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Gene Expression

DNA Damage-Induced Phosphorylation of MdmX at Serine 367 Activates p53 by Targeting MdmX for Mdm2-Dependent Degradation

Koji Okamoto1 Radiobiology Division, National Cancer Center Research Institute, Tokyo 104-0045, and CREST and SORST, Japan Science and Technology Agency, Tokyo, JapanCorrespondence[email protected]
,
Kenji Kashima1 Radiobiology Division, National Cancer Center Research Institute, Tokyo 104-0045, and CREST and SORST, Japan Science and Technology Agency, Tokyo, Japan
,
Yaron Pereg2 David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv69978, Israel
,
Michiko Ishida1 Radiobiology Division, National Cancer Center Research Institute, Tokyo 104-0045, and CREST and SORST, Japan Science and Technology Agency, Tokyo, Japan
,
Satomi Yamazaki1 Radiobiology Division, National Cancer Center Research Institute, Tokyo 104-0045, and CREST and SORST, Japan Science and Technology Agency, Tokyo, Japan
,
Ayumi Nota1 Radiobiology Division, National Cancer Center Research Institute, Tokyo 104-0045, and CREST and SORST, Japan Science and Technology Agency, Tokyo, Japan
,
Amina Teunisse3 Department of Molecular and Cell Biology, Leiden University Medical Center, 2300 RALeiden, The Netherlands
,
Domenico Migliorini4 Department of Biological Sciences, Columbia University, New York, New York10027
,
Issay Kitabayashi5 Molecular Oncology Division, National Cancer Center Research Institute, Tokyo104-0045, Japan
,
Jean-Christophe Marine6 Laboratory of Molecular Cancer Biology, Flanders Interuniversity Institute for Biotechnology, B-9052Ghent, Belgium
,
Carol Prives4 Department of Biological Sciences, Columbia University, New York, New York10027
,
Yosef Shiloh2 David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv69978, Israel
,
Aart G. Jochemsen3 Department of Molecular and Cell Biology, Leiden University Medical Center, 2300 RALeiden, The Netherlands
&
Yoichi Taya1 Radiobiology Division, National Cancer Center Research Institute, Tokyo 104-0045, and CREST and SORST, Japan Science and Technology Agency, Tokyo, Japan
 show all
Pages 9608-9620 | Received 17 Feb 2005, Accepted 14 Aug 2005, Published online: 27 Mar 2023

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Ixaura Medina-Medina, Paola García-Beltrán, Ignacio de la Mora-de la Mora, Jesús Oria-Hernández, Guy Millot, Robin Fahraeus, Horacio Reyes-Vivas, José G. Sampedro & Vanesa Olivares-Illana. (2016) Allosteric Interactions by p53 mRNA Govern HDM2 E3 Ubiquitin Ligase Specificity under Different Conditions. Molecular and Cellular Biology 36:16, pages 2195-2205.
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Guifen He, Yi-Wei Zhang, Jun-Ho Lee, Shelya X. Zeng, Yunyuan V. Wang, Zhijun Luo, X. Charlie Dong, Benoit Viollet, Geoffrey M. Wahl & Hua Lu. (2014) AMP-Activated Protein Kinase Induces p53 by Phosphorylating MDMX and Inhibiting Its Activity. Molecular and Cellular Biology 34:2, pages 148-157.
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Shaofang Wu, Lihong Chen, Andreas Becker, Ernst Schonbrunn & Jiandong Chen. (2012) Casein Kinase 1α Regulates an MDMX Intramolecular Interaction To Stimulate p53 Binding. Molecular and Cellular Biology 32:23, pages 4821-4832.
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Lynn Biderman, Masha V. Poyurovsky, Yael Assia, James L. Manley & Carol Prives. (2012) MdmX Is Required for p53 Interaction with and Full Induction of the Mdm2 Promoter after Cellular Stress. Molecular and Cellular Biology 32:7, pages 1214-1225.
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John P Alao. (2009) The ATM regulated DNA damage response pathway as a chemo- and radiosensitisation target. Expert Opinion on Drug Discovery 4:5, pages 495-505.
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Daniele M. Gilkes, Yu Pan, Domenico Coppola, Timothy Yeatman, Gary W. Reuther & Jiandong Chen. (2008) Regulation of MDMX Expression by Mitogenic Signaling. Molecular and Cellular Biology 28:6, pages 1999-2010.
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Yetao Jin, Shelya X. Zeng, Xiao-Xin Sun, Hunjoo Lee, Christine Blattner, Zhixiong Xiao & Hua Lu. (2008) MDMX Promotes Proteasomal Turnover of p21 at G1 and Early S Phases Independently of, but in Cooperation with, MDM2. Molecular and Cellular Biology 28:4, pages 1218-1229.
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Giacomo Buscemi, Luigi Carlessi, Laura Zannini, Sofia Lisanti, Enrico Fontanella, Silvana Canevari & Domenico Delia. (2006) DNA Damage-Induced Cell Cycle Regulation and Function of Novel Chk2 Phosphoresidues. Molecular and Cellular Biology 26:21, pages 7832-7845.
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Yaron Pereg, Suzanne Lam, Amina Teunisse, Sharon Biton, Erik Meulmeester, Leonid Mittelman, Giacomo Buscemi, Koji Okamoto, Yoichi Taya, Yosef Shiloh & Aart G. Jochemsen. (2006) Differential Roles of ATM- and Chk2-Mediated Phosphorylations of Hdmx in Response to DNA Damage. Molecular and Cellular Biology 26:18, pages 6819-6831.
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