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Molecular and Cellular Biology Volume 26, 2006 - Issue 6
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Article

A Novel RNA Binding Domain in Tetrahymena Telomerase p65 Initiates Hierarchical Assembly of Telomerase Holoenzyme

Catherine M. O'ConnorDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California94720-3204
&
Kathleen CollinsDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California94720-3204Correspondence[email protected]
Pages 2029-2036 | Received 02 Nov 2005, Accepted 31 Dec 2005, Published online: 27 Mar 2023

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Daniele Hasler, Gunter Meister & Utz Fischer. (2021) Stabilize and connect: the role of LARP7 in nuclear non-coding RNA metabolism. RNA Biology 18:2, pages 290-303.
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Ilaria Laudadio, Claudia Carissimi & Valerio Fulci. (2019) How RNAi machinery enters the world of telomerase. Cell Cycle 18:10, pages 1056-1067.
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Mahavir Singh, Charles P. Choi & Juli Feigon. (2013) xRRM. RNA Biology 10:3, pages 353-359.
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Andrea J. Berman, Anne R. Gooding & Thomas R. Cech. (2010) Tetrahymena Telomerase Protein p65 Induces Conformational Changes throughout Telomerase RNA (TER) and Rescues Telomerase Reverse Transcriptase and TER Assembly Mutants. Molecular and Cellular Biology 30:20, pages 4965-4976.
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Keren L. Witkin, Ramadevi Prathapam & Kathleen Collins. (2007) Positive and Negative Regulation of Tetrahymena Telomerase Holoenzyme. Molecular and Cellular Biology 27:6, pages 2074-2083.
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Articles from other publishers (47)

Jennifer Porat, Moaine El Baidouri, Jorg Grigull, Jean-Marc Deragon & Mark A. Bayfield. (2022) The methyl phosphate capping enzyme Bmc1/Bin3 is a stable component of the fission yeast telomerase holoenzyme. Nature Communications 13:1.
Crossref
Christina Palka, Nicholas M. Forino, Jendrik Hentschel, Rhiju Das & Michael D. Stone. (2020) Folding heterogeneity in the essential human telomerase RNA three-way junction. RNA 26:12, pages 1787-1800.
Crossref
Xichan Hu, Jin-Kwang Kim, Clinton Yu, Hyun-Ik Jun, Jinqiang Liu, Banumathi Sankaran, Lan Huang & Feng Qiao. (2020) Quality-Control Mechanism for Telomerase RNA Folding in the Cell. Cell Reports 33:13, pages 108568.
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Yaqiang Wang, Lukas Sušac & Juli Feigon. (2019) Structural Biology of Telomerase. Cold Spring Harbor Perspectives in Biology 11:12, pages a032383.
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Ilaria Laudadio, Francesca Orso, Gianluca Azzalin, Carlo Calabrò, Francesco Berardinelli, Elisa Coluzzi, Silvia Gioiosa, Daniela Taverna, Antonella Sgura, Claudia Carissimi & Valerio Fulci. (2018) AGO 2 promotes telomerase activity and interaction between the telomerase components TERT and TERC . EMBO reports 20:2.
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Maria Alejandra Viviescas, Maria Isabel Nogueira Cano & Marcela Segatto. (2018) Chaperones and Their Role in Telomerase Ribonucleoprotein Biogenesis and Telomere Maintenance. Current Proteomics 16:1, pages 31-43.
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Laura C. Collopy, Tracy L. Ware, Tomas Goncalves, Sunnvør í Kongsstovu, Qian Yang, Hanna Amelina, Corinne Pinder, Ala Alenazi, Vera Moiseeva, Siân R. Pearson, Christine A. Armstrong & Kazunori Tomita. (2018) LARP7 family proteins have conserved function in telomerase assembly. Nature Communications 9:1.
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Diego J. Páez-Moscoso, Lili Pan, Rutendo F. Sigauke, Morgan R. Schroeder, Wen Tang & Peter Baumann. (2018) Pof8 is a La-related protein and a constitutive component of telomerase in fission yeast. Nature Communications 9:1.
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Abhishek Dey & Kausik Chakrabarti. (2018) Current Perspectives of Telomerase Structure and Function in Eukaryotes with Emerging Views on Telomerase in Human Parasites. International Journal of Molecular Sciences 19:2, pages 333.
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Henry ChanYaqiang WangJuli Feigon. (2017) Progress in Human and Tetrahymena Telomerase Structure Determination . Annual Review of Biophysics 46:1, pages 199-225.
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Darian D. Cash & Juli Feigon. (2017) Structure and folding of the Tetrahymena telomerase RNA pseudoknot . Nucleic Acids Research 45:1, pages 482-495.
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Heather E. Upton, Henry Chan, Juli Feigon & Kathleen Collins. (2017) Shared Subunits of Tetrahymena Telomerase Holoenzyme and Replication Protein A Have Different Functions in Different Cellular Complexes. Journal of Biological Chemistry 292:1, pages 217-228.
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Catherine D. Eichhorn, Rahul Chug & Juli Feigon. (2016) hLARP7 C-terminal domain contains an xRRM that binds the 3′ hairpin of 7SK RNA. Nucleic Acids Research, pages gkw833.
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Jiansen JiangHenry ChanDarian D. CashEdward J. MiraccoRachel R. Ogorzalek LooHeather E. UptonDuilio CascioReid O’Brien JohnsonKathleen CollinsJoseph A. LooZ. Hong ZhouJuli Feigon. (2015) Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions . Science 350:6260.
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Jeremy C. Tomcho, Magdalena R. Tillman & Brent M. Znosko. (2015) Improved Model for Predicting the Free Energy Contribution of Dinucleotide Bulges to RNA Duplex Stability. Biochemistry 54:34, pages 5290-5296.
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Wei Xue, Bao-An Song, Hong Ju Zhao, Xing Bao Qi, Yin Jiu Huang & Xin Hua Liu. (2015) Novel myricetin derivatives: Design, synthesis and anticancer activity. European Journal of Medicinal Chemistry 97, pages 155-163.
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Edward J Miracco, Jiansen Jiang, Darian D Cash & Juli Feigon. (2014) Progress in structural studies of telomerase. Current Opinion in Structural Biology 24, pages 115-124.
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Jiansen Jiang, Edward J. Miracco, Kyungah Hong, Barbara Eckert, Henry Chan, Darian D. Cash, Bosun Min, Z. Hong Zhou, Kathleen Collins & Juli Feigon. (2013) The architecture of Tetrahymena telomerase holoenzyme. Nature 496:7444, pages 187-192.
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Emily D. Egan & Kathleen Collins. (2012) Biogenesis of telomerase ribonucleoproteins. RNA 18:10, pages 1747-1759.
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E. M. Smekalova, O. S. Shubernetskaya, M. I. Zvereva, E. V. Gromenko, M. P. Rubtsova & O. A. Dontsova. (2012) Telomerase RNA biosynthesis and processing. Biochemistry (Moscow) 77:10, pages 1120-1128.
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Mahavir Singh, Zhonghua Wang, Bon-Kyung Koo, Anooj Patel, Duilio Cascio, Kathleen Collins & Juli Feigon. (2012) Structural Basis for Telomerase RNA Recognition and RNP Assembly by the Holoenzyme La Family Protein p65. Molecular Cell 47:1, pages 16-26.
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Tara Beattie & Pascal Chartrand. 2012. Telomerases. Telomerases 79 103 .
Yehuda Tzfati & Julian J.‐L. Chen. 2012. Telomerases. Telomerases 23 51 .
Johanna Mancini & Chantal Autexier. 2012. Telomerases. Telomerases 1 21 .
Benjamin M. Akiyama, John Loper, Kevin Najarro & Michael D. Stone. (2012) The C-terminal domain of Tetrahymena thermophila telomerase holoenzyme protein p65 induces multiple structural changes in telomerase RNA . RNA 18:4, pages 653-660.
Crossref
Wen Tang, Ram Kannan, Marco Blanchette & Peter Baumann. (2012) Telomerase RNA biogenesis involves sequential binding by Sm and Lsm complexes. Nature 484:7393, pages 260-264.
Crossref
Luca Schenk, Dominik M. Meinel, Katja Strässer & André P. Gerber. (2012) La-motif–dependent mRNA association with Slf1 promotes copper detoxification in yeast. RNA 18:3, pages 449-461.
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Mariana MihalusovaJohn Y. WuXiaowei Zhuang. (2011) Functional importance of telomerase pseudoknot revealed by single-molecule analysis. Proceedings of the National Academy of Sciences 108:51, pages 20339-20344.
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Kathleen Collins. (2011) Single-stranded DNA repeat synthesis by telomerase. Current Opinion in Chemical Biology 15:5, pages 643-648.
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M. I. Zvereva, D. M. Shcherbakova & O. A. Dontsova. (2011) Telomerase: Structure, functions, and activity regulation. Biochemistry (Moscow) 75:13, pages 1563-1583.
Crossref
Ping Xie. (2010) A modified model for translocation events of processive nucleotide and repeat additions by the recombinant telomerase. Biophysical Chemistry 153:1, pages 83-96.
Crossref
Mark A. Bayfield, Ruiqing Yang & Richard J. Maraia. (2010) Conserved and divergent features of the structure and function of La and La-related proteins (LARPs). Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1799:5-6, pages 365-378.
Crossref
Aaron R. Robart, Catherine M. O'Connor & Kathleen Collins. (2010) Ciliate telomerase RNA loop IV nucleotides promote hierarchical RNP assembly and holoenzyme stability. RNA 16:3, pages 563-571.
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Bosun Min & Kathleen Collins. (2009) An RPA-Related Sequence-Specific DNA-Binding Subunit of Telomerase Holoenzyme Is Required for Elongation Processivity and Telomere Maintenance. Molecular Cell 36:4, pages 609-619.
Crossref
Stephen Kearsey, Judith L Campbell, Genevieve Almouzni, Joanna Poulton, Takehiro Yasukawa, Steve Bell, Ron Laskey, Tom Kunkel, James Chong, Xinquan Ge, Julian Blow, Christian Speck, Ginger Jiang, Ellen Fanning, Helle D Ulrich, Christian Haering, James Chong, Ji-Liang Li, Tracy Bryan & Alison WaltersTracy M. Bryan. 2009. Molecular Themes in DNA Replication. Molecular Themes in DNA Replication 217 268 .
Ping Xie. (2009) A possible mechanism of processive nucleotide and repeat additions by the telomerase. Biosystems 97:3, pages 168-178.
Crossref
Kathleen Collins. 2009. Non-Protein Coding RNAs. Non-Protein Coding RNAs 285 301 .
Elvin A Alemán, Rajan Lamichhane & David Rueda. (2008) Exploring RNA folding one molecule at a time. Current Opinion in Chemical Biology 12:6, pages 647-654.
Crossref
Kathleen Collins. (2008) Physiological assembly and activity of human telomerase complexes. Mechanisms of Ageing and Development 129:1-2, pages 91-98.
Crossref
Susan Rouda & Emmanuel Skordalakes. (2007) Structure of the RNA-Binding Domain of Telomerase: Implications for RNA Recognition and Binding. Structure 15:11, pages 1403-1412.
Crossref
M Teresa Teixeira & Eric Gilson. (2007) La sets the tone for telomerase assembly. Nature Structural & Molecular Biology 14:4, pages 261-262.
Crossref
Jason D. Legassie & Michael B. Jarstfer. (2006) The Unmasking of Telomerase. Structure 14:11, pages 1603-1609.
Crossref
Amy D. Mozdy & Thomas R. Cech. (2006) Low abundance of telomerase in yeast: Implications for telomerase haploinsufficiency. RNA 12:9, pages 1721-1737.
Crossref
Rebecca J. Richards, Haihong Wu, Lukas Trantirek, Catherine M. O'Connor, Kathleen Collins & Juli Feigon. (2006) Structural study of elements of Tetrahymena telomerase RNA stem–loop IV domain important for function . RNA 12:8, pages 1475-1485.
Crossref
Yu Chen, Jessica Fender, Jason D Legassie, Michael B Jarstfer, Tracy M Bryan & Gabriele Varani. (2006) Structure of stem-loop IV of Tetrahymena telomerase RNA. The EMBO Journal 25:13, pages 3156-3166.
Crossref
Kathleen Collins. (2006) The biogenesis and regulation of telomerase holoenzymes. Nature Reviews Molecular Cell Biology 7:7, pages 484-494.
Crossref
Carla A Theimer & Juli Feigon. (2006) Structure and function of telomerase RNA. Current Opinion in Structural Biology 16:3, pages 307-318.
Crossref

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