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Boris Klimovich, Thorsten Stiewe & Oleg Timofeev. (2020) Inactivation of Mdm2 restores apoptosis proficiency of cooperativity mutant p53 in vivo. Cell Cycle 19:1, pages 109-123.
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Suhaib K. Abdeen & Rami I. Aqeilan. (2019) Decoding the link between WWOX and p53 in aggressive breast cancer. Cell Cycle 18:11, pages 1177-1186.
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Patryk Gorniak, Bozena Budziszewska, Bartosz Pula, Maja Wasylecka, Katarzyna Borg, Grazyna Nowak, Hanna Makuch-Lasica, Ewa Lech-Maranda, Krzysztof Warzocha & Przemyslaw Juszczynski. (2016) Increased expression of E3 ubiquitin ligases targeting p53 in CLL patients with wild-type TP53 exhibits associations with clinical features of the disease. Leukemia & Lymphoma 57:6, pages 1471-1473.
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Rachel Beckerman, Kathryn Yoh, Melissa Mattia-Sansobrino, Andrew Zupnick, Oleg Laptenko, Orit Karni-Schmidt, Jinwoo Ahn, In-Ja Byeon, Susan Keezer & Carol Prives. (2016) Lysines in the tetramerization domain of p53 selectively modulate G1 arrest. Cell Cycle 15:11, pages 1425-1438.
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Articles from other publishers (61)
Yuhong Zhao, Yingxi Chen, Ling Wei, Jianhua Ran, Kejian Wang, Shujuan Zhu & Qian Liu. (2023) p53 inhibits the Urea cycle and represses polyamine biosynthesis in glioma cell lines. Metabolic Brain Disease 38:4, pages 1143-1153.
Crossref
Crossref
Boris Klimovich, Nastasja Merle, Michelle Neumann, Sabrina Elmshäuser, Andrea Nist, Marco Mernberger, Daniel Kazdal, Albrecht Stenzinger, Oleg Timofeev & Thorsten Stiewe. (2021) p53 partial loss-of-function mutations sensitize to chemotherapy. Oncogene 41:7, pages 1011-1023.
Crossref
Crossref
Xiaohan Kong, Dehai Yu, Zhaoyi Wang & Sijie Li. (2021) Relationship between p53 status and the bioeffect of ionizing radiation (Review). Oncology Letters 22:3.
Crossref
Crossref
Oluwakemi A. Rotimi, Chinonye D. Onuzulu, Alisa L. Dewald, Jessa Ehlinger, Isaacson B. Adelani, Olutola E. Olasehinde, Solomon O. Rotimi & Jaclyn M. Goodrich. (2021) Early Life Exposure to Aflatoxin B1 in Rats: Alterations in Lipids, Hormones, and DNA Methylation among the Offspring. International Journal of Environmental Research and Public Health 18:2, pages 589.
Crossref
Crossref
May San Martinho, Derek J. Nancarrow, Theodore S. Lawrence, David G. Beer & Dipankar Ray. (2021) Chaperones and Ubiquitin Ligases Balance Mutant p53 Protein Stability in Esophageal and Other Digestive Cancers. Cellular and Molecular Gastroenterology and Hepatology 11:2, pages 449-464.
Crossref
Crossref
Mark J. McCabe, Mark Pinese, Chia-Ling Chan, Nisa Sheriff, Tanya J. Thompson, John Grady, Marie Wong, Marie-Emilie A. Gauthier, Clare Puttick, Velimir Gayevskiy, Elektra Hajdu, Stephen Q. Wong, Wade Barrett, Peter Earls, Robyn Lukeis, Yuen Y. Cheng, Ruby C.Y. Lin, David M. Thomas, D. Neil Watkins, Marcel E. Dinger, Ann I. McCormack & Mark J. Cowley. (2019) Genomic stratification and liquid biopsy in a rare adrenocortical carcinoma (ACC) case, with dual lung metastases. Molecular Case Studies 5:2, pages a003764.
Crossref
Crossref
Eran Kotler, Odem Shani, Guy Goldfeld, Maya Lotan-Pompan, Ohad Tarcic, Anat Gershoni, Thomas A. Hopf, Debora S. Marks, Moshe Oren & Eran Segal. (2018) A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary Conservation. Molecular Cell 71:1, pages 178-190.e8.
Crossref
Crossref
Thorsten Stiewe & Tali E. Haran. (2018) How mutations shape p53 interactions with the genome to promote tumorigenesis and drug resistance. Drug Resistance Updates 38, pages 27-43.
Crossref
Crossref
Zhi-fang An, Kang Zhao, Lin-na Wei, Zhi-jie Wang, Su-hua Li, Lian Wei & Deng-bang Wei. (2018) p53 gene cloning and response to hypoxia in the plateau zokor, Myospalax baileyi. Animal Biology 68:3, pages 289-308.
Crossref
Crossref
Vasundhara Sharma, Paola Monti, Gilberto Fronza & Alberto Inga. (2016) Human transcription factors in yeast: the fruitful examples of P53 and NF-кB. FEMS Yeast Research 16:7, pages fow083.
Crossref
Crossref
Daniel Menendez, Julie M. Lowe, Joyce Snipe & Michael A. Resnick. (2016) Ligand dependent restoration of human TLR3 signaling and death in p53 mutant cells. Oncotarget 7:38, pages 61630-61642.
Crossref
Crossref
Radion Vainer, Sarit Cohen, Anat Shahar, Raz Zarivach & Eyal Arbely. (2016) Structural Basis for p53 Lys120-Acetylation-Dependent DNA-Binding Mode. Journal of Molecular Biology 428:15, pages 3013-3025.
Crossref
Crossref
Su-Hyung Hong, Ismail Ahmed Ismail, Sung-Min Kang, Dong Cho Han & Byoung-Mog Kwon. (2016) Cinnamaldehydes in Cancer Chemotherapy. Phytotherapy Research 30:5, pages 754-767.
Crossref
Crossref
Yang ZhaoJia-Wei TangZhi YangYi-Bin CaoJi-Long RenYuval Ben-AbuKexin Li, Xue-Qun ChenJi-Zeng DuEviatar Nevo. (2016)
Adaptive methylation regulation of
p53
pathway in sympatric speciation of blind mole rats,
Spalax
. Proceedings of the National Academy of Sciences 113:8, pages 2146-2151.
Crossref
Crossref
Luis Alfonso Martinez. (2016) Mutant p53 and ETS2, a Tale of Reciprocity. Frontiers in Oncology 6.
Crossref
Crossref
Debabani Ganguly & Jianhan Chen. (2015) Modulation of the Disordered Conformational Ensembles of the p53 Transactivation Domain by Cancer-Associated Mutations. PLOS Computational Biology 11:4, pages e1004247.
Crossref
Crossref
Alessandra Bisio, Yari Ciribilli, Gilberto Fronza, Alberto Inga & Paola Monti. (2014) TP53 Mutants in the Tower of Babel of Cancer Progression. Human Mutation 35:6, pages 689-701.
Crossref
Crossref
Gengze Wu, Dongbo Liu, Ke Jiang, Li Zhang, Yijun Zeng, Peng Zhou, Dan Zhong, Min Gao, Fengtian He & Yingru Zheng. (2014) PinX1, a novel target gene of p53, is suppressed by HPV16 E6 in cervical cancer cells. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1839:2, pages 88-96.
Crossref
Crossref
Hector Viadiu, Gilberto Fronza & Alberto Inga. 2014. Mutant p53 and MDM2 in Cancer. Mutant p53 and MDM2 in Cancer
119
132
.
Yang ZhaoJi-Long RenMing-Yang WangSheng-Ting ZhangYu LiuMin LiYi-Bin CaoHu-Yue ZuXiao-Cheng ChenChung-I WuEviatar Nevo, Xue-Qun Chen & Ji-Zeng Du. (2013)
Codon 104 variation of
p53
gene provides adaptive apoptotic responses to extreme environments in mammals of the Tibet plateau
. Proceedings of the National Academy of Sciences 110:51, pages 20639-20644.
Crossref
Crossref
Yu-Cheng Liu, Chun-Pei Cheng & Vincent S Tseng. (2013) Mining differential top-k co-expression patterns from time course comparative gene expression datasets. BMC Bioinformatics 14:1.
Crossref
Crossref
Y. Ciribilli, P. Monti, A. Bisio, H. T. Nguyen, A. S. Ethayathulla, A. Ramos, G. Foggetti, P. Menichini, D. Menendez, M. A. Resnick, H. Viadiu, G. Fronza & A. Inga. (2013) Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code. Nucleic Acids Research 41:18, pages 8637-8653.
Crossref
Crossref
S Garritano, A Inga, F Gemignani & S Landi. (2013) More targets, more pathways and more clues for mutant p53. Oncogenesis 2:7, pages e54-e54.
Crossref
Crossref
Elisabet O. Berge, Johanna Huun, Johan R. Lillehaug, Per E. Lønning & Stian Knappskog. (2013) Functional characterisation of p53 mutants identified in breast cancers with suboptimal responses to anthracyclines or mitomycin. Biochimica et Biophysica Acta (BBA) - General Subjects 1830:3, pages 2790-2797.
Crossref
Crossref
Jennifer R. Diamond, S. Gail Eckhardt, Aik Choon Tan, Timothy P. Newton, Heather M. Selby, Kelsey L. Brunkow, Maria I. Kachaeva, Marileila Varella-Garcia, Todd M. Pitts, Mark R. Bray, Graham C. Fletcher & John J. Tentler. (2013) Predictive Biomarkers of Sensitivity to the Aurora and Angiogenic Kinase Inhibitor ENMD-2076 in Preclinical Breast Cancer Models. Clinical Cancer Research 19:1, pages 291-303.
Crossref
Crossref
Daniel Menendez, Maria Shatz & Michael A. Resnick. (2013) Interactions between the tumor suppressor p53 and immune responses. Current Opinion in Oncology 25:1, pages 85-92.
Crossref
Crossref
Jennifer J. Jordan, Daniel Menendez, Jenia Sharav, Itai Beno, Karin Rosenthal, Michael A. Resnick & Tali E. Haran. (2012) Low-level p53 expression changes transactivation rules and reveals superactivating sequences. Proceedings of the National Academy of Sciences 109:36, pages 14387-14392.
Crossref
Crossref
Maria Shatz, Daniel Menendez & Michael A. Resnick. (2012)
The Human
TLR
Innate Immune Gene Family Is Differentially Influenced by DNA Stress and
p53
Status in Cancer Cells
. Cancer Research 72:16, pages 3948-3957.
Crossref
Crossref
Patricia Rodrigues, Jessica Furriol, Eduardo Tormo, Sandra Ballester, Ana Lluch & Pilar Eroles. (2012) The single-nucleotide polymorphisms +936 C/T VEGF and −710 C/T VEGFR1 are associated with breast cancer protection in a Spanish population. Breast Cancer Research and Treatment 133:2, pages 769-778.
Crossref
Crossref
Daniel Menendez, Maria Shatz, Kathleen Azzam, Stavros Garantziotis, Michael B. Fessler & Michael A. Resnick. (2011) The Toll-Like Receptor Gene Family Is Integrated into Human DNA Damage and p53 Networks. PLoS Genetics 7:3, pages e1001360.
Crossref
Crossref
Jennifer J. Jordan, Alberto Inga, Kathleen Conway, Sharon Edmiston, Lisa A. Carey, Lin Wu & Michael A. Resnick. (2010) Altered-Function p53 Missense Mutations Identified in Breast Cancers Can Have Subtle Effects on Transactivation. Molecular Cancer Research 8:5, pages 701-716.
Crossref
Crossref
Daniel Menendez, Alberto Inga & Michael A. Resnick. (2010)
Estrogen receptor acting
in cis
enhances WT and mutant p53 transactivation at canonical and noncanonical p53 target sequences
. Proceedings of the National Academy of Sciences 107:4, pages 1500-1505.
Crossref
Crossref
Kian Hoe Khoo, Sebastian Mayer & Alan R. Fersht. (2009) Effects of Stability on the Biological Function of p53. Journal of Biological Chemistry 284:45, pages 30974-30980.
Crossref
Crossref
Daniel Menendez, Alberto Inga & Michael A. Resnick. (2009) The expanding universe of p53 targets. Nature Reviews Cancer 9:10, pages 724-737.
Crossref
Crossref
Jun Yan, Daniel Menendez, Xiao-Ping Yang, Michael A. Resnick & Anton M. Jetten. (2009) A Regulatory Loop Composed of RAP80-HDM2-p53 Provides RAP80-enhanced p53 Degradation by HDM2 in Response to DNA Damage. Journal of Biological Chemistry 284:29, pages 19280-19289.
Crossref
Crossref
Maher A. Noureddine, Daniel Menendez, Michelle R. Campbell, Omari J. Bandele, Monica M. Horvath, Xuting Wang, Gary S. Pittman, Brian N. Chorley, Michael A. Resnick & Douglas A. Bell. (2009) Probing the Functional Impact of Sequence Variation on p53-DNA Interactions Using a Novel Microsphere Assay for Protein-DNA Binding with Human Cell Extracts. PLoS Genetics 5:5, pages e1000462.
Crossref
Crossref
Kurinji Singaravelu, Kishor Devalaraja-Narashimha, Brynn Lastovica & Babu J. Padanilam. (2009) PERP, a p53 proapoptotic target, mediates apoptotic cell death in renal ischemia. American Journal of Physiology-Renal Physiology 296:4, pages F847-F858.
Crossref
Crossref
Marie Brázdová, Timo Quante, Lars Tögel, Korden Walter, Christine Loscher, Vlastimil Tichý, Lenka Činčárová, Wolfgang Deppert & Genrich V. Tolstonog. (2009) Modulation of gene expression in U251 glioblastoma cells by binding of mutant p53 R273H to intronic and intergenic sequences. Nucleic Acids Research 37:5, pages 1486-1500.
Crossref
Crossref
Jean-François Millau, Nathalie Bastien & Régen Drouin. (2009) P53 transcriptional activities: A general overview and some thoughts. Mutation Research/Reviews in Mutation Research 681:2-3, pages 118-133.
Crossref
Crossref
Catherine Whibley, Paul D. P. Pharoah & Monica Hollstein. (2009) p53 polymorphisms: cancer implications. Nature Reviews Cancer 9:2, pages 95-107.
Crossref
Crossref
Zaidoun Salah, Sorina Grisaru-Granovsky, Myriam Maoz, Beatrice Uziely, Irit Cohen, Hagit Turm, Tamar Peretz & Rachel Bar-Shavit*. 2009. Thrombin. Thrombin
173
188
.
Jennifer J. Jordan, Daniel Menendez, Alberto Inga, Maher Nourredine, Douglas Bell & Michael A. Resnick. (2008) Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53. PLoS Genetics 4:6, pages e1000104.
Crossref
Crossref
Andreas C. JoergerAlan R. Fersht. (2008) Structural Biology of the Tumor Suppressor p53. Annual Review of Biochemistry 77:1, pages 557-582.
Crossref
Crossref
Anil G. JeggaAlberto Inga, Daniel Menendez, Bruce J. AronowMichael A. Resnick. (2008) Functional evolution of the p53 regulatory network through its target response elements. Proceedings of the National Academy of Sciences 105:3, pages 944-949.
Crossref
Crossref
Buyong Ma & Arnold J. Levine. (2007) Probing potential binding modes of the p53 tetramer to DNA based on the symmetries encoded in p53 response elements. Nucleic Acids Research 35:22, pages 7733-7747.
Crossref
Crossref
A. Salmon, D. Amikam, N. Sodha, S. Davidson, L. Basel-Vanagaite, R.A. Eeles, D. Abeliovich & T. Peretz. (2007) Rapid Development of Post-radiotherapy Sarcoma and Breast Cancer in a Patient with a Novel Germline ‘De-Novo’ TP53 Mutation. Clinical Oncology 19:7, pages 490-493.
Crossref
Crossref
Tomoaki Tanaka, Shuichi Ohkubo, Ichiro Tatsuno & Carol Prives. (2007) hCAS/CSE1L Associates with Chromatin and Regulates Expression of Select p53 Target Genes. Cell 130:4, pages 638-650.
Crossref
Crossref
Yangde Zhang, Yanqiong Zhang, Jiji Chen, Binghua Zhang, Yifeng Pan, Lifeng Ren, Jinfen Zhao, Yulin Luo, Denggao Zhai, Shunwei Wang & Jiwei Wang. (2007) Polybutylcyanoacrylate nanoparticles as novel vectors in cancer gene therapy. Nanomedicine: Nanotechnology, Biology and Medicine 3:2, pages 144-153.
Crossref
Crossref
O Karni-Schmidt, A Friedler, A Zupnick, K McKinney, M Mattia, R Beckerman, P Bouvet, M Sheetz, A Fersht & C Prives. (2007) Energy-dependent nucleolar localization of p53 in vitro requires two discrete regions within the p53 carboxyl terminus. Oncogene 26:26, pages 3878-3891.
Crossref
Crossref
A C Joerger & A R Fersht. (2007) Structure–function–rescue: the diverse nature of common p53 cancer mutants. Oncogene 26:15, pages 2226-2242.
Crossref
Crossref
D Menendez, A Inga, J J Jordan & M A Resnick. (2007) Changing the p53 master regulatory network: ELEMENTary, my dear Mr Watson. Oncogene 26:15, pages 2191-2201.
Crossref
Crossref
Roberta Magrini, Debora Russo, Gilberto Fronza, Alberto Inga & Paola Menichini. (2007) The kinetics of p53-binding and histone acetylation at target promoters do not strictly correlate with gene expression after UV damage. Journal of Cellular Biochemistry 100:5, pages 1276-1287.
Crossref
Crossref
N. Calonghi, E. Pagnotta, C. Parolin, C. Molinari, C. Boga, F. Dal Piaz, G.L. Brusa, M.A. Santucci & L. Masotti. (2007) Modulation of apoptotic signalling by 9-hydroxystearic acid in osteosarcoma cells. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1771:2, pages 139-146.
Crossref
Crossref
Takashi Watanabe, Kaori Tobe, Yutaka Nakachi, Yasumitsu Kondoh, Madoka Nakajima, Shuichi Hamada, Chiaki Namiki, Takayoshi Suzuki, Satoru Maeda, Ayami Tadakuma, Mikiya Sakurai, Yuko Arai, Atsushi Hyogo, Masako Hoshino, Tomoko Tashiro, Hisashi Ito, Hiroshige Inazumi, Yoshiyuki Sakaki, Hideo Tashiro & Chie Furihata. (2007) Differential Gene Expression Induced by Two Genotoxic N-nitroso Carcinogens, Phenobarbital and Ethanol in Mouse Liver Examined with Oligonucleotide Microarray and Quantitative Real-time PCR. Genes and Environment 29:3, pages 115-127.
Crossref
Crossref
L M Rozan & W S El-Deiry. (2006) p53 downstream target genes and tumor suppression: a classical view in evolution. Cell Death & Differentiation 14:1, pages 3-9.
Crossref
Crossref
Andreas C. Joerger & Alan R. Fersht. 2007.
1
23
.
Karen H. Vousden. (2006) Outcomes of p53 activation - spoilt for choice. Journal of Cell Science 119:24, pages 5015-5020.
Crossref
Crossref
Andreas C. Joerger, Hwee Ching Ang & Alan R. Fersht. (2006) Structural basis for understanding oncogenic p53 mutations and designing rescue drugs. Proceedings of the National Academy of Sciences 103:41, pages 15056-15061.
Crossref
Crossref
Melissa J. Peart & Carol Prives. (2006) Mutant p53 gain of function: The NF-Y connection. Cancer Cell 10:3, pages 173-174.
Crossref
Crossref
Hwee Ching Ang, Andreas C. Joerger, Sebastian Mayer & Alan R. Fersht. (2006) Effects of Common Cancer Mutations on Stability and DNA Binding of Full-length p53 Compared with Isolated Core Domains. Journal of Biological Chemistry 281:31, pages 21934-21941.
Crossref
Crossref
Andrew Zupnick & Carol Prives. (2006) Mutational Analysis of the p53 Core Domain L1 Loop. Journal of Biological Chemistry 281:29, pages 20464-20473.
Crossref
Crossref