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Signal Transduction

Werner Protein Protects Nonproliferating Cells from Oxidative DNA Damage

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Pages 10492-10506 | Received 01 Dec 2004, Accepted 31 Aug 2005, Published online: 27 Mar 2023

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Guido Keijzers, Scott Maynard, Raghavendra A. Shamanna, Lene Juel Rasmussen, Deborah L. Croteau & Vilhelm A. Bohr. (2014) The role of RecQ helicases in non-homologous end-joining. Critical Reviews in Biochemistry and Molecular Biology 49:6, pages 463-472.
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Venkateswarlu Popuri, Takashi Tadokoro, Deborah L. Croteau & Vilhelm A. Bohr. (2013) Human RECQL5: Guarding the crossroads of DNA replication and transcription and providing backup capability. Critical Reviews in Biochemistry and Molecular Biology 48:3, pages 289-299.
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Articles from other publishers (67)

Yujun Hou, Jae-Hyeon Park, Xiuli Dan, Xixia Chu, Beimeng Yang, Mansoor Hussain, Deborah L. Croteau & Vilhelm A. Bohr. (2023) RecQ dysfunction contributes to social and depressive-like behavior and affects aldolase activity in mice. Neurobiology of Disease 180, pages 106092.
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Feng Cui, Xueying Han, Xiaoqian Zhang, Siqi Wang, Na Liang, Qing Tan, Wuga Sha & Jun Li. (2022) ML216 Prevents DNA Damage-Induced Senescence by Modulating DBC1–BLM Interaction. Cells 12:1, pages 145.
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May Nasser Bin-Jumah, Muhammad Shahid Nadeem, Sadaf Jamal Gilani, Fahad A. Al-Abbasi, Inam Ullah, Sami I. Alzarea, Mohammed M. Ghoneim, Sultan Alshehri, Aziz Uddin, Bibi Nazia Murtaza & Imran Kazmi. (2022) Genes and Longevity of Lifespan. International Journal of Molecular Sciences 23:3, pages 1499.
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Lucie AumailleyMichel Lebel. (2021) The Impact of Vitamin C on Different System Models of Werner Syndrome. Antioxidants & Redox Signaling 34:11, pages 856-874.
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Mansoor Hussain, Sudarshan Krishnamurthy, Jaimin Patel, Edward Kim, Beverly A. Baptiste, Deborah L. Croteau & Vilhelm A. Bohr. (2021) Skin Abnormalities in Disorders with DNA Repair Defects, Premature Aging, and Mitochondrial Dysfunction. Journal of Investigative Dermatology 141:4, pages 968-975.
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Alexandra M. D’Amico & Karen M. Vasquez. (2021) The multifaceted roles of DNA repair and replication proteins in aging and obesity. DNA Repair 99, pages 103049.
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Arindam Datta, Srijita Dhar, Sanket Awate & Robert M. BroshJrJr. (2021) Synthetic Lethal Interactions of RECQ Helicases. Trends in Cancer 7:2, pages 146-161.
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Constantinos Savva, Maaz Sadiq, Omar Sheikh, Syed Karim, Sachin Trivedi, Andrew R. Green, Emad A. Rakha, Srinivasan Madhusudan & Arvind Arora. (2021) Werner Syndrome Protein Expression in Breast Cancer. Clinical Breast Cancer 21:1, pages 57-73.e7.
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Yuxiao SunLianying FangMengmeng YangNingning HeJinhan WangManman ZhangKaihua JiQin WangYang LiuLiqing DuYan WangChang XuQiang Liu. (2021) Identification and Bioinformatic Assessment of circRNA Expression After RMI1 Knockdown and Ionizing Radiation Exposure . DNA and Cell Biology 40:1, pages 80-92.
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Juan Manuel Iglesias-Pedraz, Diego Matia Fossatti-Jara, Valeria Valle-Riestra-Felice, Sergio Rafael Cruz-Visalaya, Jose Antonio Ayala Felix & Lucio Comai. (2020) WRN modulates translation by influencing nuclear mRNA export in HeLa cancer cells. BMC Molecular and Cell Biology 21:1.
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Kim Jee Goh, Jian-Hua Chen, Nuno Rocha & Robert K. Semple. (2020) Human pluripotent stem cell-based models suggest preadipocyte senescence as a possible cause of metabolic complications of Werner and Bloom Syndromes. Scientific Reports 10:1.
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Jiajie Tu, Chao Wan, Fengjie Zhang, Lianbao Cao, Patrick Wai Nok Law, Yuyao Tian, Gang Lu, Owen M. Rennert, Wai‐Yee Chan & Hoi‐Hung Cheung. (2020) Genetic correction of Werner syndrome gene reveals impaired pro‐angiogenic function and HGF insufficiency in mesenchymal stem cells. Aging Cell 19:5.
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Agnieszka Tudek, Jolanta Czerwińska, Konrad Kosicki, Daria Zdżalik-Bielecka, Somayeh Shahmoradi Ghahe, Milena Bażlekowa-Karaban, Ewelina M. Borsuk & Elżbieta Speina. (2020) DNA damage, repair and the improvement of cancer therapy – A tribute to the life and research of Barbara Tudek. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 852, pages 503160.
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Sofie Lautrup, Domenica Caponio, Hoi-Hung Cheung, Claudia Piccoli, Tinna Stevnsner, Wai-Yee Chan & Evandro F. Fang. (2019) Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases. Biogerontology 20:3, pages 255-269.
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Chin Wai Hui, Marie-Kim St-Pierre, Jérôme Detuncq, Lucie Aumailley, Marie-Julie Dubois, Vanessa Couture, Daniel Skuk, André Marette, Jacques P. Tremblay, Michel Lebel & Marie-Ève Tremblay. (2018) Nonfunctional mutant Wrn protein leads to neurological deficits, neuronal stress, microglial alteration, and immune imbalance in a mouse model of Werner syndrome. Brain, Behavior, and Immunity 73, pages 450-469.
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Jack D. Crouch & Robert M. BroshJr.Jr.. (2017) Mechanistic and biological considerations of oxidatively damaged DNA for helicase-dependent pathways of nucleic acid metabolism. Free Radical Biology and Medicine 107, pages 245-257.
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Christelle de Renty & Nathan A. Ellis. (2017) Bloom’s syndrome: Why not premature aging?. Ageing Research Reviews 33, pages 36-51.
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Sei-ichiro Motegi, Akihiko Uchiyama, Kazuya Yamada, Sachiko Ogino, Yoko Yokoyama, Buddhini Perera, Yuko Takeuchi & Osamu Ishikawa. (2016) Increased susceptibility to oxidative stress- and ultraviolet A-induced apoptosis in fibroblasts in atypical progeroid syndrome/atypical Werner syndrome with LMNA mutation . Experimental Dermatology 25, pages 20-27.
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A. John Callegari. (2016) Does transcription-associated DNA damage limit lifespan?. DNA Repair 41, pages 1-7.
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Hiroyuki Kamiya, Daiki Yamazaki, Eri Nakamura, Tetsuaki Makino, Miwako Kobayashi, Ichiro Matsuoka & Hideyoshi Harashima. (2015) Action-at-a-Distance Mutagenesis Induced by Oxidized Guanine in Werner Syndrome Protein-Reduced Human Cells. Chemical Research in Toxicology 28:4, pages 621-628.
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Jolanta Czerwińska, Jarosław Poznański, Janusz Dębski, Zuzanna Bukowy, Vilhelm A. Bohr, Barbara Tudek & Elżbieta Speina. (2014) Catalytic activities of Werner protein are affected by adduction with 4-hydroxy-2-nonenal. Nucleic Acids Research 42:17, pages 11119-11135.
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Jun-Ho Jang, Shannon Bruse, Salam Huneidi, Ronald M. Schrader, Martha M. Monick, Yong Lin, A. Brent Carter, Aloysius J. Klingelhutz & Toru Nyunoya. (2014) Acrolein-Exposed Normal Human Lung Fibroblasts in Vitro : Cellular Senescence, Enhanced Telomere Erosion, and Degradation of Werner’s Syndrome Protein . Environmental Health Perspectives 122:9, pages 955-962.
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Elyse Bolterstein, Rachel Rivero, Melissa Marquez & Mitch McVey. (2014) The Drosophila Werner Exonuclease Participates in an Exonuclease-Independent Response to Replication Stress . Genetics 197:2, pages 643-652.
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Bidisha Saha, Alexander Cypro, George M. Martin & Junko Oshima. (2014) Rapamycin decreases DNA damage accumulation and enhances cell growth of WRN ‐deficient human fibroblasts . Aging Cell 13:3, pages 573-575.
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H Lu, E F Fang, P Sykora, T Kulikowicz, Y Zhang, K G Becker, D L Croteau & V A Bohr. (2014) Senescence induced by RECQL4 dysfunction contributes to Rothmund–Thomson syndrome features in mice. Cell Death & Disease 5:5, pages e1226-e1226.
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A. Jain, A. Bacolla, I. M. del Mundo, J. Zhao, G. Wang & K. M. Vasquez. (2013) DHX9 helicase is involved in preventing genomic instability induced by alternatively structured DNA in human cells. Nucleic Acids Research 41:22, pages 10345-10357.
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F Fausti, S Di Agostino, M Cioce, P Bielli, C Sette, P P Pandolfi, M Oren, M Sudol, S Strano & G Blandino. (2013) ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence. Cell Death & Differentiation 20:11, pages 1498-1509.
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Leslie K. Ferrarelli, Venkateswarlu Popuri, Avik K. Ghosh, Takashi Tadokoro, Chandrika Canugovi, Joseph K. Hsu, Deborah L. Croteau & Vilhelm A. Bohr. (2013) The RECQL4 protein, deficient in Rothmund–Thomson syndrome is active on telomeric D-loops containing DNA metabolism blocking lesions. DNA Repair 12:7, pages 518-528.
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YASUKO KITAGISHI & SATORU MATSUDA. (2013) Redox regulation of tumor suppressor PTEN in cancer and aging. International Journal of Molecular Medicine 31:3, pages 511-515.
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Venkateswarlu Popuri, Jing Huang, Mahesh Ramamoorthy, Takashi Tadokoro, Deborah L. Croteau & Vilhelm A. Bohr. (2013) RECQL5 plays co-operative and complementary roles with WRN syndrome helicase. Nucleic Acids Research 41:2, pages 881-899.
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Jochen Kuper & Caroline Kisker. 2013. DNA Helicases and DNA Motor Proteins. DNA Helicases and DNA Motor Proteins 203 224 .
Takashi Tadokoro, Mahesh Ramamoorthy, Venkateswarlu Popuri, Alfred May, Jingyan Tian, Peter Sykora, Ivana Rybanska, David M. WilsonIIIIII, Deborah L. Croteau & Vilhelm A. Bohr. (2012) Human RECQL5 participates in the removal of endogenous DNA damage. Molecular Biology of the Cell 23:21, pages 4273-4285.
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Adam Labbé, Véronique N. Lafleur, David A. Patten, Geneviève A. Robitaille, Chantal Garand, Laurent Lamalice, Michel Lebel & Darren E. Richard. (2012) The Werner syndrome gene product (WRN): a repressor of hypoxia-inducible factor-1 activity. Experimental Cell Research 318:14, pages 1620-1632.
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Giovanni Pagano, Annarita Aiello Talamanca, Giuseppe Castello, Federico V. Pallardó, Adriana Zatterale & Paolo Degan. (2012) Oxidative stress in Fanconi anaemia: from cells and molecules towards prospects in clinical management. Biological Chemistry 393:1-2, pages 11-21.
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Birija Sankar Patro, Rikke Frøhlich, Vilhelm A. Bohr & Tinna Stevnsner. (2011) WRN helicase regulates the ATR–CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I–DNA covalent complexes. Journal of Cell Science 124:23, pages 3967-3979.
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Dennis Kjølhede Jeppesen, Vilhelm A. Bohr & Tinna Stevnsner. (2011) DNA repair deficiency in neurodegeneration. Progress in Neurobiology 94:2, pages 166-200.
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Albino Bacolla, Guliang Wang, Aklank Jain, Nadia A. Chuzhanova, Regina Z. Cer, Jack R. Collins, David N. Cooper, Vilhelm A. Bohr & Karen M. Vasquez. (2011) Non-B DNA-forming Sequences and WRN Deficiency Independently Increase the Frequency of Base Substitution in Human Cells. Journal of Biological Chemistry 286:12, pages 10017-10026.
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Xuefeng Ren, Sophia Lim, Zhiying Ji, Jessica Yuh, Vivian Peng, Martyn T. Smith & Luoping Zhang. (2011) Comparison of Proliferation and Genomic Instability Responses to WRN Silencing in Hematopoietic HL60 and TK6 Cells. PLoS ONE 6:1, pages e14546.
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Sudha Sharma. (2011) Non-B DNA Secondary Structures and Their Resolution by RecQ Helicases. Journal of Nucleic Acids 2011, pages 1-15.
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Venkateswarlu Popuri, Deborah L. Croteau & Vilhelm A. Bohr. (2010) Substrate specific stimulation of NEIL1 by WRN but not the other human RecQ helicases. DNA Repair 9:6, pages 636-642.
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L Massip, C Garand, A Labbé, È Perreault, R V N Turaga, V A Bohr & M Lebel. (2009) Depletion of WRN protein causes RACK1 to activate several protein kinase C isoforms. Oncogene 29:10, pages 1486-1497.
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Marie L. Rossi, Avik K. Ghosh & Vilhelm A. Bohr. (2010) Roles of Werner syndrome protein in protection of genome integrity. DNA Repair 9:3, pages 331-344.
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Kiranjit K. Dhillon, Julia M. Sidorova, Tina M. Albertson, Judith B. Anderson, Warren C. Ladiges, Peter S. Rabinovitch, Bradley D. Preston & Raymond J. MonnatJr.Jr.. (2010) Divergent cellular phenotypes of human and mouse cells lacking the Werner syndrome RecQ helicase. DNA Repair 9:1, pages 11-22.
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Xuefeng Ren, Sophia Lim, Martyn T. Smith & Luoping Zhang. (2009) Werner Syndrome Protein, WRN, Protects Cells from DNA Damage Induced by the Benzene Metabolite Hydroquinone. Toxicological Sciences 107:2, pages 367-375.
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