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Gene Expression

DNA-Binding and Transactivation Activities Are Essential for TAp63 Protein Degradation

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Pages 6154-6164 | Received 07 Dec 2004, Accepted 26 Apr 2005, Published online: 27 Mar 2023

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Ivano Amelio, Francesca Grespi, Margherita Annicchiarico-Petruzzelli & Gerry Melino. (2012) p63 the guardian of human reproduction. Cell Cycle 11:24, pages 4545-4551.
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Yongfeng Xu, Xiaojuan Yang, Qunli Xiong, Junhong Han & Qing Zhu. (2023) The dual role of p63 in cancer. Frontiers in Oncology 13.
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Alexander Strubel, Philipp Münick, Apirat Chaikuad, Birgit Dreier, Jonas Schaefer, Jakob Gebel, Christian Osterburg, Marcel Tuppi, Birgit Schäfer, Stefan Knapp, Andreas Plückthun & Volker Dötsch. (2022) Designed Ankyrin Repeat Proteins as a tool box for analyzing p63. Cell Death & Differentiation 29:12, pages 2445-2458.
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Xueying Fan, Wei He, Ke Hu, Huimin Chen, Li Chen, Shijie Fan & Chenghua Li. (2021) Pin1 and JNK1 cooperatively modulate TAp63γ. FEBS Open Bio 11:3, pages 890-897.
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Hanyuan Liu, Chenchen Zhu, Zhihao Xu, Juan Wang, Lili Qian, Qingqing Zhou, Zhen Shen, Weidong Zhao, Weihua Xiao, Liang Chen & Ying Zhou. (2020) lncRNA PART1 and MIR17HG as ΔNp63α direct targets regulate tumor progression of cervical squamous cell carcinoma. Cancer Science 111:11, pages 4129-4141.
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Ying Zhou, Hanyuan Liu, Juan Wang, Xiaolin Wang, Lili Qian, Fei Xu, Weiguo Song, Dabao Wu, Zhen Shen, Dingqing Feng, Bin Ling, Weihua Xiao, Ge Shan & Liang Chen. (2019) ΔNp63α exerts antitumor functions in cervical squamous cell carcinoma. Oncogene 39:4, pages 905-921.
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Daniel Coutandin, Christian Osterburg, Ratnesh Kumar Srivastav, Manuela Sumyk, Sebastian Kehrloesser, Jakob Gebel, Marcel Tuppi, Jens Hannewald, Birgit Schäfer, Eidarus Salah, Sebastian Mathea, Uta Müller-Kuller, James Doutch, Manuel Grez, Stefan Knapp & Volker Dötsch. (2016) Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level. eLife 5.
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Sabita Saldanha, Kendra Royston, Neha Udayakumar & Trygve Tollefsbol. (2015) Epigenetic Regulation of Epidermal Stem Cell Biomarkers and Their Role in Wound Healing. International Journal of Molecular Sciences 17:1, pages 16.
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Decai Li, Chenghua Li, Min Wu, Qiongqiong Chen, Qiao Wang, Jian Ren & Yujun Zhang. (2015) PKCδ stabilizes TAp63 to promote cell apoptosis. FEBS Letters 589:16, pages 2094-2099.
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J Bergholz, Y Zhang, J Wu, L Meng, E M Walsh, A Rai, M Y Sherman & Z-X Jim Xiao. (2012) ΔNp63α regulates Erk signaling via MKP3 to inhibit cancer metastasis. Oncogene 33:2, pages 212-224.
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Chenghua Li & Zhi-Xiong Xiao. (2014) Regulation of p63 Protein Stability via Ubiquitin-Proteasome Pathway. BioMed Research International 2014, pages 1-8.
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C Li, D L Chang, Z Yang, J Qi, R Liu, H He, D Li & Z X Xiao. (2013) Pin1 modulates p63α protein stability in regulation of cell survival, proliferation and tumor formation. Cell Death & Disease 4:12, pages e943-e943.
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Pengjun Su, Yuhang Yuan, Ying Huang, Weilin Wang & Zhibo Zhang. (2013) Anorectal malformation associated with a mutation in the P63 gene in a family with split hand–foot malformation. International Journal of Colorectal Disease 28:12, pages 1621-1627.
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Marta Nekulova, Jitka Holcakova, Rudolf Nenutil, Rembert Stratmann, Pavla Bouchalova, Petr Müller, Lucie Mouková, Philip J. Coates & Borivoj Vojtesek. (2013) Characterization of specific p63 and p63-N-terminal isoform antibodies and their application for immunohistochemistry. Virchows Archiv 463:3, pages 415-425.
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Emma Vernersson Lindahl, Elvin L. Garcia & Alea A. Mills. (2013) An allelic series of Trp63 mutations defines TAp63 as a modifier of EEC syndrome . American Journal of Medical Genetics Part A 161:8, pages 1961-1971.
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Maria B. Fonseca, Ana F. Nunes, Ana L. Morgado, Susana Solá & Cecília M. P. Rodrigues. (2012) TAp63γ Demethylation Regulates Protein Stability and Cellular Distribution during Neural Stem Cell Differentiation. PLoS ONE 7:12, pages e52417.
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Johann Bergholz & Zhi-Xiong Xiao. (2012) Role of p63 in Development, Tumorigenesis and Cancer Progression. Cancer Microenvironment 5:3, pages 311-322.
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Takashi Matsuura, Viviane K.S. Kawata, Hirokazu Nagoshi, Yasuhiro Tomooka, Keiichi Sasaki & Shuntaro Ikawa. (2012) Regulation of proliferation and differentiation of mouse tooth germ epithelial cells by distinct isoforms of p51/p63. Archives of Oral Biology 57:8, pages 1108-1115.
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Youcef Ben Khalifa, Sébastien Teissier, Meng-Kwang Marcus Tan, Quang Tien Phan, Mathieu Daynac, Wei Qi Wong & Françoise Thierry. (2011) The Human Papillomavirus E6 Oncogene Represses a Cell Adhesion Pathway and Disrupts Focal Adhesion through Degradation of TAp63β upon Transformation. PLoS Pathogens 7:9, pages e1002256.
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Zaklina Kovacevic, Sutharshani Sivagurunathan, Helena Mangs, Sherin Chikhani, Daohai Zhang & Des R. Richardson. (2011) The metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1), upregulates p21 via p53-independent mechanisms. Carcinogenesis 32:5, pages 732-740.
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Annette F. Muttray, Teagan F. O'Toole, Wendy Morrill, Rebecca J. Van Beneden & Susan A. Baldwin. (2010) An invertebrate mdm homolog interacts with p53 and is differentially expressed together with p53 and ras in neoplastic Mytilus trossulus haemocytes. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 156:4, pages 298-308.
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Károly Fátyol & Ingrid Grummt. (2008) Proteasomal ATPases are associated with rDNA: The ubiquitin proteasome system plays a direct role in RNA polymerase I transcription. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1779:12, pages 850-859.
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Tongxiu Luo, Weishi Yu, Zengjin Yuan, Yun Deng, Yulian Zhao, Wuzhou Yuan, Jing Xiao, Yuequn Wang, Na Luo, Xiaoyang Mo, Yongqing Li, Mingyao Liu & Xiushan Wu. (2008) A novel mutation of p63 in a Chinese family with inherited syndactyly and adactylism. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 637:1-2, pages 182-189.
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Elisa Kier-Swiatecka, Marianne Kock, Peter Marker, Hans Eiberg & Klaus Wilbrandt Kjaer. (2007) The ADULT-EEC spectrum: An R280C mutation with a borderline phenotype. American Journal of Medical Genetics Part A 143A:8, pages 891-894.
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Ian R. Watson & Meredith S. Irwin. (2006) Ubiquitin and Ubiquitin-Like Modifications of the p53 Family. Neoplasia 8:8, pages 655-666.
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