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Signal Transduction

The Pleckstrin Homology Domain-Containing Protein CKIP-1 Is Involved in Regulation of Cell Morphology and the Actin Cytoskeleton and Interaction with Actin Capping Protein

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Pages 3519-3534 | Received 23 Dec 2004, Accepted 19 Jan 2005, Published online: 27 Mar 2023

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Matthew R. Avenarius, Jocelyn F. Krey, Rachel A. Dumont, Clive P. Morgan, Connor B. Benson, Sarath Vijayakumar, Christopher L. Cunningham, Deborah I. Scheffer, David P. Corey, Ulrich Müller, Sherri M. Jones & Peter G. Barr-Gillespie. (2017) Heterodimeric capping protein is required for stereocilia length and width regulation. Journal of Cell Biology 216:11, pages 3861-3881.
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Marc Edwards, Yun Liang, Taekyung Kim & John A. Cooper. (2013) Physiological role of the interaction between CARMIL1 and capping protein. Molecular Biology of the Cell 24:19, pages 3047-3055.
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Ping Li, Yuli Xu, Xin Li & Mark Bartlam. (2013) Crystallization and preliminary X-ray crystallographic analysis of the human CKIP-1 pleckstrin homology domain. Acta Crystallographica Section F Structural Biology and Crystallization Communications 69:3, pages 324-327.
Crossref
Jing Nie, Lin Liu, Fuchu He, Xiaobing Fu, Weidong Han & Lingqiang Zhang. (2013) CKIP-1: A scaffold protein and potential therapeutic target integrating multiple signaling pathways and physiological functions. Ageing Research Reviews 12:1, pages 276-281.
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Taekyung Kim, Geoffrey E. Ravilious, David Sept & John A. Cooper. (2012) Mechanism for CARMIL Protein Inhibition of Heterodimeric Actin-capping Protein. Journal of Biological Chemistry 287:19, pages 15251-15262.
Crossref
Suryani Lukman, Robert C. Robinson, David Wales & Chandra S. Verma. (2012) Conformational dynamics of capping protein and interaction partners: Simulation studies. Proteins: Structure, Function, and Bioinformatics 80:4, pages 1066-1077.
Crossref
Charles-Peter Xavier, Raphael H. Rastetter, Margit Blömacher, Maria Stumpf, Mirko Himmel, Reginald O. Morgan, Maria-Pilar Fernandez, Conan Wang, Asiah Osman, Yoshihiko Miyata, Ruth A. Gjerset, Ludwig Eichinger, Andreas Hofmann, Stefan Linder, Angelika A. Noegel & Christoph S. Clemen. (2012) Phosphorylation of CRN2 by CK2 regulates F-actin and Arp2/3 interaction and inhibits cell migration. Scientific Reports 2:1.
Crossref
Dominique Baas, Sabine Caussanel-Boude, Alexandre Guiraud, Frederico Calhabeu, Emilie Delaune-Henry, Fanny Pilot, Emilie Chopin, Irma Machuca-Gayet, Aurélia Vernay, Stéphanie Bertrand, Jean-François Rual, Pierre Jurdic, David E. Hill, Marc Vidal, Laurent Schaeffer & Evelyne Goillot. (2012) CKIP-1 REGULATES MAMMALIAN AND ZEBRAFISH MYOBLAST FUSION. Journal of Cell Science.
Crossref
Shuichi Takeda, Ryotaro Koike, Yasushi Nitanai, Shiho Minakata, Yuichiro Maéda & Motonori Ota. (2011) Actin capping protein and its inhibitor CARMIL: how intrinsically disordered regions function. Physical Biology 8:3, pages 035005.
Crossref
Adam Zwolak, Takehito Uruno, Grzegorz Piszczek, John A. HammerIIIIII & Nico Tjandra. (2010) Molecular Basis for Barbed End Uncapping by CARMIL Homology Domain 3 of Mouse CARMIL-1. Journal of Biological Chemistry 285:37, pages 29014-29026.
Crossref
Adam Zwolak, Ikuko Fujiwara, John A. HammerIIIIII & Nico Tjandra. (2010) Structural Basis for Capping Protein Sequestration by Myotrophin (V-1). Journal of Biological Chemistry 285:33, pages 25767-25781.
Crossref
Matthew Herring, Nick Davenport, Kendra Stephan, Shawna Campbell, Rebecca White, Jonathan Kark & Tom D. Wolkow. (2010) Fission yeast Rad26ATRIP delays spindle-pole-body separation following interphase microtubule damage. Journal of Cell Science 123:9, pages 1537-1545.
Crossref
Changaram S. Venugopal, Luiz Claudio N. Mendes, Juliana R. Peiró, Susan S. Laborde, Ashley M. Stokes & Rustin M. Moore. (2010) Transcriptional changes associated with recurrent airway obstruction in affected and unaffected horses. American Journal of Veterinary Research 71:4, pages 476-482.
Crossref
Maria Hernandez-Valladares, Taekyung Kim, Balakrishnan Kannan, Alvin Tung, Adeleke H Aguda, Mårten Larsson, John A Cooper & Robert C Robinson. (2010) Structural characterization of a capping protein interaction motif defines a family of actin filament regulators. Nature Structural & Molecular Biology 17:4, pages 497-503.
Crossref
Shenli Xi, Yi Tie, Kefeng Lu, Minghua Zhang, Xiushan Yin, Jie Chen, Guichun Xing, Chunyan Tian, Xiaofei Zheng, Fuchu He & Lingqiang Zhang. (2010) N-terminal PH domain and C-terminal auto-inhibitory region of CKIP-1 coordinate to determine its nucleus-plasma membrane shuttling. FEBS Letters 584:6, pages 1223-1230.
Crossref
Jacob P. Turowec, James S. Duncan, Ashley C. French, Laszlo Gyenis, Nicole A. St. Denis, Greg Vilk & David W. Litchfield. 2010. Constitutive Activity in Receptors and Other Proteins, Part A. Constitutive Activity in Receptors and Other Proteins, Part A 471 493 .
Pekka Lappalainen, Maarit Makkonen & Hongxia Zhao. 2010. Actin-based Motility. Actin-based Motility 213 235 .
Sin-Ichi Odagaki, Haruko Kumanogoh, Shun Nakamura & Shohei Maekawa. (2009) Biochemical interaction of an actin-capping protein, CapZ, with NAP-22. Journal of Neuroscience Research 87:9, pages 1980-1985.
Crossref
Laszlo Gyenis & David W. Litchfield. (2008) The emerging CK2 interactome: insights into the regulation and functions of CK2. Molecular and Cellular Biochemistry 316:1-2, pages 5-14.
Crossref
Kefeng Lu, Xiushan Yin, Tujun Weng, Shenli Xi, Li Li, Guichun Xing, Xuan Cheng, Xiao Yang, Lingqiang Zhang & Fuchu He. (2008) Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1. Nature Cell Biology 10:8, pages 994-1002.
Crossref
Jenn-Yah Yu, Kwan-Ho Chung, Monika Deo, Robert C. Thompson & David L. Turner. (2008) MicroRNA miR-124 regulates neurite outgrowth during neuronal differentiation. Experimental Cell Research 314:14, pages 2618-2633.
Crossref
James S. Duncan & David W. Litchfield. (2008) Too much of a good thing: The role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1784:1, pages 33-47.
Crossref
John A. Cooper & David Sept. 2008. 183 206 .
Dirk Haubert, Nina Gharib, Francisco Rivero, Katja Wiegmann, Marianna Hösel, Martin Krönke & Hamid Kashkar. (2007) PtdIns(4,5)P-restricted plasma membrane localization of FAN is involved in TNF-induced actin reorganization. The EMBO Journal 26:14, pages 3308-3321.
Crossref
Lingqiang Zhang, Ying Tang, Yi Tie, Chunyan Tian, Jian Wang, Yan Dong, Zhixian Sun & Fuchu He. (2007) The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling. Cellular Signalling 19:5, pages 932-944.
Crossref
Jianping Xu, Joseph T. Jensen, Yinan Liang, Donald Belisle & J. David Miller. (2007) The biology and immunogenicity of a 34-kDa antigen of Stachybotrys chartarum sensu lato. International Biodeterioration & Biodegradation 60:4, pages 308-318.
Crossref
Erin E Baschal, Kuan J Chen, Lee G Elliott, Matthew J Herring, Shawn C Verde & Tom D Wolkow. (2006) The fission yeast DNA structure checkpoint protein Rad26ATRIP/LCD1/UVSD accumulates in the cytoplasm following microtubule destabilization. BMC Cell Biology 7:1.
Crossref
Tilmann Bürckstümmer, Keiryn L Bennett, Adrijana Preradovic, Gregor Schütze, Oliver Hantschel, Giulio Superti-Furga & Angela Bauch. (2006) An efficient tandem affinity purification procedure for interaction proteomics in mammalian cells. Nature Methods 3:12, pages 1013-1019.
Crossref
David A. Canton, Mary Ellen K. Olsten, Hanspeter Niederstrasser, John A. Cooper & David W. Litchfield. (2006) The Role of CKIP-1 in Cell Morphology Depends on Its Interaction with Actin-capping Protein. Journal of Biological Chemistry 281:47, pages 36347-36359.
Crossref
Nandini Bhattacharya, Shatadal Ghosh, David Sept & John A. Cooper. (2006) Binding of Myotrophin/V-1 to Actin-capping Protein. Journal of Biological Chemistry 281:41, pages 31021-31030.
Crossref
Serawit Bruck, Tobias B. Huber, Robert J. Ingham, Kyoungtae Kim, Hanspeter Niederstrasser, Paul M. Allen, Tony Pawson, John A. Cooper & Andrey S. Shaw. (2006) Identification of a Novel Inhibitory Actin-capping Protein Binding Motif in CD2-associated Protein. Journal of Biological Chemistry 281:28, pages 19196-19203.
Crossref
Mary Ellen Olsten & David Litchfield. (2006) Ckip1. AfCS-Nature Molecule Pages.
Crossref
David A. Canton & David W. Litchfield. (2006) The shape of things to come: An emerging role for protein kinase CK2 in the regulation of cell morphology and the cytoskeleton. Cellular Signalling 18:3, pages 267-275.
Crossref
Piotr Zien, James S. Duncan, Janusz Skierski, Maria Bretner, David W. Litchfield & David Shugar. (2005) Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective inhibitors of protein kinase CK2: Evaluation of their effects on cells and different molecular forms of human CK2. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1754:1-2, pages 271-280.
Crossref
Minzhou Huang, Martin Pring, Changsong Yang, Masato Taoka & Sally H. Zigmond. (2005) Presence of a novel inhibitor of capping protein in neutrophil extract. Cell Motility and the Cytoskeleton 62:4, pages 232-243.
Crossref
Changsong Yang, Martin Pring, Martin A. Wear, Minzhou Huang, John A. Cooper, Tatyana M. Svitkina & Sally H. Zigmond. (2005) Mammalian CARMIL Inhibits Actin Filament Capping by Capping Protein. Developmental Cell 9:2, pages 209-221.
Crossref

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