Advanced search
Publication Cover
Molecular and Cellular Biology Volume 25, 2005 - Issue 2
Submit an article Journal homepage
25
Views
38
CrossRef citations to date
0
Altmetric
Gene Expression

The C-Terminal Domain of RNA Polymerase II Functions as a Phosphorylation-Dependent Splicing Activator in a Heterologous Protein

Scott MillhouseDepartment of Biological Sciences, Columbia University, New York, New York
&
James L. ManleyDepartment of Biological Sciences, Columbia University, New York, New YorkCorrespondence[email protected]
Pages 533-544 | Received 03 Sep 2004, Accepted 18 Oct 2004, Published online: 27 Mar 2023

Citations (38)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (6)

Surbhi Sharma & Martin R. Schiller. (2019) The carboxy-terminus, a key regulator of protein function. Critical Reviews in Biochemistry and Molecular Biology 54:2, pages 85-102.
Read now
Noélia Custódio & Maria Carmo-Fonseca. (2016) Co-transcriptional splicing and the CTD code. Critical Reviews in Biochemistry and Molecular Biology 51:5, pages 395-411.
Read now
Kuo-Ming Lee & Woan-Yuh Tarn. (2013) Coupling pre-mRNA processing to transcription on the RNA factory assembly line. RNA Biology 10:3, pages 380-390.
Read now
Charles J. David & James L. Manley. (2011) The RNA polymerase C-terminal domain. Transcription 2:5, pages 221-225.
Read now
Adelene Y. Tan & James L. Manley. (2010) TLS Inhibits RNA Polymerase III Transcription. Molecular and Cellular Biology 30:1, pages 186-196.
Read now
Frank Rigo & Harold G. Martinson. (2008) Functional Coupling of Last-Intron Splicing and 3′-End Processing to Transcription In Vitro: the Poly(A) Signal Couples to Splicing before Committing to Cleavage. Molecular and Cellular Biology 28:2, pages 849-862.
Read now

Articles from other publishers (32)

Satoru Shinriki, Mayumi Hirayama, Akiko Nagamachi, Akihiko Yokoyama, Takeshi Kawamura, Akinori Kanai, Hidehiko Kawai, Junichi Iwakiri, Rin Liu, Manabu Maeshiro, Saruul Tungalag, Masayoshi Tasaki, Mitsuharu Ueda, Kazuhito Tomizawa, Naoyuki Kataoka, Takashi Ideue, Yutaka Suzuki, Kiyoshi Asai, Tokio Tani, Toshiya Inaba & Hirotaka Matsui. (2022) DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic cells. Leukemia 36:11, pages 2605-2620.
Crossref
Katherine Dwyer, Neha Agarwal, Lori Pile & Athar Ansari. (2021) Gene Architecture Facilitates Intron-Mediated Enhancement of Transcription. Frontiers in Molecular Biosciences 8.
Crossref
Changfu Liu, Weihao Zhang & Wenge Xing. (2020) Diverse and conserved roles of the protein Ssu72 in eukaryotes: from yeast to higher organisms. Current Genetics 67:2, pages 195-206.
Crossref
Michael Tellier, Isabella Maudlin & Shona Murphy. (2020) Transcription and splicing: A two‐way street. WIREs RNA 11:5.
Crossref
Fei-Yu Chen, Xiang Li, Hong-Ping Zhu & Wei Huang. (2020) Regulation of the Ras-Related Signaling Pathway by Small Molecules Containing an Indole Core Scaffold: A Potential Antitumor Therapy. Frontiers in Pharmacology 11.
Crossref
Hiroshi Maita & Shinichi Nakagawa. (2019) What is the switch for coupling transcription and splicing? RNA Polymerase II C‐terminal domain phosphorylation, phase separation and beyond. WIREs RNA 11:1.
Crossref
James E. Delorme, Varna Kodoth & Sara J. Aton. (2019) Sleep loss disrupts Arc expression in dentate gyrus neurons. Neurobiology of Learning and Memory 160, pages 73-82.
Crossref
Seema Patel. (2017) Pathogenicity-associated protein domains: The fiercely-conserved evolutionary signatures. Gene Reports 7, pages 127-141.
Crossref
Seema Patel. (2016) In silico analysis of Hepatitis C virus (HCV) polyprotein domains and their comparison with other pathogens and allergens to gain insight on pathogenicity mechanisms. Computational Biology and Chemistry 65, pages 91-102.
Crossref
Dror Hollander, Shiran Naftelberg, Galit Lev-Maor, Alberto R. Kornblihtt & Gil Ast. (2016) How Are Short Exons Flanked by Long Introns Defined and Committed to Splicing?. Trends in Genetics 32:10, pages 596-606.
Crossref
Amy Larson, Benjamin Jung Fair & Jeffrey A Pleiss. (2016) Interconnections Between RNA-Processing Pathways Revealed by a Sequencing-Based Genetic Screen for Pre-mRNA Splicing Mutants in Fission Yeast. G3 Genes|Genomes|Genetics 6:6, pages 1513-1523.
Crossref
Ying Liu, Jinfeng Liu, Zenyuan Wang & Johnny J He. (2015) Tip110 binding to U6 small nuclear RNA and its participation in pre-mRNA splicing. Cell & Bioscience 5:1.
Crossref
Dominik M. Meinel & Katja Sträßer. (2015) Co-transcriptional mRNP formation is coordinated within a molecular mRNP packaging station in S. cerevisiae . BioEssays 37:6, pages 666-677.
Crossref
Jeffry L. Corden. (2013) RNA Polymerase II C-Terminal Domain: Tethering Transcription to Transcript and Template. Chemical Reviews 113:11, pages 8423-8455.
Crossref
Bo Gu, Dirk Eick & Olivier Bensaude. (2013) CTD serine-2 plays a critical role in splicing and termination factor recruitment to RNA polymerase II in vivo. Nucleic Acids Research 41:3, pages 1591-1603.
Crossref
Dorota Sikora, Dajiang Zhang, Teodora Bojic, Yasnee Beeharry, Ali Tanara & Martin Pelchat. (2013) Identification of a Binding Site for ASF/SF2 on an RNA Fragment Derived from the Hepatitis delta Virus Genome. PLoS ONE 8:1, pages e54832.
Crossref
Ignacio E. Schor, Luciana I. Gómez Acuña & Alberto R. Kornblihtt. 2013. RNA and Cancer. RNA and Cancer 1 24 .
Jing-Ping Hsin & James L. Manley. (2012) The RNA polymerase II CTD coordinates transcription and RNA processing. Genes & Development 26:19, pages 2119-2137.
Crossref
Charles J. David, Alex R. Boyne, Scott R. Millhouse & James L. Manley. (2011) The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65–Prp19 complex. Genes & Development 25:9, pages 972-983.
Crossref
Shuhong Wu, Li Wang, Wei Guo, Xiaoying Liu, Jinsong Liu, Xiaoli Wei & Bingliang Fang. (2011) Analogues and Derivatives of Oncrasin-1, a Novel Inhibitor of the C-Terminal Domain of RNA Polymerase II and Their Antitumor Activities. Journal of Medicinal Chemistry 54:8, pages 2668-2679.
Crossref
Manzar J. Hossain, Reshma Korde, Prashant K. Singh, Shivani Kanodia, Ravi Ranjan, Geeta Ram, Gaganjot Singh Kalsey, Rita Singh & Pawan Malhotra. (2010) Plasmodium falciparum Tudor Staphylococcal Nuclease interacting proteins suggest its role in nuclear as well as splicing processes. Gene 468:1-2, pages 48-57.
Crossref
B.J. Clark. 2010. Comprehensive Toxicology. Comprehensive Toxicology 51 69 .
Ignacio E. Schor, Nicolás Rascovan, Federico Pelisch, Mariano Alló & Alberto R. Kornblihtt. (2009) Neuronal cell depolarization induces intragenic chromatin modifications affecting NCAM alternative splicing. Proceedings of the National Academy of Sciences 106:11, pages 4325-4330.
Crossref
Jean-François Fisette, Laetitia Michelle, Timothée Revil & Benoit Chabot. (2009) Guider et intégrer pour un épissage diversifié. médecine/sciences 25:2, pages 175-180.
Crossref
Syuzo Kaneko, Chun Chu, Aaron J. Shatkin & James L. Manley. (2007) Human capping enzyme promotes formation of transcriptional R loops in vitro . Proceedings of the National Academy of Sciences 104:45, pages 17620-17625.
Crossref
Jie Yang, Tuuli Välineva, Jingxin Hong, Tianxu Bu, Zhi Yao, Ole N. Jensen, Mikko J. Frilander & Olli Silvennoinen. (2007) Transcriptional co-activator protein p100 interacts with snRNP proteins and facilitates the assembly of the spliceosome. Nucleic Acids Research 35:13, pages 4485-4494.
Crossref
M. V. Sobennikova, E. K. Shematorova & G. V. Shpakovski. (2007) C-terminal domain of subunit Rpb1 of nuclear RNA polymerase II and its role in the transcription cycle. Molecular Biology 41:3, pages 387-401.
Crossref
Alberto R. Kornblihtt. 2007. Alternative Splicing in the Postgenomic Era. Alternative Splicing in the Postgenomic Era 175 189 .
Syuzo Kaneko & James L. Manley. (2005) The Mammalian RNA Polymerase II C-Terminal Domain Interacts with RNA to Suppress Transcription-Coupled 3′ End Formation. Molecular Cell 20:1, pages 91-103.
Crossref
Xialu Li & James L. Manley. (2005) Inactivation of the SR Protein Splicing Factor ASF/SF2 Results in Genomic Instability. Cell 122:3, pages 365-378.
Crossref
Alberto R Kornblihtt. (2005) Promoter usage and alternative splicing. Current Opinion in Cell Biology 17:3, pages 262-268.
Crossref
David L Bentley. (2005) Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factors. Current Opinion in Cell Biology 17:3, pages 251-256.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.