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Molecular and Cellular Biology Volume 25, 2005 - Issue 9
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Mammalian Genetic Models with Minimal or Complex Phenotypes

Targeted Disruption of Tgif, the Mouse Ortholog of a Human Holoprosencephaly Gene, Does Not Result in Holoprosencephaly in Mice

Jun ShenHoward Hughes Medical Institute, Department of Neurology, Beth Israel Deaconess Medical Center, and Program in Neuroscience, Division of Medical Sciences, Graduate School of Arts and Sciences, Harvard University, Boston, Massachusetts02115
&
Christopher A. WalshHoward Hughes Medical Institute, Department of Neurology, Beth Israel Deaconess Medical Center, and Program in Neuroscience, Division of Medical Sciences, Graduate School of Arts and Sciences, Harvard University, Boston, Massachusetts02115Correspondence[email protected]
Pages 3639-3647 | Received 08 Jan 2005, Accepted 05 Feb 2005, Published online: 27 Mar 2023

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Anoush E. Anderson, Kenichiro Taniguchi, Yi Hao, Tiffany A. Melhuish, Anant Shah, Stephen D. Turner, Ann E. Sutherland & David Wotton. (2017) Tgif1 and Tgif2 Repress Expression of the RabGAP Evi5l. Molecular and Cellular Biology 37:5.
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Lynn Mar & Pamela A. Hoodless. (2006) Embryonic Fibroblasts from Mice Lacking Tgif Were Defective in Cell Cycling. Molecular and Cellular Biology 26:11, pages 4302-4310.
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Laurent Bartholin, Shannon E. Powers, Tiffany A. Melhuish, Samuel Lasse, Michael Weinstein & David Wotton. (2006) TGIF Inhibits Retinoid Signaling. Molecular and Cellular Biology 26:3, pages 990-1001.
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Martin Andres Estermann, Claire Elizabeth Hirst, Andrew Thomas Major & Craig Allen Smith. (2021) The homeobox gene TGIF1 is required for chicken ovarian cortical development and generation of the juxtacortical medulla . Development 148:16.
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Marina Reichlmeir, Lena Elias & Dorothea Schulte. (2021) Posttranslational Modifications in Conserved Transcription Factors: A Survey of the TALE-Homeodomain Superclass in Human and Mouse. Frontiers in Cell and Developmental Biology 9.
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Zhuangbiao Zhang, Xiaoyun He, Qiuyue Liu, Jishun Tang, Ran Di & Mingxing Chu. (2020) TGIF1 and SF1 polymorphisms are associated with litter size in Small Tail Han sheep . Reproduction in Domestic Animals 55:9, pages 1145-1153.
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Erich Roessler, Ping Hu & Maximilian Muenke. (2018) Holoprosencephaly in the genomics era. American Journal of Medical Genetics Part C: Seminars in Medical Genetics 178:2, pages 165-174.
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David Wotton & Kenichiro Taniguchi. (2018) Functions of TGIF homeodomain proteins and their roles in normal brain development and holoprosencephaly. American Journal of Medical Genetics Part C: Seminars in Medical Genetics 178:2, pages 128-139.
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Isabela Nelly Machado, Juliana Karina Heinrich & Ricardo Barini. (2011) Genomic imbalances detected through array CGH in fetuses with holoprosencephaly. Arquivos de Neuro-Psiquiatria 69:1, pages 3-8.
Crossref
Sarah E. Coy & Anne-Gaëlle Borycki. (2010) Expression analysis of TALE family transcription factors during avian development. Developmental Dynamics 239:4, pages 1234-1245.
Crossref
Erich Roessler & Maximilian Muenke. (2010) The molecular genetics of holoprosencephaly. American Journal of Medical Genetics Part C: Seminars in Medical Genetics 154C:1, pages 52-61.
Crossref
Shannon E. PowersKenichiro TaniguchiWeiwei YenTiffany A. MelhuishJun ShenChristopher A. WalshAnn E. SutherlandDavid Wotton. (2010) Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation. Development 137:2, pages 249-259.
Crossref
Xin Geng & Guillermo Oliver. (2009) Pathogenesis of holoprosencephaly. Journal of Clinical Investigation 119:6, pages 1403-1413.
Crossref
Eleni Roussa, Oliver von Bohlen und Halback & Kerstin Krieglstein. 2009. Development and Engineering of Dopamine Neurons. Development and Engineering of Dopamine Neurons 81 90 .
Shinya Satoh & Sumiko Watanabe. (2008) TGIF, a homeodomain transcription factor, regulates retinal progenitor cell differentiation. Experimental Eye Research 87:6, pages 571-579.
Crossref
Tyler C. Kerr, Tawny N. Cuykendall, Laura C. Luettjohann & Douglas W. Houston. (2008) Maternal Tgif1 regulates nodal gene expression in Xenopus. Developmental Dynamics 237:10, pages 2862-2873.
Crossref
C. Elso, X. Lu, S. Morrison, A. Tarver, H. Thompson, H. Thurkow, N.. A. Yamada & L. Stubbs. (2008) Germline Translocations in Mice: Unique Tools for Analyzing Gene Function and Long-Distance Regulatory Mechanisms. JNCI Monographs 2008:39, pages 91-95.
Crossref
Laurent Bartholin, Tiffany A. Melhuish, Shannon E. Powers, Sophie Goddard-Léon, Isabelle Treilleux, Ann E. Sutherland & David Wotton. (2008) Maternal Tgif is required for vascularization of the embryonic placenta. Developmental Biology 319:2, pages 285-297.
Crossref
M Fernandes & JM Hébert. (2008) The ups and downs of holoprosencephaly: dorsal versus ventral patterning forces. Clinical Genetics 73:5, pages 413-423.
Crossref
Patricia A. Gongal & Andrew J. Waskiewicz. (2008) Zebrafish model of holoprosencephaly demonstrates a key role for TGIF in regulating retinoic acid metabolism. Human Molecular Genetics 17:4, pages 525-538.
Crossref
Karen A. Schachter & Robert S. Krauss. 2008. Mouse Models of Developmental Genetic Disease. Mouse Models of Developmental Genetic Disease 139 170 .
Monica Hayhurst, Bryan B. Gore, Marc Tessier-Lavigne & Susan K. McConnell. (2008) Ongoing sonic hedgehog signaling is required for dorsal midline formation in the developing forebrain. Developmental Neurobiology 68:1, pages 83-100.
Crossref
Kohei Shiota, Shigehito Yamada, Munekazu Komada & Makoto Ishibashi. (2007) Embryogenesis of holoprosencephaly. American Journal of Medical Genetics Part A 143A:24, pages 3079-3087.
Crossref
Christèle Dubourg, Claude Bendavid, Laurent Pasquier, Catherine Henry, Sylvie Odent & Véronique David. (2007) Holoprosencephaly. Orphanet Journal of Rare Diseases 2:1.
Crossref
Robert S. Krauss. (2007) Holoprosencephaly: new models, new insights. Expert Reviews in Molecular Medicine 9:26, pages 1-17.
Crossref
Edwin S. Monuki. (2007) The Morphogen Signaling Network in Forebrain Development and Holoprosencephaly. Journal of Neuropathology & Experimental Neurology 66:7, pages 566-575.
Crossref
Daisuke Higashiyama, Hirotomo Saitsu, Munekazu Komada, Toshiya Takigawa, Makoto Ishibashi & Kohei Shiota. (2007) Sequential developmental changes in holoprosencephalic mouse embryos exposed to ethanol during the gastrulation period. Birth Defects Research Part A: Clinical and Molecular Teratology 79:7, pages 513-523.
Crossref
Nathalie Ferrand, Christine Demange, Céline Prunier, Su Ryeon Seo & Azeddine Atfi. (2006) A mechanism for mutational inactivation of the homeodomain protein TGIF in holoprosencephaly. The FASEB Journal 21:2, pages 488-496.
Crossref
Kenia B. El-Jaick, Shannon E. Powers, Laurent Bartholin, Kenneth R. Myers, Jin Hahn, Ieda M. Orioli, Maia Ouspenskaia, Felicitas Lacbawan, Erich Roessler, David Wotton & Maximilian Muenke. (2007) Functional analysis of mutations in TGIF associated with holoprosencephaly. Molecular Genetics and Metabolism 90:1, pages 97-111.
Crossref
Chenzhong Kuang, Yan Xiao, Ling Yang, Qian Chen, Zhenzhen Wang, Simon J. Conway & Yan Chen. (2006) Intragenic deletion of Tgif causes defectsin brain development. Human Molecular Genetics 15:24, pages 3508-3519.
Crossref
Xun Cheng, Ching-mei Hsu, D. Spencer Currle, Jia Sheng Hu, A. James Barkovich & Edwin S. Monuki. (2006) Central Roles of the Roof Plate in Telencephalic Development and Holoprosencephaly. The Journal of Neuroscience 26:29, pages 7640-7649.
Crossref
Jessica L. Knepper, Alison C. James & Jeffrey E. Ming. (2006) TGIF, a gene associated with human brain defects, regulates neuronal development. Developmental Dynamics 235:6, pages 1482-1490.
Crossref
Jiu-Zhen Jin, Shi Gu, Patrick McKinney & Jixiang Ding. (2006) Expression and functional analysis ofTgif during mouse midline development. Developmental Dynamics 235:2, pages 547-553.
Crossref
Fang Liu. 2006. Gene Expression and Regulation. Gene Expression and Regulation 185 206 .

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