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Molecular and Cellular Biology Volume 25, 2005 - Issue 6
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Gene Expression

Structural and Functional Characterization of PC2 and RNA Polymerase II-Associated Subpopulations of Metazoan Mediator

Sohail MalikLaboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New YorkCorrespondence[email protected]
,
Hwa Jin BaekLaboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York
,
Weizhen WuLaboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York
&
Robert G. RoederLaboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York
Pages 2117-2129 | Received 12 Jul 2004, Accepted 06 Dec 2004, Published online: 27 Mar 2023

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Naveen Malik, Pinky Agarwal & Akhilesh Tyagi. (2017) Emerging functions of multi-protein complex Mediator with special emphasis on plants. Critical Reviews in Biochemistry and Molecular Biology 52:5, pages 475-502.
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Madesh Belakavadi & Joseph D. Fondell. (2010) Cyclin-Dependent Kinase 8 Positively Cooperates with Mediator To Promote Thyroid Hormone Receptor-Dependent Transcriptional Activation. Molecular and Cellular Biology 30:10, pages 2437-2448.
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Xiaohui Liu, Marina Vorontchikhina, Yuan-Liang Wang, Francesco Faiola & Ernest Martinez. (2008) STAGA Recruits Mediator to the MYC Oncoprotein To Stimulate Transcription and Cell Proliferation. Molecular and Cellular Biology 28:1, pages 108-121.
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Articles from other publishers (36)

Tomoyoshi Nakadai, Miho Shimada, Keiichi Ito, Murat Alper Cevher, Chi-Shuen Chu, Kohei Kumegawa, Reo Maruyama, Sohail Malik & Robert G Roeder. (2023) Two target gene activation pathways for orphan ERR nuclear receptors. Cell Research 33:2, pages 165-183.
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Yanfeng HeShigeo SatoChieri Tomomori-SatoShiyuan ChenZach H. GoodeJoan W. Conaway & Ronald C. Conaway. (2021) Elongin functions as a loading factor for Mediator at ATF6α-regulated ER stress response genes. Proceedings of the National Academy of Sciences 118:39.
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Xizi Chen, Xiaotong Yin, Jiabei Li, Zihan Wu, Yilun Qi, Xinxin Wang, Weida Liu & Yanhui Xu. (2021) Structures of the human Mediator and Mediator-bound preinitiation complex. Science 372:6546.
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Dou Yeon Youn, Alus M. Xiaoli, Haihong Zong, Junichi Okada, Li Liu, Jacob Pessin, Jeffrey E. Pessin & Fajun Yang. (2021) The Mediator complex kinase module is necessary for fructose regulation of liver glycogen levels through induction of glucose-6-phosphatase catalytic subunit (G6pc). Molecular Metabolism 48, pages 101227.
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Qikun Liu, Sylvain Bischof, C. Jake Harris, Zhenhui Zhong, Lingyu Zhan, Calvin Nguyen, Andrew Rashoff, William D. Barshop, Fei Sun, Suhua Feng, Magdalena Potok, Javier Gallego-Bartolome, Jixian Zhai, James A. Wohlschlegel, Michael F. Carey, Jeffrey A. Long & Steven E. Jacobsen. (2020) The characterization of Mediator 12 and 13 as conditional positive gene regulators in Arabidopsis. Nature Communications 11:1.
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Dou Yeon Youn, Alus M. Xiaoli, Hyokjoon Kwon, Fajun Yang & Jeffrey E. Pessin. (2019) The subunit assembly state of the Mediator complex is nutrient-regulated and is dysregulated in a genetic model of insulin resistance and obesity. Journal of Biological Chemistry 294:23, pages 9076-9083.
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Neha Nagpal, Shivani Sharma, Sourobh Maji, Giorgio Durante, Manuela Ferracin, Jitendra K. Thakur & Ritu Kulshreshtha. (2018) Essential role of MED1 in the transcriptional regulation of ER-dependent oncogenic miRNAs in breast cancer. Scientific Reports 8:1.
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Julie Soutourina. (2017) Transcription regulation by the Mediator complex. Nature Reviews Molecular Cell Biology 19:4, pages 262-274.
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Sohail Malik, Henrik Molina & Zhu Xue. (2017) PIC Activation through Functional Interplay between Mediator and TFIIH. Journal of Molecular Biology 429:1, pages 48-63.
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Sohail Malik & Robert G. Roeder. (2016) Mediator: A Drawbridge across the Enhancer-Promoter Divide. Molecular Cell 64:3, pages 433-434.
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Natalia Petrenko, Yi Jin, Koon Ho Wong & Kevin Struhl. (2016) Mediator Undergoes a Compositional Change during Transcriptional Activation. Molecular Cell 64:3, pages 443-454.
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Célia Jeronimo, Marie-France Langelier, Alain R. Bataille, John M. Pascal, B. Franklin Pugh & François Robert. (2016) Tail and Kinase Modules Differently Regulate Core Mediator Recruitment and Function In Vivo. Molecular Cell 64:3, pages 455-466.
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Sohail Malik. (2016) Eukaryotic Transcription Regulation: Getting to the Heart of the Matter: Commentary on Mediator Architecture and RNA Polymerase II Function by Plaschka et al. Journal of Molecular Biology 428:12, pages 2575-2580.
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Sabrina Croce & Frédéric Chibon. (2015) MED12 and uterine smooth muscle oncogenesis: State of the art and perspectives. European Journal of Cancer 51:12, pages 1603-1610.
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Xiao-Jun Xie, Fu-Ning Hsu, Xinsheng Gao, Wu Xu, Jian-Quan Ni, Yue Xing, Liying Huang, Hao-Ching Hsiao, Haiyan Zheng, Chenguang Wang, Yani Zheng, Alus M. Xiaoli, Fajun Yang, Sarah E. Bondos & Jun-Yuan Ji. (2015) CDK8-Cyclin C Mediates Nutritional Regulation of Developmental Transitions through the Ecdysone Receptor in Drosophila. PLOS Biology 13:7, pages e1002207.
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Hyung Suk Oh & David M. Knipe. (2015) Proteomic analysis of the herpes simplex virus 1 virion protein 16 transactivator protein in infected cells. PROTEOMICS 15:12, pages 1957-1967.
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Yusuke Akimoto, Seiji Yamamoto, Satoshi Iida, Yutaka Hirose, Aki Tanaka, Fumio Hanaoka & Yoshiaki Ohkuma. (2014) Transcription cofactor PC4 plays essential roles in collaboration with the small subunit of general transcription factor TFIIE. Genes to Cells 19:12, pages 879-890.
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Murat A Cevher, Yi Shi, Dan Li, Brian T Chait, Sohail Malik & Robert G Roeder. (2014) Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit. Nature Structural & Molecular Biology 21:12, pages 1028-1034.
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Aya Fukuda, Miho Shimada, Tomoyoshi Nakadai, Ken Nishimura & Koji Hisatake. (2013) Heterogeneous Nuclear Ribonucleoprotein R Cooperates with Mediator to Facilitate Transcription Reinitiation on the c-Fos Gene. PLoS ONE 8:8, pages e72496.
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Tilman Borggrefe & Xiaojing Yue. (2011) Interactions between subunits of the Mediator complex with gene-specific transcription factors. Seminars in Cell & Developmental Biology 22:7, pages 759-768.
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Carrie Bernecky, Patricia Grob, Christopher C. Ebmeier, Eva Nogales & Dylan J. Taatjes. (2011) Molecular Architecture of the Human Mediator–RNA Polymerase II–TFIIF Assembly. PLoS Biology 9:3, pages e1000603.
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Jeanho Yun, Choon Hee Son, Soo Jung Um, Hyuk Chan Kwon, Kyung Eun Lee, Phil Jo Choi & Mee Sook Roh. (2011) A different TRAP220 expression in distinct histologic subtypes of lung adenocarcinoma and the prognostic significance. Lung Cancer 71:3, pages 312-318.
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Sohail Malik & Robert G. Roeder. (2010) The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nature Reviews Genetics 11:11, pages 761-772.
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Dylan J. Taatjes. (2010) The human Mediator complex: a versatile, genome-wide regulator of transcription. Trends in Biochemical Sciences 35:6, pages 315-322.
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Sara J. Buhrlage, Caleb A. Bates, Steven P. Rowe, Aaron R. Minter, Brian B. Brennan, Chinmay Y. Majmudar, David E. Wemmer, Hashim Al-Hashimi & Anna K. Mapp. (2009) Amphipathic Small Molecules Mimic the Binding Mode and Function of Endogenous Transcription Factors. ACS Chemical Biology 4:5, pages 335-344.
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Sohail Malik, María J. Barrero & Tara Jones. (2007) Identification of a regulator of transcription elongation as an accessory factor for the human Mediator coactivator. Proceedings of the National Academy of Sciences 104:15, pages 6182-6187.
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Nicolas Loncle, Muriel Boube, Laurent Joulia, Claire Boschiero, Michel Werner, David L Cribbs & Henri-Marc Bourbon. (2007) Distinct roles for Mediator Cdk8 module subunits in Drosophila development. The EMBO Journal 26:4, pages 1045-1054.
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Tadashi Furumoto, Aki Tanaka, Mitsuhiro Ito, Sohail Malik, Yutaka Hirose, Fumio Hanaoka & Yoshiaki Ohkuma. (2007) A kinase subunit of the human mediator complex, CDK8, positively regulates transcriptional activation. Genes to Cells 12:1, pages 119-132.
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Thomas Uhlmann, Stefan Boeing, Michael Lehmbacher & Michael Meisterernst. (2007) The VP16 Activation Domain Establishes an Active Mediator Lacking CDK8 in Vivo. Journal of Biological Chemistry 282:4, pages 2163-2173.
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Andrew C. PaolettiTari J. ParmelyChieri Tomomori-SatoShigeo SatoDongxiao ZhuRonald C. Conaway, Joan Weliky Conaway, Laurence FlorensMichael P. Washburn. (2006) Quantitative proteomic analysis of distinct mammalian Mediator complexes using normalized spectral abundance factors. Proceedings of the National Academy of Sciences 103:50, pages 18928-18933.
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Xiaopeng HuSohail Malik, Costin Catalin NegroiuKyle HubbardChidambaram Natesa VelalarBrian Hampton, Dan GrosuJennifer CatalanoRobert G. Roeder & Averell Gnatt. (2006) A Mediator-responsive form of metazoan RNA polymerase II. Proceedings of the National Academy of Sciences 103:25, pages 9506-9511.
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Hwa Jin Baek, Yun Kyoung Kang & Robert G. Roeder. (2006) Human Mediator Enhances Basal Transcription by Facilitating Recruitment of Transcription Factor IIB during Preinitiation Complex Assembly. Journal of Biological Chemistry 281:22, pages 15172-15181.
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M. Belakavadi & J. D. Fondell. 2006. Reviews of Physiology, Biochemistry and Pharmacology. Reviews of Physiology, Biochemistry and Pharmacology 23 43 .
Sung Wook Park, Guangjin Li, Ya-Ping Lin, Maria J. Barrero, Kai Ge, Robert G. Roeder & Li-Na Wei. (2005) Thyroid Hormone-Induced Juxtaposition of Regulatory Elements/Factors and Chromatin Remodeling of Crabp1 Dependent on MED1/TRAP220. Molecular Cell 19:5, pages 643-653.
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Xiaoting Zhang, Andrew Krutchinsky, Aya Fukuda, Wei Chen, Soichiro Yamamura, Brian T. Chait & Robert G. Roeder. (2005) MED1/TRAP220 Exists Predominantly in a TRAP/ Mediator Subpopulation Enriched in RNA Polymerase II and Is Required for ER-Mediated Transcription. Molecular Cell 19:1, pages 89-100.
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Sohail Malik & Robert G. Roeder. (2005) Dynamic regulation of pol II transcription by the mammalian Mediator complex. Trends in Biochemical Sciences 30:5, pages 256-263.
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