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Molecular and Cellular Biology Volume 26, 2006 - Issue 3
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Article

The RA Domain of Ste50 Adaptor Protein Is Required for Delivery of Ste11 to the Plasma Membrane in the Filamentous Growth Signaling Pathway of the Yeast Saccharomyces cerevisiae

Dagmar M. TrucksesDepartment of Molecular and Cell Biology, Division of Biochemistry and Molecular Biology, University of California, Room 401, Barker Hall, Berkeley, California94720-3202
,
Joshua E. BloomekatzDepartment of Molecular and Cell Biology, Division of Biochemistry and Molecular Biology, University of California, Room 401, Barker Hall, Berkeley, California94720-3202
&
Jeremy ThornerDepartment of Molecular and Cell Biology, Division of Biochemistry and Molecular Biology, University of California, Room 401, Barker Hall, Berkeley, California94720-3202Correspondence[email protected]
Pages 912-928 | Received 25 Dec 2004, Accepted 03 Nov 2005, Published online: 27 Mar 2023

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Katsuyoshi Yamamoto, Kazuo Tatebayashi & Haruo Saito. (2016) Binding of the Extracellular Eight-Cysteine Motif of Opy2 to the Putative Osmosensor Msb2 Is Essential for Activation of the Yeast High-Osmolarity Glycerol Pathway. Molecular and Cellular Biology 36:3, pages 475-487.
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Hema Adhikari, Nadia Vadaie, Jacky Chow, Lauren M. Caccamise, Colin A. Chavel, Boyang Li, Alexander Bowitch, Christopher J. Stefan & Paul J. Cullen. (2015) Role of the Unfolded Protein Response in Regulating the Mucin-Dependent Filamentous-Growth Mitogen-Activated Protein Kinase Pathway. Molecular and Cellular Biology 35:8, pages 1414-1432.
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Andrew Pitoniak, Colin A. Chavel, Jacky Chow, Jeremy Smith, Diawoye Camara, Sheelarani Karunanithi, Boyang Li, Kennith H. Wolfe & Paul J. Cullen. (2015) Cdc42p-Interacting Protein Bem4p Regulates the Filamentous-Growth Mitogen-Activated Protein Kinase Pathway. Molecular and Cellular Biology 35:2, pages 417-436.
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Renata Tisi, Fiorella Belotti & Enzo Martegani. 2014. Ras Signaling. Ras Signaling 359 390 .
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Crossref
Javier MaciaSergi RegotTom PeetersNúria CondeRicard SoléFrancesc Posas. (2009) Dynamic Signaling in the Hog1 MAPK Pathway Relies on High Basal Signal Transduction. Science Signaling 2:63.
Crossref
Adriana Galvis, Hugo Giambini, Zoilmar Villasana & M. Alejandro Barbieri. (2009) Functional determinants of ras interference 1 mutants required for their inhbitory activity on endocytosis. Experimental Cell Research 315:5, pages 820-835.
Crossref
Anirban Bhunia, Prerna N. Domadia, Harini Mohanram & Surajit Bhattacharjya. (2009) NMR structural studies of the Ste11 SAM domain in the dodecyl phosphocholine micelle. Proteins: Structure, Function, and Bioinformatics 74:2, pages 328-343.
Crossref
Nan Hao, Yaxue Zeng, Timothy C. Elston & Henrik G. Dohlman. (2008) Control of MAPK Specificity by Feedback Phosphorylation of Shared Adaptor Protein Ste50. Journal of Biological Chemistry 283:49, pages 33798-33802.
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Robert B. Annan, Cunle Wu, Daniel D. Waller, Malcolm Whiteway & David Y. Thomas. (2008) Rho5p Is Involved in Mediating the Osmotic Stress Response in Saccharomyces cerevisiae , and Its Activity Is Regulated via Msi1p and Npr1p by Phosphorylation and Ubiquitination . Eukaryotic Cell 7:9, pages 1441-1449.
Crossref
Brian D. Slaughter, Joseph M. Huff, Winfried Wiegraebe, Joel W. Schwartz & Rong Li. (2008) SAM Domain-Based Protein Oligomerization Observed by Live-Cell Fluorescence Fluctuation Spectroscopy. PLoS ONE 3:4, pages e1931.
Crossref
Steven J. Klosterman, Alfredo D. Martinez-Espinoza, David L. Andrews, Jeffrey R. Seay & Scott E. Gold. (2008) Ubc2, an Ortholog of the Yeast Ste50p Adaptor, Possesses a Basidiomycete-Specific Carboxy Terminal Extension Essential for Pathogenicity Independent of Pheromone Response. Molecular Plant-Microbe Interactions® 21:1, pages 110-121.
Crossref
Eulàlia de Nadal, Francisco X. Real & Francesc Posas. (2007) Mucins, osmosensors in eukaryotic cells?. Trends in Cell Biology 17:12, pages 571-574.
Crossref
Kazuo Tatebayashi, Keiichiro Tanaka, Hui-Yu Yang, Katsuyoshi Yamamoto, Yusaku Matsushita, Taichiro Tomida, Midori Imai & Haruo Saito. (2007) Transmembrane mucins Hkr1 and Msb2 are putative osmosensors in the SHO1 branch of yeast HOG pathway. The EMBO Journal 26:15, pages 3521-3533.
Crossref
Raymond E. Chen & Jeremy Thorner. (2007) Function and regulation in MAPK signaling pathways: Lessons learned from the yeast Saccharomyces cerevisiae. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1773:8, pages 1311-1340.
Crossref
B. H. Bluhm, X. Zhao, J. E. Flaherty, J.-R. Xu & L. D. Dunkle. (2007) RAS2 Regulates Growth and Pathogenesis in Fusarium graminearum . Molecular Plant-Microbe Interactions® 20:6, pages 627-636.
Crossref
Eric M. Rubenstein & Martin C. Schmidt. (2007) Mechanisms Regulating the Protein Kinases of Saccharomyces cerevisiae . Eukaryotic Cell 6:4, pages 571-583.
Crossref
Andreas Poplinski, Claudia Hopp & Massoud Ramezani-Rad. (2007) Ste50 adaptor protein influences Ras/cAMP-driven stress-response and cell survival in Saccharomyces cerevisiae. Current Genetics 51:4, pages 257-268.
Crossref
Hay-Oak Park & Erfei Bi. (2007) Central Roles of Small GTPases in the Development of Cell Polarity in Yeast and Beyond. Microbiology and Molecular Biology Reviews 71:1, pages 48-96.
Crossref
Rohan Fernandes, Chen-Yu Tsao, Yoshifumi Hashimoto, Liang Wang, Thomas K. Wood, Gregory F. Payne & William E. Bentley. (2007) Magnetic nanofactories: Localized synthesis and delivery of quorum-sensing signaling molecule autoinducer-2 to bacterial cell surfaces. Metabolic Engineering 9:2, pages 228-239.
Crossref
Melanie Heinrich, Tim Köhler & Hans-Ulrich Mösch. (2007) Role of Cdc42-Cla4 Interaction in the Pheromone Response of Saccharomyces cerevisiae . Eukaryotic Cell 6:2, pages 317-327.
Crossref
Eulàlia de Nadal & Francesc Posas. 2008. Stress-Activated Protein Kinases. Stress-Activated Protein Kinases 81 97 .
Gyungsoon Park, Chaoyang Xue, Xinhua Zhao, Yangseon Kim, Marc Orbach & Jin-Rong Xu. (2006) Multiple Upstream Signals Converge on the Adaptor Protein Mst50 in Magnaporthe grisea . The Plant Cell 18:10, pages 2822-2835.
Crossref
Patrick J. Westfall & Jeremy Thorner. (2006) Analysis of Mitogen-Activated Protein Kinase Signaling Specificity in Response to Hyperosmotic Stress: Use of an Analog-Sensitive HOG1 Allele . Eukaryotic Cell 5:8, pages 1215-1228.
Crossref
. (2006) Current awareness on yeast. Yeast 23:11, pages 841-848.
Crossref
Kazuo Tatebayashi, Katsuyoshi Yamamoto, Keiichiro Tanaka, Taichiro Tomida, Takashi Maruoka, Eri Kasukawa & Haruo Saito. (2006) Adaptor functions of Cdc42, Ste50, and Sho1 in the yeast osmoregulatory HOG MAPK pathway. The EMBO Journal 25:13, pages 3033-3044.
Crossref
Roby P. BhattacharyyaAttila ReményiBrian J. YehWendell A. Lim. (2006) Domains, Motifs, and Scaffolds: The Role of Modular Interactions in the Evolution and Wiring of Cell Signaling Circuits. Annual Review of Biochemistry 75:1, pages 655-680.
Crossref

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