regulator of Lipid Accumulation in Yarrowia lipolytica. Applied and Environmental Microbiology 79:23, pages 7360-7370.
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Kobi J. Simpson-Lavy & Mark Johnston. (2013) SUMOylation regulates the SNF1 protein kinase. Proceedings of the National Academy of Sciences 110:43, pages 17432-17437.
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Sarah T. ClementGauri DixitHenrik G. Dohlman. (2013) Regulation of Yeast G Protein Signaling by the Kinases That Activate the AMPK Homolog Snf1. Science Signaling 6:291.
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Amparo Ruiz, Yang Liu, Xinjing Xu & Marian Carlson. (2012) Heterotrimer-independent regulation of activation-loop phosphorylation of Snf1 protein kinase involves two protein phosphatases. Proceedings of the National Academy of Sciences 109:22, pages 8652-8657.
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Yuxun Zhang, Rhonda R. McCartney, Dakshayini G. Chandrashekarappa, Simmanjeet Mangat & Martin C. Schmidt. (2011) Reg1 Protein Regulates Phosphorylation of All Three Snf1 Isoforms but Preferentially Associates with the Gal83 Isoform. Eukaryotic Cell 10:12, pages 1628-1636.
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Ruben Ghillebert, Erwin Swinnen, Jing Wen, Lies Vandesteene, Matthew Ramon, Koen Norga, Filip Rolland & Joris Winderickx. (2011) The AMPK/SNF1/SnRK1 fuel gauge and energy regulator: structure, function and regulation. FEBS Journal 278:21, pages 3978-3990.
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Milica Momcilovic & Marian Carlson. (2011) Alterations at Dispersed Sites Cause Phosphorylation and Activation of SNF1 Protein Kinase during Growth on High Glucose. Journal of Biological Chemistry 286:26, pages 23544-23551.
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Andreas M. Raab, Verena Hlavacek, Natalia Bolotina & Christine Lang. (2011) Shifting the Fermentative/Oxidative Balance in Saccharomyces cerevisiae by Transcriptional Deregulation of Snf1 via Overexpression of the Upstream Activating Kinase Sak1p . Applied and Environmental Microbiology 77:6, pages 1981-1989.
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Yang Liu, Xinjing Xu & Marian Carlson. (2011) Interaction of SNF1 Protein Kinase with Its Activating Kinase Sak1. Eukaryotic Cell 10:3, pages 313-319.
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Jie Zhang, Lisbeth Olsson & Jens Nielsen. (2010) The β-subunits of the Snf1 kinase in Saccharomyces cerevisiae, Gal83 and Sip2, but not Sip1, are redundant in glucose derepression and regulation of sterol biosynthesis. Molecular Microbiology 77:2, pages 371-383.
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Stefano Busti, Paola Coccetti, Lilia Alberghina & Marco Vanoni. (2010) Glucose Signaling-Mediated Coordination of Cell Growth and Cell Cycle in Saccharomyces Cerevisiae. Sensors 10:6, pages 6195-6240.
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Simmanjeet Mangat, Dakshayini Chandrashekarappa, Rhonda R. McCartney, Karin Elbing & Martin C. Schmidt. (2010) Differential Roles of the Glycogen-Binding Domains of β Subunits in Regulation of the Snf1 Kinase Complex. Eukaryotic Cell 9:1, pages 173-183.
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Marianna Orlova, Hamit Ozcetin, LaKisha Barrett & Sergei Kuchin. (2010) Roles of the Snf1-Activating Kinases during Nitrogen Limitation and Pseudohyphal Differentiation in Saccharomyces cerevisiae . Eukaryotic Cell 9:1, pages 208-214.
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Shadia ZamanSoyeon Im LippmanXin ZhaoJames R. Broach. (2008) How Saccharomyces Responds to Nutrients . Annual Review of Genetics 42:1, pages 27-81.
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Milica Momcilovic, Surtaj H. Iram, Yang Liu & Marian Carlson. (2008) Roles of the Glycogen-binding Domain and Snf4 in Glucose Inhibition of SNF1 Protein Kinase. Journal of Biological Chemistry 283:28, pages 19521-19529.
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Brian R. Kupchak, Ibon Garitaonandia, Nancy Y. Villa, Matthew B. Mullen, Marilee G. Weaver, Lisa M. Regalla, Elizabeth A. Kendall & Thomas J. Lyons. (2007) Probing the mechanism of FET3 repression by Izh2p overexpression. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1773:7, pages 1124-1132.
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Michael J. Rudolph, Gabriele A. Amodeo, Surtaj H. Iram, Seung-Pyo Hong, Giorgia Pirino, Marian Carlson & Liang Tong. (2007) Structure of the Bateman2 Domain of Yeast Snf4: Dimeric Association and Relevance for AMP Binding. Structure 15:1, pages 65-74.
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Kristina Hedbacker & Marian Carlson. (2006) Regulation of the Nucleocytoplasmic Distribution of Snf1-Gal83 Protein Kinase. Eukaryotic Cell 5:12, pages 1950-1956.
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Milica Momcilovic, Seung-Pyo Hong & Marian Carlson. (2006) Mammalian TAK1 Activates Snf1 Protein Kinase in Yeast and Phosphorylates AMP-activated Protein Kinase in Vitro. Journal of Biological Chemistry 281:35, pages 25336-25343.
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Eric M. Rubenstein, Rhonda R. McCartney & Martin C. Schmidt. (2006) Regulatory Domains of Snf1-Activating Kinases Determine Pathway Specificity. Eukaryotic Cell 5:4, pages 620-627.
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Karin ElbingRhonda R. McCartneyMartin C. Schmidt. (2006) Purification and characterization of the three Snf1-activating kinases of Saccharomyces cerevisiae . Biochemical Journal 393:3, pages 797-805.
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Seung-Pyo Hong, Milica Momcilovic & Marian Carlson. (2005) Function of Mammalian LKB1 and Ca2+/Calmodulin-dependent Protein Kinase Kinase α as Snf1-activating Kinases in Yeast. Journal of Biological Chemistry 280:23, pages 21804-21809.
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Rhonda R. McCartney, Eric M. Rubenstein & Martin C. Schmidt. (2005) Snf1 kinase complexes with different beta subunits display stress-dependent preferences for the three Snf1-activating kinases. Current Genetics 47:6, pages 335-344.
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Myoung-Dong Kim, Seung-Pyo Hong & Marian Carlson. (2005) Role of Tos3, a Snf1 Protein Kinase Kinase, during Growth of Saccharomyces cerevisiae on Nonfermentable Carbon Sources . Eukaryotic Cell 4:5, pages 861-866.
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