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Gene Expression

The Runx2 Osteogenic Transcription Factor Regulates Matrix Metalloproteinase 9 in Bone Metastatic Cancer Cells and Controls Cell Invasion

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Pages 8581-8591 | Received 07 Jan 2005, Accepted 20 Jun 2005, Published online: 27 Mar 2023

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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
T. Hoppe, V. Göser, D. Kraus, R. Probstmeier, M. Frentzen, M. Wenghoefer, S. Jepsen & J. Winter. (2018) Response of MG63 osteoblasts on bacterial challenge is dependent on the state of differentiation. Molecular Oral Microbiology 33:2, pages 133-142.
Crossref
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Crossref
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Crossref
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Crossref
Myoung Sook Kim, Ramkishore Gernapudi, Eun Yong Choi, Rena G. Lapidus & Antonino Passaniti. (2017) Characterization of CADD522, a small molecule that inhibits RUNX2-DNA binding and exhibits antitumor activity. Oncotarget 8:41, pages 70916-70940.
Crossref
Alessandra I. Riggio & Karen Blyth. (2017) The enigmatic role of RUNX1 in female-related cancers - current knowledge & future perspectives. The FEBS Journal 284:15, pages 2345-2362.
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Takehiro Ogata, Mizuyo Nakamura, Meijie Sang, Hiroyuki Yoda, Kiriko Hiraoka, Danjing Yin, Mexiang Sang, Osamu Shimozato & Toshinori Ozaki. (2017) Depletion of runt-related transcription factor 2 (RUNX2) enhances SAHA sensitivity of p53-mutated pancreatic cancer cells through the regulation of mutant p53 and TAp63. PLOS ONE 12:7, pages e0179884.
Crossref
M. Vishal, R. Swetha, G. Thejaswini, B. Arumugam & N. Selvamurugan. (2017) Role of Runx2 in breast cancer-mediated bone metastasis. International Journal of Biological Macromolecules 99, pages 608-614.
Crossref
Rinath JeselsohnMacIntosh CornwellMatthew PunGilles BuchwalterMai NguyenClyde BangoYing HuangYanan KuangCloud PaweletzXiaoyong FuAgostina NardoneCarmine De AngelisSimone DetreAndrew DodsonHisham MohammedJason S. CarrollMichaela BowdenPrakash RaoHenry W. LongFugen LiMitchell Dowsett, Rachel SchiffMyles Brown. (2017) Embryonic transcription factor SOX9 drives breast cancer endocrine resistance. Proceedings of the National Academy of Sciences 114:22.
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Chun-Hay Ko, Grace Gar-Lee Yue, Si Gao, Ke-Wang Luo, Wing-Sum Siu, Wai-Ting Shum, Hoi-Ting Shiu, Julia Kin-Ming Lee, Gang Li, Ping-Chung Leung, Andreas Evdokiou & Clara Bik-San Lau. (2017) Evaluation of the combined use of metronomic zoledronic acid and Coriolus versicolor in intratibial breast cancer mouse model. Journal of Ethnopharmacology 204, pages 77-85.
Crossref
Rama Garimella, Priyanka Tadikonda, Ossama Tawfik, Sumedha Gunewardena, Peter Rowe & Peter Van Veldhuizen. (2017) Vitamin D Impacts the Expression of Runx2 Target Genes and Modulates Inflammation, Oxidative Stress and Membrane Vesicle Biogenesis Gene Networks in 143B Osteosarcoma Cells. International Journal of Molecular Sciences 18:3, pages 642.
Crossref
Zi Cao, Baocun Sun, Xiulan Zhao, Yanhui Zhang, Qiang Gu, Xiaohui Liang, Xueyi Dong & Nan Zhao. (2017) The Expression and Functional Significance of Runx2 in Hepatocellular Carcinoma: Its Role in Vasculogenic Mimicry and Epithelial–Mesenchymal Transition. International Journal of Molecular Sciences 18:3, pages 500.
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Melissa Colden, Altaf A Dar, Sharanjot Saini, Priya V Dahiya, Varahram Shahryari, Soichiro Yamamura, Yuichiro Tanaka, Gary Stein, Rajvir Dahiya & Shahana Majid. (2017) MicroRNA-466 inhibits tumor growth and bone metastasis in prostate cancer by direct regulation of osteogenic transcription factor RUNX2. Cell Death & Disease 8:1, pages e2572-e2572.
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Dominic Chih-Cheng Voon & Jean Paul Thiery. 2017. RUNX Proteins in Development and Cancer. RUNX Proteins in Development and Cancer 471 489 .
Sun Hee Lee, Sarala Manandhar & You Mie Lee. 2017. RUNX Proteins in Development and Cancer. RUNX Proteins in Development and Cancer 449 469 .
Antonino Passaniti, Jessica L. Brusgard, Yiting Qiao, Marius Sudol & Megan Finch-Edmondson. 2017. RUNX Proteins in Development and Cancer. RUNX Proteins in Development and Cancer 435 448 .
Qian Wang, Wei Yu, Tao Huang, Yan Zhu & Changshan Huang. (2016) RUNX2 promotes hepatocellular carcinoma cell migration and invasion by upregulating MMP9 expression. Oncology Reports 36:5, pages 2777-2784.
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Toshinori Ozaki, Mizuyo Nakamura, Takehiro Ogata, Meijie Sang, Hiroyuki Yoda, Kiriko Hiraoka, Meixiang Sang & Osamu Shimozato. (2016) Depletion of pro-oncogenic RUNX2 enhances gemcitabine (GEM) sensitivity of p53 -mutated pancreatic cancer Panc-1 cells through the induction of pro-apoptotic TAp63 . Oncotarget 7:44, pages 71937-71950.
Crossref
Weiwei Zhao, Shanxing Zhang, Baoli Wang, Jian Huang, William W. Lu & Di Chen. (2016) Runx2 and microRNA regulation in bone and cartilage diseases. Annals of the New York Academy of Sciences 1383:1, pages 80-87.
Crossref
A. Jaruga, E. Hordyjewska, G. Kandzierski & P. Tylzanowski. (2016) Cleidocranial dysplasia and RUNX2-clinical phenotype-genotype correlation. Clinical Genetics 90:5, pages 393-402.
Crossref
Chuan-Hui Guo, Zhan-Peng Yue, Zhi-Kun Bai, Dang-Dang Li, Zhan-Qing Yang & Bin Guo. (2016) Runx2 acts downstream of C/EBPβ to regulate the differentiation of uterine stromal cells in mice. Cell and Tissue Research 366:2, pages 393-401.
Crossref
Venu G. Varanasi, Tetsurou Odatsu, Timothy Bishop, Joyce Chang, Jeremy Owyoung & Peter M. Loomer. (2016) Enhanced osteoprogenitor elongated collagen fiber matrix formation by bioactive glass ionic silicon dependent on Sp7 (osterix) transcription. Journal of Biomedical Materials Research Part A 104:10, pages 2604-2615.
Crossref
M Tandon, Z Chen, A H Othman & J Pratap. (2016) Role of Runx2 in IGF-1Rβ/Akt- and AMPK/Erk-dependent growth, survival and sensitivity towards metformin in breast cancer bone metastasis. Oncogene 35:36, pages 4730-4740.
Crossref
Teruyo Nakatani, Tiffany Chen & Nicola C. Partridge. (2016) MMP-13 is one of the critical mediators of the effect of HDAC4 deletion on the skeleton. Bone 90, pages 142-151.
Crossref
Frances E. Carr, Phillip W. L. Tai, Michael S. Barnum, Noelle E. Gillis, Katherine G. Evans, Thomas H. Taber, Jeffrey H. White, Jennifer A. Tomczak, Diane M. Jaworski, Sayyed K. Zaidi, Jane B. Lian, Janet L. Stein & Gary S. Stein. (2016) Thyroid Hormone Receptor-β (TRβ) Mediates Runt-Related Transcription Factor 2 (Runx2) Expression in Thyroid Cancer Cells: A Novel Signaling Pathway in Thyroid Cancer. Endocrinology 157:8, pages 3278-3292.
Crossref
Nur Mohammad Monsur Hassan, Abhayjit Dhillon & Boyen Huang. (2016) Cleidocranial dysplasia: Clinical overview and genetic considerations. Pediatric Dental Journal 26:2, pages 45-50.
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Saba Mohamed El-Gendi & Mohamed Farouk Mostafa. (2015) Runx2 Expression as a Potential Prognostic Marker in Invasive Ductal Breast Carcinoma. Pathology & Oncology Research 22:3, pages 461-470.
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Jen-Chih Tseng, Ching-Yu Lin, Liang-Chen Su, Hsiao-Hui Fu, Shiaw-Der Yang & Chih-Pin Chuu. (2016) CAPE suppresses migration and invasion of prostate cancer cells via activation of non-canonical Wnt signaling. Oncotarget 7:25, pages 38010-38024.
Crossref
Tanu Sharma, James A. Radosevich, Geeta Pachori & Chandi C. Mandal. (2016) A Molecular View of Pathological Microcalcification in Breast Cancer. Journal of Mammary Gland Biology and Neoplasia 21:1-2, pages 25-40.
Crossref
Li‐An Wu, Feng Wang, Kevin J. Donly, Andrew Baker, Chunyan Wan, Daoshu Luo, Mary MacDougall & Shuo Chen. (2015) Establishment of Immortalized BMP2/4 Double Knock‐Out Osteoblastic Cells Is Essential for Study of Osteoblast Growth, Differentiation, and Osteogenesis. Journal of Cellular Physiology 231:6, pages 1189-1198.
Crossref
Paola Bendinelli, Paola Maroni, Emanuela Matteucci & Maria Desiderio. (2016) Cell and Signal Components of the Microenvironment of Bone Metastasis Are Affected by Hypoxia. International Journal of Molecular Sciences 17:5, pages 706.
Crossref
JIAN-CHUN ZONG, XING WANG, XIANG ZHOU, CHEN WANG, LIANG CHEN, LIANG-JUN YIN, BAI-CHENG HE & ZHONG-LIANG DENG. (2016) Gut-derived serotonin induced by depression promotes breast cancer bone metastasis through the RUNX2/PTHrP/RANKL pathway in mice. Oncology Reports 35:2, pages 739-748.
Crossref
Bo Peng, Hua Zhu, Christian Klausen, Liyang Ma, Yan-ling Wang & Peter C.K. Leung. (2016) GnRH regulates trophoblast invasion via RUNX2-mediated MMP2/9 expression. Molecular Human Reproduction 22:2, pages 119-129.
Crossref
Karine A. Cohen-Solal, Rajeev K. Boregowda & Ahmed Lasfar. (2015) RUNX2 and the PI3K/AKT axis reciprocal activation as a driving force for tumor progression. Molecular Cancer 14:1.
Crossref
Chieh Huo, Yung-Hsi Kao & Chih-Pin Chuu. (2015) Androgen receptor inhibits epithelial–mesenchymal transition, migration, and invasion of PC-3 prostate cancer cells. Cancer Letters 369:1, pages 103-111.
Crossref
Lian Wu, Feng Wang, Kevin J. Donly, Chunyan Wan, Daoshu Luo, Stephen E. Harris, Mary MacDougall & Shuo Chen. (2015) Establishment of Immortalized Mouse Bmp2 Knock-Out Dental Papilla Mesenchymal Cells Necessary for Study of Odontoblastic Differentiation and Odontogenesis. Journal of Cellular Physiology 230:11, pages 2588-2595.
Crossref
Toshinori Ozaki, Mizuyo Nakamura & Osamu Shimozato. (2015) Novel Implications of DNA Damage Response in Drug Resistance of Malignant Cancers Obtained from the Functional Interaction between p53 Family and RUNX2. Biomolecules 5:4, pages 2854-2876.
Crossref
Gillian Browne, Hanna Taipaleenmäki, Nicole M. Bishop, Sharath C. Madasu, Leslie M. Shaw, Andre J. van Wijnen, Janet L. Stein, Gary S. Stein & Jane B. Lian. (2015) Runx1 is associated with breast cancer progression in MMTV-PyMT transgenic mice and its depletion in vitro inhibits migration and invasion. Journal of Cellular Physiology 230:10, pages 2522-2532.
Crossref
Jessica L. Brusgard, Moran Choe, Saranya Chumsri, Keli Renoud, Alexander D. MacKerellJr.Jr., Marius Sudol & Antonino Passaniti. (2015) RUNX2 and TAZ-dependent signaling pathways regulate soluble E-Cadherin levels and tumorsphere formation in breast cancer cells. Oncotarget 6:29, pages 28132-28150.
Crossref
Daniel Wysokinski, Janusz Blasiak & Elzbieta Pawlowska. (2015) Role of RUNX2 in Breast Carcinogenesis. International Journal of Molecular Sciences 16:9, pages 20969-20993.
Crossref
Sara Del Mare & Rami I. Aqeilan. (2015) Tumor Suppressor WWOX inhibits osteosarcoma metastasis by modulating RUNX2 function. Scientific Reports 5:1.
Crossref
H Sugimoto, M Nakamura, H Yoda, K Hiraoka, K Shinohara, M Sang, K Fujiwara, O Shimozato, H Nagase & T Ozaki. (2015) Silencing of RUNX2 enhances gemcitabine sensitivity of p53-deficient human pancreatic cancer AsPC-1 cells through the stimulation of TAp63-mediated cell death. Cell Death Discovery 1:1.
Crossref
J. Ge, S. Guo, Y. Fu, P. Zhou, P. Zhang, Y. Du, M. Li, J. Cheng & H. Jiang. (2015) Dental Follicle Cells Participate in Tooth Eruption via the RUNX2-MiR-31-SATB2 Loop. Journal of Dental Research 94:7, pages 936-944.
Crossref
Timothy N. TrotterMei LiQianying PanDeniz PekerPatrick D. RowanJuan LiFenghuang ZhanLarry J. Suva, Amjad Javed & Yang Yang. (2015) Myeloma cell–derived Runx2 promotes myeloma progression in bone. Blood 125:23, pages 3598-3608.
Crossref
Valentina Sancisi, Greta Gandolfi, Davide Carlo Ambrosetti & Alessia Ciarrocchi. (2015) Histone Deacetylase Inhibitors Repress Tumoral Expression of the Proinvasive Factor RUNX2. Cancer Research 75:9, pages 1868-1882.
Crossref
Shan-Shan Sun, Lun Zhang, Jingxuan Yang & Xuan Zhou. (2015) Role of runt-related transcription factor 2 in signal network of tumors as an inter-mediator. Cancer Letters 361:1, pages 1-7.
Crossref
JUNCHAO MA, HONG LU, SHAN WANG, BIN CHEN, ZHAOJIE LIU, XIAOQIN KE, TING LIU & JIANJIANG FU. (2015) The anthraquinone derivative Emodin inhibits angiogenesis and metastasis through downregulating Runx2 activity in breast cancer. International Journal of Oncology 46:4, pages 1619-1628.
Crossref
Hanna Taipaleenmäki, Gillian Browne, Jacqueline Akech, Jozef Zustin, Andre J. van Wijnen, Janet L. Stein, Eric Hesse, Gary S. Stein & Jane B. Lian. (2015) Targeting of Runx2 by miR-135 and miR-203 Impairs Progression of Breast Cancer and Metastatic Bone Disease. Cancer Research 75:7, pages 1433-1444.
Crossref
Xuhui Zhang, Jacqueline Akech, Gillian Browne, Stacey Russell, John J. Wixted, Janet L. Stein, Gary S. Stein & Jane B. Lian. (2015) Runx2-smad signaling impacts the progression of tumor-induced bone disease. International Journal of Cancer 136:6, pages 1321-1332.
Crossref
M. Gokulnath, N. C. Partridge & N. Selvamurugan. (2014) Runx2, a target gene for activating transcription factor-3 in human breast cancer cells. Tumor Biology 36:3, pages 1923-1931.
Crossref
Kimberly T. LeBlanc, Marie E. Walcott, Tripti Gaur, Shannon L. O'Connell, Kirti Basil, Christina P. Tadiri, April Mason-Savas, Jason A. Silva, Andre J. van Wijnen, Janet L. Stein, Gary S. Stein, David C. Ayers, Jane B. Lian & Paul J. Fanning. (2015) Runx1 Activities in Superficial Zone Chondrocytes, Osteoarthritic Chondrocyte Clones and Response to Mechanical Loading. Journal of Cellular Physiology 230:2, pages 440-448.
Crossref
Chih-Hao Chang, Tan-Chi Fan, Jyh-Cherng Yu, Guo-Shiou Liao, You-Chin Lin, Arthur Chun-Chieh Shih, Wen-Hsiung Li & Alice Lin-Tsing Yu. (2014) The prognostic significance of RUNX2 and miR-10a/10b and their inter-relationship in breast cancer. Journal of Translational Medicine 12:1.
Crossref
WEI WANG, BIN CHEN, RUOLAN ZOU, XIUYING TU, SONGLIN TAN, HONG LU, ZHAOJIE LIU & JIANJIANG FU. (2014) Codonolactone, a sesquiterpene lactone isolated from Chloranthus henryi Hemsl, inhibits breast cancer cell invasion, migration and metastasis by downregulating the transcriptional activity of Runx2. International Journal of Oncology 45:5, pages 1891-1900.
Crossref
L H Chan, W Wang, W Yeung, Y Deng, P Yuan & K K Mak. (2013) Hedgehog signaling induces osteosarcoma development through Yap1 and H19 overexpression. Oncogene 33:40, pages 4857-4866.
Crossref
Thomas W. Owens, Renee L. Rogers, Sarah A. Best, Anita Ledger, Anne-Marie Mooney, Alison Ferguson, Paul Shore, Alexander Swarbrick, Christopher J. Ormandy, Peter T. Simpson, Jason S. Carroll, Jane E. Visvader & Matthew J. Naylor. (2014) Runx2 Is a Novel Regulator of Mammary Epithelial Cell Fate in Development and Breast Cancer. Cancer Research 74:18, pages 5277-5286.
Crossref
Balabhadrapatruni V. S. K. Chakravarthi, Satya S. Pathi, Moloy T. Goswami, Marcin Cieślik, Heng Zheng, Sivakumar Nallasivam, Subramanyeswara R. Arekapudi, Xiaojun Jing, Javed Siddiqui, Jyoti Athanikar, Shannon L. Carskadon, Robert J. Lonigro, Lakshmi P. Kunju, Arul M. Chinnaiyan, Nallasivam Palanisamy & Sooryanarayana Varambally. (2014) The miR-124-Prolyl Hydroxylase P4HA1-MMP1 axis plays a critical role in prostate cancer progression. Oncotarget 5:16, pages 6654-6669.
Crossref
ZHAOJIE LIU, HONG LU, RONG LIU, BIN CHEN, SHAN WANG, JUNCHAO MA & JIANJIANG FU. (2014) The dineolignan from Saururus chinensis, manassantin B, inhibits tumor-induced angiogenesis via downregulation of matrix metalloproteinases 9 in human endothelial cells. Oncology Reports 32:2, pages 659-667.
Crossref
David L. Waning & Theresa A. Guise. (2014) Molecular Mechanisms of Bone Metastasis and Associated Muscle Weakness. Clinical Cancer Research 20:12, pages 3071-3077.
Crossref
Paola Bendinelli, Paola Maroni, Emanuela Matteucci, Alessandro Luzzati, Giuseppe Perrucchini & Maria Alfonsina Desiderio. (2014) Microenvironmental stimuli affect Endothelin-1 signaling responsible for invasiveness and osteomimicry of bone metastasis from breast cancer. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1843:4, pages 815-826.
Crossref
Jian-Ping Li, Sen Chen, Hao Peng, Jian-Lin Zhou & Hong-Song Fang. (2014) Pulsed electromagnetic fields protect the balance between adipogenesis and osteogenesis on steroid-induced osteonecrosis of femoral head at the pre-collapse stage in rats. Bioelectromagnetics 35:3, pages 170-180.
Crossref
Anindita Dutta, Jing Li, Huimin Lu, Jacqueline Akech, Jitesh Pratap, Tao Wang, Brad J. Zerlanko, Thomas J. FitzGerald, Zhong Jiang, Ruth Birbe, John Wixted, Shelia M. Violette, Janet L. Stein, Gary S. Stein, Jane B. Lian & Lucia R. Languino. (2014) Integrin αvβ6 Promotes an Osteolytic Program in Cancer Cells by Upregulating MMP2. Cancer Research 74:5, pages 1598-1608.
Crossref
Manish Tandon, Zujian Chen & Jitesh Pratap. (2014) Runx2 activates PI3K/Akt signaling via mTORC2 regulation in invasive breast cancer cells. Breast Cancer Research 16:1.
Crossref
Laura McDonaldNicola FerrariAnne TerryMargaret BellZahra M. MohammedClare OrangeAlma JenkinsWilliam J. Muller, Barry A. GustersonJames C. NeilJoanne EdwardsJoanna S. MorrisEwan R. CameronKaren Blyth. (2014) RUNX2 in subtype specific breast cancer and mammary gland differentiation. Disease Models & Mechanisms.
Crossref
Steven L. Wood & Janet E. Brown. 2014. Bone Metastases. Bone Metastases 125 153 .
Jessica L. Brusgard & Antonino Passaniti. 2014. Nuclear Signaling Pathways and Targeting Transcription in Cancer. Nuclear Signaling Pathways and Targeting Transcription in Cancer 57 86 .
Martin Kuhlwilm, Armaity Davierwala & Svante Pääbo. (2013) Identification of Putative Target Genes of the Transcription Factor RUNX2. PLoS ONE 8:12, pages e83218.
Crossref
Adam H. Greer, Thomas Yong, Katie Fennell, Yara W. Moustafa, Marcie Fowler, Floyd Galiano, Shu-Wing Ng, Ross S. Berkowitz, James Cardelli, Shari Meyers & J. Nathan Davis. (2013) Knockdown of core binding factorβ alters sphingolipid metabolism. Journal of Cellular Physiology 228:12, pages 2350-2364.
Crossref
Zhi-Qiang Wang, Mamadou Keita, Magdalena Bachvarova, Stephane Gobeil, Chantale Morin, Marie Plante, Jean Gregoire, Marie-Claude Renaud, Alexandra Sebastianelli, Xuan Bich Trinh & Dimcho Bachvarov. (2013) Inhibition of RUNX2 Transcriptional Activity Blocks the Proliferation, Migration and Invasion of Epithelial Ovarian Carcinoma Cells. PLoS ONE 8:10, pages e74384.
Crossref
Jee In Kim, Hee-Seong Jang, Jae-Hwan Jeong, Mi Ra Noh, Je-Yong Choi & Kwon Moo Park. (2013) Defect in Runx2 gene accelerates ureteral obstruction-induced kidney fibrosis via increased TGF-β signaling pathway. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1832:10, pages 1520-1527.
Crossref
Da-Chuan Wang, Hai-Feng Wang & Ze-Nong Yuan. (2013) Runx2 induces bone osteolysis by transcriptional suppression of TSSC1. Biochemical and Biophysical Research Communications 438:4, pages 635-639.
Crossref
Jin Wook Kang, Ki Dae Park, Youngju Choi, Dae Hyun Baek, Wan-Seob Cho, Mina Choi, Jae Hyun Park, Kyoung Suk Choi, Hyung Soo Kim & Tae Moo Yoo. (2013) Biodistribution and in vivo efficacy of genetically modified human mesenchymal stem cells systemically transplanted into a mouse bone fracture model. Archives of Pharmacal Research 36:8, pages 1013-1022.
Crossref
Sandhya Pande, Gillian Browne, Srivatsan Padmanabhan, Sayyed K. Zaidi, Jane B. Lian, Andre J. van Wijnen, Janet L. Stein & Gary S. Stein. (2013) Oncogenic cooperation between PI3K/Akt signaling and transcription factor Runx2 promotes the invasive properties of metastatic breast cancer cells. Journal of Cellular Physiology 228:8, pages 1784-1792.
Crossref
Rachelle W. Johnson & Julie A. Sterling. 2013. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism 686 693 .
Tong Ming LiuEng Hin Lee. (2013) Transcriptional Regulatory Cascades in Runx2-Dependent Bone Development. Tissue Engineering Part B: Reviews 19:3, pages 254-263.
Crossref
Hong Li, Ren-Jie Zhou, Guo-Qiang Zhang & Jian-Ping Xu. (2013) Clinical significance of RUNX2 expression in patients with nonsmall cell lung cancer: a 5-year follow-up study. Tumor Biology 34:3, pages 1807-1812.
Crossref
Nicola Ferrari, Laura McDonald, Joanna S. Morris, Ewan R. Cameron & Karen Blyth. (2013) RUNX2 in mammary gland development and breast cancer. Journal of Cellular Physiology 228:6, pages 1137-1142.
Crossref
Ashley A. AminiLakshmi S. Nair. (2013) Evaluation of the Bioactivity of Recombinant Human Lactoferrins Toward Murine Osteoblast-Like Cells for Bone Tissue Engineering. Tissue Engineering Part A 19:9-10, pages 1047-1055.
Crossref
Juan A Ardura, Ana B Sanz, Alberto Ortiz & Pedro Esbrit. (2013) Parathyroid hormone–related protein protects renal tubuloepithelial cells from apoptosis by activating transcription factor Runx2. Kidney International 83:5, pages 825-834.
Crossref
Cornelia Johanna Franziska Scheitz & Tudorita Tumbar. (2013) New insights into the role of Runx1 in epithelial stem cell biology and pathology. Journal of Cellular Biochemistry 114:5, pages 985-993.
Crossref
N-O Chimge & B Frenkel. (2012) The RUNX family in breast cancer: relationships with estrogen signaling. Oncogene 32:17, pages 2121-2130.
Crossref
T Ozaki, D Wu, H Sugimoto, H Nagase & A Nakagawara. (2013) Runt-related transcription factor 2 (RUNX2) inhibits p53-dependent apoptosis through the collaboration with HDAC6 in response to DNA damage. Cell Death & Disease 4:4, pages e610-e610.
Crossref
Hosea F. S. Huang, Ping Shu, Thomas F. Murphy, Seena Aisner, Valerie A. Fitzhugh & Mark L. Jordan. (2013) Significance of Divergent Expression of Prostaglandin EP4 and EP3 Receptors in Human Prostate Cancer. Molecular Cancer Research 11:4, pages 427-439.
Crossref
Claudia M.J. Lucero, Oscar A. Vega, Mariana M. Osorio, Julio C. Tapia, Marcelo Antonelli, Gary S. Stein, Andre J. van Wijnen & Mario A. Galindo. (2013) The cancer-related transcription factor Runx2 modulates cell proliferation in human osteosarcoma cell lines. Journal of Cellular Physiology 228:4, pages 714-723.
Crossref
Mamadou Keita, Zhi-Qiang Wang, Jean-Francois Pelletier, Magdalena Bachvarova, Marie Plante, Jean Gregoire, Marie-Claude Renaud, Anne-Marie Mes-Masson, Éric R. Paquet & Dimcho Bachvarov. (2013) Global methylation profiling in serous ovarian cancer is indicative for distinct aberrant DNA methylation signatures associated with tumor aggressiveness and disease progression. Gynecologic Oncology 128:2, pages 356-363.
Crossref
Y-H. Zhang, B. Li, L. Shen, Y. Shen & X-D. Chen. (2013) The Role and Clinical Significance of Yes-Associated Protein 1 in Human Osteosarcoma. International Journal of Immunopathology and Pharmacology 26:1, pages 157-167.
Crossref
Zuguang Gu, Chenyu Zhang & Jin Wang. (2012) Gene regulation is governed by a core network in hepatocellular carcinoma. BMC Systems Biology 6:1.
Crossref
Aditi Gupta, Wei Cao & Meenakshi A Chellaiah. (2012) Integrin αvβ3 and CD44 pathways in metastatic prostate cancer cells support osteoclastogenesis via a Runx2/Smad 5/receptor activator of NF-κB ligand signaling axis. Molecular Cancer 11:1.
Crossref
Manish Tandon, Karthiga Gokul, Syed A Ali, Zujian Chen, Jane Lian, Gary S Stein & Jitesh Pratap. (2012) Runx2 mediates epigenetic silencing of the bone morphogenetic protein-3B (BMP-3B/GDF10) in lung cancer cells. Molecular Cancer 11:1.
Crossref
Tomohiko Sase, Takashi Suzuki, Koh Miura, Kenichi Shiiba, Ikuro Sato, Yasuhiro Nakamura, Kiyoshi Takagi, Yoshiaki Onodera, Yasuhiro Miki, Mika Watanabe, Kazuyuki Ishida, Shinobu Ohnuma, Hiroyuki Sasaki, Ryuichiro Sato, Hideaki Karasawa, Chikashi Shibata, Michiaki Unno, Iwao Sasaki & Hironobu Sasano. (2012) Runt-related transcription factor 2 in human colon carcinoma: A potent prognostic factor associated with estrogen receptor. International Journal of Cancer 131:10, pages 2284-2293.
Crossref
Valentina Sancisi, Gloria Borettini, Sally Maramotti, Moira Ragazzi, Ione Tamagnini, Davide Nicoli, Simonetta Piana & Alessia Ciarrocchi. (2012) Runx2 Isoform I Controls a Panel of Proinvasive Genes Driving Aggressiveness of Papillary Thyroid Carcinomas. The Journal of Clinical Endocrinology & Metabolism 97:10, pages E2006-E2015.
Crossref
Dong-Feng Niu, Tetsuo Kondo, Tadao Nakazawa, Naoki Oishi, Tomonori Kawasaki, Kunio Mochizuki, Tetsu Yamane & Ryohei Katoh. (2012) Transcription factor Runx2 is a regulator of epithelial–mesenchymal transition and invasion in thyroid carcinomas. Laboratory Investigation 92:8, pages 1181-1190.
Crossref
Karl E. Miletti-González, Kyle Murphy, Muthu N. Kumaran, Abhilash K. Ravindranath, Roman P. Wernyj, Swayamjot Kaur, Gregory D. Miles, Elaine Lim, Rigel Chan, Marina Chekmareva, Debra S. Heller, David Foran, Wenjin Chen, Michael Reiss, Elisa V. Bandera, Kathleen Scotto & Lorna Rodríguez-Rodríguez. (2012) Identification of Function for CD44 Intracytoplasmic Domain (CD44-ICD). Journal of Biological Chemistry 287:23, pages 18995-19007.
Crossref
Dionysios J. Papachristou, Efthimia K. Basdra & Athanasios G. Papavassiliou. (2012) Bone Metastases: Molecular Mechanisms and Novel Therapeutic Interventions. Medicinal Research Reviews 32:3, pages 611-636.
Crossref
Sanjeev K. Baniwal, Gillian H. Little, Nyam-Osor Chimge & Baruch Frenkel. (2012) Runx2 controls a feed-forward loop between androgen and prolactin-induced protein (PIP) in stimulating T47D cell proliferation. Journal of Cellular Physiology 227:5, pages 2276-2282.
Crossref
Laura L. HernandezKaren A. Gregerson & Nelson D. Horseman. (2012) Mammary gland serotonin regulates parathyroid hormone-related protein and other bone-related signals. American Journal of Physiology-Endocrinology and Metabolism 302:8, pages E1009-E1015.
Crossref
Jingjing Quan, Chuanxiang Zhou, Newell W. Johnson, Glenn Francis, Jane E. Dahlstrom & Jin Gao. (2012) Molecular pathways involved in crosstalk between cancer cells, osteoblasts and osteoclasts in the invasion of bone by oral squamous cell carcinoma. Pathology 44:3, pages 221-227.
Crossref
Nyam-Osor Chimge, Sanjeev K. Baniwal, Jingqin Luo, Simon Coetzee, Omar Khalid, Benjamin P. Berman, Debu Tripathy, Matthew J. Ellis & Baruch Frenkel. (2012) Opposing Effects of Runx2 and Estradiol on Breast Cancer Cell Proliferation: In Vitro Identification of Reciprocally Regulated Gene Signature Related to Clinical Letrozole Responsiveness . Clinical Cancer Research 18:3, pages 901-911.
Crossref
Margaretha van der Deen, Jacqueline Akech, David Lapointe, Sneha Gupta, Daniel W. Young, Martin A. Montecino, Mario Galindo, Jane B. Lian, Janet L. Stein, Gary S. Stein & Andre J. van Wijnen. (2012) Genomic Promoter Occupancy of Runt-related Transcription Factor RUNX2 in Osteosarcoma Cells Identifies Genes Involved in Cell Adhesion and Motility. Journal of Biological Chemistry 287:7, pages 4503-4517.
Crossref
Weiping Li, Shujuan Xu, Shuang Lin & Wei Zhao. (2012) Overexpression of Runt-Related Transcription Factor-2 Is Associated with Advanced Tumor Progression and Poor Prognosis in Epithelial Ovarian Cancer. Journal of Biomedicine and Biotechnology 2012, pages 1-7.
Crossref
Thomas Doetschman, Joey V. Barnett, Raymond B. Runyan, Todd D. Camenisch, Ronald L. Heimark, Henk L. Granzier, Simon J. Conway & Mohamad Azhar. (2011) Transforming growth factor beta signaling in adult cardiovascular diseases and repair. Cell and Tissue Research 347:1, pages 203-223.
Crossref
Adam D. Pierce, Ian E. Anglin, Michele I. Vitolo, Maria T. Mochin, Karen F. Underwood, Simeon E. Goldblum, Sravya Kommineni & Antonino Passaniti. (2012) Glucose-activated RUNX2 phosphorylation promotes endothelial cell proliferation and an angiogenic phenotype. Journal of Cellular Biochemistry 113:1, pages 282-292.
Crossref
Jianjiang Fu, Wei Wang, Yu-Hui Liu, Hong Lu & Yongming Luo. (2011) In vitro anti-angiogenic properties of LGD1069, a selective retinoid X-receptor agonist through down-regulating Runx2 expression on Human endothelial cells. BMC Cancer 11:1.
Crossref
Anjali Mishra, Yusuke Shiozawa, Kenneth J. Pienta & Russell S. Taichman. (2011) Homing of Cancer Cells to the Bone. Cancer Microenvironment 4:3, pages 221-235.
Crossref
Scott A. Guelcher & Julie A. Sterling. (2011) Contribution of Bone Tissue Modulus to Breast Cancer Metastasis to Bone. Cancer Microenvironment 4:3, pages 247-259.
Crossref
Jae-Hwan Jeong & Je-Yong Choi. (2011) Interrelationship of Runx2 and estrogen pathway in skeletal tissues. BMB Reports 44:10, pages 613-618.
Crossref
Pierre-Luc Mercier, Magdalena Bachvarova, Marie Plante, Jean Gregoire, Marie-Claude Renaud, Karim Ghani, Bernard Têtu, Isabelle Bairati & Dimcho Bachvarov. (2011) Characterization of DOK1, a candidate tumor suppressor gene, in epithelial ovarian cancer. Molecular Oncology 5:5, pages 438-453.
Crossref
Sibyll Hein, Volkmar Müller, Nadine Köhler, Harriet Wikman, Sylke Krenkel, Thomas Streichert, Michaela Schweizer, Sabine Riethdorf, Volker Assmann, Maike Ihnen, Katrin Beck, Rana Issa, Fritz Jänicke, Klaus Pantel & Karin Milde-Langosch. (2010) Biologic role of activated leukocyte cell adhesion molecule overexpression in breast cancer cell lines and clinical tumor tissue. Breast Cancer Research and Treatment 129:2, pages 347-360.
Crossref
Sebastián Giulianelli, Jason I. Herschkowitz, Vyomesh Patel, Caroline A. Lamb, J. Silvio Gutkind, Alfredo Molinolo, Charles M. Perou & Claudia Lanari. (2010) MPA-induced gene expression and stromal and parenchymal gene expression profiles in luminal murine mammary carcinomas with different hormonal requirements. Breast Cancer Research and Treatment 129:1, pages 49-67.
Crossref
Virginia Llopis-Hernández, Patricia Rico, José Ballester-Beltrán, David Moratal & Manuel Salmerón-Sánchez. (2011) Role of Surface Chemistry in Protein Remodeling at the Cell-Material Interface. PLoS ONE 6:5, pages e19610.
Crossref
Haijun Zhang, Yunqian Pan, Li Zheng, Chungyoul Choe, Bruce Lindgren, Eric D. Jensen, Jennifer J. Westendorf, Liang Cheng & Haojie Huang. (2011) FOXO1 Inhibits Runx2 Transcriptional Activity and Prostate Cancer Cell Migration and Invasion. Cancer Research 71:9, pages 3257-3267.
Crossref
Yibin Kang. 2012. Cancer Metastasis. Cancer Metastasis 215 222 .
J. W. Martin, M. Zielenska, G. S. Stein, A. J. van Wijnen & J. A. Squire. (2011) The Role of RUNX2 in Osteosarcoma Oncogenesis. Sarcoma 2011, pages 1-13.
Crossref
Nilay Sethi & Yibin Kang. (2011) Dysregulation of developmental pathways in bone metastasis. Bone 48:1, pages 16-22.
Crossref
Jitesh Pratap, Jane B. Lian & Gary S. Stein. (2011) Metastatic bone disease: Role of transcription factors and future targets. Bone 48:1, pages 30-36.
Crossref
Daniel Mendoza-Villanueva, Wensheng Deng, Cesar Lopez-Camacho & Paul Shore. (2010) The Runx transcriptional co-activator, CBFβ, is essential for invasion of breast cancer cells. Molecular Cancer 9:1.
Crossref
Elisabeth Ytteborg, Grete Baeverfjord, Jacob Torgersen, Kirsti Hjelde & Harald Takle. (2010) Molecular pathology of vertebral deformities in hyperthermic Atlantic salmon (Salmo salar). BMC Physiology 10:1.
Crossref
Yoshiaki Onodera, Yasuhiro Miki, Takashi Suzuki, Kiyoshi Takagi, Jun-ichi Akahira, Takuya Sakyu, Mika Watanabe, Satoshi Inoue, Takanori Ishida, Noriaki Ohuchi & Hironobu Sasano. (2010) Runx2 in human breast carcinoma: its potential roles in cancer progression. Cancer Science 101:12, pages 2670-2675.
Crossref
J. Nathan Davis, Donna Rogers, Lisa Adams, Thomas Yong, Jette S. Jung, Bing Cheng, Katie Fennell, Erkut Borazanci, Yara W. Moustafa, Amanda Sun, Runhua Shi, Jonathan Glass, J. Michael Mathis, B. Jill Williams & Shari Meyers. (2010) Association of core-binding factor β with the malignant phenotype of prostate and ovarian cancer cells. Journal of Cellular Physiology 225:3, pages 875-887.
Crossref
Marci D. Jones, Julie C. Liu, Thomas K. Barthel, Sadiq Hussain, Erik Lovria, Dengfeng Cheng, Jesse A. Schoonmaker, Sudhanshu Mulay, David C. Ayers, Mary L. Bouxsein, Gary S. Stein, Siddhartha Mukherjee & Jane B. Lian. (2010) A Proteasome Inhibitor, Bortezomib, Inhibits Breast Cancer Growth and Reduces Osteolysis by Downregulating Metastatic Genes. Clinical Cancer Research 16:20, pages 4978-4989.
Crossref
Huijuan Liu & Baojie Li. (2010) p53 control of bone remodeling. Journal of Cellular Biochemistry 111:3, pages 529-534.
Crossref
David T Leong, Joleen Lim, Xuewei Goh, Jitesh Pratap, Barry P Pereira, Hui Si Kwok, Saminathan Suresh Nathan, Jason R Dobson, Jane B Lian, Yoshiaki Ito, P Mathijs Voorhoeve, Gary S Stein, Manuel Salto-Tellez, Simon M Cool & Andre J van Wijnen. (2010) Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility. Breast Cancer Research 12:5.
Crossref
Karen Blyth, Francois Vaillant, Alma Jenkins, Laura McDonald, Marie Anne Pringle, Camille Huser, Torsten Stein, James Neil & Ewan R. Cameron. (2010) Runx2 in normal tissues and cancer cells: A developing story. Blood Cells, Molecules, and Diseases 45:2, pages 117-123.
Crossref
Kyle C. Kurek, Sara Del Mare, Zaidoun Salah, Suhaib Abdeen, Hussain Sadiq, Suk-hee Lee, Eugenio Gaudio, Nicola Zanesi, Kevin B. Jones, Barry DeYoung, Gail Amir, Mark Gebhardt, Matthew Warman, Gary S. Stein, Janet L. Stein, Jane B. Lian & Rami I. Aqeilan. (2010) Frequent Attenuation of the WWOX Tumor Suppressor in Osteosarcoma Is Associated with Increased Tumorigenicity and Aberrant RUNX2 Expression. Cancer Research 70:13, pages 5577-5586.
Crossref
J Akech, J J Wixted, K Bedard, M van der Deen, S Hussain, T A Guise, A J van Wijnen, J L Stein, L R Languino, D C Altieri, J Pratap, E Keller, G S Stein & J B Lian. (2009) Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions. Oncogene 29:6, pages 811-821.
Crossref
Minyoung Lim, Chen Zhong, Shangxin Yang, Adam M Bell, Michael B Cohen & Pradip Roy-Burman. (2010) Runx2 regulates survivin expression in prostate cancer cells. Laboratory Investigation 90:2, pages 222-233.
Crossref
Li-Fang Lin, Chih-Hung Chuang, Chien-Feng Li, Ching-Chun Liao, Chun-Pei Cheng, Tian-Lu Cheng, Meng-Ru Shen, Joseph T. Tseng, Wen-Chang Chang, Wen-Hwa Lee & Ju-Ming Wang. (2010) ZBRK1 Acts as a Metastatic Suppressor by Directly Regulating MMP9 in Cervical Cancer . Cancer Research 70:1, pages 192-201.
Crossref
Pierrick G.J. Fournier, Lauren K. Dunn, Gregory A. Clines & Theresa A. Guise. 2010. Bone Cancer. Bone Cancer 9 40 .
Margaretha van der Deen, Jacqueline Akech, Tao Wang, Thomas J. FitzGerald, Dario C. Altieri, Lucia R. Languino, Jane B. Lian, Andre J. van Wijnen, Janet L. Stein & Gary S. Stein. (2010) The cancer-related Runx2 protein enhances cell growth and responses to androgen and TGFβ in prostate cancer cells. Journal of Cellular Biochemistry, pages n/a-n/a.
Crossref
Inga A. San Martin, Nelson Varela, Marcia Gaete, Karina Villegas, Mariana Osorio, Julio C. Tapia, Marcelo Antonelli, Edna E. Mancilla, Barry P. Pereira, Saminathan S. Nathan, Jane B. Lian, Janet L. Stein, Gary S. Stein, Andre J. van Wijnen & Mario Galindo. (2009) Impaired cell cycle regulation of the osteoblast-related heterodimeric transcription factor Runx2-Cbfβ in osteosarcoma cells. Journal of Cellular Physiology 221:3, pages 560-571.
Crossref
Geraldine Gueron, Adriana De Siervi, Mercedes Ferrando, Marcelo Salierno, Paola De Luca, Belen Elguero, Roberto Meiss, Nora Navone & Elba S. Vazquez. (2009) Critical Role of Endogenous Heme Oxygenase 1 as a Tuner of the Invasive Potential of Prostate Cancer Cells. Molecular Cancer Research 7:11, pages 1745-1755.
Crossref
Sandra Casimiro, Theresa A. Guise & John Chirgwin. (2009) The critical role of the bone microenvironment in cancer metastases. Molecular and Cellular Endocrinology 310:1-2, pages 71-81.
Crossref
Sukyee Kwok, Susan R. Rittling, Nicola C. Partridge, Chellakkan S. Benson, Mayuranathan Thiyagaraj, Narasimhan Srinivasan & Nagarajan Selvamurugan. (2009) Transforming growth factor-β1 regulation of ATF-3 and identification of ATF-3 target genes in breast cancer cells. Journal of Cellular Biochemistry 108:2, pages 408-414.
Crossref
Kai SUN, Li-xin WEI & Meng-chao WU. (2009) Effect of tissue microenvironment on development and progression of cancer. Academic Journal of Second Military Medical University 28:10, pages 1239-1243.
Crossref
Jitesh Pratap, Karen M. Imbalzano, Jean M. Underwood, Nathalie Cohet, Karthiga Gokul, Jacqueline Akech, Andre J. van Wijnen, Janet L. Stein, Anthony N. Imbalzano, Jeffrey A. Nickerson, Jane B. Lian & Gary S. Stein. (2009) Ectopic Runx2 Expression in Mammary Epithelial Cells Disrupts Formation of Normal Acini Structure: Implications for Breast Cancer Progression. Cancer Research 69:17, pages 6807-6814.
Crossref
V. Alonso, F.C. Pérez-Martínez, F.J. Calahorra & P. Esbrit. (2009) Phytoestrogen modulation of bone-related cytokines and its impact on cell viability in human prostate cancer cells. Life Sciences 85:11-12, pages 421-430.
Crossref
Kakoli Das, David Tai Leong, Anurag Gupta, Liang Shen, Thomas Putti, Gary S. Stein, Andre J. van Wijnen & Manuel Salto-Tellez. (2009) Positive association between nuclear Runx2 and oestrogen-progesterone receptor gene expression characterises a biological subtype of breast cancer. European Journal of Cancer 45:13, pages 2239-2248.
Crossref
Isabella W.Y. Mak, Robert W. Cowan, Snezana Popovic, Nigel Colterjohn, Gurmit Singh & Michelle Ghert. (2009) Upregulation of MMP-13 via Runx2 in the stromal cell of Giant Cell Tumor of Bone. Bone 45:2, pages 377-386.
Crossref
Dario C. Altieri, Lucia R. Languino, Jane B. Lian, Janet L. Stein, Irwin Leav, Andre J. van Wijnen, Zhong Jiang & Gary S. Stein. (2009) Prostate cancer regulatory networks. Journal of Cellular Biochemistry 107:5, pages 845-852.
Crossref
Chee-Wai Chua, Yung-Tuen Chiu, Hiu-Fung Yuen, Kwok-Wah Chan, Kwan Man, Xianghong Wang, Ming-Tat Ling & Yong-Chuan Wong. (2009) Suppression of Androgen-Independent Prostate Cancer Cell Aggressiveness by FTY720: Validating Runx2 as a Potential Antimetastatic Drug Screening Platform. Clinical Cancer Research 15:13, pages 4322-4335.
Crossref
James A. Coffman. (2009) Is Runx a linchpin for developmental signaling in metazoans?. Journal of Cellular Biochemistry 107:2, pages 194-202.
Crossref

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