Advanced search
Publication Cover
Molecular and Cellular Biology Volume 24, 2004 - Issue 19
Submit an article Journal homepage
11
Views
35
CrossRef citations to date
0
Altmetric
Transcriptional Regulation

The Ku Protein Complex Interacts with YY1, Is Up-Regulated in Human Heart Failure, and Represses α Myosin Heavy-Chain Gene Expression

Carmen C. Sucharov1 Department of Molecular, Cellular and Developmental Biology, University of Colorado, BoulderCorrespondence[email protected]
,
Steve M. Helmke2 Division of Cardiology, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado
,
Stephen J. Langer1 Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder
,
M. Benjamin Perryman2 Division of Cardiology, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado
,
Michael Bristow2 Division of Cardiology, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado
&
Leslie Leinwand1 Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder
Pages 8705-8715 | Received 08 Apr 2004, Accepted 04 Jul 2004, Published online: 27 Mar 2023

Citations (35)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Kristina Zaprazna & Michael L. Atchison. (2012) YY1 Controls Immunoglobulin Class Switch Recombination and Nuclear Activation-Induced Deaminase Levels. Molecular and Cellular Biology 32:8, pages 1542-1554.
Read now
Tushar K. Ghosh, Fei Fei Song, Elizabeth A. Packham, Sarah Buxton, Thelma E. Robinson, Jonathan Ronksley, Tim Self, Andrew J. Bonser & J. David Brook. (2009) Physical Interaction between TBX5 and MEF2C Is Required for Early Heart Development. Molecular and Cellular Biology 29:8, pages 2205-2218.
Read now
Huating Wang, Erin Hertlein, Nadine Bakkar, Hao Sun, Swarnali Acharyya, Jingxin Wang, Micheal Carathers, Ramana Davuluri & Denis C. Guttridge. (2007) NF-κB Regulation of YY1 Inhibits Skeletal Myogenesis through Transcriptional Silencing of Myofibrillar Genes. Molecular and Cellular Biology 27:12, pages 4374-4387.
Read now

Articles from other publishers (32)

Thi Khanh Le, Chaïma Cherif, Kenneth Omabe, Clément Paris, François Lannes, Stéphane Audebert, Emilie Baudelet, Mourad Hamimed, Dominique Barbolosi, Pascal Finetti, Cyrille Bastide, Ladan Fazli, Martin Gleave, François Bertucci, David Taïeb & Palma Rocchi. (2023) DDX5 mRNA-targeting antisense oligonucleotide as a new promising therapeutic in combating castration-resistant prostate cancer. Molecular Therapy 31:2, pages 471-486.
Crossref
Pan SongJian HongYuan WangXuelian YaoYiqun ZhanRonghua YinMiao YuChangyan LiXiaoming YangChanghui Ge. (2021) Transcriptional regulation of human abraxas brother protein 1 expression by yin yang 1. Biochemistry and Cell Biology 99:2, pages 223-230.
Crossref
Sanna Abbasi & Caroline Schild-Poulter. (2021) Identification of Ku70 Domain-Specific Interactors Using BioID2. Cells 10:3, pages 646.
Crossref
Lang Li, Yanjun Li, Ian Timothy Sembiring Meliala, Vivi Kasim & Shourong Wu. (2020) Biological roles of Yin Yang 2: Its implications in physiological and pathological events. Journal of Cellular and Molecular Medicine 24:22, pages 12886-12899.
Crossref
Vitaly O. Kheyfets, Melanie J. Dufva, Mario Boehm, Xuefeit Tian, Xulei Qin, Jennifer E. Tabakh, Uyen Truong, Dunbar Ivy & Edda Spiekerkoetter. (2020) The left ventricle undergoes biomechanical and gene expression changes in response to increased right ventricular pressure overload. Physiological Reports 8:9.
Crossref
Yi Zhang, Ilimbek Beketaev, Ana Maria Segura, Wei Yu, Yutao Xi, Jiang Chang, Yanlin Ma & Jun Wang. (2020) Contribution of Increased Expression of Yin Yang 2 to Development of Cardiomyopathy. Frontiers in Molecular Biosciences 7.
Crossref
Rui Xiao, Jia-Yu Chen, Zhengyu Liang, Daji Luo, Geng Chen, Zhi John Lu, Yang Chen, Bing Zhou, Hairi Li, Xian Du, Yang Yang, Mingkui San, Xintao Wei, Wen Liu, Eric Lécuyer, Brenton R. Graveley, Gene W. Yeo, Christopher B. Burge, Michael Q. Zhang, Yu Zhou & Xiang-Dong Fu. (2019) Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-Based Regulation of Transcription. Cell 178:1, pages 107-121.e18.
Crossref
Sanna Abbasi & Caroline Schild-Poulter. (2018) Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells. Journal of Proteome Research 18:3, pages 1064-1077.
Crossref
Qiurong Wang, Chaoqun Zhu, Mingming Sun, Rexiati Maimaiti, Stephen P. Ford, Peter W. Nathanielsz, Jun Ren & Wei Guo. (2018) Maternal obesity impairs fetal cardiomyocyte contractile function in sheep. The FASEB Journal 33:2, pages 2587-2598.
Crossref
Serge Gregoire, Guang Li, Anthony C. Sturzu, Robert J. Schwartz & Sean M. Wu. (2017) YY1 Expression Is Sufficient for the Maintenance of Cardiac Progenitor Cell State. Stem Cells 35:8, pages 1913-1923.
Crossref
Damiano Fantini, Shuo Huang, John M. Asara, Srilata Bagchi & Pradip Raychaudhuri. (2017) Chromatin association of XRCC5/6 in the absence of DNA damage depends on the XPE gene product DDB2. Molecular Biology of the Cell 28:1, pages 192-200.
Crossref
E. S. Knyazhanskaya, O. A. Shadrina, A. N. Anisenko & M. B. Gottikh. (2016) Role of DNA-dependent protein kinase in the HIV-1 replication cycle. Molecular Biology 50:4, pages 567-579.
Crossref
Brian L. Stauffer, Karen Dockstader, Gloria Russell, Jamie Hijmans, Lisa Walker, Mackenzie Cecil, Kimberly Demos-Davies, Allen Medway, Timothy A. McKinsey & Carmen C. Sucharov. (2015) Transgenic over-expression of YY1 induces pathologic cardiac hypertrophy in a sex-specific manner. Biochemical and Biophysical Research Communications 462:2, pages 131-137.
Crossref
Ilimbek Beketaev, Yi Zhang, Eun Young Kim, Wei Yu, Ling Qian & Jun Wang. (2015) Critical role of YY1 in cardiac morphogenesis. Developmental Dynamics 244:5, pages 669-680.
Crossref
Guillaume Adelmant, Anne S. Calkins, Brijesh K. Garg, Joseph D. Card, Manor Askenazi, Alex Miron, Bijan Sobhian, Yi Zhang, Yoshihiro Nakatani, Pamela A. Silver, J. Dirk Iglehart, Jarrod A. Marto & Jean-Bernard Lazaro. (2012) DNA Ends Alter the Molecular Composition and Localization of Ku Multicomponent Complexes. Molecular & Cellular Proteomics 11:8, pages 411-421.
Crossref
Daniela De Zio, Matteo Bordi & Francesco Cecconi. (2012) Oxidative DNA Damage in Neurons: Implication of Ku in Neuronal Homeostasis and Survival. International Journal of Cell Biology 2012, pages 1-8.
Crossref
D De Zio, M Bordi, E Tino, C Lanzuolo, E Ferraro, E Mora, F Ciccosanti, G M Fimia, V Orlando & F Cecconi. (2010) The DNA repair complex Ku70/86 modulates Apaf1 expression upon DNA damage. Cell Death & Differentiation 18:3, pages 516-527.
Crossref
Grégory Nolens, Jean-Christophe Pignon, Benjamin Koopmansch, Benaïssa Elmoualij, Willy Zorzi, Edwin De Pauw & Rosita Winkler. (2009) Ku proteins interact with activator protein-2 transcription factors and contribute to ERBB2overexpression in breast cancer cell lines. Breast Cancer Research 11:6.
Crossref
Denis J. GlennFeng WangSongcang ChenMinobu NishimotoDavid G. Gardner. (2009) Endothelin-Stimulated Human B-Type Natriuretic Peptide Gene Expression Is Mediated by Yin Yang 1 in Association With Histone Deacetylase 2. Hypertension 53:3, pages 549-555.
Crossref
Kumar Pandya, John Cowhig, Joe Brackhan, Hyung Suk Kim, John Hagaman, Mauricio Rojas, Charles W. CarterJrJr, Lan Mao, Howard A. Rockman, Nobuyo Maeda & Oliver Smithies. (2008) Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo . Proceedings of the National Academy of Sciences 105:35, pages 13063-13068.
Crossref
Jyothish B. Pillai, Martin Chen, Senthilkumar B. Rajamohan, Sadhana Samant, Vinodkumar B. Pillai, Madhu Gupta & Mahesh P. Gupta. (2008) Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the α-myosin heavy chain expression. American Journal of Physiology-Heart and Circulatory Physiology 294:3, pages H1388-H1397.
Crossref
Mahesh P. Gupta. (2007) Factors controlling cardiac myosin-isoform shift during hypertrophy and heart failure. Journal of Molecular and Cellular Cardiology 43:4, pages 388-403.
Crossref
Luni Emdad, Devanand Sarkar, Zao-Zhong Su, Seok-Geun Lee, Dong-Chul Kang, Jeffrey N. Bruce, David J. Volsky & Paul B. Fisher. (2007) Astrocyte elevated gene-1: Recent insights into a novel gene involved in tumor progression, metastasis and neurodegeneration. Pharmacology & Therapeutics 114:2, pages 155-170.
Crossref
Heinz RuppBernhard Maisch. (2007) Separation of large mammalian ventricular myosin differing in ATPase activityThis paper is one of a selection of papers published in this Special Issue, entitled The Cellular and Molecular Basis of Cardiovascular Dysfunction, Dhalla 70th Birthday Tribute.. Canadian Journal of Physiology and Pharmacology 85:3-4, pages 326-331.
Crossref
Masashi Idogawa, Mitsuko Masutani, Miki Shitashige, Kazufumi Honda, Takashi Tokino, Yasuhisa Shinomura, Kohzoh Imai, Setsuo Hirohashi & Tesshi Yamada. (2007) Ku70 and Poly(ADP-Ribose) Polymerase-1 Competitively Regulate β-Catenin and T-Cell Factor-4–Mediated Gene Transactivation: Possible Linkage of DNA Damage Recognition and Wnt Signaling. Cancer Research 67:3, pages 911-918.
Crossref
M. Rouleau, D. McDonald, P. Gagné, M.-E. Ouellet, A. Droit, J.M. Hunter, S. Dutertre, C. Prigent, M.J. Hendzel & G.G. Poirier. (2007) PARP-3 associates with polycomb group bodies and with components of the DNA damage repair machinery. Journal of Cellular Biochemistry 100:2, pages 385-401.
Crossref
KAROLINA RAFALSKI, AICHA ABDOURAHMAN & JOHN G. EDWARDS. (2007) Early Adaptations to Training. Medicine & Science in Sports & Exercise 39:1, pages 75-82.
Crossref
Seok-Geun LeeZao-Zhong SuLuni EmdadDevanand SarkarPaul B. Fisher. (2006) Astrocyte elevated gene-1 ( AEG-1 ) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc . Proceedings of the National Academy of Sciences 103:46, pages 17390-17395.
Crossref
Carmen C. Sucharov, Stephen Langer, Michael Bristow & Leslie Leinwand. (2006) Shuttling of HDAC5 in H9C2 cells regulates YY1 function through CaMKIV/PKD and PP2A. American Journal of Physiology-Cell Physiology 291:5, pages C1029-C1037.
Crossref
Bradley M. Palmer. (2005) Thick Filament Proteins and Performance in Human Heart Failure. Heart Failure Reviews 10:3, pages 187-197.
Crossref
DeeAnn M. Rivera & Brian D. Lowes. (2005) Molecular remodeling in the failing human heart. Current Heart Failure Reports 2:1, pages 5-9.
Crossref
Peter D. Mariner, Stephen W. Luckey, Carlin S. Long, Carmen C. Sucharov & Leslie A. Leinwand. (2004) Yin Yang 1 represses α-myosin heavy chain gene expression in pathologic cardiac hypertrophy. Biochemical and Biophysical Research Communications 326:1, pages 79-86.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.