81
Views
54
CrossRef citations to date
0
Altmetric
Mammalian Genetic Models with Minimal or Complex Phenotypes

The Class II Phosphoinositide 3-Kinase C2β Is Not Essential for Epidermal Differentiation

, , &
Pages 11122-11130 | Received 22 Aug 2005, Accepted 30 Sep 2005, Published online: 27 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Claire Petitjean, Natasha M. Setiabakti, Jessica K. Mountford, Jane F. Arthur, Sarah Ellis & Justin R. Hamilton. (2016) Combined deficiency of PI3KC2α and PI3KC2β reveals a nonredundant role for PI3KC2α in regulating mouse platelet structure and thrombus stability. Platelets 27:5, pages 402-409.
Read now
Miriam Martini, Maria Chiara De Santis, Laura Braccini, Federico Gulluni & Emilio Hirsch. (2014) PI3K/AKT signaling pathway and cancer: an updated review. Annals of Medicine 46:6, pages 372-383.
Read now
Shekhar Srivastava, Xinjiang Cai, Zhai Li, Yi Sun & Edward Y. Skolnik. (2012) Phosphatidylinositol-3-Kinase C2β and TRIM27 Function To Positively and Negatively Regulate IgE Receptor Activation of Mast Cells. Molecular and Cellular Biology 32:15, pages 3132-3139.
Read now
David P. Harris, Peter Vogel, Marie Wims, Karen Moberg, Juliane Humphries, Kanchan G. Jhaver, Christopher M. DaCosta, Melanie K. Shadoan, Nianhua Xu, Gwenn M. Hansen, Sanjeevi Balakrishnan, Jan Domin, David R. Powell & Tamas Oravecz. (2011) Requirement for Class II Phosphoinositide 3-Kinase C2α in Maintenance of Glomerular Structure and Function. Molecular and Cellular Biology 31:1, pages 63-80.
Read now

Articles from other publishers (50)

Benoît Thibault, Fernanda Ramos-Delgado & Julie Guillermet-Guibert. (2023) Targeting Class I-II-III PI3Ks in Cancer Therapy: Recent Advances in Tumor Biology and Preclinical Research. Cancers 15:3, pages 784.
Crossref
Luca Gozzelino, Gaga Kochlamazashvili, Sara Baldassari, Albert Ian Mackintosh, Laura Licchetta, Emanuela Iovino, Yu Chi Liu, Caitlin A Bennett, Mark F Bennett, John A Damiano, Gábor Zsurka, Caterina Marconi, Tania Giangregorio, Pamela Magini, Marijn Kuijpers, Tanja Maritzen, Giuseppe Danilo Norata, Stéphanie Baulac, Laura Canafoglia, Marco Seri, Paolo Tinuper, Ingrid E Scheffer, Melanie Bahlo, Samuel F Berkovic, Michael S Hildebrand, Wolfram S Kunz, Lucio Giordano, Francesca Bisulli, Miriam Martini, Volker Haucke, Emilio Hirsch & Tommaso Pippucci. (2022) Defective lipid signalling caused by mutations in PIK3C2B underlies focal epilepsy . Brain 145:7, pages 2313-2331.
Crossref
Emily Yan Zhi Heng & Tania Maffucci. 2022. PI3K and AKT Isoforms in Immunity. PI3K and AKT Isoforms in Immunity 51 68 .
Waltraud C. Schrottmaier, Marion Mussbacher, Manuel Salzmann, Julia B. Kral-Pointner & Alice Assinger. 2022. PI3K and AKT Isoforms in Immunity. PI3K and AKT Isoforms in Immunity 255 285 .
Elissa K. Deenick, Julia Bier & Anthony Lau. 2022. PI3K and AKT Isoforms in Immunity. PI3K and AKT Isoforms in Immunity 235 254 .
Typhaine Anquetil, Romain Solinhac, Aude Jaffre, Gaëtan Chicanne, Julien Viaud, Jean Darcourt, Cyrille Orset, Eva Geuss, Christoph Kleinschnitz, Bart Vanhaesebroeck, Denis Vivien, Karim Hnia, Vincent Larrue, Bernard Payrastre & Marie‐Pierre Gratacap. (2021) PI3KC2β inactivation stabilizes VE‐cadherin junctions and preserves vascular integrity. EMBO reports 22:6.
Crossref
Kazuaki Yoshioka. (2021) Class II phosphatidylinositol 3-kinase isoforms in vesicular trafficking. Biochemical Society Transactions 49:2, pages 893-901.
Crossref
Shahidul Islam, Kazuaki Yoshioka, Sho Aki, Kazuhiro Ishimaru, Hiroki Yamada, Noriko Takuwa & Yoh Takuwa. (2020) Class II phosphatidylinositol 3-kinase α and β isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice. The Journal of Physiological Sciences 70:1.
Crossref
Tom N. Durrant & Ingeborg Hers. (2020) PI3K inhibitors in thrombosis and cardiovascular disease. Clinical and Translational Medicine 9:1.
Crossref
Ouma Cisse, Muzthahid Quraishi, Federico Gulluni, Federica Guffanti, Ioanna Mavrommati, Methushaa Suthanthirakumaran, Lara C. R. Oh, Jessica N. Schlatter, Ambisha Sarvananthan, Massimo Broggini, Emilio Hirsch, Marco Falasca & Tania Maffucci. (2019) Downregulation of class II phosphoinositide 3-kinase PI3K-C2β delays cell division and potentiates the effect of docetaxel on cancer cell growth. Journal of Experimental & Clinical Cancer Research 38:1.
Crossref
Clémentine Escouflaire, Emmanuelle Rebours, Mathieu Charles, Sébastien Orellana, Margarita Cano, Julie Rivière, Cécile Grohs, Hélène Hayes & Aurélien Capitan. (2019) Α de novo 3.8-Mb inversion affecting the EDA and XIST genes in a heterozygous female calf with generalized hypohidrotic ectodermal dysplasia. BMC Genomics 20:1.
Crossref
Benoit Bilanges, York Posor & Bart Vanhaesebroeck. (2019) PI3K isoforms in cell signalling and vesicle trafficking. Nature Reviews Molecular Cell Biology 20:9, pages 515-534.
Crossref
Chen-Che Jeff Huang & Yuan Kang. (2019) The transient cortical zone in the adrenal gland: the mystery of the adrenal X-zone. Journal of Endocrinology 241:1, pages R51-R63.
Crossref
Federico Gulluni, Maria Chiara De Santis, Jean Piero Margaria, Miriam Martini & Emilio Hirsch. (2019) Class II PI3K Functions in Cell Biology and Disease. Trends in Cell Biology 29:4, pages 339-359.
Crossref
Md Azadul Kabir Sarker, Sho Aki, Kazuaki Yoshioka, Kouji Kuno, Yasuo Okamoto, Kazuhiro Ishimaru, Noriko Takuwa & Yoh Takuwa. (2019) Class II PI3Ks α and β Are Required for Rho-Dependent Uterine Smooth Muscle Contraction and Parturition in Mice. Endocrinology 160:1, pages 235-248.
Crossref
Gina R. Leisching. (2018) Susceptibility to Tuberculosis Is Associated With PI3K-Dependent Increased Mobilization of Neutrophils. Frontiers in Immunology 9.
Crossref
Danielle C. Robinson, Anna E. Mammel, Anne M. Logan, Aubree A. Larson, Eric J. Schmidt, Alec F. Condon & Fred L. Robinson. (2018) An In Vitro Model of Charcot-Marie-Tooth Disease Type 4B2 Provides Insight Into the Roles of MTMR13 and MTMR2 in Schwann Cell Myelination . ASN Neuro 10, pages 175909141880328.
Crossref
Marcus Kind, Jolanta Klukowska-Rötzler, Sabina Berezowska, Alexandre Arcaro & Roch-Philippe Charles. (2017) Questioning the role of selected somatic PIK3C2B mutations in squamous non-small cell lung cancer oncogenesis. PLOS ONE 12:10, pages e0187308.
Crossref
Shekhar Srivastava, Zhai Li & Edward Y. Skolnik. (2017) Phosphatidlyinositol-3-kinase C2 beta (PI3KC2β) is a potential new target to treat IgE mediated disease. PLOS ONE 12:8, pages e0183474.
Crossref
Joanna Janus, Ryan O’Shaughnessy, Catherine Harwood & Tania Maffucci. (2017) Phosphoinositide 3-Kinase-Dependent Signalling Pathways in Cutaneous Squamous Cell Carcinomas. Cancers 9:7, pages 86.
Crossref
Andrea L. Marat, Alexander Wallroth, Wen-Ting Lo, Rainer Müller, Giuseppe Danilo NorataMarco Falasca, Carsten SchultzVolker Haucke. (2017) mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate. Science 356:6341, pages 968-972.
Crossref
Marco Falasca, Justin R. Hamilton, Maria Selvadurai, Krithika Sundaram, Aleksandra Adamska & Philip E. Thompson. (2016) Class II Phosphoinositide 3-Kinases as Novel Drug Targets. Journal of Medicinal Chemistry 60:1, pages 47-65.
Crossref
Jason S. L. Yu & Wei Cui. (2016) Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination. Development 143:17, pages 3050-3060.
Crossref
Nesrin Sabha, Jonathan R. Volpatti, Hernan Gonorazky, Aaron Reifler, Ann E. Davidson, Xingli Li, Nadine M. Eltayeb, Claudia Dall’Armi, Gilbert Di Paolo, Susan V. Brooks, Ana Buj-Bello, Eva L. Feldman & James J. Dowling. (2016) PIK3C2B inhibition improves function and prolongs survival in myotubular myopathy animal models. Journal of Clinical Investigation 126:9, pages 3613-3625.
Crossref
Samira Alliouachene, Benoit Bilanges, Claire Chaussade, Wayne Pearce, Lazaros C. Foukas, Cheryl L. Scudamore, Larissa S. Moniz & Bart Vanhaesebroeck. (2016) Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice. Diabetologia 59:7, pages 1503-1512.
Crossref
Colin Valet, Sonia Severin, Gaëtan Chicanne, Pierre Alexandre Laurent, Frédérique Gaits-Iacovoni, Marie-Pierre Gratacap & Bernard Payrastre. (2016) The role of class I, II and III PI 3-kinases in platelet production and activation and their implication in thrombosis. Advances in Biological Regulation 61, pages 33-41.
Crossref
Ioanna Mavrommati, Ouma Cisse, Marco Falasca & Tania Maffucci. (2016) Novel roles for class II Phosphoinositide 3-Kinase C2β in signalling pathways involved in prostate cancer cell invasion. Scientific Reports 6:1.
Crossref
M.Z. Zhu, W.D. Le & G. Jin. (2016) Ropinirole alters gene expression profiles in SH-SY5Y cells: a whole genome microarray study. Brazilian Journal of Medical and Biological Research 49:2.
Crossref
Samira Alliouachene, Benoit Bilanges, Gaëtan Chicanne, Karen E. Anderson, Wayne Pearce, Khaled Ali, Colin Valet, York Posor, Pei Ching Low, Claire Chaussade, Cheryl L. Scudamore, Rachel S. Salamon, Jonathan M. Backer, Len Stephens, Phill T. Hawkins, Bernard Payrastre & Bart Vanhaesebroeck. (2015) Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity. Cell Reports 13:9, pages 1881-1894.
Crossref
Adrien Lupieri, Natalia Smirnova, Nicole Malet, Stéphanie Gayral & Muriel Laffargue. (2015) PI3K signaling in arterial diseases: Non redundant functions of the PI3K isoforms. Advances in Biological Regulation 59, pages 4-18.
Crossref
Laura Braccini, Elisa Ciraolo, Carlo C. Campa, Alessia Perino, Dario L. Longo, Gianpaolo Tibolla, Marco Pregnolato, Yanyan Cao, Beatrice Tassone, Federico Damilano, Muriel Laffargue, Enzo Calautti, Marco Falasca, Giuseppe D. Norata, Jonathan M. Backer & Emilio Hirsch. (2015) PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling. Nature Communications 6:1.
Crossref
P.T. Hawkins & L.R. Stephens. (2015) PI3K signalling in inflammation. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1851:6, pages 882-897.
Crossref
Jessica K. Mountford, Claire Petitjean, Harun W. Kusuma Putra, Jonathan A. McCafferty, Natasha M. Setiabakti, Hannah Lee, Lotte L. Tønnesen, James D. McFadyen, Simone M. Schoenwaelder, Anita Eckly, Christian Gachet, Sarah Ellis, Anne K. Voss, Ross A. Dickins, Justin R. Hamilton & Shaun P. Jackson. (2015) The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function. Nature Communications 6:1.
Crossref
Sho Aki, Kazuaki Yoshioka, Yasuo Okamoto, Noriko Takuwa & Yoh Takuwa. (2015) Phosphatidylinositol 3-Kinase Class II α-Isoform PI3K-C2α Is Required for Transforming Growth Factor β-induced Smad Signaling in Endothelial Cells. Journal of Biological Chemistry 290:10, pages 6086-6105.
Crossref
Lauren M. Thorpe, Haluk Yuzugullu & Jean J. Zhao. (2014) PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting. Nature Reviews Cancer 15:1, pages 7-24.
Crossref
Fergal O′Farrell, Tor E. Rusten & Harald Stenmark. (2013) Phosphoinositide 3-kinases as accelerators and brakes of autophagy. FEBS Journal 280:24, pages 6322-6337.
Crossref
Tamas Balla. (2013) Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation. Physiological Reviews 93:3, pages 1019-1137.
Crossref
Klaus Okkenhaug. (2013) Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells. Annual Review of Immunology 31:1, pages 675-704.
Crossref
Gianpaolo Tibolla, Roberto Piñeiro, Daniela Chiozzotto, Ioanna Mavrommati, Ann P. Wheeler, Giuseppe Danilo Norata, Alberico Luigi Catapano, Tania Maffucci & Marco Falasca. (2013) Class II Phosphoinositide 3-Kinases Contribute to Endothelial Cells Morphogenesis. PLoS ONE 8:1, pages e53808.
Crossref
Kazuaki YOSHIOKA, Noriko TAKUWA, Yasuo OKAMOTO & Yoh TAKUWA. (2013) Analysis of PI3K-C2α-mediated endothelial signaling using live-cell fluorescence imaging. Japanese Journal of Thrombosis and Hemostasis 24:6, pages 560-568.
Crossref
Marco FalascaTania Maffucci. (2012) Regulation and cellular functions of class II phosphoinositide 3-kinases. Biochemical Journal 443:3, pages 587-601.
Crossref
Matthias Wymann. 2012. Phosphoinositides I: Enzymes of Synthesis and Degradation. Phosphoinositides I: Enzymes of Synthesis and Degradation 111 181 .
Bart Vanhaesebroeck, Julie Guillermet-Guibert, Mariona Graupera & Benoit Bilanges. (2010) The emerging mechanisms of isoform-specific PI3K signalling. Nature Reviews Molecular Cell Biology 11:5, pages 329-341.
Crossref
Takehiko Sasaki, Shunsuke Takasuga, Junko Sasaki, Satoshi Kofuji, Satoshi Eguchi, Masakazu Yamazaki & Akira Suzuki. (2009) Mammalian phosphoinositide kinases and phosphatases. Progress in Lipid Research 48:6, pages 307-343.
Crossref
Jason A. Reuter, Susana Ortiz-Urda, Markus Kretz, John Garcia, Florence A. Scholl, Anna M.G. Pasmooij, David Cassarino, Howard Y. Chang & Paul A. Khavari. (2009) Modeling Inducible Human Tissue Neoplasia Identifies an Extracellular Matrix Interaction Network Involved in Cancer Progression. Cancer Cell 15:6, pages 477-488.
Crossref
Robert J. Cain & Anne J. Ridley. (2009) Phosphoinositide 3-kinases in cell migration. Biology of the Cell 101:1, pages 13-29.
Crossref
Karen E. AndersonKeith B. BoyleKeith DavidsonTamara A. M. ChessaSuhasini KulkarniGavin E. JarvisAnca Sindrilaru, Karin Scharffetter-Kochanek, Oliver Rausch, Len R. StephensPhillip T. Hawkins. (2008) CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks. Blood 112:13, pages 5202-5211.
Crossref
E. Sarró, O. Tornavaca, M. Plana, A. Meseguer & E. Itarte. (2008) Phosphoinositide 3-kinase inhibitors protect mouse kidney cells from cyclosporine-induced cell death. Kidney International 73:1, pages 77-85.
Crossref
A K Stoeckman, E C Baechler, W A Ortmann, T W Behrens, C J Michet & E J Peterson. (2006) A distinct inflammatory gene expression profile in patients with psoriatic arthritis. Genes & Immunity 7:7, pages 583-591.
Crossref
Atsuo T. Sasaki & Richard A. Firtel. (2006) Regulation of chemotaxis by the orchestrated activation of Ras, PI3K, and TOR. European Journal of Cell Biology 85:9-10, pages 873-895.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.