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Molecular and Cellular Biology Volume 25, 2005 - Issue 9
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Signal Transduction

Cyclins D2 and D1 Are Essential for Postnatal Pancreatic β-Cell Growth

Jake A. Kushner1 Howard Hughes Medical Institute, Division of Endocrinology, Children's Hospital, Harvard Medical School, Boston, Massachusetts02115;2 Division of Endocrinology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania19104Correspondence[email protected]
,
Maria A. Ciemerych3 Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts02115
,
Ewa Sicinska3 Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts02115
,
Lynn M. Wartschow1 Howard Hughes Medical Institute, Division of Endocrinology, Children's Hospital, Harvard Medical School, Boston, Massachusetts02115
,
Monica Teta2 Division of Endocrinology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania19104
,
Simon Y. Long2 Division of Endocrinology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania19104
,
Piotr Sicinski3 Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts02115
&
Morris F. White1 Howard Hughes Medical Institute, Division of Endocrinology, Children's Hospital, Harvard Medical School, Boston, Massachusetts02115
 show all
Pages 3752-3762 | Received 18 Nov 2004, Accepted 31 Jan 2005, Published online: 27 Mar 2023

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Qianrong Wang, Anna Han, Liyan Chen, Jie Sun, Zhenhua Lin, Xianglan Zhang & Xiangshan Ren. (2019) Paip1 overexpression is involved in the progression of gastric cancer and predicts shorter survival of diagnosed patients. OncoTargets and Therapy 12, pages 6565-6576.
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Shuen-ing Tschen, Chun Zeng, Loren Field, Sangeeta Dhawan, Anil Bhushan & Senta Georgia. (2017) Cyclin D2 is sufficient to drive β cell self-renewal and regeneration. Cell Cycle 16:22, pages 2183-2191.
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Joanna Kaplon, Loes van Dam & Daniel Peeper. (2015) Two-way communication between the metabolic and cell cycle machineries: the molecular basis. Cell Cycle 14:13, pages 2022-2032.
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Heather L. Hayes, Larry G. Moss, Jonathan C. Schisler, Jonathan M. Haldeman, Zhushan Zhang, Paul B. Rosenberg, Christopher B. Newgard & Hans E. Hohmeier. (2013) Pdx-1 Activates Islet α- and β-Cell Proliferation via a Mechanism Regulated by Transient Receptor Potential Cation Channels 3 and 6 and Extracellular Signal-Regulated Kinases 1 and 2. Molecular and Cellular Biology 33:20, pages 4017-4029.
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Shuyuan Chen, Masayuki Shimoda, Jiaxi Chen, Shinichi Matsumoto & Paul A. Grayburn. (2012) Transient overexpression of cyclin D2/CDK4/GLP1 genes induces proliferation and differentiation of adult pancreatic progenitors and mediates islet regeneration. Cell Cycle 11:4, pages 695-705.
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Seung-Hee Lee, Ergeng Hao, Fred Levine & Pamela Itkin-Ansari. (2011) Id3 upregulates BrdU incorporation associated with a DNA damage response, not replication, in human pancreatic β-cells. Islets 3:6, pages 358-366.
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Jeffrey Stein, Wieslawa M. Milewski, Manami Hara, Donald F. Steiner & Arunangsu Dey. (2011) GSK-3 inactivation or depletion promotes β-cell replication via down regulation of the CDK inhibitor, p27 (Kip1). Islets 3:1, pages 21-34.
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Matthew M. Rankin & Jake A. Kushner. (2010) Aging induces a distinct gene expression program in mouse islets . Islets 2:6, pages 345-352.
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Alexey Podcheko, Paul Northcott, George Bikopoulos, Andrew Lee, Swaroop R. Bommareddi, Jake A. Kushner, Janet Farhang-Fallah & Maria Rozakis-Adcock. (2007) Identification of a WD40 Repeat-Containing Isoform of PHIP as a Novel Regulator of β-Cell Growth and Survival. Molecular and Cellular Biology 27:18, pages 6484-6496.
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Etsuo Susaki, Keiko Nakayama & Keiichi I. Nakayama. (2007) Cyclin D2 Translocates p27 out of the Nucleus and Promotes Its Degradation at the G0-G1 Transition. Molecular and Cellular Biology 27:13, pages 4626-4640.
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Bowen Xing, Jian Ma, Zongzhe Jiang, Zijie Feng, Sunbin Ling, Katy Szigety, Wen Su, Longmei Zhang, Ruirui Jia, Yanmei Sun, Lin Zhang, Xiangchen Kong, Xiaosong Ma & Xianxin Hua. (2019) GLP-1 signaling suppresses menin’s transcriptional block by phosphorylation in β cells. Journal of Cell Biology 218:3, pages 855-870.
Crossref
Risheng Ye, Toshiharu Onodera & Philipp E Scherer. (2019) Lipotoxicity and β Cell Maintenance in Obesity and Type 2 Diabetes. Journal of the Endocrine Society 3:3, pages 617-631.
Crossref
David A. Alagpulinsa, Jenny J.L. Cao, Don Sobell & Mark C. Poznansky. (2019) Harnessing CXCL12 signaling to protect and preserve functional β-cell mass and for cell replacement in type 1 diabetes. Pharmacology & Therapeutics 193, pages 63-74.
Crossref
Weihua Tao, Yao Zhang, Lijuan Ma, Chujun Deng, Hualin Duan, Xuehua Liang, Rui Liao, Shaoqiang Lin, Tao Nie, Wanqun Chen, Cunchuan Wang, Carmen Birchmeier & Shiqi Jia. (2018) Haploinsufficiency of Insm1 Impairs Postnatal Baseline β-Cell Mass. Diabetes 67:12, pages 2615-2625.
Crossref
Waleed A. Mohamed & Mona F. Schaalan. (2018) Antidiabetic efficacy of lactoferrin in type 2 diabetic pediatrics; controlling impact on PPAR-γ, SIRT-1, and TLR4 downstream signaling pathway. Diabetology & Metabolic Syndrome 10:1.
Crossref
Mengju Liu, Jian Peng, Ningwen Tai, James A. Pearson, Changyun Hu, Junhua Guo, Lin Hou, Hongyu Zhao, F. Susan Wong & Li Wen. (2018) Toll-like receptor 9 negatively regulates pancreatic islet beta cell growth and function in a mouse model of type 1 diabetes. Diabetologia 61:11, pages 2333-2343.
Crossref
Miriam S. Udler, Jaegil Kim, Marcin von Grotthuss, Sílvia Bonàs-Guarch, Joanne B. Cole, Joshua Chiou, Michael Boehnke, Markku Laakso, Gil Atzmon, Benjamin Glaser, Josep M. Mercader, Kyle Gaulton, Jason Flannick, Gad Getz & Jose C. Florez. (2018) Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis. PLOS Medicine 15:9, pages e1002654.
Crossref
Daniel S. Langfermann, Oliver G. Rössler & Gerald Thiel. (2018) Stimulation of B-Raf increases c-Jun and c-Fos expression and upregulates AP-1-regulated gene transcription in insulinoma cells. Molecular and Cellular Endocrinology 472, pages 126-139.
Crossref
Silvia Giannattasio, Giacomo Giacovazzo, Agnese Bonato, Carla Caruso, Siro Luvisetto, Roberto Coccurello & Maurizia Caruso. (2018) Lack of cyclin D3 induces skeletal muscle fiber-type shifting, increased endurance performance and hypermetabolism. Scientific Reports 8:1.
Crossref
Naoki Harada, Yasuhiro Yoda, Yusuke Yotsumoto, Tatsuya Masuda, Yuji Takahashi, Takahiro Katsuki, Kenji Kai, Nobuaki Shiraki, Hiroshi Inui & Ryoichi Yamaji. (2018) Androgen signaling expands β-cell mass in male rats and β-cell androgen receptor is degraded under high-glucose conditions. American Journal of Physiology-Endocrinology and Metabolism 314:3, pages E274-E286.
Crossref
Mustafa Cagdas Ozturk, Qian Xu & Ali Cinar. (2018) Agent-based modeling of the interaction between CD8+ T cells and Beta cells in type 1 diabetes. PLOS ONE 13:1, pages e0190349.
Crossref
Ilona Kalaszczynska & Maria A. Ciemerych. 2018. D-type Cyclins and Cancer. D-type Cyclins and Cancer 27 59 .
Charles J. Sherr & Peter Sicinski. 2018. D-type Cyclins and Cancer. D-type Cyclins and Cancer 1 26 .
Thu H. Le, Ole F. Christensen, Bjarne Nielsen & Goutam Sahana. (2017) Genome-wide association study for conformation traits in three Danish pig breeds. Genetics Selection Evolution 49:1.
Crossref
Chunyu Bai, Yuhua Gao, Xiangchen Li, Kunfu Wang, Hui Xiong, Zhiqiang Shan, Ping Zhang, Wenjie Wang, Weijun Guan & Yuehui Ma. (2017) MicroRNAs can effectively induce formation of insulin-producing cells from mesenchymal stem cells. Journal of Tissue Engineering and Regenerative Medicine 11:12, pages 3457-3468.
Crossref
Prosenjit Mondal, Amit Prasad & Khyati Girdhar. (2017) Interventions to improve β-cell mass and function. Annales d'Endocrinologie 78:5, pages 469-477.
Crossref
M. M. Mzhelskaya, M. G. Klinnikova, E. V. Koldysheva & E. L. Lushnikova. (2017) Expression of Flk-1 and Cyclin D2 mRNA in the Myocardium of Rats with Doxorubicin-Induced Cardiomyopathy and after Treatment with Betulonic Acid Amide. Bulletin of Experimental Biology and Medicine 163:6, pages 809-813.
Crossref
Dan Kawamori, Jun Shirakawa, Chong Wee Liew, Jiang Hu, Tomoaki Morioka, Alokesh Duttaroy, Bryan Burkey & Rohit N. Kulkarni. (2017) GLP-1 signalling compensates for impaired insulin signalling in regulating beta cell proliferation in βIRKO mice. Diabetologia 60:8, pages 1442-1453.
Crossref
Brian Hsueh, Vanessa M. Burns, Philip Pauerstein, Katherine Holzem, Li Ye, Kristin Engberg, Ai-Chi Wang, Xueying Gu, Harini Chakravarthy, H. Efsun Arda, Gregory Charville, Hannes Vogel, Igor R. Efimov, Seung Kim & Karl Deisseroth. (2017) Pathways to clinical CLARITY: volumetric analysis of irregular, soft, and heterogeneous tissues in development and disease. Scientific Reports 7:1.
Crossref
Yusuke Nakatsu, Keiichi Mori, Yasuka Matsunaga, Takeshi Yamamotoya, Koji Ueda, Yuki Inoue, Keiko Mitsuzaki-Miyoshi, Hideyuki Sakoda, Midori Fujishiro, Suguru Yamaguchi, Akifumi Kushiyama, Hiraku Ono, Hisamitsu Ishihara & Tomoichiro Asano. (2017) The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretion. Journal of Biological Chemistry 292:28, pages 11886-11895.
Crossref
Chun Zeng, Francesca Mulas, Yinghui Sui, Tiffany Guan, Nathanael Miller, Yuliang Tan, Fenfen Liu, Wen Jin, Andrea C. Carrano, Mark O. Huising, Orian S. Shirihai, Gene W. Yeo & Maike Sander. (2017) Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal β Cell Proliferation. Cell Metabolism 25:5, pages 1160-1175.e11.
Crossref
Xianjie Wen & Yisheng Yang. (2017) Emerging roles of GLIS3 in neonatal diabetes, type 1 and type 2 diabetes. Journal of Molecular Endocrinology 58:2, pages R73-R85.
Crossref
Jingjing Wang & Hongjun Wang. (2017) Oxidative Stress in Pancreatic Beta Cell Regeneration. Oxidative Medicine and Cellular Longevity 2017, pages 1-9.
Crossref
Yutong Su, Xiuli Jiang, Yanli Li, Feng Li, Yulong Cheng, Ying Peng, Dalong Song, Jie Hong, Guang Ning, Yanan Cao & Weiqing Wang. (2016) Maternal Low Protein Isocaloric Diet Suppresses Pancreatic β-Cell Proliferation in Mouse Offspring via miR-15b. Endocrinology 157:12, pages 4782-4793.
Crossref
Ahmed El-Badawy & Nagwa El-Badri. (2016) The cell cycle as a brake for β-cell regeneration from embryonic stem cells. Stem Cell Research & Therapy 7:1.
Crossref
Yahui Kong, Rohit B. Sharma, Benjamin U. Nwosu & Laura C. Alonso. (2016) Islet biology, the CDKN2A/B locus and type 2 diabetes risk. Diabetologia 59:8, pages 1579-1593.
Crossref
Yaojie Liang, Aihua Tan, Danyan Liang, Xiaobo Yang, Ming Liao, Yong Gao, Yonghua Jiang, Ziting Yao, Xinggu Lin, Zheng Lu, Chunlei Wu, Shijun Zhang, Yanlin Hu, Xue Qin, Zengnan Mo, Hong Li & Haiying Zhang. (2015) Low osteocalcin level is a risk factor for impaired glucose metabolism in a Chinese male population. Journal of Diabetes Investigation 7:4, pages 522-528.
Crossref
Wenyi li, Hongli Zhang, Aifang Nie, Qicheng Ni, Fengying Li, Guang Ning, Xiaoying Li, Yanyun Gu & Qidi Wang. (2016) mTORC1 pathway mediates beta cell compensatory proliferation in 60 % partial-pancreatectomy mice. Endocrine 53:1, pages 117-128.
Crossref
Mette Korre Andersen, Casper-Emil Tingskov Pedersen, Ida Moltke, Torben Hansen, Anders Albrechtsen & Niels Grarup. (2016) Genetics of Type 2 Diabetes: the Power of Isolated Populations. Current Diabetes Reports 16:7.
Crossref
Yisheng YangLawrence Chan. (2016) Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes. Endocrine Reviews 37:3, pages 190-222.
Crossref
Stéphane Cauchi. (2016) Une variation génétique rare réduit de moitié le risque de diabète de type 2. Médecine des Maladies Métaboliques 10:3, pages 41-42.
Crossref
Jayalakshmi Lakshmipathi, Juan Carlos Alvarez-Perez, Carolina Rosselot, Gabriella P. Casinelli, Rachel E. Stamateris, Francisco Rausell-Palamos, Christopher P. O’Donnell, Rupangi C. Vasavada, Donald K. Scott, Laura C. Alonso & Adolfo Garcia-Ocaña. (2016) PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2. Diabetes 65:5, pages 1283-1296.
Crossref
Binbin Guan, Wenyi Li, Fengying Li, Yun Xie, Qicheng Ni, Yanyun Gu, Xiaoying Li, Qidi Wang, Hongli Zhang & Guang Ning. (2016) Sfrp5 mediates glucose-induced proliferation in rat pancreatic β-cells. Journal of Endocrinology 229:2, pages 73-83.
Crossref
Per Hydbring, Marcos Malumbres & Piotr Sicinski. (2016) Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases. Nature Reviews Molecular Cell Biology 17:5, pages 280-292.
Crossref
Husnia I. Marrif & Salma I. Al-Sunousi. (2016) Pancreatic β Cell Mass Death. Frontiers in Pharmacology 7.
Crossref
Rachel E. Stamateris, Rohit B. Sharma, Yahui Kong, Pantea Ebrahimpour, Deepika Panday, Pavana Ranganath, Baobo Zou, Helena Levitt, Nisha Abraham Parambil, Christopher P. O’Donnell, Adolfo García-Ocaña & Laura C. Alonso. (2016) Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin Receptor. Diabetes 65:4, pages 981-995.
Crossref
Jihye Kim, Kyung Jin Lee, Jung Seok Kim, Jun Gi Rho, Jung Jae Shin, Woo Keun Song, Eun Kyung Lee, Josephine M. Egan & Wook Kim. (2016) Cannabinoids Regulate Bcl-2 and Cyclin D2 Expression in Pancreatic β Cells. PLOS ONE 11:3, pages e0150981.
Crossref
Ziwei Lin, Yu Zhao, Lige Song, Kaida Mu, Mingliang Zhang, Hongxia Liu, Xiaowen Li, Jian Zhao, Chen Wang & Weiping Jia. (2016) Deletion of β-Arrestin2 in Mice Limited Pancreatic β-Cell Expansion under Metabolic Stress through Activation of the JNK Pathway. Molecular Medicine 22:1, pages 74-84.
Crossref
Matias De Vas & Jorge Ferrer. (2016) Can Insulin Production Suppress β Cell Growth?. Cell Metabolism 23:1, pages 4-5.
Crossref
Marta Szabat, Melissa M. Page, Evgeniy Panzhinskiy, Søs Skovsø, Majid Mojibian, Juan Fernandez-Tajes, Jennifer E. Bruin, Michael J. Bround, Jason T.C. Lee, Eric E. Xu, Farnaz Taghizadeh, Shannon O’Dwyer, Martijn van de Bunt, Kyung-Mee Moon, Sunita Sinha, Jun Han, Yong Fan, Francis C. Lynn, Massimo Trucco, Christoph H. Borchers, Leonard J. Foster, Corey Nislow, Timothy J. Kieffer & James D. Johnson. (2016) Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation. Cell Metabolism 23:1, pages 179-193.
Crossref
Hainan Chen, Jeffrey W. Kleinberger, Karen K. Takane, Fatimah Salim, Nathalie Fiaschi-Taesch, Kyrie Pappas, Ramon Parsons, Jing Jiang, Yue Zhang, Hongtao Liu, Peng Wang, Aaron S. Bender, Stuart J. Frank & Andrew F. Stewart. (2015) Augmented Stat5 Signaling Bypasses Multiple Impediments to Lactogen-Mediated Proliferation in Human β-Cells. Diabetes 64:11, pages 3784-3797.
Crossref
Lorena Boquete Vilariño & Timothy M. Frayling. (2015) The Hunt for Low-Frequency Alleles Predisposing to Type 2 Diabetes and Related Cardiovascular Risk Factors. Current Cardiovascular Risk Reports 9:11.
Crossref
Yoon Sin Oh, Seungjin Shin, Hui Ying Li, Eun-Young Park, Song Mi Lee, Cheol Soo Choi, Yong Lim, Hye Seung Jung & Hee-Sook Jun. (2015) Betacellulin ameliorates hyperglycemia in obese diabetic db/db mice. Journal of Molecular Medicine 93:11, pages 1235-1245.
Crossref
Alexandre Zampieri, Julien Champagne, Baptiste Auzemery, Ivanna Fuentes, Benjamin Maurel & Frédéric Bienvenu. (2015) Hyper sensitive protein detection by Tandem-HTRF reveals Cyclin D1 dynamics in adult mouse. Scientific Reports 5:1.
Crossref
Shiwani Tiwari, Chris Roel, Rachel Wills, Gabriella Casinelli, Mansoor Tanwir, Karen K. Takane & Nathalie M. Fiaschi-Taesch. (2015) Early and Late G1/S Cyclins and Cdks Act Complementarily to Enhance Authentic Human β-Cell Proliferation and Expansion. Diabetes 64:10, pages 3485-3498.
Crossref
A.L. Márquez-Aguirre, A.A. Canales-Aguirre, E. Padilla-Camberos, H. Esquivel-Solis & N.E. Díaz-Martínez. (2015) Development of the endocrine pancreas and novel strategies for β-cell mass restoration and diabetes therapy. Brazilian Journal of Medical and Biological Research 48:9, pages 765-776.
Crossref
Caroline M. Gorvin. (2015) The prolactin receptor: Diverse and emerging roles in pathophysiology. Journal of Clinical & Translational Endocrinology 2:3, pages 85-91.
Crossref
Christiaan de Bruin & Andrew Dauber. (2015) Insights from exome sequencing for endocrine disorders. Nature Reviews Endocrinology 11:8, pages 455-464.
Crossref
Paloma Alonso-Magdalena, Marta García-Arévalo, Iván Quesada & Ángel Nadal. (2015) Bisphenol-A Treatment During Pregnancy in Mice: A New Window of Susceptibility for the Development of Diabetes in Mothers Later in Life. Endocrinology 156:5, pages 1659-1670.
Crossref
Teresa L. Mastracci, Raghavendra G. Mirmira & Ryan M. Anderson. 2015. International Textbook of Diabetes Mellitus. International Textbook of Diabetes Mellitus 53 68 .
Peng Wang, Nathalie M. Fiaschi-Taesch, Rupangi C. Vasavada, Donald K. Scott, Adolfo García-Ocaña & Andrew F. Stewart. (2015) Diabetes mellitus—advances and challenges in human β-cell proliferation. Nature Reviews Endocrinology 11:4, pages 201-212.
Crossref
JINXIAO WU, XIYAN YANG, BIN CHEN & XIUPING XU. (2015) Pancreas β cell regeneration and type 1 diabetes (Review). Experimental and Therapeutic Medicine 9:3, pages 653-657.
Crossref
Brandon L. Taylor, Jacqueline Benthuysen & Maike Sander. (2015) Postnatal β-Cell Proliferation and Mass Expansion Is Dependent on the Transcription Factor Nkx6.1. Diabetes 64:3, pages 897-903.
Crossref
T. Oda, H. Taneichi, K. Takahashi, H. Togashi, M. Hangai, R. Nakagawa, M. Ono, M. Matsui, T. Sasai, K. Nagasawa, H. Honma, T. Kajiwara, Y. Takahashi, N. Takebe, Y. Ishigaki & J. Satoh. (2015) Positive association of free triiodothyronine with pancreatic β-cell function in people with prediabetes. Diabetic Medicine 32:2, pages 213-219.
Crossref
Uzma Asghar, Agnieszka K. Witkiewicz, Nicholas C. Turner & Erik S. Knudsen. (2015) The history and future of targeting cyclin-dependent kinases in cancer therapy. Nature Reviews Drug Discovery 14:2, pages 130-146.
Crossref
Ahmed M. ABDELLATIF, Kiyohito OGATA, Takashi KUDO, Gulibaikelamu XIAFUKAITI, Yu-Hsin CHANG, Megumi C. KATOH, Salah E. EL-MORSY, Hisashi OISHI & Satoru TAKAHASHI. (2015) Role of large MAF transcription factors in the mouse endocrine pancreas. Experimental Animals 64:3, pages 305-312.
Crossref
David R. Grattan & Paul Le Tissier. 2015. Knobil and Neill's Physiology of Reproduction. Knobil and Neill's Physiology of Reproduction 469 526 .
Zhong Ge, Bao Zhang, Xiangyang Bu, Youlong Wang, Lei Xiang & Jingwang Tan. (2014) Molecular mechanism of activating protein-4 regulated growth of hepatocellular carcinoma. Tumor Biology 35:12, pages 12441-12447.
Crossref
Ayelet Lenz, Ginat Toren-Haritan & Shimon Efrat. (2014) Redifferentiation of Adult Human β Cells Expanded In Vitro by Inhibition of the WNT Pathway. PLoS ONE 9:11, pages e112914.
Crossref
Zhenshan ZhaoYen S. LowNeali A. ArmstrongJennifer Hyoje RyuSara A. SunAnthony C. ArvanitesJennifer Hollister-Lock, Nigam H. ShahGordon C. Weir & Justin P. Annes. (2014) Repurposing cAMP-Modulating Medications to Promote β-Cell Replication. Molecular Endocrinology 28:10, pages 1682-1697.
Crossref
Tongfu Xu, Liu Yang, Cheng Yan, Xiaoxia Wang, Ping Huang, Feng Zhao, Liyun Zhao, Mingliang Zhang, Weiping Jia, Xiangdong Wang & Yong Liu. (2014) The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cells. Cell Research 24:9, pages 1137-1140.
Crossref
Noemí Alejandra Saavedra-ÁvilaUpasana SenguptaBegoña SánchezEster SalaLaura HabaThomas StratmannJoan VerdaguerDídac MauricioBelén MezquitaAna Belén Ropero, Ángel Nadal & Conchi Mora. (2014) Cyclin D3 promotes pancreatic β-cell fitness and viability in a cell cycle-independent manner and is targeted in autoimmune diabetes. Proceedings of the National Academy of Sciences 111:33.
Crossref
Koki Eto, Wataru Nishimura, Hisashi Oishi, Haruhide Udagawa, Miho Kawaguchi, Masaki Hiramoto, Toshiyoshi Fujiwara, Satoru Takahashi & Kazuki Yasuda. (2014) MafA Is Required for Postnatal Proliferation of Pancreatic β-Cells. PLoS ONE 9:8, pages e104184.
Crossref
Ramamani Arumugam, Don Fleenor & Michael Freemark. (2013) Knockdown of prolactin receptors in a pancreatic beta cell line: effects on DNA synthesis, apoptosis, and gene expression. Endocrine 46:3, pages 568-576.
Crossref
Teresa Mezza & Rohit N. Kulkarni. (2014) The regulation of pre- and post-maturational plasticity of mammalian islet cell mass. Diabetologia 57:7, pages 1291-1303.
Crossref
Hai-Lian Wang, Chun-Yang Li, Bin Zhang, Yuan-De Liu, Bang-Min Lu, Zheng Shi, Na An, Liang-Kai Zhao, Jing-Jing Zhang, Jin-Ku Bao & Yi Wang. (2014) Mangiferin Facilitates Islet Regeneration and β-Cell Proliferation through Upregulation of Cell Cycle and β-Cell Regeneration Regulators. International Journal of Molecular Sciences 15:5, pages 9016-9035.
Crossref
Xiangwei Xiao, Iljana Gaffar, Ping Guo, John Wiersch, Shane Fischbach, Lauren Peirish, Zewen Song, Yousef El-Gohary, Krishna Prasadan, Chiyo Shiota & George K. Gittes. (2014) M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7. Proceedings of the National Academy of Sciences 111:13.
Crossref
Amedeo Vetere, Amit Choudhary, Sean M. Burns & Bridget K. Wagner. (2014) Targeting the pancreatic β-cell to treat diabetes. Nature Reviews Drug Discovery 13:4, pages 278-289.
Crossref
Jianwen Wei, Timothy Hanna, Nina Suda, Gerard Karsenty & Patricia Ducy. (2014) Osteocalcin Promotes β-Cell Proliferation During Development and Adulthood Through Gprc6a. Diabetes 63:3, pages 1021-1031.
Crossref
Valgerdur Steinthorsdottir, Gudmar Thorleifsson, Patrick Sulem, Hannes Helgason, Niels Grarup, Asgeir Sigurdsson, Hafdis T Helgadottir, Hrefna Johannsdottir, Olafur T Magnusson, Sigurjon A Gudjonsson, Johanne M Justesen, Marie N Harder, Marit E Jørgensen, Cramer Christensen, Ivan Brandslund, Annelli Sandbæk, Torsten Lauritzen, Henrik Vestergaard, Allan Linneberg, Torben Jørgensen, Torben Hansen, Maryam S Daneshpour, Mohammad-Sadegh Fallah, Astradur B Hreidarsson, Gunnar Sigurdsson, Fereidoun Azizi, Rafn Benediktsson, Gisli Masson, Agnar Helgason, Augustine Kong, Daniel F Gudbjartsson, Oluf Pedersen, Unnur Thorsteinsdottir & Kari Stefansson. (2014) Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes. Nature Genetics 46:3, pages 294-298.
Crossref
Kai-Ting Yang, Jennifer-Ann Bayan, Ni Zeng, Richa Aggarwal, Lina He, Zhechu Peng, Anketse Kassa, Melissa Kim, Zhiou Luo, Zhenrong Shi, Vivian Medina, Keerthi Boddupally & Bangyan L. Stiles. (2013) Adult-onset deletion of Pten increases islet mass and beta cell proliferation in mice. Diabetologia 57:2, pages 352-361.
Crossref
Juan Carlos Alvarez-Perez, Sara Ernst, Cem Demirci, Gabriella P. Casinelli, Jose Manuel D. Mellado-Gil, Francisco Rausell-Palamos, Rupangi C. Vasavada & Adolfo Garcia-Ocaña. (2014) Hepatocyte Growth Factor/c-Met Signaling Is Required for β-Cell Regeneration. Diabetes 63:1, pages 216-223.
Crossref
Daniel J. Sartori, Christopher J. Wilbur, Simon Y. Long, Matthew M. Rankin, Changhong Li, Jonathan P. Bradfield, Hakon Hakonarson, Struan F. A. Grant, William T. Pu & Jake A. Kushner. (2014) GATA Factors Promote ER Integrity and β-Cell Survival and Contribute to Type 1 Diabetes Risk. Molecular Endocrinology 28:1, pages 28-39.
Crossref
Shan-Shan Chen, Teng Jiang, Yi Wang, Li-Ze Gu, Hui-Wen Wu, Lan Tan & Jun Guo. (2014) Activation of double-stranded RNA-dependent protein kinase inhibits proliferation of pancreatic β-cells. Biochemical and Biophysical Research Communications 443:3, pages 814-820.
Crossref
Ni Zeng, Kai-Ting Yang, Jennifer-Ann Bayan, Lina He, Richa Aggarwal, Joseph W. Stiles, Xiaogang Hou, Vivian Medina, Danny Abad, Beth M. Palian, Ismail Al-Abdullah, Fouad Kandeel, Deborah L. Johnson & Bangyan L. Stiles. (2013) PTEN controls β-cell regeneration in aged mice by regulating cell cycle inhibitor p16 ink4a . Aging Cell 12:6, pages 1000-1011.
Crossref
Yi Wang, HuiWen Wu, LiLi Gao, ShanShan Chen, LiZe Gu, ZhengZheng Ding & Jun Guo. (2013) Elevated toll-like receptor 3 inhibits pancreatic β-cell proliferation through G1 phase cell cycle arrest. Molecular and Cellular Endocrinology 377:1-2, pages 112-122.
Crossref
Brandon L. Taylor, Fen-Fen Liu & Maike Sander. (2013) Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta Cells. Cell Reports 4:6, pages 1262-1275.
Crossref
Giuseppe R. DiaferiaAntonio J. Jimenez-CalianiPrerana RanjitkarWendy YangGary HardimanChristopher J. RhodesLaura CrisaVincenzo Cirulli. (2013) β1 integrin is a crucial regulator of pancreatic β-cell expansion. Development 140:16, pages 3360-3372.
Crossref
Jalal Taneera, Joao Fadista, Emma Ahlqvist, Mengze Zhang, Nils Wierup, Erik Renström & Leif Groop. (2013) Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes. Molecular and Cellular Endocrinology 375:1-2, pages 35-42.
Crossref
Rachel E. Stamateris, Rohit B. Sharma, Douglas A. Hollern & Laura C. Alonso. (2013) Adaptive β-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression. American Journal of Physiology-Endocrinology and Metabolism 305:1, pages E149-E159.
Crossref
Hao Yin, Soo-Young Park, Xiao-Jun Wang, Ryosuke Misawa, Eric J. Grossman, Jing Tao, Rong Zhong, Piotr Witkowski, Graeme I. Bell & Anita S. Chong. (2013) Enhancing Pancreatic Beta-Cell Regeneration In Vivo with Pioglitazone and Alogliptin. PLoS ONE 8:6, pages e65777.
Crossref
Peng Yi, Ji-Sun Park & Douglas A. Melton. (2013) RETRACTED: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation. Cell 153:4, pages 747-758.
Crossref
N. Wakae-Takada, S. Xuan, K. Watanabe, P. Meda & R. L. Leibel. (2013) Molecular basis for the regulation of islet beta cell mass in mice: the role of E-cadherin. Diabetologia 56:4, pages 856-866.
Crossref
Akiko Mizokami, Yu Yasutake, Jing Gao, Miho Matsuda, Ichiro Takahashi, Hiroshi Takeuchi & Masato Hirata. (2013) Osteocalcin Induces Release of Glucagon-Like Peptide-1 and Thereby Stimulates Insulin Secretion in Mice. PLoS ONE 8:2, pages e57375.
Crossref
Alex Gutteridge, J. Michael Rukstalis, Daniel Ziemek, Mark Tié, Lin Ji, Rebeca Ramos-Zayas, Nancy A. Nardone, Lisa D. Norquay, Martin B. Brenner, Kim Tang, John D. McNeish & Rebecca K. Rowntree. (2013) Novel Pancreatic Endocrine Maturation Pathways Identified by Genomic Profiling and Causal Reasoning. PLoS ONE 8:2, pages e56024.
Crossref
Kazuki Orime, Jun Shirakawa, Yu Togashi, Kazuki Tajima, Hideaki Inoue, Yuzuru Ito, Koichiro Sato, Akinobu Nakamura, Kazutaka Aoki, Yoshio Goshima & Yasuo Terauchi. (2013) Trefoil Factor 2 Promotes Cell Proliferation in Pancreatic β-Cells through CXCR-4-Mediated ERK1/2 Phosphorylation. Endocrinology 154:1, pages 54-64.
Crossref
Alessandra Puddu, Roberta Sanguineti, François Mach, Franco Dallegri, Giorgio Luciano Viviani & Fabrizio Montecucco. (2013) Update on the Protective Molecular Pathways Improving Pancreatic Beta-Cell Dysfunction. Mediators of Inflammation 2013, pages 1-14.
Crossref
Yisheng Yang, Benny Hung‐Junn Chang & Lawrence Chan. (2012) Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults. EMBO Molecular Medicine 5:1, pages 92-104.
Crossref
Ahmed Mansouri. (2012) Development and Regeneration in the Endocrine Pancreas. ISRN Endocrinology 2012, pages 1-12.
Crossref
Rohit N. Kulkarni, Ernesto-Bernal Mizrachi, Adolfo Garcia Ocana & Andrew F. Stewart. (2012) Human β-Cell Proliferation and Intracellular Signaling. Diabetes 61:9, pages 2205-2213.
Crossref
Mallikarjuna R. Metukuri, Pili Zhang, Mahesh K. Basantani, Connie Chin, Rachel E. Stamateris, Laura C. Alonso, Karen K. Takane, Roberto Gramignoli, Stephen C. Strom, Robert M. O’Doherty, Andrew F. Stewart, Rupangi C. Vasavada, Adolfo Garcia-Ocaña & Donald K. Scott. (2012) ChREBP Mediates Glucose-Stimulated Pancreatic β-Cell Proliferation. Diabetes 61:8, pages 2004-2015.
Crossref
Z. C. Feng, J. Li, B. A. Turco, M. Riopel, S. P. Yee & R. Wang. (2012) Critical role of c-Kit in beta cell function: increased insulin secretion and protection against diabetes in a mouse model. Diabetologia 55:8, pages 2214-2225.
Crossref
William R. Goodyer, Xueying Gu, Yinghua Liu, Rita Bottino, Gerald R. Crabtree & Seung K. Kim. (2012) Neonatal β Cell Development in Mice and Humans Is Regulated by Calcineurin/NFAT. Developmental Cell 23:1, pages 21-34.
Crossref
Ayse G. Kayali, Ana D. Lopez, Ergeng Hao, Andrew Hinton, Alberto Hayek & Charles C. King. (2012) The SDF-1α/CXCR4 Axis is Required for Proliferation and Maturation of Human Fetal Pancreatic Endocrine Progenitor Cells. PLoS ONE 7:6, pages e38721.
Crossref
M. Blandino-Rosano, E. U. Alejandro, A. Sathyamurthy, J. O. Scheys, B. Gregg, A. Y. Chen, L. Rachdi, A. Weiss, D. J. Barker, A. P. Gould, L. Elghazi & E. Bernal-Mizrachi. (2012) Enhanced beta cell proliferation in mice overexpressing a constitutively active form of Akt and one allele of p21 Cip. Diabetologia 55:5, pages 1380-1389.
Crossref
Zhi-Chao Feng, Lisa Donnelly, Jinming Li, Mansa Krishnamurthy, Matthew Riopel & Rennian Wang. (2012) Inhibition of Gsk3β activity improves β-cell function in c-Kit male mice. Laboratory Investigation 92:4, pages 543-555.
Crossref
Xiaojin Li, Bing Xue, Xuan Wang, Lianqing Sun, Tingting Zhang, Ling Qu, Xiaoman Zou & Yiming Mu. (2012) Reduced expression of the LRP16 gene in mouse insulinoma (MIN6) cells exerts multiple effects on insulin content, proliferation and apoptosis. Journal of Huazhong University of Science and Technology [Medical Sciences] 32:2, pages 190-198.
Crossref
Jordan Pascoe, Douglas Hollern, Rachel Stamateris, Munira Abbasi, Lia C. Romano, Baobo Zou, Christopher P. O’Donnell, Adolfo Garcia-Ocana & Laura C. Alonso. (2012) Free Fatty Acids Block Glucose-Induced β-Cell Proliferation in Mice by Inducing Cell Cycle Inhibitors p16 and p18. Diabetes 61:3, pages 632-641.
Crossref
Yi Wang, Yuande Liu, Hailian Wang, Chunyang Li, Ping Qi & Jinku Bao. (2012) Agaricus bisporus lectins mediates islet β -cell proliferation through regulation of cell cycle proteins . Experimental Biology and Medicine 237:3, pages 287-296.
Crossref
Huizhen Wang & T. Rajendra Kumar. (2012) Segment- and cell-specific expression of D-type cyclins in the postnatal mouse epididymis. Gene Expression Patterns 12:3-4, pages 136-144.
Crossref
Matthew KeefeHui WangJean-Paul De La OAmeena KhanMatthew A. Firpo & L. Charles Murtaugh. (2012) Beta-catenin is selectively required for the expansion and regeneration of mature pancreatic acinar cells. Disease Models & Mechanisms.
Crossref
Amedeo Vetere & Bridget K. Wagner. (2012) Chemical Methods to Induce Beta-Cell Proliferation. International Journal of Endocrinology 2012, pages 1-8.
Crossref
Elena Tarabra, Stella Pelengaris & Michael Khan. (2012) A Simple Matter of Life and Death—The Trials of Postnatal Beta-Cell Mass Regulation. International Journal of Endocrinology 2012, pages 1-20.
Crossref
Zhenwei Gong & Radhika H. Muzumdar. (2012) Pancreatic Function, Type 2 Diabetes, and Metabolism in Aging. International Journal of Endocrinology 2012, pages 1-13.
Crossref
Jennifer L. Plank, Audrey Y. Frist, Alison W. LeGrone, Mark A. Magnuson & Patricia A. Labosky. (2011) Loss of Foxd3 Results in Decreased β-Cell Proliferation and Glucose Intolerance During Pregnancy. Endocrinology 152:12, pages 4589-4600.
Crossref
Dorothee Newbern & Michael Freemark. (2011) Placental hormones and the control of maternal metabolism and fetal growth. Current Opinion in Endocrinology, Diabetes & Obesity 18:6, pages 409-416.
Crossref
Franco Folli, Terumasa Okada, Carla Perego, Jenny Gunton, Chong Wee Liew, Masaru Akiyama, Anna D'Amico, Stefano La Rosa, Claudia Placidi, Roberto Lupi, Piero Marchetti, Giorgio Sesti, Marc Hellerstein, Lucia Perego & Rohit N. Kulkarni. (2011) Altered Insulin Receptor Signalling and β-Cell Cycle Dynamics in Type 2 Diabetes Mellitus. PLoS ONE 6:11, pages e28050.
Crossref
Mia C. Åkerfeldt & D. Ross Laybutt. (2011) Inhibition of Id1 Augments Insulin Secretion and Protects Against High-Fat Diet–Induced Glucose Intolerance. Diabetes 60:10, pages 2506-2514.
Crossref
Silvia Velazquez-Garcia, Shelley Valle, Taylor C. Rosa, Karen K. Takane, Cem Demirci, Juan C. Alvarez-Perez, Jose M. Mellado-Gil, Sara Ernst, Donald K. Scott, Rupangi C. Vasavada, Laura C. Alonso & Adolfo Garcia-Ocaña. (2011) Activation of Protein Kinase C-ζ in Pancreatic β-Cells In Vivo Improves Glucose Tolerance and Induces β-Cell Expansion via mTOR Activation. Diabetes 60:10, pages 2546-2559.
Crossref
Hainan Chen, Xueying Gu, Yinghua Liu, Jing Wang, Stacey E. Wirt, Rita Bottino, Hubert Schorle, Julien Sage & Seung K. Kim. (2011) PDGF signalling controls age-dependent proliferation in pancreatic β-cells. Nature 478:7369, pages 349-355.
Crossref
Yan Hang & Roland Stein. (2011) MafA and MafB activity in pancreatic β cells. Trends in Endocrinology & Metabolism 22:9, pages 364-373.
Crossref
Ting Guo, Weiping Wang, Hui Zhang, Yinan Liu, Ping Chen, Kangtao Ma & Chunyan Zhou. (2011) ISL1 Promotes Pancreatic Islet Cell Proliferation. PLoS ONE 6:8, pages e22387.
Crossref
Gaya Thanabalasingham, Anna L Gloyn & Katharine R Owen. (2011) Genome-wide association studies of Type 2 diabetes: are these ready to make an impact in the clinic?. Diabetes Management 1:4, pages 379-387.
Crossref
Seth J. SalpeterAgnes KlochendlerNoa Weinberg-CoremShay PoratZvi GranotA. M. James ShapiroMark A. MagnusonAmir EdenJoseph Grimsby, Benjamin GlaserYuval Dor. (2011) Glucose Regulates Cyclin D2 Expression in Quiescent and Replicating Pancreatic β-Cells Through Glycolysis and Calcium Channels. Endocrinology 152:7, pages 2589-2598.
Crossref
Marcos Malumbres. (2011) Physiological Relevance of Cell Cycle Kinases. Physiological Reviews 91:3, pages 973-1007.
Crossref
Anna A. SzypowskaBoudewijn M.T. Burgering. (2011) The Peroxide Dilemma: Opposing and Mediating Insulin Action. Antioxidants & Redox Signaling 15:1, pages 219-232.
Crossref
So Yoon Kim & Sushil G. Rane. (2011) The Cdk4-E2f1 pathway regulates early pancreas development by targeting Pdx1+ progenitors and Ngn3+ endocrine precursors. Development 138:10, pages 1903-1912.
Crossref
Charlotte Hinault, Dan Kawamori, Chong Wee Liew, Bernhard Maier, Jiang Hu, Susanna R. Keller, Raghavendra G. Mirmira, Heidi Scrable & Rohit N. Kulkarni. (2011) Δ40 Isoform of p53 Controls β-Cell Proliferation and Glucose Homeostasis in Mice. Diabetes 60:4, pages 1210-1222.
Crossref
Ramamani Arumugam, Donald Fleenor, Danhong Lu & Michael Freemark. (2011) Differential and Complementary Effects of Glucose and Prolactin on Islet DNA Synthesis and Gene Expression. Endocrinology 152:3, pages 856-868.
Crossref
Elizabeth Hughes & Carol Huang. (2011) Participation of Akt, Menin, and p21 in Pregnancy-Induced β-Cell Proliferation. Endocrinology 152:3, pages 847-855.
Crossref
Christina U. Köhler, Marvin Olewinski, Andrea Tannapfel, Wolfgang E. Schmidt, Helga Fritsch & Juris J. Meier. (2011) Cell cycle control of β-cell replication in the prenatal and postnatal human pancreas. American Journal of Physiology-Endocrinology and Metabolism 300:1, pages E221-E230.
Crossref
Jeffrey B. Halter. 2011. Handbook of the Biology of Aging. Handbook of the Biology of Aging 373 384 .
Thomas L. Jetton, Dhananjay Gupta & Mina Peshavaria. 2011. Management of Pediatric Obesity and Diabetes. Management of Pediatric Obesity and Diabetes 43 70 .
Scott A. Soleimanpour, Michael F. Crutchlow, Alana M. Ferrari, Jeffrey C. Raum, David N. Groff, Matthew M. Rankin, Chengyang Liu, Diva D. De León, Ali Naji, Jake A. Kushner & Doris A. Stoffers. (2010) Calcineurin Signaling Regulates Human Islet β-Cell Survival. Journal of Biological Chemistry 285:51, pages 40050-40059.
Crossref
Anna Kalousova, Anastasia Mavropoulos, Bruce A. Adams, Nada Nekrep, Zhongmei Li, Stephan Krauss, Didier Y. Stainier & Michael S. German. (2010) Dachshund homologues play a conserved role in islet cell development. Developmental Biology 348:2, pages 143-152.
Crossref
James Lausier, William C. Diaz, Violet Roskens, Kyla LaRock, Kristi Herzer, Christopher G. Fong, Martin G. Latour, Mina Peshavaria & Thomas L. Jetton. (2010) Vagal control of pancreatic β-cell proliferation. American Journal of Physiology-Endocrinology and Metabolism 299:5, pages E786-E793.
Crossref
Seth J. Salpeter, Allon M. Klein, Danwei Huangfu, Joseph Grimsby & Yuval Dor. (2010) Glucose and aging control the quiescence period that follows pancreatic beta cell replication. Development 137:19, pages 3205-3213.
Crossref
Patrick Collombat, Xiaobo Xu, Harry Heimberg & Ahmed Mansouri. (2010) Pancreatic beta-cells: From generation to regeneration. Seminars in Cell & Developmental Biology 21:8, pages 838-844.
Crossref
G Thanabalasingham & KR Owen. (2010) Translating type 2 diabetes genetics: what does it add to clinical practice?. Practical Diabetes International 27:7, pages 264-266.
Crossref
Victor Aguilar & Lluis Fajas. (2010) Cycling through metabolism. EMBO Molecular Medicine 2:9, pages 338-348.
Crossref
Nathalie M. Fiaschi-TaeschFatimah SalimJeffrey KleinbergerRonnie TroxellIrene Cozar-CastellanoKaren SelkEdward CherokKaren K. TakaneDonald K. ScottAndrew F. Stewart. (2010) Induction of Human β-Cell Proliferation and Engraftment Using a Single G1/S Regulatory Molecule, cdk6. Diabetes 59:8, pages 1926-1936.
Crossref
Fumihiko Furuya, Hiroki Shimura, Sayaka Yamashita, Toyoshi Endo & Tetsuro Kobayashi. (2010) Liganded Thyroid Hormone Receptor-α Enhances Proliferation of Pancreatic β-Cells. Journal of Biological Chemistry 285:32, pages 24477-24486.
Crossref
Zhuo Fu, Wen Zhang, Wei Zhen, Hazel Lum, Jerry Nadler, Josep Bassaganya-Riera, Zhenquan Jia, Yanwen Wang, Hara Misra & Dongmin Liu. (2010) Genistein Induces Pancreatic β-Cell Proliferation through Activation of Multiple Signaling Pathways and Prevents Insulin-Deficient Diabetes in Mice. Endocrinology 151:7, pages 3026-3037.
Crossref
Daniel Kopinke & L Charles Murtaugh. (2010) Exocrine-to-endocrine differentiation is detectable only prior to birth in the uninjured mouse pancreas. BMC Developmental Biology 10:1.
Crossref
Senta GeorgiaCharlotte HinaultDan KawamoriJiang HuJohn MeyerMurtaza KanjiAnil BhushanRohit N. Kulkarni. (2010) Cyclin D2 Is Essential for the Compensatory β-Cell Hyperplastic Response to Insulin Resistance in Rodents. Diabetes 59:4, pages 987-996.
Crossref
Sapna Puri & Matthias Hebrok. (2010) Cellular Plasticity within the Pancreas— Lessons Learned from Development. Developmental Cell 18:3, pages 342-356.
Crossref
Florence Figeac, Benjamin Uzan, Monique Faro, Noura Chelali, Bernard Portha & Jamileh Movassat. (2010) Neonatal growth and regeneration of β-cells are regulated by the Wnt/β-catenin signaling in normal and diabetic rats. American Journal of Physiology-Endocrinology and Metabolism 298:2, pages E245-E256.
Crossref
Justin M. Gregory, Jessica S. Lilley, Amanda A. Misfeldt, Daniela L. Buscariollo, William E. Russell & Daniel J. Moore. (2010) Incorporating Type 1 Diabetes Prevention Into Clinical Practice. Clinical Diabetes 28:2, pages 61-70.
Crossref
Omid TavanaNahum Puebla-OsorioMei SangChengming Zhu. (2010) Absence of p53-Dependent Apoptosis Combined With Nonhomologous End-Joining Deficiency Leads to a Severe Diabetic Phenotype in Mice. Diabetes 59:1, pages 135-142.
Crossref
Catherine E. Gleason, Yun Ning, Tara P. Cominski, Rana Gupta, Klaus H. Kaestner, John E. Pintar & Morris J. Birnbaum. (2010) Role of Insulin-Like Growth Factor-Binding Protein 5 (IGFBP5) in Organismal and Pancreatic β-Cell Growth. Molecular Endocrinology 24:1, pages 178-192.
Crossref
Fangnian WangHongsheng LiuWanda P. BlantonAnna BelkinaNathan K. LebrasseurGerald V. Denis. (2009) Brd2 disruption in mice causes severe obesity without Type 2 diabetes . Biochemical Journal 425:1, pages 71-85.
Crossref
Xiaobo Xu, Joke D’Hoker, Nico De Leu, Xiangwei Xiao, Yves Heremans, Mark Van De Casteele & Harry Heimberg. 2010. Stem Cell Therapy for Diabetes. Stem Cell Therapy for Diabetes 105 122 .
Nathalie Fiaschi-Taesch, George Harb, Esra Karsiloglu, Karen K. Takane & Andrew F. Stewart. 2010. Stem Cell Therapy for Diabetes. Stem Cell Therapy for Diabetes 85 103 .
Hui You & Suzanne G. Laychock. (2009) Atrial Natriuretic Peptide Promotes Pancreatic Islet β-Cell Growth and Akt/Foxo1a/Cyclin D2 Signaling. Endocrinology 150:12, pages 5455-5465.
Crossref
Ehab H. SarsourManeesh G. KumarLeena ChaudhuriAmanda L. KalenPrabhat C. Goswami. (2009) Redox Control of the Cell Cycle in Health and Disease. Antioxidants & Redox Signaling 11:12, pages 2985-3011.
Crossref
Lu Mei He, Daniel J. Sartori, Monica Teta, Lynn M. Opare-Addo, Matthew M. Rankin, Simon Y. Long, J. Alan Diehl & Jake A. Kushner. (2009) Cyclin D2 Protein Stability Is Regulated in Pancreatic β-Cells. Molecular Endocrinology 23:11, pages 1865-1875.
Crossref
Lisa D. Norquay, Katharine E. D'Aquino, Lynn M. Opare-Addo, Alexandra Kuznetsova, Michael Haas, Jeffrey A. Bluestone & Morris F. White. (2009) Insulin Receptor Substrate-2 in β-Cells Decreases Diabetes in Nonobese Diabetic Mice. Endocrinology 150:10, pages 4531-4540.
Crossref
X. Wu, L. Wang, S. Schroer, D. Choi, P. Chen, H. Okada & M. Woo. (2009) Perinatal survivin is essential for the establishment of pancreatic beta cell mass in mice. Diabetologia 52:10, pages 2130-2141.
Crossref
Xiaojuan Chen, Xiaomin Zhang, Fei Chen, Courtney S. Larson, Ling-Jia Wang & Dixon B. Kaufman. (2009) Comparative Study of Regenerative Potential of β Cells From Young and Aged Donor Mice Using a Novel Islet Transplantation Model. Transplantation 88:4, pages 496-503.
Crossref
Géraldine Parnaud, Eva Hammar, Pascale Ribaux, Marc Y. Donath, Thierry Berney & Philippe A. Halban. (2009) Signaling Pathways Implicated in the Stimulation of β-Cell Proliferation by Extracellular Matrix. Molecular Endocrinology 23:8, pages 1264-1271.
Crossref
Jean-Sébastien Annicotte, Emilie Blanchet, Carine Chavey, Irena Iankova, Safia Costes, Said Assou, Jacques Teyssier, Stéphane Dalle, Claude Sardet & Lluis Fajas. (2009) The CDK4–pRB–E2F1 pathway controls insulin secretion. Nature Cell Biology 11:8, pages 1017-1023.
Crossref
Lynda Elghazi & Ernesto Bernal-Mizrachi. (2009) Akt and PTEN: β-cell mass and pancreas plasticity. Trends in Endocrinology & Metabolism 20:5, pages 243-251.
Crossref
Matthew M. RankinJake A. Kushner. (2009) Adaptive β-Cell Proliferation Is Severely Restricted With Advanced Age. Diabetes 58:6, pages 1365-1372.
Crossref
Vera Chesnokova, Chris Wong, Svetlana Zonis, Anna Gruszka, Kolja Wawrowsky, Song-Guang Ren, Anat BenShlomo & Run Yu. (2009) Diminished Pancreatic β-Cell Mass in Securin-Null Mice Is Caused by β-Cell Apoptosis and Senescence. Endocrinology 150:6, pages 2603-2610.
Crossref
Hainan Chen, Xueying Gu, I-hsin Su, Rita Bottino, Juan L. Contreras, Alexander Tarakhovsky & Seung K. Kim. (2009) Polycomb protein Ezh2 regulates pancreatic β-cell Ink4a/Arf expression and regeneration in diabetes mellitus . Genes & Development 23:8, pages 975-985.
Crossref
Robert L. Sorenson & Todd C. Brelje. (2009) Prolactin Receptors Are Critical to the Adaptation of Islets to Pregnancy. Endocrinology 150:4, pages 1566-1569.
Crossref
Alex Rafacho, Tânia M. Cestari, Sebastião R. Taboga, Antonio C. Boschero & José R. Bosqueiro. (2009) High doses of dexamethasone induce increased β-cell proliferation in pancreatic rat islets. American Journal of Physiology-Endocrinology and Metabolism 296:4, pages E681-E689.
Crossref
Norman Balcazar, Aruna Sathyamurthy, Lynda Elghazi, Aaron Gould, Aaron Weiss, Ichiro Shiojima, Kenneth Walsh & Ernesto Bernal-Mizrachi. (2009) mTORC1 Activation Regulates β-Cell Mass and Proliferation by Modulation of Cyclin D2 Synthesis and Stability. Journal of Biological Chemistry 284:12, pages 7832-7842.
Crossref
Anke Assmann, Charlotte Hinault & Rohit N Kulkarni. (2009) Growth factor control of pancreatic islet regeneration and function. Pediatric Diabetes 10:1, pages 14-32.
Crossref
Ying C. Lee & Jens Høiriis Nielsen. (2009) Regulation of beta cell replication. Molecular and Cellular Endocrinology 297:1-2, pages 18-27.
Crossref

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