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Cell Growth and Development

Bromodomain Protein Brd4 Binds to GTPase-Activating SPA-1, Modulating Its Activity and Subcellular Localization

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Pages 9059-9069 | Received 25 Feb 2004, Accepted 27 Jul 2004, Published online: 27 Mar 2023

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Ballachanda N Devaiah, Anne Gegonne & Dinah S Singer. (2016) Bromodomain 4: a cellular Swiss army knife. Journal of Leukocyte Biology 100:4, pages 679-686.
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M. Lee & N.P.S. Crawford. 2016. Molecular and Cellular Basis of Metastasis: Road to Therapy. Molecular and Cellular Basis of Metastasis: Road to Therapy 73 109 .
G Wedeh, S Cerny-Reiterer, G Eisenwort, H Herrmann, K Blatt, E Hadzijusufovic, I Sadovnik, L Müllauer, J Schwaab, T Hoffmann, J E Bradner, D Radia, W R Sperr, G Hoermann, A Reiter, H-P Horny, J Zuber, M Arock & P Valent. (2015) Identification of bromodomain-containing protein-4 as a novel marker and epigenetic target in mast cell leukemia. Leukemia 29:11, pages 2230-2237.
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Crossref
Y Zhang, Y Gong, D Hu, P Zhu, N Wang, Q Zhang, M Wang, A Aldeewan, H Xia, X Qu, B Z Ring, N Minato & L Su. (2014) Nuclear SIPA1 activates integrin β1 promoter and promotes invasion of breast cancer cells. Oncogene 34:11, pages 1451-1462.
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Anjali Shukla, Jude Alsarraj & Kent Hunter. (2014) Understanding susceptibility to breast cancer metastasis: the genetic approach. Breast Cancer Management 3:2, pages 165-172.
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Ningning Zhao & Caroline A. Enns. (2013) N-Linked Glycosylation Is Required for Transferrin-Induced Stabilization of Transferrin Receptor 2, but Not for Transferrin Binding or Trafficking to the Cell Surface. Biochemistry 52:19, pages 3310-3319.
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Crossref
Ranran Wang, Qing Li, Christine M. Helfer, Jing Jiao & Jianxin You. (2012) Bromodomain Protein Brd4 Associated with Acetylated Chromatin Is Important for Maintenance of Higher-order Chromatin Structure. Journal of Biological Chemistry 287:14, pages 10738-10752.
Crossref
Jude Alsarraj & Kent W. Hunter. (2012) Bromodomain-Containing Protein 4: A Dynamic Regulator of Breast Cancer Metastasis through Modulation of the Extracellular Matrix. International Journal of Breast Cancer 2012, pages 1-7.
Crossref
Nigel P. S. Crawford & Kent W. Hunter. 2012. Cancer Metastasis. Cancer Metastasis 96 104 .
Jude Alsarraj, Renard C. Walker, Joshua D. Webster, Thomas R. Geiger, Nigel P.S. Crawford, R. Mark Simpson, Keiko Ozato & Kent W. Hunter. (2011) Deletion of the Proline-Rich Region of the Murine Metastasis Susceptibility Gene Brd4 Promotes Epithelial-to-Mesenchymal Transition- and Stem Cell-Like Conversion. Cancer Research 71:8, pages 3121-3131.
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Crossref
Jiangfang WangEmma L. Reuschel, Jason M. ShackelfordLauren JeangDebra K. ShiversJ. Alan Diehl, Xiao-Fang Yu & Terri H. Finkel. (2011) HIV-1 Vif promotes the G1- to S-phase cell-cycle transition. Blood 117:4, pages 1260-1269.
Crossref
Gerald V. Denis, Barbara S. Nikolajczyk & Gavin R. Schnitzler. (2010) An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis. FEBS Letters 584:15, pages 3260-3268.
Crossref
Friederike Vollmuth, Wulf Blankenfeldt & Matthias Geyer. (2009) Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution. Journal of Biological Chemistry 284:52, pages 36547-36556.
Crossref
J. Chad Brenner & Arul M. Chinnaiyan. (2009) Translocations in epithelial cancers. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1796:2, pages 201-215.
Crossref
Nigel P.S. Crawford, Hailiu Yang, Katherine R. Mattaini & Kent W. Hunter. (2009) The Metastasis Efficiency Modifier Ribosomal RNA Processing 1 Homolog B (RRP1B) Is a Chromatin-associated Factor. Journal of Biological Chemistry 284:42, pages 28660-28673.
Crossref
Michele M. Fluck & Brian S. Schaffhausen. (2009) Lessons in Signaling and Tumorigenesis from Polyomavirus Middle T Antigen. Microbiology and Molecular Biology Reviews 73:3, pages 542-563.
Crossref
Meisheng Zhou, Keven Huang, Kyung-Jin Jung, Won-Kyung Cho, Zach Klase, Fatah Kashanchi, Cynthia A. Pise-Masison & John N. Brady. (2009) Bromodomain Protein Brd4 Regulates Human Immunodeficiency Virus Transcription through Phosphorylation of CDK9 at Threonine 29. Journal of Virology 83:2, pages 1036-1044.
Crossref
Nagahiro Minato & Masakazu Hattori. (2009) Spa-1 (Sipa1) and Rap signaling in leukemia and cancer metastasis. Cancer Science 100:1, pages 17-23.
Crossref
Scott F. Winter & Kent W. Hunter. (2008) Mouse Modifier Genes in Mammary Tumorigenesis and Metastasis. Journal of Mammary Gland Biology and Neoplasia 13:3, pages 337-342.
Crossref
Tom K. Kerppola. (2008) Bimolecular Fluorescence Complementation (BiFC) Analysis as a Probe of Protein Interactions in Living Cells. Annual Review of Biophysics 37:1, pages 465-487.
Crossref
Ying Liu, Xiqing Wang, Jiahai Zhang, Hongda Huang, Bo Ding, Jihui Wu & Yunyu Shi. (2008) Structural Basis and Binding Properties of the Second Bromodomain of Brd4 with Acetylated Histone Tails. Biochemistry 47:24, pages 6403-6417.
Crossref
Nigel P. S. Crawford, Renard C. Walker, Luanne Lukes, Jennifer S. Officewala, Robert W. Williams & Kent W. Hunter. (2008) The Diasporin Pathway: a tumor progression-related transcriptional network that predicts breast cancer survival. Clinical & Experimental Metastasis 25:4, pages 357-369.
Crossref
Nigel P. S. Crawford, Jude Alsarraj, Luanne Lukes, Renard C. Walker, Jennifer S. Officewala, Howard H. Yang, Maxwell P. Lee, Keiko Ozato & Kent W. Hunter. (2008) Bromodomain 4 activation predicts breast cancer survival . Proceedings of the National Academy of Sciences 105:17, pages 6380-6385.
Crossref
C A French, C L Ramirez, J Kolmakova, T T Hickman, M J Cameron, M E Thyne, J L Kutok, J A Toretsky, A K Tadavarthy, U R Kees, J A Fletcher & J C Aster. (2007) BRD–NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells. Oncogene 27:15, pages 2237-2242.
Crossref
Kazuki Mochizuki, Akira Nishiyama, Moon Kyoo Jang, Anup Dey, Anu Ghosh, Tomohiko Tamura, Hiroko Natsume, Hongjie Yao & Keiko Ozato. (2008) The Bromodomain Protein Brd4 Stimulates G1 Gene Transcription and Promotes Progression to S Phase. Journal of Biological Chemistry 283:14, pages 9040-9048.
Crossref
Tom K. Kerppola. 2008. Fluorescent Proteins. Fluorescent Proteins 431 470 .
Severine I. GharbiMarketa J. ZvelebilStephen J. ShuttleworthTim HancoxNahid SaghirJohn F. TimmsMichael D. Waterfield. (2007) Exploring the specificity of the PI3K family inhibitor LY294002. Biochemical Journal 404:1, pages 15-21.
Crossref
Shwu-Yuan Wu & Cheng-Ming Chiang. (2007) The Double Bromodomain-containing Chromatin Adaptor Brd4 and Transcriptional Regulation. Journal of Biological Chemistry 282:18, pages 13141-13145.
Crossref
Takashi Nagashima, Tetsuo Maruyama, Masataka Furuya, Takashi Kajitani, Hiroshi Uchida, Hirotaka Masuda, Masanori Ono, Toru Arase, Keiko Ozato & Yasunori Yoshimura. (2007) Histone acetylation and subcellular localization of chromosomal protein BRD4 during mouse oocyte meiosis and mitosis†. MHR: Basic science of reproductive medicine 13:3, pages 141-148*.
Crossref
Nagahiro Minato, Kohei Kometani,Masakazu Hattori. 2007. 229 264 .
Tom K Kerppola. (2006) Design and implementation of bimolecular fluorescence complementation (BiFC) assays for the visualization of protein interactions in living cells. Nature Protocols 1:3, pages 1278-1286.
Crossref
Tom K. Kerppola. (2006) Visualization of molecular interactions by fluorescence complementation. Nature Reviews Molecular Cell Biology 7:6, pages 449-456.
Crossref
Eliana M. Assmann, Marcos R. Alborghetti, Maria E.R. Camargo & Jörg Kobarg. (2006) FEZ1 Dimerization and Interaction with Transcription Regulatory Proteins Involves Its Coiled-coil Region. Journal of Biological Chemistry 281:15, pages 9869-9881.
Crossref
Chang‐Deng Hu, Asya V. Grinberg & Tom K. Kerppola. (2006) Visualization of Protein Interactions in Living Cells Using Bimolecular Fluorescence Complementation ( Bi FC ) Analysis . Current Protocols in Cell Biology 29:1.
Crossref
Yeong-Gwan Park, Xiaohong Zhao, Fabienne Lesueur, Douglas R Lowy, Mindy Lancaster, Paul Pharoah, Xiaolan Qian & Kent W Hunter. (2005) Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1. Nature Genetics 37:10, pages 1055-1062.
Crossref
Moon Kyoo Jang, Kazuki Mochizuki, Meisheng Zhou, Ho-Sang Jeong, John N. Brady & Keiko Ozato. (2005) The Bromodomain Protein Brd4 Is a Positive Regulatory Component of P-TEFb and Stimulates RNA Polymerase II-Dependent Transcription. Molecular Cell 19:4, pages 523-534.
Crossref
Chang‐Deng Hu, Asya V. Grinberg & Tom K. Kerppola. (2005) Visualization of Protein Interactions in Living Cells Using Bimolecular Fluorescence Complementation ( Bi FC ) Analysis . Current Protocols in Protein Science 41:1.
Crossref
Hideshi IshiiKoshi MimoriMasaki MoriAndrea Vecchione. (2005) Differentially Expressed Genes in Endothelial Differentiation. DNA and Cell Biology 24:7, pages 432-437.
Crossref
Chang‐Deng Hu, Asya V. Grinberg & Tom K. Kerppola. (2005) Visualization of Protein Interactions in Living Cells Using Bimolecular Fluorescence Complementation ( Bi FC ) Analysis . Current Protocols in Cell Biology 26:1.
Crossref

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