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Molecular and Cellular Biology Volume 25, 2005 - Issue 21
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Gene Expression

Peptidyl-Prolyl Isomerase 1 (Pin1) Serves as a Coactivator of Steroid Receptor by Regulating the Activity of Phosphorylated Steroid Receptor Coactivator 3 (SRC-3/AIB1)

Ping Yi1 Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas77030
,
Ray-Chang Wu1 Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas77030
,
Joshua Sandquist2 Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina27710
,
Jiemin Wong1 Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas77030
,
Sophia Y. Tsai1 Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas77030
,
Ming-Jer Tsai1 Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas77030
,
Anthony R. Means2 Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina27710
&
Bert W. O'Malley1 Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas77030Correspondence[email protected]
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Pages 9687-9699 | Received 15 Mar 2005, Accepted 04 Aug 2005, Published online: 27 Mar 2023

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Amy S. Farrell, Carl Pelz, Xiaoyan Wang, Colin J. Daniel, Zhiping Wang, Yulong Su, Mahnaz Janghorban, Xiaoli Zhang, Charlie Morgan, Soren Impey & Rosalie C. Sears. (2013) Pin1 Regulates the Dynamics of c-Myc DNA Binding To Facilitate Target Gene Regulation and Oncogenesis. Molecular and Cellular Biology 33:15, pages 2930-2949.
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Prashant Rajbhandari, Greg Finn, Natalia M. Solodin, Kiran K. Singarapu, Sarata C. Sahu, John L. Markley, Kelley J. Kadunc, Stephanie J. Ellison-Zelski, Anastasia Kariagina, Sandra Z. Haslam, Kun Ping Lu & Elaine T. Alarid. (2012) Regulation of Estrogen Receptor α N-Terminus Conformation and Function by Peptidyl Prolyl Isomerase Pin1. Molecular and Cellular Biology 32:2, pages 445-457.
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Zhuojuan Luo, Andrea Wijeweera, Yingzi Oh, Yih-Cherng Liou & Philippa Melamed. (2010) Pin1 Facilitates the Phosphorylation-Dependent Ubiquitination of SF-1 To Regulate Gonadotropin β-Subunit Gene Transcription. Molecular and Cellular Biology 30:3, pages 745-763.
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Li Qin, Lan Liao, Aisling Redmond, Leonie Young, Yuhui Yuan, Hongwu Chen, Bert W. O'Malley & Jianming Xu. (2008) The AIB1 Oncogene Promotes Breast Cancer Metastasis by Activation of PEA3-Mediated Matrix Metalloproteinase 2 (MMP2) and MMP9 Expression. Molecular and Cellular Biology 28:19, pages 5937-5950.
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Erin L. Reineke, Minh Lam, Qing Liu, Yu Liu, Kristopher J. Stanya, Kun-Sang Chang, Anthony R. Means & Hung-Ying Kao. (2008) Degradation of the Tumor Suppressor PML by Pin1 Contributes to the Cancer Phenotype of Breast Cancer MDA-MB-231 Cells. Molecular and Cellular Biology 28:3, pages 997-1006.
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Chao Li, Ray-Chang Wu, Larbi Amazit, Sophia Y. Tsai, Ming-Jer Tsai & Bert W. O'Malley. (2007) Specific Amino Acid Residues in the Basic Helix-Loop-Helix Domain of SRC-3 Are Essential for Its Nuclear Localization and Proteasome-Dependent Turnover. Molecular and Cellular Biology 27:4, pages 1296-1308.
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Qin Feng, Ping Yi, Jiemin Wong & Bert W. O'Malley. (2006) Signaling within a Coactivator Complex: Methylation of SRC-3/AIB1 Is a Molecular Switch for Complex Disassembly. Molecular and Cellular Biology 26:21, pages 7846-7857.
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Maggie C. Louie, Alexey S. Revenko, June X. Zou, Jennifer Yao & Hong-Wu Chen. (2006) Direct Control of Cell Cycle Gene Expression by Proto-Oncogene Product ACTR, and Its Autoregulation Underlies Its Transforming Activity. Molecular and Cellular Biology 26:10, pages 3810-3823.
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Articles from other publishers (66)

Xiangming Hu & Lin-Feng Chen. (2020) Pinning Down the Transcription: A Role for Peptidyl-Prolyl cis-trans Isomerase Pin1 in Gene Expression. Frontiers in Cell and Developmental Biology 8.
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Alessandro Zannini, Alessandra Rustighi, Elena Campaner & Giannino Del Sal. (2019) Oncogenic Hijacking of the PIN1 Signaling Network. Frontiers in Oncology 9.
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Garam Kim, Poshan Yugal Bhattarai & Hong Seok Choi. (2019) Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 as a molecular target in breast cancer: a therapeutic perspective of gynecological cancer. Archives of Pharmacal Research 42:2, pages 128-139.
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Maguie El Boustani, Lucia De Stefano, Isabella Caligiuri, Nayla Mouawad, Carlotta Granchi, Vincenzo Canzonieri, Tiziano Tuccinardi, Antonio Giordano & Flavio Rizzolio. (2019) A Guide to PIN1 Function and Mutations Across Cancers. Frontiers in Pharmacology 9.
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Alessandra Rustighi, Alessandro Zannini, Elena Campaner, Yari Ciani, Silvano Piazza & Giannino Del Sal. (2016) PIN1 in breast development and cancer: a clinical perspective. Cell Death & Differentiation 24:2, pages 200-211.
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Sang-Hyun Min, Xiao Zhen Zhou & Kun Ping Lu. (2016) The role of Pin1 in the development and treatment of cancer. Archives of Pharmacal Research 39:12, pages 1609-1620.
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Xiao Zhen Zhou & Kun Ping Lu. (2016) The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target. Nature Reviews Cancer 16:7, pages 463-478.
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Prashant Rajbhandari, Mary Szatkowski Ozers, Natalia M. Solodin, Christopher L. Warren & Elaine T. Alarid. (2015) Peptidylprolyl Isomerase Pin1 Directly Enhances the DNA Binding Functions of Estrogen Receptor α. Journal of Biological Chemistry 290:22, pages 13749-13762.
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Jing-Zhang Wang, Bao-Guo Liu & Yong Zhang. (2015) Pin1-based diagnostic and therapeutic strategies for breast cancer. Pharmacological Research 93, pages 28-35.
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Qin Feng & Bert W. O’Malley. (2014) Nuclear receptor modulation – Role of coregulators in selective estrogen receptor modulator (SERM) actions. Steroids 90, pages 39-43.
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Subhamoy Dasgupta & Bert W O'Malley. (2014) Transcriptional coregulators: emerging roles of SRC family of coactivators in disease pathology. Journal of Molecular Endocrinology 53:2, pages R47-R59.
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Zhimin Lu & Tony Hunter. (2014) Prolyl isomerase Pin1 in cancer. Cell Research 24:9, pages 1033-1049.
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Subhamoy DasguptaDavid M. LonardBert W. O'Malley. (2014) Nuclear Receptor Coactivators: Master Regulators of Human Health and Disease. Annual Review of Medicine 65:1, pages 279-292.
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Prem Khanal, Garam Kim, Sung‐Chul Lim, Hyo‐Jeong Yun, Kwang Youl Lee, Hoo‐Kyun Choi & Hong Seok Choi. (2013) Prolyl isomerase Pin1 negatively regulates the stability of SUV39H1 to promote tumorigenesis in breast cancer. The FASEB Journal 27:11, pages 4606-4618.
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V J Sanchez-Arévalo Lobo, M Doni, A Verrecchia, S Sanulli, G Fagà, A Piontini, M Bianchi, M Conacci-Sorrell, G Mazzarol, V Peg, J H Losa, P Ronchi, M Ponzoni, R N Eisenman, C Doglioni & B Amati. (2013) Dual regulation of Myc by Abl. Oncogene 32:45, pages 5261-5271.
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T. M. Poolman, S. N. Farrow, L. Matthews, A. S. Loudon & D. W. Ray. (2013) Pin1 promotes GR transactivation by enhancing recruitment to target genes. Nucleic Acids Research 41:18, pages 8515-8525.
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Y-H Nicole Tsang, X-W Wu, J-S Lim, C Wee Ong, M Salto-Tellez, K Ito, Y Ito & L-F Chen. (2012) Prolyl isomerase Pin1 downregulates tumor suppressor RUNX3 in breast cancer. Oncogene 32:12, pages 1488-1496.
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Chiara Lucchetti, Isabella Caligiuri, Giuseppe Toffoli, Antonio Giordano & Flavio Rizzolio. (2013) The Prolyl Isomerase Pin1 Acts Synergistically with CDK2 to Regulate the Basal Activity of Estrogen Receptor α in Breast Cancer. PLoS ONE 8:2, pages e55355.
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Vera V. Saul, Laureano de la Vega, Maja Milanovic, Marcus Krüger, Thomas Braun, Karin Fritz-Wolf, Katja Becker & M. Lienhard Schmitz. (2013) HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop. Journal of Molecular Cell Biology 5:1, pages 27-38.
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P Khanal, H J Yun, S C Lim, S G Ahn, H E Yoon, K W Kang, R Hong & H S Choi. (2011) Proyl isomerase Pin1 facilitates ubiquitin-mediated degradation of cyclin-dependent kinase 10 to induce tamoxifen resistance in breast cancer cells. Oncogene 31:34, pages 3845-3856.
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Sang-Hyun Min, Alan W. Lau, Tae Ho Lee, Hiroyuki Inuzuka, Shuo Wei, Pengyu Huang, Shavali Shaik, Daniel Yenhong Lee, Greg Finn, Martin Balastik, Chun-Hau Chen, Manli Luo, Adriana E. Tron, James A. DeCaprio, Xiao Zhen Zhou, Wenyi Wei & Kun Ping Lu. (2012) Negative Regulation of the Stability and Tumor Suppressor Function of Fbw7 by the Pin1 Prolyl Isomerase. Molecular Cell 46:6, pages 771-783.
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David DilworthGeoff GudaviciusAndrew LeungChristopher J. Nelson. (2012) The roles of peptidyl-proline isomerases in gene regulation 1 This review is part of Special Issue entitled Asilomar Chromatin and has undergone the Journal’s usual peer review process. . Biochemistry and Cell Biology 90:1, pages 55-69.
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Krista K. Hill, Sarah C. Roemer, Mair E.A. Churchill & Dean P. Edwards. (2012) Structural and functional analysis of domains of the progesterone receptor. Molecular and Cellular Endocrinology 348:2, pages 418-429.
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Macarena Ferrero & Jaime Font Mora. 2012. Cell Signaling & Molecular Targets in Cancer. Cell Signaling & Molecular Targets in Cancer 129 166 .
Yih-Cherng Liou, Xiao Zhen Zhou & Kun Ping Lu. (2011) Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins. Trends in Biochemical Sciences 36:10, pages 501-514.
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Brian L. Teng, Kathryn E. Hacker, Shufen Chen, Anthony R. Means & W. Kimryn Rathmell. (2011) Tumor suppressive activity of prolyl isomerase Pin1 in renal cell carcinoma. Molecular Oncology 5:5, pages 465-474.
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Tae Ho Lee, Lucia Pastorino & Kun Ping Lu. (2011) Peptidyl-prolyl cis–trans isomerase Pin1 in ageing, cancer and Alzheimer disease. Expert Reviews in Molecular Medicine 13.
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Agnieszka Dziedzic-Letka, Grzegorz Rymarczyk, Tomasz M. Kapłon, Andrzej Górecki, Agnieszka Szamborska-Gbur, Magdalena Wojtas, Piotr Dobryszycki & Andrzej Ożyhar. (2011) Intrinsic disorder of Drosophila melanogaster hormone receptor 38 N-terminal domain. Proteins: Structure, Function, and Bioinformatics 79:2, pages 376-392.
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