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Molecular and Cellular Biology Volume 24, 2004 - Issue 6
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Cell Growth and Development

Jab1/CSN5, a Component of the COP9 Signalosome, Regulates Transforming Growth Factor β Signaling by Binding to Smad7 and Promoting Its Degradation

Byung-Chul Kim1 Laboratory of Cell Regulation and Carcinogenesis;2 Division of Life Science, College of Natural Science, Kangwon National University, Chuncheon, Kangwon-do
,
Ho-Jae Lee1 Laboratory of Cell Regulation and Carcinogenesis
,
Seok Hee Park3 Inha University College of Medicine, Incheon, Korea
,
Sae Ra Lee1 Laboratory of Cell Regulation and Carcinogenesis
,
Tatiana S. Karpova4 Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, Maryland20892-5055
,
James G. McNally4 Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, Maryland20892-5055
,
Angelina Felici1 Laboratory of Cell Regulation and Carcinogenesis
,
Dug Keun Lee1 Laboratory of Cell Regulation and Carcinogenesis
&
Seong-Jin Kim1 Laboratory of Cell Regulation and CarcinogenesisCorrespondence[email protected]
 show all
Pages 2251-2262 | Received 25 Sep 2003, Accepted 16 Dec 2003, Published online: 27 Mar 2023

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Pinglong Xu, Xia Lin & Xin-Hua Feng. (2016) Posttranslational Regulation of Smads. Cold Spring Harbor Perspectives in Biology 8:12, pages a022087.
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Crossref
Qinglei Li. (2015) Inhibitory SMADs: Potential Regulators of Ovarian Function1. Biology of Reproduction 92:2.
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Navin K. Verma & Dermot Kelleher. (2014) Adaptor regulation of LFA-1 signaling in T lymphocyte migration: Potential druggable targets for immunotherapies?. European Journal of Immunology 44:12, pages 3484-3499.
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Lindsay A. Bashur, Dongxing Chen, Zhijun Chen, Bojian Liang, Ruggero Pardi, Shunichi Murakami & Guang Zhou. (2014) Loss of Jab1 in Osteochondral Progenitor Cells Severely Impairs Embryonic Limb Development in Mice. Journal of Cellular Physiology 229:11, pages 1607-1617.
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Crossref
Lingyu Luo, Nianshuang Li, Nonghua Lv & Deqiang Huang. (2014) SMAD7: a timer of tumor progression targeting TGF-β signaling. Tumor Biology 35:9, pages 8379-8385.
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Sreedhara Sangadala, Katsuhito Yoshioka, Yoshio Enyo, Yunshan Liu, Louisa Titus & Scott D. Boden. (2013) Characterization of a unique motif in LIM mineralization protein-1 that interacts with jun activation-domain-binding protein 1. Molecular and Cellular Biochemistry 385:1-2, pages 145-157.
Crossref
P Jiang, J Wang, Z Kang, D Li & D Zhang. (2013) Porcine JAB1 significantly enhances apoptosis induced by staurosporine. Cell Death & Disease 4:10, pages e823-e823.
Crossref
Lisa M. DenBoer, Aarti Iyer, Adam R.R. McCluggage, Yu Li, Amanda C. Martyn & Ray Lu. (2013) JAB1/CSN5 inhibits the activity of Luman/CREB3 by promoting its degradation. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1829:9, pages 921-929.
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Crossref
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Yaw Asare, Erdenechimeg Shagdarsuren, Johannes Schmid, Pathricia Tilstam, Jochen Grommes, Omar El Bounkari, Anke Schütz, Christian Weber, Menno de Winther, Heidi Noels & Jürgen Bernhagen. (2017) Endothelial CSN5 impairs NF-κB activation and monocyte adhesion to endothelial cells and is highly expressed in human atherosclerotic lesions. Thrombosis and Haemostasis 110:07, pages 141-152.
Crossref
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Crossref
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Crossref
Woo-Kwang Jeon, Hey-Young Hong, Won-Chan Seo, Kyu-Hyoung Lim, Hui-Young Lee, Woo-Jin Kim, Seo-Young Song & Byung-Chul Kim. (2012) Smad7 sensitizes A549 lung cancer cells to cisplatin-induced apoptosis through heme oxygenase-1 inhibition. Biochemical and Biophysical Research Communications 420:2, pages 288-292.
Crossref
Sevil Cayli, Ahmet Eyibilen, Levent Gurbuzler, Sema Koc, Gulsen Arslan Atay, Adnan Ekici & Ibrahim Aladağ. (2012) Jab1 expression is associated with TGF-β1 signaling in chronic rhinosinusitis and nasal polyposis. Acta Histochemica 114:1, pages 12-17.
Crossref
Daizo Koinuma, Masahiko Shinozaki, Yoshiko Nagano, Hiroaki Ikushima, Kana Horiguchi, Kouichiro Goto, Tokuhiro Chano, Masao Saitoh, Takeshi Imamura, Kohei Miyazono & Keiji Miyazawa. (2011) RB1CC1 Protein Positively Regulates Transforming Growth Factor-β Signaling through the Modulation of Arkadia E3 Ubiquitin Ligase Activity. Journal of Biological Chemistry 286:37, pages 32502-32512.
Crossref
Xiaohua Yan & Ye-Guang Chen. (2011) Smad7: not only a regulator, but also a cross-talk mediator of TGF-β signalling. Biochemical Journal 434:1, pages 1-10.
Crossref
Sevil Cayli, Seda Ocakli, Fikret Erdemir, Ufuk Tas, Huseyin Aslan, Tamer Yener & Zafer Karaca. (2011) Developmental expression of p97/VCP (Valosin-containing protein) and Jab1/CSN5 in the rat testis and epididymis. Reproductive Biology and Endocrinology 9:1, pages 117.
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María del Pilar Alatorre-Carranza, Alejandra Miranda-Díaz, Irinea Yañez-Sánchez, Oscar Pizano-Martínez, José M Hermosillo-Sandoval, Mónica Vázquez-Del Mercado, Sebastián Hernández-Hoyos, Ricardo Martínez-Abundis, Mary Fafutis-Morris, Jorge Segura-Ortega & Vidal Delgado-Rizo. (2009) Liver fibrosis secondary to bile duct injury: correlation of Smad7 with TGF-β and extracellular matrix proteins. BMC Gastroenterology 9:1.
Crossref
Sevil Cayli, Jörg Klug, Julius Chapiro, Suada Fröhlich, Gabriela Krasteva, Lukas Orel & Andreas Meinhardt. (2009) COP9 Signalosome Interacts ATP-dependently with p97/Valosin-containing Protein (VCP) and Controls the Ubiquitination Status of Proteins Bound to p97/VCP. Journal of Biological Chemistry 284:50, pages 34944-34953.
Crossref
Jun-ya Kato & Noriko Yoneda-Kato. (2009) Mammalian COP9 signalosome. Genes to Cells 14:11, pages 1209-1225.
Crossref
Jun Li, Yun Wang, Chaozhe Yang, Pengfei Wang, Denise K. Oelschlager, Yong Zheng, De-An Tian, William E. Grizzle, Donald J. Buchsbaum & Mei Wan. (2009) Polyethylene Glycosylated Curcumin Conjugate Inhibits Pancreatic Cancer Cell Growth through Inactivation of Jab1. Molecular Pharmacology 76:1, pages 81-90.
Crossref
Eun-Woo Lee, Sang-Sik Lee & Jae-Whan Song. (2009) Jab1 has negative effects on p53-mediated genotoxic stresses. BMB Reports 42:5, pages 299-303.
Crossref
Moshe Dessau, Yair Halimi, Tamir Erez, Orna Chomsky-Hecht, Daniel A. Chamovitz & Joel A. Hirsch. (2008) The Arabidopsis COP9 Signalosome Subunit 7 Is a Model PCI Domain Protein with Subdomains Involved in COP9 Signalosome Assembly . The Plant Cell 20:10, pages 2815-2834.
Crossref
Hiromi Ikeda & Tom K. Kerppola. (2008) Lysosomal Localization of Ubiquitinated Jun Requires Multiple Determinants in a Lysine-27–Linked Polyubiquitin Conjugate. Molecular Biology of the Cell 19:11, pages 4588-4601.
Crossref
Marion Le Foll, Sophie Blanchet, Laurine Millan, Chantal Mathieu, Catherine Bergounioux & Nathalie Glab. (2008) The plant CDK inhibitor NtKIS1a interferes with dedifferentiation, is specifically down regulated during development and interacts with a JAB1 homolog. Plant Science 175:4, pages 513-523.
Crossref
Katharine H. Wrighton & Xin-Hua Feng. (2008) To (TGF)β or not to (TGF)β: Fine-tuning of Smad signaling via post-translational modifications. Cellular Signalling 20:9, pages 1579-1591.
Crossref
Yevhen Filyak, Oksana Filyak, Serhiy Souchelnytskyi & Rostyslav Stoika. (2008) Doxorubicin inhibits TGF-β signaling in human lung carcinoma A549 cells. European Journal of Pharmacology 590:1-3, pages 67-73.
Crossref
Gaëlle Tanguy, Loïc Drévillon, Nicole Arous, Afia Hasnain, Alexandre Hinzpeter, Janine Fritsch, Michel Goossens & Pascale Fanen. (2008) CSN5 binds to misfolded CFTR and promotes its degradation. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1783:6, pages 1189-1199.
Crossref
Martina Panattoni, Francesca Sanvito, Veronica Basso, Claudio Doglioni, Giulia Casorati, Eugenio Montini, Jeffrey R. Bender, Anna Mondino & Ruggero Pardi. (2008) Targeted inactivation of the COP9 signalosome impairs multiple stagesof T cell development. Journal of Experimental Medicine 205:2, pages 465-477.
Crossref
Adam S. Adler, Laurie E. Littlepage, Meihong Lin, Tiara L.A. Kawahara, David J. Wong, Zena Werb & Howard Y. Chang. (2008) CSN5 Isopeptidase Activity Links COP9 Signalosome Activation to Breast Cancer Progression. Cancer Research 68:2, pages 506-515.
Crossref
Xiangjun Liu, Zhi Pan, Lingqiang Zhang, Qiao Sun, Jinghong Wan, Chunyan Tian, Guichun Xing, Juntao Yang, Xiaolin Liu, Jizhi Jiang & Fuchu He. (2008) JAB1 accelerates mitochondrial apoptosis by interaction with proapoptotic BclGs. Cellular Signalling 20:1, pages 230-240.
Crossref
Kohei Miyazono & Tomomasa Shimanuki. 2008. Principles of Bone Biology. Principles of Bone Biology 1177 1196 .
Christina Sieber, Gerburg K. Schwaerzer & Petra Knaus. 2008. Bone Morphogenetic Proteins: From Local to Systemic Therapeutics. Bone Morphogenetic Proteins: From Local to Systemic Therapeutics 81 114 .
Sonia B. JakowlewSusumu Itoh, Hiroyuki Suzuki, Fumiko Itoh, Kohei Miyazono & Mitsuyasu Kato. 2008. Transforming Growth Factor-β in Cancer Therapy, Volume I. Transforming Growth Factor-β in Cancer Therapy, Volume I 649 661 .
Sonia B. JakowlewSonia B. Jakowlew. 2008. Transforming Growth Factor-β in Cancer Therapy, Volume I. Transforming Growth Factor-β in Cancer Therapy, Volume I 3 21 .
Ian M. C. Dixon, Baiqiu Wang, Kristen M. Bedosky, Ryan H. Cunnington, Sunil G. Rattan & Ahmed Almaqrhi. 2008. Signal Transduction in the Cardiovascular System in Health and Disease. Signal Transduction in the Cardiovascular System in Health and Disease 249 266 .
Suntaek Hong, Chan Lee & Seong-Jin Kim. (2007) Smad7 Sensitizes Tumor Necrosis Factor–Induced Apoptosis through the Inhibition of Antiapoptotic Gene Expression by Suppressing Activation of the Nuclear Factor-κB Pathway. Cancer Research 67:19, pages 9577-9583.
Crossref
Huang-Ge Zhang, Helen Kim, Cunren Liu, Shaohua Yu, Jianhua Wang, William E. Grizzle, Robert P. Kimberly & Stephen Barnes. (2007) Curcumin reverses breast tumor exosomes mediated immune suppression of NK cell tumor cytotoxicity. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1773:7, pages 1116-1123.
Crossref
H-J Lee, C-H Yun, S H Lim, B-C Kim, K G Baik, J-M Kim, W-H Kim & S-J Kim. (2006) SRF is a nuclear repressor of Smad3-mediated TGF-β signaling. Oncogene 26:2, pages 173-185.
Crossref
Jochen Haag & Thomas Aigner. (2006) Jun activation domain-binding protein 1 binds Smad5 and inhibits bone morphogenetic protein signaling. Arthritis & Rheumatism 54:12, pages 3878-3884.
Crossref
Fengrui Zhang, Yujun Di, Jinjun Li, Yan Shi, Liping Zhang, Chunyan Wang, Xianghuo He, Yongzhong Liu, Dafang Wan, Keke Huo & Jianren Gu. (2006) Molecular cloning and characterization of human Aph2 gene, involved in AP-1 regulation by interaction with JAB1. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1759:11-12, pages 514-525.
Crossref
Wonkyung Oh, Mi-Ran Yang, Eun-Woo Lee, Ki-moon Park, Suhkneung Pyo, Joo-sung Yang, Han-Woong Lee & Jaewhan Song. (2006) Jab1 Mediates Cytoplasmic Localization and Degradation of West Nile Virus Capsid Protein. Journal of Biological Chemistry 281:40, pages 30166-30174.
Crossref
Kyung-Chul Choi, Youn Sook Lee, Seunghwan Lim, Hyo Kyoung Choi, Chang-Hun Lee, Eun-Kyung Lee, Suntaek Hong, In-Hoo Kim, Seong-Jin Kim & Seok Hee Park. (2006) Smad6 negatively regulates interleukin 1-receptor–Toll-like receptor signaling through direct interaction with the adaptor Pellino-1. Nature Immunology 7:10, pages 1057-1065.
Crossref
Wonkyung Oh, Eun-Woo Lee, Young Hoon Sung, Mi-Ran Yang, Jaewang Ghim, Han-Woong Lee & Jaewhan Song. (2006) Jab1 Induces the Cytoplasmic Localization and Degradation of p53 in Coordination with Hdm2. Journal of Biological Chemistry 281:25, pages 17457-17465.
Crossref
Hongqi Lue, Aphrodite Kapurniotu, Günter Fingerle-Rowson, Thierry Roger, Lin Leng, Michael Thiele, Thierry Calandra, Richard Bucala & Jürgen Bernhagen. (2006) Rapid and transient activation of the ERK MAPK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on JAB1/CSN5 and Src kinase activity. Cellular Signalling 18:5, pages 688-703.
Crossref
Adam S Adler, Meihong Lin, Hugo Horlings, Dimitry S A Nuyten, Marc J van de Vijver & Howard Y Chang. (2006) Genetic regulators of large-scale transcriptional signatures in cancer. Nature Genetics 38:4, pages 421-430.
Crossref
Kazutoshi Kameda, Mitsuhiro Fukao, Takeshi Kobayashi, Masaaki Tsutsuura, Masato Nagashima, Yoichi Yamada, Toshihiko Yamashita & Noritsugu Tohse. (2006) CSN5/Jab1 inhibits cardiac L-type Ca2+ channel activity through protein–protein interactions. Journal of Molecular and Cellular Cardiology 40:4, pages 562-569.
Crossref
Weibo Luo, Yingfei Wang, Theodor Hanck, Rolf Stricker & Georg Reiser. (2006) Jab1, a Novel Protease-activated Receptor-2 (PAR-2)-interacting Protein, Is Involved in PAR-2-induced Activation of Activator Protein-1. Journal of Biological Chemistry 281:12, pages 7927-7936.
Crossref
Xin-Hua Feng & Xia Lin. 2006. Smad Signal Transduction. Smad Signal Transduction 253 276 .
Katharine S. Richardson & Wayne Zundel. (2005) The Emerging Role of the COP9 Signalosome in Cancer. Molecular Cancer Research 3:12, pages 645-653.
Crossref
Mohini A. Patil, Ines Gütgemann, Ji Zhang, Coral Ho, Siu-Tim Cheung, David Ginzinger, Rui Li, Karl J. Dykema, Samuel So, Sheung-Tat Fan, Sanjay Kakar, Kyle A. Furge, Reinhard Büttner & Xin Chen. (2005) Array-based comparative genomic hybridization reveals recurrent chromosomal aberrations and Jab1 as a potential target for 8q gain in hepatocellular carcinoma. Carcinogenesis 26:12, pages 2050-2057.
Crossref
Hee-Jin Kwak, Sung Hak Kim, Hyeon Gyeong Yoo, Seok Hee Park & Chang-Hun Lee. (2005) Jun activation domain-binding protein 1 is required for mitotic checkpoint activation via its involvement in hyperphosphorylation of 53BP1. Journal of Cancer Research and Clinical Oncology 131:12, pages 789-796.
Crossref
Giovanni Monteleone, Giovanna Del Vecchio Blanco, Ivan Monteleone, Daniele Fina, Roberta Caruso, Valentina Gioia, Sabrina Ballerini, Giorgio Federici, Sergio Bernardini, Francesco Pallone & Thomas T. MacDonald. (2005) Post-transcriptional Regulation of Smad7 in the Gut of Patients With Inflammatory Bowel Disease. Gastroenterology 129:5, pages 1420-1429.
Crossref
Maria D. Serafica, Tetsuya Goto & Alan O. Trounson. (2005) Transcripts from a human primordial follicle cDNA library. Human Reproduction 20:8, pages 2074-2091.
Crossref
Jianning Bi, Huiyu Xia, Fei Li, Xuegong Zhang & Yanda Li. (2005) The effect of U1 snRNA binding free energy on the selection of 5′ splice sites. Biochemical and Biophysical Research Communications 333:1, pages 64-69.
Crossref
Anita Morén, Takeshi Imamura, Kohei Miyazono, Carl-Henrik Heldin & Aristidis Moustakas. (2005) Degradation of the Tumor Suppressor Smad4 by WW and HECT Domain Ubiquitin Ligases. Journal of Biological Chemistry 280:23, pages 22115-22123.
Crossref
Kohei Miyazono, Shingo Maeda & Takeshi Imamura. (2005) BMP receptor signaling: Transcriptional targets, regulation of signals, and signaling cross-talk. Cytokine & Growth Factor Reviews 16:3, pages 251-263.
Crossref
Go KURATOMI, Akiyoshi KOMURO, Kouichiro GOTO, Masahiko SHINOZAKI, Keiji MIYAZAWA, Kohei MIYAZONO & Takeshi IMAMURA. (2005) NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-β (transforming growth factor-β) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-β type I receptor. Biochemical Journal 386:3, pages 461-470.
Crossref
Seok-Hee Park. (2005) Fine Tuning and Cross-talking of TGF-β Signal by Inhibitory Smads. BMB Reports 38:1, pages 9-16.
Crossref
Isaac YiKim, Moses M. Kim & Seong-Jin Kim. (2005) Transforming Growth Factor-β: Biology and Clinical Relevance. BMB Reports 38:1, pages 1-8.
Crossref
Giovanni Monteleone, Francesco Pallone & Thomas T. MacDonald. (2004) Smad7 in TGF-β-mediated negative regulation of gut inflammation. Trends in Immunology 25:10, pages 513-517.
Crossref

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