Advanced search
Publication Cover
Molecular and Cellular Biology Volume 25, 2005 - Issue 11
Submit an article Journal homepage
39
Views
86
CrossRef citations to date
0
Altmetric
Signal Transduction

Gadd45a Expression Induces Bim Dissociation from the Cytoskeleton and Translocation to Mitochondria

Tong Tong1 State Key Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing100021, People’s Republic of China
,
Junfang Ji1 State Key Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing100021, People’s Republic of China
,
Shunqian Jin1 State Key Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing100021, People’s Republic of China;2 Department of Radiation Oncology, Cancer Institute and University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania15213
,
Xianxing Li1 State Key Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing100021, People’s Republic of China
,
Wenhong Fan3 Department of Neurobiology, Institute of Basic Medical Sciences, Beijing100850, People’s Republic of China
,
Yongmei Song1 State Key Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing100021, People’s Republic of China
,
Minrong Wang1 State Key Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing100021, People’s Republic of China
,
Zhihua Liu1 State Key Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing100021, People’s Republic of China
,
Min Wu1 State Key Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing100021, People’s Republic of China
&
Qimin Zhan1 State Key Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing100021, People’s Republic of ChinaCorrespondence[email protected]
 show all
Pages 4488-4500 | Received 04 Sep 2004, Accepted 17 Mar 2005, Published online: 27 Mar 2023

Citations (86)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Qiwen Shi, Vijaykumar Sutariya, Sheeba Varghese Gupta & Deepak Bhatia. (2019) GADD45α-targeted suicide gene therapy driven by synthetic CArG promoter E9NS sensitizes NSCLC cells to cisplatin, resveratrol, and radiation regardless of p53 status. OncoTargets and Therapy 12, pages 3161-3170.
Read now
Mingyang Wang, Yi Zhang, Lu Feng, Ji Zheng, Shujie Fan, Junya Liu, Nan Yang, Yanyong Liu & Pingping Zuo. (2017) Compound porcine cerebroside and ganglioside injection attenuates cerebral ischemia–reperfusion injury in rats by targeting multiple cellular processes. Neuropsychiatric Disease and Treatment 13, pages 927-935.
Read now
Dongdong Zhang, Weimin Zhang, Dan Li, Ming Fu, Runsheng Chen & Qimin Zhan. (2015) GADD45A inhibits autophagy by regulating the interaction between BECN1 and PIK3C3. Autophagy 11:12, pages 2247-2258.
Read now
Alexander Shtilbans, Soon-Gang Choi, Mary E. Fowkes, Greg Khitrov, Mona Shahbazi, Jess Ting, Weijia Zhang, Yezhou Sun, Stuart C. Sealfon & Dale J. Lange. (2011) Differential gene expression in patients with amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis 12:4, pages 250-256.
Read now

Articles from other publishers (82)

Lingyun Liao, Min Liu, Yijie Gao, Xiaohong Wei, Yangxue Yin, Linbo Gao & Rong Zhou. (2022) The long noncoding RNA TARID regulates the CXCL3/ERK/MAPK pathway in trophoblasts and is associated with preeclampsia. Reproductive Biology and Endocrinology 20:1.
Crossref
Michelle Przedborski, David Sharon, Severine Cathelin, Steven Chan & Mohammad Kohandel. (2022) An integrative systems biology approach to overcome venetoclax resistance in acute myeloid leukemia. PLOS Computational Biology 18:9, pages e1010439.
Crossref
Jonathan Wooten, Nicole Mavingire, Cristina A. Araújo, Joyce Aja, Shaniece Wauchope, Rupika Delgoda & Eileen Brantley. (2022) Dibenzyl trisulfide induces caspase-independent death and lysosomal membrane permeabilization of triple-negative breast cancer cells. Fitoterapia 160, pages 105203.
Crossref
Yu-Lan Li, Xiao-Min Zhu, Nan-Feng Chen, Shao-Ting Chen, Yang Yang, Hong Liang & Zhen-Feng Chen. (2022) Anticancer activity of ruthenium(II) plumbagin complexes with polypyridyl as ancillary ligands via inhibiting energy metabolism and GADD45A-mediated cell cycle arrest. European Journal of Medicinal Chemistry 236, pages 114312.
Crossref
Gurushankar Chandramouly. 2022. Gadd45 Stress Sensor Genes. Gadd45 Stress Sensor Genes 55 67 .
Arslon Humayun & Albert J. FornaceJrJr. 2022. Gadd45 Stress Sensor Genes. Gadd45 Stress Sensor Genes 1 22 .
Saswat Mohapatra, Varsha Gupta, Prasenjit Mondal, Shreyam Chatterjee, Debmalya Bhunia & Surajit Ghosh. (2021) A Small Molecule with Bridged Carbonyl and Tri‐fluoro‐aceto‐phenone Groups Impedes Microtubule Dynamics and Subsequently Triggers Cancer Cell Apoptosis. ChemMedChem 16:17, pages 2703-2714.
Crossref
Minting Chen, Hsin Ling Wu, Tsz Sin Wong, Baisen Chen, Rui-Hong Gong, Hoi Leong Xavier Wong, Haitao Xiao, Zhaoxiang Bian & Hiu Yee Kwan. (2021) Combination of Wogonin and Artesunate Exhibits Synergistic anti-Hepatocellular Carcinoma Effect by Increasing DNA-Damage-Inducible Alpha, Tumor Necrosis Factor α and Tumor Necrosis Factor Receptor-Associated Factor 3-mediated Apoptosis. Frontiers in Pharmacology 12.
Crossref
Pei Ma, Yutian Pan, Fan Yang, Yuan Fang, Weitao Liu, Chenhui Zhao, Tao Yu, Mengyan Xie, Xingming Jing, Xi Wu, Chongqi Sun, Wei Li, Tongpeng Xu & Yongqian Shu. (2020) KLF5-Modulated lncRNA NEAT1 Contributes to Tumorigenesis by Acting as a Scaffold for BRG1 to Silence GADD45A in Gastric Cancer. Molecular Therapy - Nucleic Acids 22, pages 382-395.
Crossref
Wenjing You, Ziye Xu, Ye Sun, Teresa G. Valencak, Yizhen Wang & Tizhong Shan. (2020) GADD45α drives brown adipose tissue formation through upregulating PPARγ in mice. Cell Death & Disease 11:7.
Crossref
Rafal Bartoszewski, Magdalena Gebert, Anna Janaszak‐Jasiecka, Aleksandra Cabaj, Jarosław Króliczewski, Sylwia Bartoszewska, Aleksandra Sobolewska, David K. Crossman, Renata Ochocka, Wojciech Kamysz, Leszek Kalinowski, Michał Dąbrowski & James F. Collawn. (2020) Genome‐wide mRNA profiling identifies RCAN1 and GADD45A as regulators of the transitional switch from survival to apoptosis during ER stress . The FEBS Journal 287:14, pages 2923-2947.
Crossref
Angelika Długosz-Pokorska, Joanna Drogosz, Marlena Pięta, Tomasz Janecki, Urszula Krajewska, Marek Mirowski & Anna Janecka. (2020) New Uracil Analogs with Exocyclic Methylidene Group as Potential Anticancer Agents. Anti-Cancer Agents in Medicinal Chemistry 20:3, pages 359-368.
Crossref
Liping Xie, Limin Jia, Jinyue Qu, Dong Chen, Yanhong Lv, Haixia Li & Jinhua Zheng. (2020) Expression and prognostic significance of the P53‐related DNA damage repair proteins checkpoint kinase 1 (CHK1) and growth arrest and DNA‐damage‐inducible 45 alpha (GADD45A) in human oral squamous cell carcinoma. European Journal of Oral Sciences 128:2, pages 128-135.
Crossref
Tongtong Li, Lele Xu, Jinglei Teng, Yunping Ma, Wenzhong Liu, Yan Wang, Xinming Chi, Shujuan Shao, Yan Dong, Qimin Zhan & Xuefeng Liu. (2019) GADD45G Interacts with E-cadherin to Suppress the Migration and Invasion of Esophageal Squamous Cell Carcinoma. Digestive Diseases and Sciences 65:4, pages 1032-1041.
Crossref
Gulnur Aslan, Ahmet Atessahin & Engin Sahna. (2020) The inhibition of apoptosis through myocardial postconditioning by affecting Fas/FasIg signaling through miR139‐3p and miR181a‐1. Journal of Cardiac Surgery 35:3, pages 564-570.
Crossref
Fang Yang, Wang-wang Liu, Hui Chen, Jia Zhu, Ai-hua Huang, Fei Zhou, Yi Gan, Yan-hua Zhang & Li Ma. (2019) Carfilzomib inhibits the growth of lung adenocarcinoma via upregulation of Gadd45a expressionCarfilzomib 通过上调 Gadd45a 表达抑制肺腺癌细胞生长. Journal of Zhejiang University-SCIENCE B 21:1, pages 64-76.
Crossref
Duckgue Lee, Daniel Hokinson, Soyoung Park, Rosalie Elvira, Fedho Kusuma, Ji-Min Lee, Miyong Yun, Seok-Geun Lee & Jaeseok Han. (2019) ER Stress Induces Cell Cycle Arrest at the G2/M Phase Through eIF2α Phosphorylation and GADD45α. International Journal of Molecular Sciences 20:24, pages 6309.
Crossref
Bo-Ram Bang, Kyung Ho Han, Goo-Young Seo, Michael Croft & Young Jun Kang. (2019) The protein tyrosine kinase SYK regulates the alternative p38 activation in liver during acute liver inflammation. Scientific Reports 9:1.
Crossref
Wenjing You, Ziye Xu & Tizhong Shan. (2019) Regulatory Roles of GADD45α in Skeletal Muscle and Adipocyte. Current Protein & Peptide Science 20:9, pages 918-925.
Crossref
Zhaoqing Zheng, Man Wu, Juan Zhang, Wenwei Fu, Naihan Xu, Yuanzhi Lao, Lan Lin & Hongxi Xu. (2019) The Natural Compound Neobractatin Induces Cell Cycle Arrest by Regulating E2F1 and Gadd45α. Frontiers in Oncology 9.
Crossref
Benedikt Jacobs, Aline Pfefferle, Dennis Clement, Axel Berg-Larsen, Michelle L. Saetersmoen, Susanne Lorenz, Merete Thune Wiiger, Jodie P. Goodridge & Karl-Johan Malmberg. (2019) Induction of the BIM Short Splice Variant Sensitizes Proliferating NK Cells to IL-15 Withdrawal. The Journal of Immunology 202:3, pages 736-746.
Crossref
Nannan Ao, Yingchu Dai, Qianping Chen, Yang Feng, Jingping Yu, Chang Wang, Fenju Liu, Ming Li & Geng Liu. (2019) Genome-Wide Profiling of the Toxic Effect of Bortezomib on Human Esophageal Carcinoma Epithelial Cells. Technology in Cancer Research & Treatment 18, pages 153303381984254.
Crossref
Bo Wang, Chaoyang Liang, Huifeng Liu, Jixing Lin, Bailin Wang, Kaijie Fan, Zhipeng Ren, Bin Wang, Tong Li, Kang Qi & Xiaodong Tian. (2019) The expression of mouse double minute 2 homolog and P73 had no correlation with growth arrest DNA damage-inducible gene 45α in patients with non-small-cell lung carcinoma. Medicine 98:51, pages e17944.
Crossref
Chunmin Li, Yanan Ming, Zhengyang Wang, Qingling Xu, Lvfeng Yao, Dongke Xu, Yingyue Tang, Xiaohong Lei, Xiaobo Li & Yimin Mao. (2018) GADD45α alleviates acetaminophen-induced hepatotoxicity by promoting AMPK activation. Cellular and Molecular Life Sciences 76:1, pages 129-145.
Crossref
Meng-Qi Su, Yi-Ran Zhou, Xuan Rao, Hong Yang, Xin‑Hao Zhuang, Xue-Jia Ke, Guang-Yong Peng, Chang-Lin Zhou, Bai-Yong Shen & Jie Dou. (2018) Baicalein induces the apoptosis of HCT116�human colon cancer cells via the upregulation of DEPP/Gadd45a and activation of MAPKs. International Journal of Oncology.
Crossref
Takeshi Tsubata. (2017) B-cell tolerance and autoimmunity. F1000Research 6, pages 391.
Crossref
Yiwei Zhao, Lin Zhu, Shaojun Yu, Jing Zhu & Chong Wang. (2016) CaMKII inhibition promotes neuronal apoptosis by transcriptionally upregulating Bim expression. NeuroReport 27:14, pages 1018-1023.
Crossref
Daowen Li, Chongshan Dai, Yan Zhou, Xiayun Yang, Kena Zhao, Xilong Xiao & Shusheng Tang. (2016) Effect of GADD45a on olaquindox-induced apoptosis in human hepatoma G2 cells: Involvement of mitochondrial dysfunction. Environmental Toxicology and Pharmacology 46, pages 140-146.
Crossref
Ralph Pietrofesa, Anastasia Velalopoulou, Stacey Lehman, Evguenia Arguiri, Pantelis Solomides, Cameron Koch, Om Mishra, Constantinos Koumenis, Thomas Goodwin & Melpo Christofidou-Solomidou. (2016) Novel Double-Hit Model of Radiation and Hyperoxia-Induced Oxidative Cell Damage Relevant to Space Travel. International Journal of Molecular Sciences 17:6, pages 953.
Crossref
Alicia Gonzalez-Martin, Brian D Adams, Maoyi Lai, Jovan Shepherd, Maria Salvador-Bernaldez, Jesus M Salvador, Jun Lu, David Nemazee & Changchun Xiao. (2016) The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity. Nature Immunology 17:4, pages 433-440.
Crossref
Hemanth Naick, Shunqian Jin & R. Baskaran. (2016) GADD45α modulates curcumin sensitivity through c-Abl- and JNK-dependent signaling pathways in a mismatch repair-dependent manner. Molecular and Cellular Biochemistry 414:1-2, pages 13-22.
Crossref
Daniel J. Tarrant, Mariarita Stirpe, Michelle Rowe, Mark J. Howard, Tobias von der Haar & Campbell W. Gourlay. (2016) Inappropriate expression of the translation elongation factor 1A disrupts genome stability and metabolism. Journal of Cell Science.
Crossref
Dan Li, Nan Kang, Junfang Ji & Qimin Zhan. (2015) BRCA1 regulates transforming growth factor-β (TGF-β1) signaling through Gadd45a by enhancing the protein stability of Smad4. Molecular Oncology 9:8, pages 1655-1666.
Crossref
Ronit Vogt Sionov, Spiros A. Vlahopoulos & Zvi Granot. (2015) Regulation of Bim in Health and Disease. Oncotarget 6:27, pages 23058-23134.
Crossref
Qiwen Shi, Werner Geldenhuys, Vijaykumar Sutariya, Anupam Bishayee, Isha Patel & Deepak Bhatia. (2015) CArG-driven GADD45α activated by resveratrol inhibits lung cancer cells. Genes & Cancer 6:5-6, pages 220-230.
Crossref
Maximilian W. Popp & Lynne E. Maquat. (2015) Attenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics. Nature Communications 6:1.
Crossref
Yang Guo, Andreas Ziesch, Sandra Hocke, Eric Kampmann, Stephanie Ochs, Enrico N. De Toni, Burkhard Göke & Eike Gallmeier. (2014) Overexpression of heat shock protein 27 ( HSP 27) increases gemcitabine sensitivity in pancreatic cancer cells through S‐phase arrest and apoptosis . Journal of Cellular and Molecular Medicine 19:2, pages 340-350.
Crossref
倩倩 彭. (2015) Influence of Gadd45 Gene Expression Regulation on Tumor Genesis. Immunology Studies 03:02, pages 19-24.
Crossref
Ji Zhou, Hui Bi, Ping Zhan, Cunjie Chang, Chunhua Xu, Xiaojing Huang, Like Yu, Xin Yao & Jun Yan. (2014) Overexpression of HP1γ is associated with poor prognosis in non-small cell lung cancer cell through promoting cell survival. Tumor Biology 35:10, pages 9777-9785.
Crossref
Xiao Li, Jing Suo, Shujuan Shao, Liyan Xue, Wei Chen, Lijia Dong, Ji Shi, Ming Fu, Ning Lu, Qimin Zhan & Tong Tong. (2014) Overexpression of OLC1 Promotes Tumorigenesis of Human Esophageal Squamous Cell Carcinoma. PLoS ONE 9:3, pages e90958.
Crossref
Yulin ChenXiaoming MaMeimei ZhangXiaomin WangChangxin WangHu WangPeng GuoWeiping YuanKarl Lenhard Rudolph, Qimin Zhan & Zhenyu Ju. (2014) Gadd45a regulates hematopoietic stem cell stress responses in mice. Blood 123:6, pages 851-862.
Crossref
Kathleen I. Pishas, Susan J. Neuhaus, Mark T. Clayer, Andreas W. Schreiber, David M. Lawrence, Michelle Perugini, Robert J. Whitfield, Gelareh Farshid, Jim Manavis, Steve Chryssidis, Bronwen J. Mayo, Rebecca C. Haycox, Kristen Ho, Michael P. Brown, Richard J. D'Andrea, Andreas Evdokiou, David M. Thomas, Jayesh Desai, David F. Callen & Paul M. Neilsen. (2014) Nutlin-3a Efficacy in Sarcoma Predicted by Transcriptomic and Epigenetic Profiling. Cancer Research 74:3, pages 921-931.
Crossref
ZAKIR HOSSAIN, TATSUYA SUGAWARA & TAKASHI HIRATA. (2013) Sphingoid bases from sea cucumber induce apoptosis in human hepatoma HepG2 cells through p-AKT and DR5. Oncology Reports 29:3, pages 1201-1207.
Crossref
Fang Yang, Weimin Zhang, Dan Li & Qimin Zhan. (2013) Gadd45a Suppresses Tumor Angiogenesis via Inhibition of the mTOR/STAT3 Protein Pathway*. Journal of Biological Chemistry 288:9, pages 6552-6560.
Crossref
Jesús M. Salvador, Joshua D. Brown-Clay & Albert J. FornaceJr.Jr.. 2013. Gadd45 Stress Sensor Genes. Gadd45 Stress Sensor Genes 1 19 .
Richard J. Rickles, Winnie F. Tam, Thomas P. GiordanoIIIIII, Laura T. Pierce, Melissa Farwell, Douglas W. McMillin, Antoaneta Necheva, David Crowe, Mei Chen, William Avery, Vikram Kansra, Steffan T. Nawrocki, Jennifer S. Carew, Francis J. Giles, Constantine S. Mitsiades, Alexis A. Borisy, Kenneth C. Anderson & Margaret S. Lee. (2012) Adenosine A2A and Beta-2 Adrenergic Receptor Agonists: Novel Selective and Synergistic Multiple Myeloma Targets Discovered through Systematic Combination Screening. Molecular Cancer Therapeutics 11:7, pages 1432-1442.
Crossref
Caroline H. Topham, Nicholas Billinton & Richard M. Walmsley. (2012) Nongenotoxic Apoptosis Inducers Do Not Produce Misleading Positive Results in the TK6 Cell-Based GADD45a-GFP Genotoxicity Assay. Toxicological Sciences 128:1, pages 79-91.
Crossref
Thomas Hubert, Joël Vandekerckhove & Jan Gettemans. (2011) Cdk1 and BRCA1 target γ-tubulin to microtubule domains. Biochemical and Biophysical Research Communications 414:1, pages 240-245.
Crossref
G. Mendez, C. Policarpi, C. Cenciarelli, C. Tanzarella & A. Antoccia. (2011) Role of Bim in apoptosis induced in H460 lung tumor cells by the spindle poison Combretastatin-A4. Apoptosis 16:9, pages 940-949.
Crossref
A. Rovini, A. Savry, D. Braguer & M. Carré. (2011) Microtubule-targeted agents: When mitochondria become essential to chemotherapy. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1807:6, pages 679-688.
Crossref
L Lembo-Fazio, G Nigro, G Noël, G Rossi, F Chiara, K Tsilingiri, M Rescigno, A Rasola & M L Bernardini. (2011) Gadd45α activity is the principal effector of Shigella mitochondria-dependent epithelial cell death in vitro and ex vivo. Cell Death & Disease 2:2, pages e122-e122.
Crossref
Xiao-ying Zhang, Xun Qu, Cheng-qin Wang, Cheng-jun Zhou, Gui-xiang Liu, Feng-cai Wei & Shan-zhen Sun. (2011) Over-expression of Gadd45a enhances radiotherapy efficacy in human Tca8113 cell line. Acta Pharmacologica Sinica 32:2, pages 253-258.
Crossref
Aleksandar Rakovic, Anne Grünewald, Lisa Voges, Sarah Hofmann, Slobodanka Orolicki, Katja Lohmann & Christine Klein. (2011) PINK1-Interacting Proteins: Proteomic Analysis of Overexpressed PINK1. Parkinson's Disease 2011, pages 1-9.
Crossref
Yi-Chen Chia, Ranjan Rajbanshi, Colonya Calhoun & Robert H. Chiu. (2010) Anti-Neoplastic Effects of Gallic Acid, a Major Component of Toona sinensis Leaf Extract, on Oral Squamous Carcinoma Cells. Molecules 15:11, pages 8377-8389.
Crossref
Sarah E. Aiyar, Hoyong Park, Paulomi B. Aldo, Gil Mor, John J. Gildea, Aaron L. Miller, E. Brad Thompson, J. David Castle, Sanghee Kim & Richard J. Santen. (2010) TMS, a chemically modified herbal derivative of Resveratrol, induces cell death by targeting Bax. Breast Cancer Research and Treatment 124:1, pages 265-277.
Crossref
Young Bong Choi & John Nicholas. (2010) Bim Nuclear Translocation and Inactivation by Viral Interferon Regulatory Factor. PLoS Pathogens 6:8, pages e1001031.
Crossref
Kirsty M. Brodie & Beric R. Henderson. (2010) Differential modulation of BRCA1 and BARD1 nuclear localisation and foci assembly by DNA damage. Cellular Signalling 22:2, pages 291-302.
Crossref
Takayuki Kojima, Takanari Norose, Keita Tsuchiya & Kazuichi Sakamoto. (2009) Mouse 3T3-L1 cells acquire resistance against oxidative stress as the adipocytes differentiate via the transcription factor FoxO. Apoptosis 15:1, pages 83-93.
Crossref
F. Gillardon. (2009) Interaction of elongation factor 1-alpha with leucine-rich repeat kinase 2 impairs kinase activity and microtubule bundling in vitro. Neuroscience 163:2, pages 533-539.
Crossref
Marcus Maier, Emanuel V. Geiger, Dirk Henrich, Ramin Ebrahimi, Sebastian Wutzler, Mark Lehnert & Ingo Marzi. (2009) Apoptosis differs in dendritic cell subsets early after severe trauma. Human Immunology 70:10, pages 803-808.
Crossref
Yang Yang, Ying Zhao, Wenjuan Liao, Jing Yang, Lipeng Wu, Zhixing Zheng, Yu Yu, Wen Zhou, Lian Li, Jingnan Feng, Haiying Wang & Wei-Guo Zhu. (2009) Acetylation of FoxO1 Activates Bim Expression to Induce Apoptosis in Response to Histone Deacetylase Inhibitor Depsipeptide Treatment. Neoplasia 11:4, pages 313-IN1.
Crossref
Kavitha Ramachandran, Gopal Gopisetty, Edna Gordian, Loida Navarro, Christiane Hader, Isildinha M. Reis, Wolfgang A. Schulz & Rakesh Singal. (2009) Methylation-Mediated Repression of GADD45α in Prostate Cancer and Its Role as a Potential Therapeutic Target . Cancer Research 69:4, pages 1527-1535.
Crossref
Yunfeng Li, Haili Qian, Xiao Li, Haijuan Wang, Jing Yu, Yongjun Liu, Xueyan Zhang, Xiao Liang, Ming Fu, Qimin Zhan & Chen Lin. (2009) Adenoviral-mediated gene transfer of Gadd45a results in suppression by inducing apoptosis and cell cycle arrest in pancreatic cancer cell. The Journal of Gene Medicine 11:1, pages 3-13.
Crossref
Cheng Yang, Yuehui Li, Zhijie Zhang, Chen Luo, Yongqing Tong, Guohua Zhou, Pingli Xie, Jinyue Hu & Guancheng Li. (2008) Effects of space flight exposure on cell growth, tumorigenicity and gene expression in cancer cells. Advances in Space Research 42:12, pages 1898-1905.
Crossref
S Kraljevic Pavelic, T Cacev & M Kralj. (2008) A dual role of p21waf1/cip1 gene in apoptosis of HEp-2 treated with cisplatin or methotrexate. Cancer Gene Therapy 15:9, pages 576-590.
Crossref
Alejo A. Morales, Delia Gutman, Kelvin P. Lee & Lawrence H. Boise. (2008) BH3-only proteins Noxa, Bmf, and Bim are necessary for arsenic trioxide–induced cell death in myeloma. Blood 111:10, pages 5152-5162.
Crossref
Xiangdong Lu, Chunyu Yang, Reginald Hill, Chaoyin Yin, M. Christine Hollander, Albert J. FornaceJrJr & Terry Van Dyke. (2008) Inactivation of gadd45a Sensitizes Epithelial Cancer Cells to Ionizing Radiation In vivo Resulting in Prolonged Survival . Cancer Research 68:10, pages 3579-3583.
Crossref
Khaldoun Al-Romaih, Bekim Sadikovic, Maisa Yoshimoto, Yuzhuo Wang, Maria Zielenska & Jeremy A. Squire. (2008) Decitabine-Induced Demethylation of 5′ CpG Island in GADD45A Leads to Apoptosis in Osteosarcoma Cells. Neoplasia 10:5, pages 471-480.
Crossref
Katherine E. Galvin, Hong Ye, Derek J. Erstad, Rod Feddersen & Cynthia Wetmore. (2008) Gli1 Induces G2/M Arrest and Apoptosis in Hippocampal but Not Tumor-Derived Neural Stem Cells. Stem Cells 26:4, pages 1027-1036.
Crossref
D A Fennell, A Chacko & L Mutti. (2007) BCL-2 family regulation by the 20S proteasome inhibitor bortezomib. Oncogene 27:9, pages 1189-1197.
Crossref
Ka Chen, Yizeng Tu, Yongjun Zhang, Harry C. Blair, Lin Zhang & Chuanyue Wu. (2008) PINCH-1 Regulates the ERK-Bim Pathway and Contributes to Apoptosis Resistance in Cancer Cells. Journal of Biological Chemistry 283:5, pages 2508-2517.
Crossref
Chi Chen, Peter G Fuhrken, Li Ting Huang, Pani Apostolidis, Min Wang, Carlos J Paredes, William M Miller & Eleftherios T Papoutsakis. (2007) A systems-biology analysis of isogenic megakaryocytic and granulocytic cultures identifies new molecular components of megakaryocytic apoptosis. BMC Genomics 8:1.
Crossref
Gabriella Peretz, Anna Bakhrat & Uri Abdu. (2007) Expression of the Drosophila melanogaster GADD45 Homolog (CG11086) Affects Egg Asymmetric Development That Is Mediated by the c-Jun N-Terminal Kinase Pathway . Genetics 177:3, pages 1691-1702.
Crossref
J Ji, R Liu, T Tong, Y Song, S Jin, M Wu & Q Zhan. (2007) Gadd45a regulates β-catenin distribution and maintains cell–cell adhesion/contact. Oncogene 26:44, pages 6396-6405.
Crossref
Tianying Jiang, Dianne Robert Soprano & Kenneth J. Soprano. (2007) GADD45A is a mediator of CD437 induced apoptosis in ovarian carcinoma cells. Journal of Cellular Physiology 212:3, pages 771-779.
Crossref
Varsha Tembe & Beric R. Henderson. (2007) Protein trafficking in response to DNA damage. Cellular Signalling 19:6, pages 1113-1120.
Crossref
Roy Blum, Ran Elkon, Shira Yaari, Adi Zundelevich, Jasmine Jacob-Hirsch, Gideon Rechavi, Ron Shamir & Yoel Kloog. (2007) Gene Expression Signature of Human Cancer Cell Lines Treated with the Ras Inhibitor Salirasib ( S -Farnesylthiosalicylic Acid) . Cancer Research 67:7, pages 3320-3328.
Crossref
Steven B. Johnson, Matthew Lissauer, Grant V. Bochicchio, Richard Moore, Alan S. Cross & Thomas M. Scalea. (2007) Gene Expression Profiles Differentiate Between Sterile SIRS and Early Sepsis. Annals of Surgery 245:4, pages 611-621.
Crossref
Sandeep Singh, Ankur Kumar Upadhyay, Amrendra Kumar Ajay & Manoj Kumar Bhat. (2007) Gadd45α does not modulate the carboplatin or 5-fluorouracil-induced apoptosis in human papillomavirus-positive cells. Journal of Cellular Biochemistry 100:5, pages 1191-1199.
Crossref
David K. Moss & Jon D. Lane. (2006) Microtubules: forgotten players in the apoptotic execution phase. Trends in Cell Biology 16:7, pages 330-338.
Crossref
Sean M. O'Donnell, Geoffrey H. Holm, Janene M. Pierce, Bing Tian, Melissa J. Watson, Ravi S. Chari, Dean W. Ballard, Allan R. Brasier & Terence S. Dermody. (2006) Identification of an NF-κB-Dependent Gene Network in Cells Infected by Mammalian Reovirus. Journal of Virology 80:3, pages 1077-1086.
Crossref
Beric R. Henderson. (2005) Regulation of BRCA1, BRCA2 and BARD1 intracellular trafficking. BioEssays 27:9, pages 884-893.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.