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Molecular and Cellular Biology Volume 24, 2004 - Issue 24
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Gene Expression

Leukemogenesis Caused by Incapacitated GATA-1 Function

Ritsuko Shimizu1 Graduate School of Comprehensive Human Sciences, Center for Tsukuba Advanced Research Alliance;2 ERATO Environmental Response Project, University of Tsukuba, Tsukuba, Japan
,
Takashi Kuroha1 Graduate School of Comprehensive Human Sciences, Center for Tsukuba Advanced Research Alliance
,
Osamu Ohneda1 Graduate School of Comprehensive Human Sciences, Center for Tsukuba Advanced Research Alliance;2 ERATO Environmental Response Project, University of Tsukuba, Tsukuba, Japan
,
Xiaoqing Pan1 Graduate School of Comprehensive Human Sciences, Center for Tsukuba Advanced Research Alliance;2 ERATO Environmental Response Project, University of Tsukuba, Tsukuba, Japan
,
Kinuko Ohneda1 Graduate School of Comprehensive Human Sciences, Center for Tsukuba Advanced Research Alliance;2 ERATO Environmental Response Project, University of Tsukuba, Tsukuba, Japan
,
Satoru Takahashi1 Graduate School of Comprehensive Human Sciences, Center for Tsukuba Advanced Research Alliance
,
Sjaak Philipsen3 Department of Cell Biology, Medical Genetics Cluster, Erasmus MC, Rotterdam, The Netherlands
&
Masayuki Yamamoto1 Graduate School of Comprehensive Human Sciences, Center for Tsukuba Advanced Research Alliance;2 ERATO Environmental Response Project, University of Tsukuba, Tsukuba, JapanCorrespondence[email protected]
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Pages 10814-10825 | Received 28 Aug 2004, Accepted 27 Sep 2004, Published online: 27 Mar 2023

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Te Ling, John D. Crispino, Maria Zingariello, Fabrizio Martelli & Anna Rita Migliaccio. (2018) GATA1 insufficiencies in primary myelofibrosis and other hematopoietic disorders: consequences for therapy. Expert Review of Hematology 11:3, pages 169-184.
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Ana C Xavier, Yubin Ge & Jeffrey Taub. (2010) Unique clinical and biological features of leukemia in Down syndrome children. Expert Review of Hematology 3:2, pages 175-186.
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Mikiko Suzuki, Takashi Moriguchi, Kinuko Ohneda & Masayuki Yamamoto. (2009) Differential Contribution of the Gata1 Gene Hematopoietic Enhancer to Erythroid Differentiation. Molecular and Cellular Biology 29:5, pages 1163-1175.
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Zahra Kadri, Leila Maouche-Chretien, Heather M. Rooke, Stuart H. Orkin, Paul-Henri Romeo, Patrick Mayeux, Philippe Leboulch & Stany Chretien. (2005) Phosphatidylinositol 3-Kinase/Akt Induced by Erythropoietin Renders the Erythroid Differentiation Factor GATA-1 Competent for TIMP-1 Gene Transactivation. Molecular and Cellular Biology 25:17, pages 7412-7422.
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Amy Geddis. (2005) The molecular basis of congenital thrombocytopenias: Insights into megakaryopoiesis. Hematology 10:sup1, pages 299-305.
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Veerendra Munugalavadla, Louis C. Dore, Bai Lin Tan, Li Hong, Melanie Vishnu, Mitchell J. Weiss & Reuben Kapur. (2005) Repression of c-Kit and Its Downstream Substrates by GATA-1 Inhibits Cell Proliferation during Erythroid Maturation. Molecular and Cellular Biology 25:15, pages 6747-6759.
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Articles from other publishers (51)

Ritsuko Shimizu & Masayuki Yamamoto. (2023) Recent progress in analyses of GATA1 in hematopoietic disorders: a mini-review. Frontiers in Hematology 2.
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Shuichi Ozono, Shoichiro Yano, Saori Oishi, Miho Mitsuo, Shinichiro Nakagawa, Tsutomu Toki, Kiminori Terui & Etsuro Ito. (2022) A Case of Congenital Leukemia With MYB-GATA1 Fusion Gene in a Female Patient. Journal of Pediatric Hematology/Oncology 44:1, pages e250-e252.
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Vincent Fregona, Manon Bayet & Bastien Gerby. (2021) Oncogene-Induced Reprogramming in Acute Lymphoblastic Leukemia: Towards Targeted Therapy of Leukemia-Initiating Cells. Cancers 13:21, pages 5511.
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Kensaku Kohrogi, Shinjiro Hino, Akihisa Sakamoto, Kotaro Anan, Ryuta Takase, Hirotaka Araki, Yuko Hino, Kazutaka Araki, Tetsuya Sato, Kimitoshi Nakamura & Mitsuyoshi Nakao. (2021) LSD1 defines erythroleukemia metabolism by controlling the lineage-specific transcription factors GATA1 and C/EBPα. Blood Advances 5:9, pages 2305-2318.
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Marlies P. Rossmann & Leonard I. Zon. (2021) ‘Enhancing’ red cell fate through epigenetic mechanisms. Current Opinion in Hematology 28:3, pages 129-137.
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Alexandre Fagnan, Maria-Riera Piqué-Borràs, Samantha Tauchmann, Thomas Mercher & Juerg Schwaller. (2021) Molecular Landscapes and Models of Acute Erythroleukemia. HemaSphere 5:5, pages e558.
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John Strouboulis. (2020) Erythroleukemia: all roads lead to GATA1?. Blood 136:6, pages 648-649.
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Eunju Shin, Jong-Gwan Jeong, Hyunmin Chung, Haiyoung Jung, Charny Park, Suk Ran Yoon, Tae-Don Kim, Seung Jin Lee, Inpyo Choi & Ji-Yoon Noh. (2020) The Gata1 murine megakaryocyte–erythroid progenitor cells expand robustly and alter differentiation potential. Biochemical and Biophysical Research Communications 528:1, pages 46-53.
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Katharina Leonards, Marwa Almosailleakh, Samantha Tauchmann, Frederik Otzen Bagger, Cécile Thirant, Sabine Juge, Thomas Bock, Hélène Méreau, Matheus F. Bezerra, Alexandar Tzankov, Robert Ivanek, Régine Losson, Antoine H. F. M. Peters, Thomas Mercher & Juerg Schwaller. (2020) Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia. Nature Communications 11:1.
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Maureen McNulty & John D. Crispino. (2020) Acute Megakaryocytic Leukemia. Cold Spring Harbor Perspectives in Medicine 10:2, pages a034884.
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Laura Gutiérrez, Noemí Caballero, Luis Fernández‐Calleja, Elena Karkoulia & John Strouboulis. (2019) Regulation of GATA1 levels in erythropoiesis. IUBMB Life 72:1, pages 89-105.
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Te Ling & John D. Crispino. (2019) GATA1 mutations in red cell disorders. IUBMB Life 72:1, pages 106-118.
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Thalia Papayannopoulou & Anna Rita Migliaccio. 2018. Hematology. Hematology 297 320.e14 .
Atsushi Hasegawa & Ritsuko Shimizu. (2017) GATA1 Activity Governed by Configurations of cis-Acting Elements. Frontiers in Oncology 6.
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Etsuro Ito, Kiminori Terui & Tsutomu Toki. 2017. Hematological Disorders in Children. Hematological Disorders in Children 145 170 .
Ritsuko Shimizu & Masayuki Yamamoto. (2016) GATA-related hematologic disorders. Experimental Hematology 44:8, pages 696-705.
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Satoshi Saida. (2016) Evolution of myeloid leukemia in children with Down syndrome. International Journal of Hematology 103:4, pages 365-372.
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Kameshwar P. SinghJohn A. BennettFanny L. CasadoJason L. WalrathStephen L. WelleThomas A. Gasiewicz. (2014) Loss of Aryl Hydrocarbon Receptor Promotes Gene Changes Associated with Premature Hematopoietic Stem Cell Exhaustion and Development of a Myeloproliferative Disorder in Aging Mice. Stem Cells and Development 23:2, pages 95-106.
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Harumi Y. Mukai, Mikiko Suzuki, Masumi Nagano, Shin'ya Ohmori, Akihito Otsuki, Kouhei Tsuchida, Takashi Moriguchi, Kinuko Ohneda, Ritsuko Shimizu, Osamu Ohneda & Masayuki Yamamoto. (2013) Establishment of erythroleukemic GAK14 cells and characterization of GATA1 N-terminal domain. Genes to Cells, pages n/a-n/a.
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Ashley Pandolfi, Laura Barreyro & Ulrich Steidl. (2013) Concise Review: Preleukemic Stem Cells: Molecular Biology and Clinical Implications of the Precursors to Leukemia Stem Cells. Stem Cells Translational Medicine 2:2, pages 143-150.
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Ritsuko Shimizu & Masayuki Yamamoto. (2012) Contribution of GATA1 dysfunction to multi-step leukemogenesis. Cancer Science 103:12, pages 2039-2044.
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Mikiko Suzuki, Ritsuko Shimizu & Masayuki Yamamoto. (2011) Transcriptional regulation by GATA1 and GATA2 during erythropoiesis. International Journal of Hematology 93:2, pages 150-155.
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Rika KanezakiTsutomu TokiKiminori TeruiGang XuRuNan WangAkira ShimadaAsahito HamaHirokazu KaneganeKiyoshi KawakamiMikiya EndoDaisuke HasegawaKazuhiro KogawaSouichi AdachiYasuhiko IkedaShotaro IwamotoTakashi Taga, Yoshiyuki Kosaka, Seiji KojimaYasuhide HayashiEtsuro Ito. (2010) Down syndrome and GATA1 mutations in transient abnormal myeloproliferative disorder: mutation classes correlate with progression to myeloid leukemia. Blood 116:22, pages 4631-4638.
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P Burda, P Laslo & T Stopka. (2010) The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis. Leukemia 24:7, pages 1249-1257.
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Gergely T. Kozma, Fabrizio Martelli, Maria Verrucci, Laura Gutiérrez, Giovanni Migliaccio, Massimo Sanchez, Elena Alfani, Sjaak Philipsen & Anna Rita Migliaccio. (2010) Dynamic regulation of Gata1 expression during the maturation of conventional dendritic cells. Experimental Hematology 38:6, pages 489-503.e1.
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Eri Kobayashi, Ritsuko Shimizu, Yuko Kikuchi, Satoru Takahashi & Masayuki Yamamoto. (2010) Loss of the Gata1 Gene IE Exon Leads to Variant Transcript Expression and the Production of a GATA1 Protein Lacking the N-terminal Domain. Journal of Biological Chemistry 285:1, pages 773-783.
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Akira Niwa, Katsutsugu Umeda, Hsi Chang, Megumu Saito, Keisuke Okita, Kazutoshi Takahashi, Masato Nakagawa, Shinya Yamanaka, Tatsutoshi Nakahata & Toshio Heike. (2009) Orderly hematopoietic development of induced pluripotent stem cells via Flk-1 + hemoangiogenic progenitors . Journal of Cellular Physiology 221:2, pages 367-377.
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Ritsuko Shimizu, Eri Kobayashi, James Douglas Engel & Masayuki Yamamoto. (2009) Induction of hyperproliferative fetal megakaryopoiesis by an N-terminally truncated GATA1 mutant. Genes to Cells 14:9, pages 1119-1131.
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Kanako Abe, Ritsuko Shimizu, Xiaoqing Pan, Hiromi Hamada, Hiroyuki Yoshikawa & Masayuki Yamamoto. (2009) Stem cells of GATA1-related leukemia undergo pernicious changes after 5-fluorouracil treatment. Experimental Hematology 37:4, pages 435-445.e1.
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Beatrice U. Mueller & Thomas Pabst. 2010. Acute Myelogenous Leukemia. Acute Myelogenous Leukemia 109 125 .
Ritsuko Shimizu, James Douglas Engel & Masayuki Yamamoto. (2008) GATA1-related leukaemias. Nature Reviews Cancer 8:4, pages 279-287.
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Shoko Saito, Kaoru Nouno, Ritsuko Shimizu, Masayuki Yamamoto & Kyosuke Nagata. (2008) Impairment of erythroid and megakaryocytic differentiation by a Leukemia-Associated and t(9;9)-derived fusion gene product, SET/TAF-Iβ-CAN/Nup214. Journal of Cellular Physiology 214:2, pages 322-333.
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Christos I. Maratheftis, Pelagia E. Bolaraki & Michael Voulgarelis. (2007) GATA-1 transcription factor is up-regulated in bone marrow hematopoietic progenitor CD34+ and erythroid CD71+ cells in myelodysplastic syndromes. American Journal of Hematology 82:10, pages 887-892.
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Fengyun SuMarianne A. JuarezChristopher L. CookeLisa LaPointeJordan A. ShavitJennifer S. YamaokaSusan E. Lyons. (2007) Differential Regulation of Primitive Myelopoiesis in the Zebrafish by Spi-1/Pu.1 and C/ebp1. Zebrafish 4:3, pages 187-199.
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Kamaleldin E. Elagib & Adam N. Goldfarb. (2007) Oncogenic pathways of AML1-ETO in acute myeloid leukemia: Multifaceted manipulation of marrow maturation. Cancer Letters 251:2, pages 179-186.
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Scott G. Payton, Mingjun Liu, Yubin Ge & Larry H. Matherly. (2005) Transcriptional regulation of the human reduced folate carrier A1/A2 promoter: Identification of critical roles for the USF and GATA families of transcription factors. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1731:2, pages 115-124.
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Xiaoqing Pan, Osamu Ohneda, Kinuko Ohneda, Fokke Lindeboom, Fumiko Iwata, Ritsuko Shimizu, Masumi Nagano, Naruyoshi Suwabe, Sjaak Philipsen, Kim-Chew Lim, James D. Engel & Masayuki Yamamoto. (2005) Graded Levels of GATA-1 Expression Modulate Survival, Proliferation, and Differentiation of Erythroid Progenitors. Journal of Biological Chemistry 280:23, pages 22385-22394.
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