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Molecular and Cellular Biology Volume 26, 2006 - Issue 6
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Article

The p110 Isoform of the CDP/Cux Transcription Factor Accelerates Entry into S Phase

Laurent Sansregret1 Molecular Oncology Group, McGill University Health Center;2 Departments of Biochemistry
,
Brigitte Goulet1 Molecular Oncology Group, McGill University Health Center;2 Departments of Biochemistry
,
Ryoko Harada1 Molecular Oncology Group, McGill University Health Center;2 Departments of Biochemistry
,
Brian Wilson1 Molecular Oncology Group, McGill University Health Center;2 Departments of Biochemistry
,
Lam Leduy1 Molecular Oncology Group, McGill University Health Center
,
Jacques Bertoglio5 INSERM U461, Faculté de Pharmacie, Paris XI, 5 rue Jean Baptiste Clément, 92296Chatenay-Malabry, France
&
Alain Nepveu1 Molecular Oncology Group, McGill University Health Center;2 Departments of Biochemistry;3 Oncology;4 Medicine, McGill University, 687 Pine Ave. West, Montreal, Quebec, CanadaH3A 1A1Correspondence[email protected]
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Pages 2441-2455 | Received 26 Sep 2005, Accepted 29 Dec 2005, Published online: 27 Mar 2023

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Muriel DAVID, Dominique PETIT & Jacques Bertoglio. (2012) Cell cycle regulation of Rho signaling pathways. Cell Cycle 11:16, pages 3003-3010.
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Laetitia Seguin, Caroline Liot, Rym Mzali, Ryoko Harada, Aurelie Siret, Alain Nepveu & Jacques Bertoglio. (2009) CUX1 and E2F1 Regulate Coordinated Expression of the Mitotic Complex Genes Ect2, MgcRacGAP, and MKLP1 in S Phase. Molecular and Cellular Biology 29:2, pages 570-581.
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Mary Truscott, Ryoko Harada, Charles Vadnais, François Robert & Alain Nepveu. (2008) p110 CUX1 Cooperates with E2F Transcription Factors in the Transcriptional Activation of Cell Cycle-Regulated Genes. Molecular and Cellular Biology 28:10, pages 3127-3138.
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Articles from other publishers (42)

Manisha Krishnan, Madhavi D. Senagolage, Jeremy T. Baeten, Donald J. Wolfgeher, Saira Khan, Stephen J. Kron & Megan E. McNerney. (2022) Genomic studies controvert the existence of the CUX1 p75 isoform. Scientific Reports 12:1.
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Liting Ren, Yongjing Li, Huiru Fu, Fuqiang Zhang, Ben Yang, Chao Tan, Qi Li & Shikai Liu. (2021) A regulatory variant of tryptophan hydroxylase gene modulates transcription activity and biases growth rate in the Pacific oyster, Crassostrea gigas. Aquaculture 542, pages 736906.
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Fan Feng, Zongqing Zhao, Yunfei Zhou, Yanhao Cheng, Xiujie Wu & Xueyuan Heng. (2021) CUX1 Facilitates the Development of Oncogenic Properties Via Activating Wnt/β-Catenin Signaling Pathway in Glioma. Frontiers in Molecular Biosciences 8.
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Heidi Griesmann, Sebastian Mühl, Jan Riedel, Katharina Theuerkorn, Bence Sipos, Irene Esposito, Gregory B. Vanden Heuvel & Patrick Michl. (2021) CUX1 Enhances Pancreatic Cancer Formation by Synergizing with KRAS and Inducing MEK/ERK-Dependent Proliferation. Cancers 13:10, pages 2462.
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Ning Liu, Qiliang Sun, Long Wan, Xuan Wang, Yu Feng, Judong Luo & Hailong Wu. (2020) CUX1, A Controversial Player in Tumor Development. Frontiers in Oncology 10.
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Xiujie Wu, Fan Feng, Chuanchao Yang, Moxuan Zhang, Yanhao Cheng, Yayun Zhao, Yayu Wang, Fengyuan Che, Jian Zhang & Xueyuan Heng. (2019) Upregulated Expression of CUX1 Correlates with Poor Prognosis in Glioma Patients: a Bioinformatic Analysis. Journal of Molecular Neuroscience 69:4, pages 527-537.
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Xiao Shen, Yi-fan Zhao, Shu-qing Xu, Long Wang, Hui-min Cao, Ying Cao, Ying Zhu, Yan Wang & Zhong-qin Liang. (2019) Cathepsin L induced PC-12 cell apoptosis via activation of B-Myb and regulation of cell cycle proteins. Acta Pharmacologica Sinica 40:11, pages 1394-1403.
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Linnea A. Weiss & Marta Nieto. (2019) The crux of Cux genes in neuronal function and plasticity. Brain Research 1705, pages 32-42.
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Cong-Lin Liu, Junli Guo, Xian Zhang, Galina K. Sukhova, Peter Libby & Guo-Ping Shi. (2018) Cysteine protease cathepsins in cardiovascular disease: from basic research to clinical trials. Nature Reviews Cardiology 15:6, pages 351-370.
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Zubaidah M. Ramdzan, Vasudeva Ginjala, Jordan B. Pinder, Dudley Chung, Caroline M. Donovan, Simran Kaur, Lam Leduy, Graham Dellaire, Shridar Ganesan & Alain Nepveu. (2017) The DNA repair function of CUX1 contributes to radioresistance . Oncotarget 8:12, pages 19021-19038.
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Daniela Stangel, Mert Erkan, Malte Buchholz, Thomas Gress, Christoph Michalski, Susanne Raulefs, Helmut Friess & Jörg Kleeff. (2015) Kif20a inhibition reduces migration and invasion of pancreatic cancer cells. Journal of Surgical Research 197:1, pages 91-100.
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Vaishali Pannu, Padmashree C.G. Rida, Angela Ogden, Ravi Chakra Turaga, Shashikiran Donthamsetty, Nathan J. Bowen, Katie Rudd, Meenakshi V. Gupta, Michelle D. Reid, Guilherme Cantuaria, Claire E. Walczak & Ritu Aneja. (2015) HSET overexpression fuels tumor progression via centrosome clustering-independent mechanisms in breast cancer patients. Oncotarget 6:8, pages 6076-6091.
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Sabine Topka, Alexander Glassmann, Gunnar Weisheit, Ulrich Schüller & Karl Schilling. (2014) The Transcription Factor Cux1 in Cerebellar Granule Cell Development and Medulloblastoma Pathogenesis. The Cerebellum 13:6, pages 698-712.
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Charles Vadnais, Peiman Shooshtarizadeh, Charles V. Rajadurai, Robert Lesurf, Laura Hulea, Sayeh Davoudi, Chantal Cadieux, Michael Hallett, Morag Park & Alain Nepveu. (2014) Autocrine Activation of the Wnt/β-Catenin Pathway by CUX1 and GLIS1 in Breast Cancers. Biology Open 3:10, pages 937-946.
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Zubaidah M. Ramdzan & Alain Nepveu. (2014) CUX1, a haploinsufficient tumour suppressor gene overexpressed in advanced cancers. Nature Reviews Cancer 14:10, pages 673-682.
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Zubaidah M. Ramdzan, Charles Vadnais, Ranjana Pal, Guillaume Vandal, Chantal Cadieux, Lam Leduy, Sayeh Davoudi, Laura Hulea, Lu Yao, Anthony N. Karnezis, Marilène Paquet, David Dankort & Alain Nepveu. (2014) RAS Transformation Requires CUX1-Dependent Repair of Oxidative DNA Damage. PLoS Biology 12:3, pages e1001807.
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Charles Vadnais, Arif A Awan, Ryoko Harada, Pier-Luc Clermont, Lam Leduy, Ginette Bérubé & Alain Nepveu. (2013) Long-range transcriptional regulation by the p110 CUX1 homeodomain protein on theENCODE array. BMC Genomics 14:1.
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Kelly K Hunt, Hannah Wingate, Tomoya Yokota, Yanna Liu, Gordon B Mills, Fan Zhang, Bingliang Fang, Chun-Hui Su, Ming Zhang, Min Yi & Khandan Keyomarsi. (2013) Elafin, an inhibitor of elastase, is a prognostic indicator in breast cancer. Breast Cancer Research 15:1.
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Tarmo Äijö, Sanna M Edelman, Tapio Lönnberg, Antti Larjo, Henna Kallionpää, Soile Tuomela, Emilia Engström, Riitta Lahesmaa & Harri Lähdesmäki. (2012) An integrative computational systems biology approach identifies differentially regulated dynamic transcriptome signatures which drive the initiation of human T helper cell differentiation. BMC Genomics 13:1.
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Charles Vadnais, Sayeh Davoudi, Mojdeh Afshin, Ryoko Harada, Rachel Dudley, Pier-Luc Clermont, Elliot Drobetsky & Alain Nepveu. (2012) CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage. Nucleic Acids Research 40:10, pages 4483-4495.
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Laura Hulea & Alain Nepveu. (2012) CUX1 transcription factors: From biochemical activities and cell-based assays to mouse models and human diseases. Gene 497:1, pages 18-26.
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Kentaro Kojima, Akemi Takata, Charles Vadnais, Motoyuki Otsuka, Takeshi Yoshikawa, Masao Akanuma, Yuji Kondo, Young Jun Kang, Takahiro Kishikawa, Naoya Kato, Zhifang Xie, Weiping J. Zhang, Haruhiko Yoshida, Masao Omata, Alain Nepveu & Kazuhiko Koike. (2011) MicroRNA122 is a key regulator of α-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma. Nature Communications 2:1.
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Binu M. Paul, Dianne Vassmer, Aaron Taylor, Lynn Magenheimer, Carol G. Carlton, Klaus B. Piontek, Gregory G. Germino & Gregory B. Vanden Heuvel. (2011) Ectopic expression of Cux1 is associated with reduced p27 expression and increased apoptosis during late stage cyst progression upon inactivation of Pkd1 in collecting ducts. Developmental Dynamics 240:6, pages 1493-1501.
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Laurent Sansregret, Charles Vadnais, Julie Livingstone, Nicholas Kwiatkowski, Arif Awan, Chantal Cadieux, Lam Leduy, Michael T. Hallett & Alain Nepveu. (2011) Cut homeobox 1 causes chromosomal instability by promoting bipolar division after cytokinesis failure. Proceedings of the National Academy of Sciences 108:5, pages 1949-1954.
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Laurent Sansregret, David Gallo, Marianne Santaguida, Lam Leduy, Ryoko Harada & Alain Nepveu. (2010) Hyperphosphorylation by Cyclin B/CDK1 in Mitosis Resets CUX1 DNA Binding Clock at Each Cell Cycle*. Journal of Biological Chemistry 285:43, pages 32834-32843.
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Partha Mukhopadhyay, Guy Brock, Vasyl Pihur, Cynthia Webb, M. Michele Pisano & Robert M. Greene. (2010) Developmental microRNA expression profiling of murine embryonic orofacial tissue. Birth Defects Research Part A: Clinical and Molecular Teratology 88:7, pages 511-534.
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Zhiqun Li, Karen C. Wolff & Charles E. Samuel. (2010) RNA adenosine deaminase ADAR1 deficiency leads to increased activation of protein kinase PKR and reduced vesicular stomatitis virus growth following interferon treatment. Virology 396:2, pages 316-322.
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Nassima Redjimi, Françoise Gaudin, Cyril Touboul, Dominique Emilie, Marc Pallardy, Armelle Biola-Vidamment, Hervé Fernandez, Sophie Prévot, Karl Balabanian & Véronique Machelon. (2009) Identification of glucocorticoid-induced leucine zipper as a key regulator of tumor cell proliferation in epithelial ovarian cancer. Molecular Cancer 8:1.
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Rania Siam, Ryoko Harada, Chantal Cadieux, Robert Battat, Charles Vadnais & Alain Nepveu. (2009) Transcriptional activation of the Lats1 tumor suppressor gene in tumors of CUX1 transgenic mice. Molecular Cancer 8:1.
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Valerie Kedinger, Laurent Sansregret, Ryoko Harada, Charles Vadnais, Chantal Cadieux, Kelly Fathers, Morag Park & Alain Nepveu. (2009) p110 CUX1 Homeodomain Protein Stimulates Cell Migration and Invasion in Part through a Regulatory Cascade Culminating in the Repression of E-cadherin and Occludin. Journal of Biological Chemistry 284:40, pages 27701-27711.
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Chantal Cadieux, Valérie Kedinger, Lu Yao, Charles Vadnais, Maria Drossos, Marilène Paquet & Alain Nepveu. (2009) Mouse Mammary Tumor Virus p75 and p110 CUX1 Transgenic Mice Develop Mammary Tumors of Various Histologic Types. Cancer Research 69:18, pages 7188-7197.
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Xi-Feng Fei, Zheng-Hong Qin, Bei Xiang, Ling-Yun Li, Feng Han, Kohji Fukunaga & Zhong-Qin Liang. (2009) Olomoucine inhibits cathepsin L nuclear translocation, activates autophagy and attenuates toxicity of 6-hydroxydopamine. Brain Research 1264, pages 85-97.
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Soji Sebastian, Prethish Sreenivas, Ramkumar Sambasivan, Sirisha Cheedipudi, Prashanth Kandalla, Grace K. Pavlath & Jyotsna Dhawan. (2009) MLL5, a trithorax homolog, indirectly regulates H3K4 methylation, represses cyclin A2 expression, and promotes myogenic differentiation. Proceedings of the National Academy of Sciences 106:12, pages 4719-4724.
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Brian J. Wilson, Ryoko Harada, Lam LeDuy, Morley D. Hollenberg & Alain Nepveu. (2009) CUX1 Transcription Factor Is a Downstream Effector of the Proteinase-activated Receptor 2 (PAR2). Journal of Biological Chemistry 284:1, pages 36-45.
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Chantal Cadieux, Ryoko Harada, Marilène Paquet, Olivier Côté, Marie Trudel, Alain Nepveu & Maxime Bouchard. (2008) Polycystic Kidneys Caused by Sustained Expression of Cux1 Isoform p75. Journal of Biological Chemistry 283:20, pages 13817-13824.
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Brigitte Goulet, Yelena Markovic, Lam Leduy & Alain Nepveu. (2008) Proteolytic Processing of Cut Homeobox 1 by Neutrophil Elastase in the MV4;11 Myeloid Leukemia Cell Line. Molecular Cancer Research 6:4, pages 644-653.
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George Stratigopoulos, Stephanie L. Padilla, Charles A. LeDuc, Elizabeth Watson, Andrew T. Hattersley, Mark I. McCarthy, Lori M. Zeltser, Wendy K. Chung & Rudolph L. Leibel. (2008) Regulation of Fto/Ftm gene expression in mice and humans . American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 294:4, pages R1185-R1196.
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Laurent Sansregret & Alain Nepveu. (2008) The multiple roles of CUX1: Insights from mouse models and cell-based assays. Gene 412:1-2, pages 84-94.
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Mary Truscott, Jean-Bernard Denault, Brigitte Goulet, Lam Leduy, Guy S. Salvesen & Alain Nepveu. (2007) Carboxyl-terminal Proteolytic Processing of CUX1 by a Caspase Enables Transcriptional Activation in Proliferating Cells. Journal of Biological Chemistry 282:41, pages 30216-30226.
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Brigitte Goulet, Laurent Sansregret, Lam Leduy, Matthew Bogyo, Ekkehard Weber, Shyam S. Chauhan & Alain Nepveu. (2007) Increased Expression and Activity of Nuclear Cathepsin L in Cancer Cells Suggests a Novel Mechanism of Cell Transformation. Molecular Cancer Research 5:9, pages 899-907.
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Chantal Cadieux, Sylvie Fournier, Alan C. Peterson, Christian Bédard, Barry J. Bedell & Alain Nepveu. (2006) Transgenic Mice Expressing the p75 CCAAT-Displacement Protein/Cut Homeobox Isoform Develop a Myeloproliferative Disease–Like Myeloid Leukemia. Cancer Research 66:19, pages 9492-9501.
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